LeishMANIAdb
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Phosphoacetylglucosamine mutase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Phosphoacetylglucosamine mutase
Gene product:
N-acetylglucosamine-phosphate mutase - putative
Species:
Leishmania infantum
UniProt:
A4HTA8_LEIIN
TriTrypDb:
LINF_070014200
Length:
597

Annotations

Annotations by Jardim et al.

Carbohydrate metabolism, Phosphoacetylglucosamine mutase-like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HTA8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTA8

Function

Biological processes
Term Name Level Count
GO:0005975 carbohydrate metabolic process 3 11
GO:0006040 amino sugar metabolic process 4 11
GO:0006047 UDP-N-acetylglucosamine metabolic process 4 11
GO:0006048 UDP-N-acetylglucosamine biosynthetic process 5 11
GO:0006139 nucleobase-containing compound metabolic process 3 11
GO:0006725 cellular aromatic compound metabolic process 3 11
GO:0006793 phosphorus metabolic process 3 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0008152 metabolic process 1 11
GO:0009058 biosynthetic process 2 11
GO:0009225 nucleotide-sugar metabolic process 4 11
GO:0009226 nucleotide-sugar biosynthetic process 5 11
GO:0009987 cellular process 1 11
GO:0018130 heterocycle biosynthetic process 4 11
GO:0019438 aromatic compound biosynthetic process 4 11
GO:0034641 cellular nitrogen compound metabolic process 3 11
GO:0034654 nucleobase-containing compound biosynthetic process 4 11
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 11
GO:0044249 cellular biosynthetic process 3 11
GO:0044271 cellular nitrogen compound biosynthetic process 4 11
GO:0044281 small molecule metabolic process 2 11
GO:0046349 amino sugar biosynthetic process 5 11
GO:0046483 heterocycle metabolic process 3 11
GO:0055086 nucleobase-containing small molecule metabolic process 3 11
GO:0071704 organic substance metabolic process 2 11
GO:1901135 carbohydrate derivative metabolic process 3 11
GO:1901137 carbohydrate derivative biosynthetic process 4 11
GO:1901360 organic cyclic compound metabolic process 3 11
GO:1901362 organic cyclic compound biosynthetic process 4 11
GO:1901576 organic substance biosynthetic process 3 11
GO:0006041 glucosamine metabolic process 6 1
GO:1901071 glucosamine-containing compound metabolic process 5 1
Molecular functions
Term Name Level Count
GO:0000287 magnesium ion binding 5 6
GO:0003824 catalytic activity 1 11
GO:0004610 phosphoacetylglucosamine mutase activity 5 11
GO:0005488 binding 1 11
GO:0016853 isomerase activity 2 11
GO:0016866 intramolecular transferase activity 3 11
GO:0016868 intramolecular transferase activity, phosphotransferases 4 11
GO:0043167 ion binding 2 11
GO:0043169 cation binding 3 11
GO:0046872 metal ion binding 4 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 540 544 PF00656 0.313
CLV_MEL_PAP_1 59 65 PF00089 0.451
CLV_NRD_NRD_1 470 472 PF00675 0.511
CLV_NRD_NRD_1 530 532 PF00675 0.332
CLV_PCSK_KEX2_1 24 26 PF00082 0.296
CLV_PCSK_KEX2_1 355 357 PF00082 0.532
CLV_PCSK_KEX2_1 470 472 PF00082 0.511
CLV_PCSK_KEX2_1 530 532 PF00082 0.332
CLV_PCSK_KEX2_1 77 79 PF00082 0.534
CLV_PCSK_PC1ET2_1 24 26 PF00082 0.296
CLV_PCSK_PC1ET2_1 355 357 PF00082 0.532
CLV_PCSK_PC1ET2_1 77 79 PF00082 0.534
CLV_PCSK_SKI1_1 359 363 PF00082 0.505
CLV_PCSK_SKI1_1 450 454 PF00082 0.517
CLV_PCSK_SKI1_1 462 466 PF00082 0.382
CLV_PCSK_SKI1_1 511 515 PF00082 0.385
CLV_PCSK_SKI1_1 530 534 PF00082 0.332
DEG_Nend_UBRbox_2 1 3 PF02207 0.716
DOC_CKS1_1 195 200 PF01111 0.376
DOC_CYCLIN_RxL_1 489 500 PF00134 0.384
DOC_CYCLIN_yCln2_LP_2 55 58 PF00134 0.348
DOC_MAPK_gen_1 355 363 PF00069 0.495
DOC_MAPK_gen_1 508 517 PF00069 0.368
DOC_MAPK_MEF2A_6 508 517 PF00069 0.385
DOC_PP1_RVXF_1 344 351 PF00149 0.336
DOC_PP2B_LxvP_1 55 58 PF13499 0.348
DOC_PP4_FxxP_1 235 238 PF00568 0.367
DOC_PP4_FxxP_1 559 562 PF00568 0.313
DOC_USP7_MATH_1 127 131 PF00917 0.479
DOC_USP7_MATH_1 213 217 PF00917 0.577
DOC_USP7_MATH_1 313 317 PF00917 0.478
DOC_USP7_MATH_1 321 325 PF00917 0.511
DOC_USP7_MATH_1 544 548 PF00917 0.315
DOC_USP7_MATH_1 61 65 PF00917 0.389
DOC_USP7_MATH_1 68 72 PF00917 0.378
DOC_USP7_UBL2_3 355 359 PF12436 0.528
DOC_WW_Pin1_4 194 199 PF00397 0.355
DOC_WW_Pin1_4 215 220 PF00397 0.522
DOC_WW_Pin1_4 234 239 PF00397 0.450
DOC_WW_Pin1_4 311 316 PF00397 0.480
DOC_WW_Pin1_4 37 42 PF00397 0.468
DOC_WW_Pin1_4 523 528 PF00397 0.333
DOC_WW_Pin1_4 531 536 PF00397 0.267
LIG_14-3-3_CanoR_1 185 194 PF00244 0.490
LIG_14-3-3_CanoR_1 273 281 PF00244 0.480
LIG_14-3-3_CanoR_1 62 66 PF00244 0.395
LIG_Actin_WH2_2 11 26 PF00022 0.526
LIG_Actin_WH2_2 171 187 PF00022 0.467
LIG_Actin_WH2_2 56 72 PF00022 0.341
LIG_APCC_ABBA_1 433 438 PF00400 0.358
LIG_APCC_ABBA_1 569 574 PF00400 0.313
LIG_BRCT_BRCA1_1 16 20 PF00533 0.512
LIG_BRCT_BRCA1_1 401 405 PF00533 0.474
LIG_deltaCOP1_diTrp_1 117 122 PF00928 0.380
LIG_FHA_1 178 184 PF00498 0.477
LIG_FHA_1 401 407 PF00498 0.368
LIG_FHA_1 442 448 PF00498 0.371
LIG_FHA_1 563 569 PF00498 0.313
LIG_FHA_1 86 92 PF00498 0.426
LIG_FHA_2 262 268 PF00498 0.472
LIG_FHA_2 281 287 PF00498 0.491
LIG_FHA_2 456 462 PF00498 0.487
LIG_FHA_2 495 501 PF00498 0.457
LIG_FHA_2 524 530 PF00498 0.312
LIG_IBAR_NPY_1 98 100 PF08397 0.457
LIG_LIR_Apic_2 81 86 PF02991 0.371
LIG_LIR_Gen_1 156 162 PF02991 0.551
LIG_LIR_Gen_1 17 27 PF02991 0.492
LIG_LIR_Gen_1 220 229 PF02991 0.485
LIG_LIR_Gen_1 276 285 PF02991 0.442
LIG_LIR_Gen_1 357 368 PF02991 0.405
LIG_LIR_Gen_1 369 380 PF02991 0.452
LIG_LIR_Gen_1 500 509 PF02991 0.348
LIG_LIR_Nem_3 102 108 PF02991 0.389
LIG_LIR_Nem_3 156 160 PF02991 0.564
LIG_LIR_Nem_3 17 23 PF02991 0.499
LIG_LIR_Nem_3 191 195 PF02991 0.446
LIG_LIR_Nem_3 220 225 PF02991 0.393
LIG_LIR_Nem_3 276 281 PF02991 0.438
LIG_LIR_Nem_3 283 287 PF02991 0.335
LIG_LIR_Nem_3 335 340 PF02991 0.336
LIG_LIR_Nem_3 357 363 PF02991 0.404
LIG_LIR_Nem_3 369 375 PF02991 0.438
LIG_LIR_Nem_3 500 504 PF02991 0.329
LIG_LYPXL_yS_3 192 195 PF13949 0.545
LIG_MAD2 346 354 PF02301 0.493
LIG_MLH1_MIPbox_1 16 20 PF16413 0.512
LIG_Pex14_1 501 505 PF04695 0.313
LIG_Pex14_2 15 19 PF04695 0.521
LIG_Rb_pABgroove_1 346 354 PF01858 0.493
LIG_SH2_CRK 157 161 PF00017 0.455
LIG_SH2_CRK 372 376 PF00017 0.375
LIG_SH2_CRK 83 87 PF00017 0.352
LIG_SH2_GRB2like 221 224 PF00017 0.447
LIG_SH2_GRB2like 397 400 PF00017 0.350
LIG_SH2_NCK_1 572 576 PF00017 0.386
LIG_SH2_SRC 397 400 PF00017 0.350
LIG_SH2_SRC 572 575 PF00017 0.356
LIG_SH2_STAP1 372 376 PF00017 0.333
LIG_SH2_STAT3 308 311 PF00017 0.508
LIG_SH2_STAT5 100 103 PF00017 0.380
LIG_SH2_STAT5 157 160 PF00017 0.461
LIG_SH2_STAT5 436 439 PF00017 0.343
LIG_SH2_STAT5 476 479 PF00017 0.406
LIG_SH2_STAT5 73 76 PF00017 0.485
LIG_SH3_3 146 152 PF00018 0.527
LIG_SH3_3 192 198 PF00018 0.446
LIG_SH3_3 35 41 PF00018 0.505
LIG_SUMO_SIM_anti_2 389 395 PF11976 0.501
LIG_SUMO_SIM_par_1 106 111 PF11976 0.309
LIG_SUMO_SIM_par_1 443 449 PF11976 0.508
LIG_TRAF2_1 169 172 PF00917 0.456
LIG_TYR_ITIM 370 375 PF00017 0.371
LIG_UBA3_1 370 378 PF00899 0.453
LIG_WRC_WIRS_1 281 286 PF05994 0.489
MOD_CDK_SPxxK_3 523 530 PF00069 0.333
MOD_CK1_1 130 136 PF00069 0.527
MOD_CK1_1 163 169 PF00069 0.452
MOD_CK1_1 237 243 PF00069 0.567
MOD_CK1_1 40 46 PF00069 0.527
MOD_CK2_1 130 136 PF00069 0.346
MOD_CK2_1 166 172 PF00069 0.451
MOD_CK2_1 261 267 PF00069 0.421
MOD_CK2_1 280 286 PF00069 0.464
MOD_CK2_1 455 461 PF00069 0.560
MOD_CK2_1 523 529 PF00069 0.313
MOD_CK2_1 548 554 PF00069 0.457
MOD_CK2_1 560 566 PF00069 0.313
MOD_CK2_1 576 582 PF00069 0.313
MOD_CMANNOS 119 122 PF00535 0.424
MOD_Cter_Amidation 75 78 PF01082 0.430
MOD_DYRK1A_RPxSP_1 531 535 PF00069 0.282
MOD_GlcNHglycan 130 133 PF01048 0.530
MOD_GlcNHglycan 168 171 PF01048 0.409
MOD_GlcNHglycan 315 318 PF01048 0.540
MOD_GlcNHglycan 319 322 PF01048 0.555
MOD_GlcNHglycan 416 419 PF01048 0.487
MOD_GlcNHglycan 562 565 PF01048 0.313
MOD_GlcNHglycan 584 587 PF01048 0.457
MOD_GSK3_1 184 191 PF00069 0.501
MOD_GSK3_1 213 220 PF00069 0.608
MOD_GSK3_1 269 276 PF00069 0.487
MOD_GSK3_1 295 302 PF00069 0.520
MOD_GSK3_1 313 320 PF00069 0.519
MOD_GSK3_1 332 339 PF00069 0.482
MOD_GSK3_1 441 448 PF00069 0.416
MOD_GSK3_1 450 457 PF00069 0.460
MOD_GSK3_1 544 551 PF00069 0.336
MOD_GSK3_1 576 583 PF00069 0.350
MOD_GSK3_1 81 88 PF00069 0.462
MOD_N-GLC_1 127 132 PF02516 0.421
MOD_N-GLC_1 185 190 PF02516 0.575
MOD_N-GLC_1 269 274 PF02516 0.428
MOD_N-GLC_1 494 499 PF02516 0.511
MOD_NEK2_1 184 189 PF00069 0.511
MOD_NEK2_1 3 8 PF00069 0.667
MOD_NEK2_1 494 499 PF00069 0.478
MOD_NEK2_1 548 553 PF00069 0.427
MOD_NEK2_2 177 182 PF00069 0.528
MOD_NEK2_2 261 266 PF00069 0.340
MOD_NEK2_2 280 285 PF00069 0.362
MOD_NEK2_2 68 73 PF00069 0.398
MOD_PIKK_1 237 243 PF00454 0.613
MOD_PIKK_1 471 477 PF00454 0.361
MOD_PKA_1 355 361 PF00069 0.430
MOD_PKA_2 163 169 PF00069 0.379
MOD_PKA_2 184 190 PF00069 0.490
MOD_PKA_2 355 361 PF00069 0.506
MOD_PKA_2 366 372 PF00069 0.365
MOD_PKA_2 521 527 PF00069 0.424
MOD_PKA_2 560 566 PF00069 0.313
MOD_PKA_2 61 67 PF00069 0.427
MOD_Plk_1 213 219 PF00069 0.401
MOD_Plk_1 295 301 PF00069 0.456
MOD_Plk_1 494 500 PF00069 0.424
MOD_Plk_4 14 20 PF00069 0.461
MOD_Plk_4 217 223 PF00069 0.536
MOD_Plk_4 280 286 PF00069 0.498
MOD_Plk_4 295 301 PF00069 0.458
MOD_Plk_4 366 372 PF00069 0.253
MOD_Plk_4 441 447 PF00069 0.334
MOD_Plk_4 61 67 PF00069 0.410
MOD_ProDKin_1 194 200 PF00069 0.353
MOD_ProDKin_1 215 221 PF00069 0.508
MOD_ProDKin_1 234 240 PF00069 0.455
MOD_ProDKin_1 311 317 PF00069 0.486
MOD_ProDKin_1 37 43 PF00069 0.469
MOD_ProDKin_1 523 529 PF00069 0.333
MOD_ProDKin_1 531 537 PF00069 0.267
MOD_SUMO_for_1 51 54 PF00179 0.350
MOD_SUMO_rev_2 353 361 PF00179 0.501
TRG_ENDOCYTIC_2 157 160 PF00928 0.461
TRG_ENDOCYTIC_2 192 195 PF00928 0.473
TRG_ENDOCYTIC_2 222 225 PF00928 0.535
TRG_ENDOCYTIC_2 372 375 PF00928 0.375
TRG_ER_diArg_1 469 471 PF00400 0.515
TRG_ER_diArg_1 520 523 PF00400 0.341
TRG_NES_CRM1_1 22 36 PF08389 0.495
TRG_Pf-PMV_PEXEL_1 378 382 PF00026 0.512
TRG_Pf-PMV_PEXEL_1 470 475 PF00026 0.406

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I5G0 Leptomonas seymouri 53% 100%
A0A0S4KHH8 Bodo saltans 36% 100%
A0A1X0NPH2 Trypanosomatidae 44% 99%
A0A3R7KD29 Trypanosoma rangeli 45% 98%
A0A3S5H601 Leishmania donovani 100% 100%
A4H3S0 Leishmania braziliensis 84% 100%
C9ZUL6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 99%
E9AL97 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
F1RQM2 Sus scrofa 38% 100%
O95394 Homo sapiens 37% 100%
P38628 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 35% 100%
P57750 Arabidopsis thaliana 35% 100%
Q09687 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 37% 100%
Q09770 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 32% 100%
Q4QIK7 Leishmania major 93% 100%
Q5Z1H8 Nocardia farcinica (strain IFM 10152) 23% 100%
Q6ZDQ1 Oryza sativa subsp. japonica 35% 100%
Q7V349 Prochlorococcus marinus subsp. pastoris (strain CCMP1986 / NIES-2087 / MED4) 23% 100%
Q8SSL7 Encephalitozoon cuniculi (strain GB-M1) 32% 100%
Q9CYR6 Mus musculus 36% 100%
Q9P4V2 Candida albicans 34% 100%
V5B892 Trypanosoma cruzi 43% 98%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS