Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HTA7_LEIIN

TriTrypDb:

LINF_070014100

Length:

352

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HTA7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTA7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	5
GO:0003723	RNA binding	4	5
GO:0005488	binding	1	5
GO:0097159	organic cyclic compound binding	2	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	161	163	PF00675	0.740
CLV_NRD_NRD_1	165	167	PF00675	0.723
CLV_NRD_NRD_1	350	352	PF00675	0.786
CLV_PCSK_KEX2_1	123	125	PF00082	0.655
CLV_PCSK_KEX2_1	350	352	PF00082	0.781
CLV_PCSK_KEX2_1	43	45	PF00082	0.506
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.789
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.506
CLV_PCSK_PC7_1	39	45	PF00082	0.552
DOC_CKS1_1	234	239	PF01111	0.776
DOC_CKS1_1	276	281	PF01111	0.757
DOC_MAPK_gen_1	43	51	PF00069	0.640
DOC_PP2B_LxvP_1	155	158	PF13499	0.683
DOC_PP2B_LxvP_1	280	283	PF13499	0.748
DOC_PP2B_LxvP_1	304	307	PF13499	0.752
DOC_PP4_FxxP_1	341	344	PF00568	0.764
DOC_PP4_MxPP_1	282	285	PF00568	0.643
DOC_USP7_UBL2_3	163	167	PF12436	0.728
DOC_USP7_UBL2_3	86	90	PF12436	0.821
DOC_WW_Pin1_4	170	175	PF00397	0.828
DOC_WW_Pin1_4	187	192	PF00397	0.625
DOC_WW_Pin1_4	233	238	PF00397	0.764
DOC_WW_Pin1_4	272	277	PF00397	0.659
DOC_WW_Pin1_4	289	294	PF00397	0.638
DOC_WW_Pin1_4	334	339	PF00397	0.653
DOC_WW_Pin1_4	5	10	PF00397	0.560
DOC_WW_Pin1_4	73	78	PF00397	0.655
DOC_WW_Pin1_4	85	90	PF00397	0.616
LIG_14-3-3_CanoR_1	20	30	PF00244	0.476
LIG_14-3-3_CanoR_1	65	73	PF00244	0.649
LIG_BIR_II_1	1	5	PF00653	0.693
LIG_EVH1_1	341	345	PF00568	0.764
LIG_FHA_1	138	144	PF00498	0.737
LIG_FHA_1	178	184	PF00498	0.745
LIG_LIR_Apic_2	271	276	PF02991	0.668
LIG_LIR_Gen_1	264	273	PF02991	0.654
LIG_LIR_Gen_1	57	66	PF02991	0.617
LIG_LIR_Gen_1	8	19	PF02991	0.527
LIG_LIR_Nem_3	264	269	PF02991	0.672
LIG_LIR_Nem_3	28	34	PF02991	0.303
LIG_LIR_Nem_3	50	56	PF02991	0.497
LIG_LIR_Nem_3	57	61	PF02991	0.391
LIG_LIR_Nem_3	8	14	PF02991	0.631
LIG_PROFILIN_1	293	299	PF00235	0.769
LIG_PROFILIN_1	318	324	PF00235	0.762
LIG_PROFILIN_1	96	102	PF00235	0.689
LIG_SH2_CRK	266	270	PF00017	0.833
LIG_SH2_CRK	273	277	PF00017	0.700
LIG_SH2_NCK_1	273	277	PF00017	0.761
LIG_SH2_STAT3	118	121	PF00017	0.713
LIG_SH2_STAT5	273	276	PF00017	0.667
LIG_SH2_STAT5	30	33	PF00017	0.628
LIG_SH3_1	273	279	PF00018	0.754
LIG_SH3_1	90	96	PF00018	0.730
LIG_SH3_2	345	350	PF14604	0.758
LIG_SH3_3	146	152	PF00018	0.806
LIG_SH3_3	188	194	PF00018	0.804
LIG_SH3_3	198	204	PF00018	0.537
LIG_SH3_3	253	259	PF00018	0.782
LIG_SH3_3	273	279	PF00018	0.646
LIG_SH3_3	290	296	PF00018	0.685
LIG_SH3_3	309	315	PF00018	0.785
LIG_SH3_3	316	322	PF00018	0.633
LIG_SH3_3	339	345	PF00018	0.640
LIG_SH3_3	90	96	PF00018	0.800
LIG_SH3_3	99	105	PF00018	0.661
LIG_SH3_CIN85_PxpxPR_1	345	350	PF14604	0.758
LIG_TYR_ITIM	51	56	PF00017	0.601
LIG_WW_3	347	351	PF00397	0.766
MOD_CDK_SPK_2	187	192	PF00069	0.685
MOD_CDK_SPK_2	5	10	PF00069	0.625
MOD_CDK_SPK_2	85	90	PF00069	0.808
MOD_CDK_SPxK_1	334	340	PF00069	0.654
MOD_CK1_1	268	274	PF00069	0.659
MOD_CK1_1	275	281	PF00069	0.650
MOD_CK1_1	334	340	PF00069	0.785
MOD_CK1_1	88	94	PF00069	0.829
MOD_CK2_1	187	193	PF00069	0.816
MOD_CK2_1	66	72	PF00069	0.607
MOD_GlcNHglycan	15	18	PF01048	0.593
MOD_GlcNHglycan	286	289	PF01048	0.801
MOD_GlcNHglycan	334	337	PF01048	0.801
MOD_GlcNHglycan	35	38	PF01048	0.628
MOD_GSK3_1	1	8	PF00069	0.757
MOD_GSK3_1	133	140	PF00069	0.624
MOD_GSK3_1	229	236	PF00069	0.667
MOD_GSK3_1	261	268	PF00069	0.818
MOD_GSK3_1	271	278	PF00069	0.674
MOD_GSK3_1	284	291	PF00069	0.565
MOD_GSK3_1	327	334	PF00069	0.796
MOD_N-GLC_1	331	336	PF02516	0.663
MOD_NEK2_1	1	6	PF00069	0.678
MOD_NEK2_1	13	18	PF00069	0.394
MOD_NEK2_1	308	313	PF00069	0.797
MOD_PIKK_1	100	106	PF00454	0.605
MOD_PIKK_1	107	113	PF00454	0.518
MOD_PIKK_1	116	122	PF00454	0.549
MOD_PIKK_1	135	141	PF00454	0.481
MOD_PIKK_1	66	72	PF00454	0.652
MOD_PIKK_1	88	94	PF00454	0.829
MOD_PKA_2	308	314	PF00069	0.793
MOD_PKB_1	124	132	PF00069	0.786
MOD_Plk_1	126	132	PF00069	0.784
MOD_Plk_4	229	235	PF00069	0.719
MOD_ProDKin_1	170	176	PF00069	0.828
MOD_ProDKin_1	187	193	PF00069	0.619
MOD_ProDKin_1	233	239	PF00069	0.769
MOD_ProDKin_1	272	278	PF00069	0.658
MOD_ProDKin_1	289	295	PF00069	0.635
MOD_ProDKin_1	334	340	PF00069	0.654
MOD_ProDKin_1	5	11	PF00069	0.546
MOD_ProDKin_1	73	79	PF00069	0.658
MOD_ProDKin_1	85	91	PF00069	0.620
MOD_SUMO_rev_2	160	168	PF00179	0.691
TRG_ENDOCYTIC_2	11	14	PF00928	0.599
TRG_ENDOCYTIC_2	266	269	PF00928	0.678
TRG_ENDOCYTIC_2	53	56	PF00928	0.596
TRG_ER_diArg_1	349	351	PF00400	0.774

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H600	Leishmania donovani	93%	95%
E9AL96	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QIK8	Leishmania major	88%	100%