Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HTA5_LEIIN

TriTrypDb:

LINF_070013800

Length:

325

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HTA5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTA5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	299	303	PF00656	0.505
CLV_NRD_NRD_1	138	140	PF00675	0.614
CLV_NRD_NRD_1	142	144	PF00675	0.577
CLV_NRD_NRD_1	220	222	PF00675	0.662
CLV_NRD_NRD_1	308	310	PF00675	0.511
CLV_PCSK_KEX2_1	137	139	PF00082	0.729
CLV_PCSK_KEX2_1	144	146	PF00082	0.475
CLV_PCSK_KEX2_1	220	222	PF00082	0.662
CLV_PCSK_KEX2_1	308	310	PF00082	0.511
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.670
CLV_PCSK_SKI1_1	117	121	PF00082	0.683
DOC_CKS1_1	192	197	PF01111	0.776
DOC_MAPK_gen_1	271	280	PF00069	0.675
DOC_PP2B_LxvP_1	103	106	PF13499	0.710
DOC_PP2B_LxvP_1	42	45	PF13499	0.740
DOC_PP4_FxxP_1	40	43	PF00568	0.614
DOC_USP7_MATH_1	10	14	PF00917	0.648
DOC_USP7_MATH_1	24	28	PF00917	0.507
DOC_USP7_MATH_1	258	262	PF00917	0.760
DOC_USP7_MATH_1	4	8	PF00917	0.700
DOC_WW_Pin1_4	160	165	PF00397	0.751
DOC_WW_Pin1_4	18	23	PF00397	0.562
DOC_WW_Pin1_4	191	196	PF00397	0.781
DOC_WW_Pin1_4	29	34	PF00397	0.530
DOC_WW_Pin1_4	319	324	PF00397	0.733
LIG_14-3-3_CanoR_1	203	208	PF00244	0.669
LIG_14-3-3_CanoR_1	273	280	PF00244	0.556
LIG_BIR_II_1	1	5	PF00653	0.714
LIG_CaM_IQ_9	213	228	PF13499	0.627
LIG_EVH1_1	40	44	PF00568	0.756
LIG_FHA_1	114	120	PF00498	0.515
LIG_FHA_1	192	198	PF00498	0.768
LIG_FHA_1	214	220	PF00498	0.656
LIG_FHA_1	254	260	PF00498	0.742
LIG_FHA_1	78	84	PF00498	0.676
LIG_FHA_1	93	99	PF00498	0.398
LIG_FHA_2	179	185	PF00498	0.749
LIG_FHA_2	235	241	PF00498	0.653
LIG_GBD_Chelix_1	287	295	PF00786	0.552
LIG_LIR_Apic_2	38	43	PF02991	0.615
LIG_PCNA_yPIPBox_3	68	78	PF02747	0.566
LIG_SH2_SRC	313	316	PF00017	0.575
LIG_SH2_STAT5	313	316	PF00017	0.575
LIG_SH3_3	189	195	PF00018	0.780
LIG_SH3_3	27	33	PF00018	0.658
LIG_SH3_3	38	44	PF00018	0.760
LIG_SUMO_SIM_anti_2	284	290	PF11976	0.643
LIG_TRAF2_1	45	48	PF00917	0.583
LIG_TRFH_1	40	44	PF08558	0.612
MOD_CK1_1	191	197	PF00069	0.754
MOD_CK1_1	199	205	PF00069	0.658
MOD_CK1_1	2	8	PF00069	0.639
MOD_CK1_1	244	250	PF00069	0.818
MOD_CK1_1	304	310	PF00069	0.626
MOD_CK1_1	58	64	PF00069	0.583
MOD_CK2_1	174	180	PF00069	0.752
MOD_CK2_1	234	240	PF00069	0.719
MOD_CK2_1	248	254	PF00069	0.730
MOD_CK2_1	91	97	PF00069	0.552
MOD_GlcNHglycan	168	171	PF01048	0.791
MOD_GlcNHglycan	176	179	PF01048	0.608
MOD_GlcNHglycan	251	254	PF01048	0.791
MOD_GlcNHglycan	256	259	PF01048	0.686
MOD_GlcNHglycan	26	29	PF01048	0.563
MOD_GlcNHglycan	280	283	PF01048	0.539
MOD_GlcNHglycan	297	301	PF01048	0.376
MOD_GSK3_1	10	17	PF00069	0.611
MOD_GSK3_1	162	169	PF00069	0.731
MOD_GSK3_1	174	181	PF00069	0.789
MOD_GSK3_1	184	191	PF00069	0.662
MOD_GSK3_1	199	206	PF00069	0.668
MOD_GSK3_1	24	31	PF00069	0.601
MOD_GSK3_1	240	247	PF00069	0.716
MOD_GSK3_1	249	256	PF00069	0.665
MOD_N-GLC_1	53	58	PF02516	0.733
MOD_NEK2_1	188	193	PF00069	0.590
MOD_NEK2_1	278	283	PF00069	0.598
MOD_NEK2_1	77	82	PF00069	0.534
MOD_NEK2_1	91	96	PF00069	0.466
MOD_PIKK_1	213	219	PF00454	0.674
MOD_PK_1	301	307	PF00069	0.493
MOD_PKA_2	307	313	PF00069	0.622
MOD_Plk_1	301	307	PF00069	0.655
MOD_Plk_1	53	59	PF00069	0.612
MOD_ProDKin_1	160	166	PF00069	0.745
MOD_ProDKin_1	18	24	PF00069	0.563
MOD_ProDKin_1	191	197	PF00069	0.779
MOD_ProDKin_1	29	35	PF00069	0.528
MOD_ProDKin_1	319	325	PF00069	0.745
TRG_ER_diArg_1	137	139	PF00400	0.775
TRG_ER_diArg_1	142	145	PF00400	0.530
TRG_ER_diArg_1	219	221	PF00400	0.701
TRG_ER_diArg_1	308	311	PF00400	0.512
TRG_NLS_MonoExtN_4	142	147	PF00514	0.675
TRG_Pf-PMV_PEXEL_1	230	235	PF00026	0.644
TRG_Pf-PMV_PEXEL_1	55	60	PF00026	0.701

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDZ9	Leptomonas seymouri	40%	100%
A0A3S7WPY2	Leishmania donovani	99%	100%
A4H531	Leishmania braziliensis	69%	99%
E9AL94	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%
Q4QIL0	Leishmania major	89%	100%