Flavoprotein subunit-like protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

flavoprotein subunit-like protein

Species:

Leishmania infantum

UniProt:

A4HTA6_LEIIN

TriTrypDb:

LINF_070013900

Length:

567

Annotations

Annotations by Jardim et al.

Membrane associated proteins, Flavo subunit-like

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HTA6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTA6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0005488	binding	1	8
GO:0016491	oxidoreductase activity	2	8
GO:0020037	heme binding	4	6
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0046906	tetrapyrrole binding	3	6
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8
GO:0000166	nucleotide binding	3	2
GO:0010181	FMN binding	4	2
GO:0032553	ribonucleotide binding	3	2
GO:0036094	small molecule binding	2	2
GO:0043168	anion binding	3	2
GO:0097367	carbohydrate derivative binding	2	2
GO:1901265	nucleoside phosphate binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	372	376	PF00656	0.417
CLV_C14_Caspase3-7	481	485	PF00656	0.598
CLV_NRD_NRD_1	208	210	PF00675	0.369
CLV_PCSK_KEX2_1	208	210	PF00082	0.405
CLV_PCSK_KEX2_1	251	253	PF00082	0.420
CLV_PCSK_KEX2_1	299	301	PF00082	0.450
CLV_PCSK_KEX2_1	312	314	PF00082	0.381
CLV_PCSK_KEX2_1	491	493	PF00082	0.583
CLV_PCSK_PC1ET2_1	251	253	PF00082	0.420
CLV_PCSK_PC1ET2_1	299	301	PF00082	0.433
CLV_PCSK_PC1ET2_1	312	314	PF00082	0.287
CLV_PCSK_PC1ET2_1	491	493	PF00082	0.583
CLV_PCSK_PC7_1	247	253	PF00082	0.416
CLV_PCSK_SKI1_1	300	304	PF00082	0.413
CLV_PCSK_SKI1_1	334	338	PF00082	0.369
CLV_PCSK_SKI1_1	422	426	PF00082	0.512
CLV_PCSK_SKI1_1	488	492	PF00082	0.593
CLV_PCSK_SKI1_1	66	70	PF00082	0.347
DEG_ODPH_VHL_1	354	367	PF01847	0.466
DOC_CYCLIN_RxL_1	419	427	PF00134	0.500
DOC_CYCLIN_RxL_1	509	520	PF00134	0.466
DOC_MAPK_gen_1	38	46	PF00069	0.417
DOC_PP1_RVXF_1	20	26	PF00149	0.466
DOC_USP7_MATH_1	321	325	PF00917	0.416
DOC_USP7_MATH_1	465	469	PF00917	0.721
DOC_WW_Pin1_4	220	225	PF00397	0.373
DOC_WW_Pin1_4	325	330	PF00397	0.457
DOC_WW_Pin1_4	475	480	PF00397	0.773
DOC_WW_Pin1_4	554	559	PF00397	0.417
LIG_14-3-3_CanoR_1	300	309	PF00244	0.466
LIG_BIR_II_1	1	5	PF00653	0.305
LIG_BIR_III_2	476	480	PF00653	0.761
LIG_BRCT_BRCA1_1	303	307	PF00533	0.341
LIG_Clathr_ClatBox_1	156	160	PF01394	0.417
LIG_deltaCOP1_diTrp_1	10	16	PF00928	0.438
LIG_eIF4E_1	244	250	PF01652	0.369
LIG_FHA_1	265	271	PF00498	0.291
LIG_FHA_1	419	425	PF00498	0.487
LIG_FHA_1	45	51	PF00498	0.369
LIG_FHA_1	517	523	PF00498	0.417
LIG_FHA_1	84	90	PF00498	0.403
LIG_FHA_2	134	140	PF00498	0.369
LIG_FHA_2	479	485	PF00498	0.702
LIG_FHA_2	492	498	PF00498	0.336
LIG_GBD_Chelix_1	510	518	PF00786	0.466
LIG_LIR_Apic_2	427	431	PF02991	0.556
LIG_LIR_Gen_1	223	234	PF02991	0.466
LIG_LIR_Gen_1	439	449	PF02991	0.581
LIG_LIR_Gen_1	47	56	PF02991	0.429
LIG_LIR_Gen_1	505	516	PF02991	0.420
LIG_LIR_Gen_1	541	552	PF02991	0.417
LIG_LIR_Nem_3	223	229	PF02991	0.417
LIG_LIR_Nem_3	273	277	PF02991	0.369
LIG_LIR_Nem_3	335	340	PF02991	0.395
LIG_LIR_Nem_3	439	444	PF02991	0.517
LIG_LIR_Nem_3	47	51	PF02991	0.466
LIG_LIR_Nem_3	505	511	PF02991	0.420
LIG_LIR_Nem_3	541	547	PF02991	0.417
LIG_MAD2	72	80	PF02301	0.426
LIG_PCNA_yPIPBox_3	398	411	PF02747	0.341
LIG_Pex14_1	11	15	PF04695	0.535
LIG_Pex14_2	111	115	PF04695	0.417
LIG_Pex14_2	303	307	PF04695	0.291
LIG_SH2_CRK	412	416	PF00017	0.509
LIG_SH2_CRK	428	432	PF00017	0.526
LIG_SH2_CRK	48	52	PF00017	0.466
LIG_SH2_GRB2like	15	18	PF00017	0.486
LIG_SH2_NCK_1	48	52	PF00017	0.466
LIG_SH2_NCK_1	493	497	PF00017	0.466
LIG_SH2_STAP1	441	445	PF00017	0.567
LIG_SH2_STAT5	15	18	PF00017	0.536
LIG_SH2_STAT5	226	229	PF00017	0.482
LIG_SH2_STAT5	244	247	PF00017	0.171
LIG_SH2_STAT5	350	353	PF00017	0.350
LIG_SH2_STAT5	360	363	PF00017	0.310
LIG_SH2_STAT5	386	389	PF00017	0.466
LIG_SH2_STAT5	423	426	PF00017	0.464
LIG_SH2_STAT5	493	496	PF00017	0.466
LIG_SH2_STAT5	556	559	PF00017	0.417
LIG_SH3_3	169	175	PF00018	0.363
LIG_SH3_3	447	453	PF00018	0.599
LIG_SH3_3	455	461	PF00018	0.623
LIG_SH3_3	520	526	PF00018	0.417
LIG_SH3_3	544	550	PF00018	0.466
LIG_SH3_3	74	80	PF00018	0.439
LIG_TYR_ITIM	410	415	PF00017	0.511
LIG_TYR_ITIM	46	51	PF00017	0.466
LIG_UBA3_1	306	312	PF00899	0.291
LIG_UBA3_1	50	59	PF00899	0.369
MOD_CK1_1	325	331	PF00069	0.465
MOD_CK1_1	472	478	PF00069	0.753
MOD_CK1_1	5	11	PF00069	0.398
MOD_CK1_1	538	544	PF00069	0.341
MOD_CK2_1	230	236	PF00069	0.466
MOD_CK2_1	252	258	PF00069	0.350
MOD_CK2_1	49	55	PF00069	0.482
MOD_CK2_1	491	497	PF00069	0.388
MOD_GlcNHglycan	166	169	PF01048	0.432
MOD_GlcNHglycan	212	215	PF01048	0.390
MOD_GlcNHglycan	231	235	PF01048	0.437
MOD_GlcNHglycan	254	257	PF01048	0.369
MOD_GlcNHglycan	291	294	PF01048	0.466
MOD_GlcNHglycan	4	7	PF01048	0.436
MOD_GlcNHglycan	470	474	PF01048	0.599
MOD_GlcNHglycan	51	54	PF01048	0.370
MOD_GSK3_1	128	135	PF00069	0.420
MOD_GSK3_1	260	267	PF00069	0.433
MOD_GSK3_1	27	34	PF00069	0.358
MOD_GSK3_1	321	328	PF00069	0.460
MOD_GSK3_1	465	472	PF00069	0.674
MOD_LATS_1	29	35	PF00433	0.417
MOD_N-GLC_1	516	521	PF02516	0.466
MOD_NEK2_1	133	138	PF00069	0.377
MOD_NEK2_1	270	275	PF00069	0.362
MOD_NEK2_1	302	307	PF00069	0.341
MOD_NEK2_1	332	337	PF00069	0.461
MOD_NEK2_1	424	429	PF00069	0.490
MOD_NEK2_1	44	49	PF00069	0.342
MOD_PKA_1	491	497	PF00069	0.369
MOD_PKA_2	2	8	PF00069	0.445
MOD_PKA_2	491	497	PF00069	0.466
MOD_PKB_1	64	72	PF00069	0.416
MOD_Plk_1	117	123	PF00069	0.381
MOD_Plk_2-3	341	347	PF00069	0.466
MOD_Plk_4	118	124	PF00069	0.347
MOD_Plk_4	302	308	PF00069	0.341
MOD_Plk_4	332	338	PF00069	0.355
MOD_Plk_4	402	408	PF00069	0.335
MOD_Plk_4	424	430	PF00069	0.501
MOD_Plk_4	436	442	PF00069	0.541
MOD_Plk_4	528	534	PF00069	0.417
MOD_ProDKin_1	220	226	PF00069	0.373
MOD_ProDKin_1	325	331	PF00069	0.457
MOD_ProDKin_1	475	481	PF00069	0.773
MOD_ProDKin_1	554	560	PF00069	0.417
MOD_SUMO_for_1	265	268	PF00179	0.291
MOD_SUMO_rev_2	369	378	PF00179	0.466
MOD_SUMO_rev_2	463	471	PF00179	0.598
MOD_SUMO_rev_2	484	490	PF00179	0.570
TRG_ENDOCYTIC_2	226	229	PF00928	0.466
TRG_ENDOCYTIC_2	412	415	PF00928	0.518
TRG_ENDOCYTIC_2	441	444	PF00928	0.517
TRG_ENDOCYTIC_2	48	51	PF00928	0.417
TRG_ER_diArg_1	64	67	PF00400	0.416

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5C0	Leptomonas seymouri	36%	94%
A0A0S4IHN0	Bodo saltans	40%	100%
A0A0S4KND3	Bodo saltans	51%	100%
A0A1X0NPF8	Trypanosomatidae	56%	84%
A0A3S7WPX2	Leishmania donovani	100%	85%
A0A3S7X915	Leishmania donovani	34%	100%
A0A422MX37	Trypanosoma rangeli	33%	86%
A4HME0	Leishmania braziliensis	35%	100%
A4HME1	Leishmania braziliensis	35%	100%
A4IB13	Leishmania infantum	34%	100%
E9AEU2	Leishmania major	35%	100%
E9AL95	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9B5Z8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
F8DIF2	Streptococcus parasanguinis (strain ATCC 15912 / DSM 6778 / CIP 104372 / LMG 14537)	32%	71%
O13755	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	100%
P0C278	Shewanella frigidimarina	33%	99%
P21375	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	100%
P32614	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	100%
P83223	Shewanella oneidensis (strain MR-1)	35%	95%
Q07WU7	Shewanella frigidimarina (strain NCIMB 400)	33%	95%
Q4QIK9	Leishmania major	95%	100%
Q8CVD0	Shewanella oneidensis (strain MR-1)	31%	97%
Q8DW88	Streptococcus mutans serotype c (strain ATCC 700610 / UA159)	28%	71%
Q9Z4P0	Shewanella frigidimarina (strain NCIMB 400)	31%	96%