J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HTA4_LEIIN

TriTrypDb:

LINF_070013700

Length:

565

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4HTA4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTA4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	142	144	PF00675	0.594
CLV_NRD_NRD_1	149	151	PF00675	0.539
CLV_NRD_NRD_1	236	238	PF00675	0.725
CLV_NRD_NRD_1	421	423	PF00675	0.348
CLV_NRD_NRD_1	467	469	PF00675	0.378
CLV_NRD_NRD_1	474	476	PF00675	0.414
CLV_NRD_NRD_1	481	483	PF00675	0.374
CLV_NRD_NRD_1	560	562	PF00675	0.454
CLV_PCSK_FUR_1	419	423	PF00082	0.406
CLV_PCSK_KEX2_1	142	144	PF00082	0.594
CLV_PCSK_KEX2_1	149	151	PF00082	0.539
CLV_PCSK_KEX2_1	176	178	PF00082	0.480
CLV_PCSK_KEX2_1	236	238	PF00082	0.725
CLV_PCSK_KEX2_1	29	31	PF00082	0.418
CLV_PCSK_KEX2_1	421	423	PF00082	0.350
CLV_PCSK_KEX2_1	454	456	PF00082	0.365
CLV_PCSK_KEX2_1	473	475	PF00082	0.304
CLV_PCSK_KEX2_1	481	483	PF00082	0.410
CLV_PCSK_PC1ET2_1	176	178	PF00082	0.480
CLV_PCSK_PC1ET2_1	29	31	PF00082	0.393
CLV_PCSK_PC1ET2_1	454	456	PF00082	0.449
CLV_PCSK_SKI1_1	172	176	PF00082	0.422
CLV_PCSK_SKI1_1	221	225	PF00082	0.610
CLV_PCSK_SKI1_1	451	455	PF00082	0.402
CLV_PCSK_SKI1_1	554	558	PF00082	0.427
DEG_Nend_UBRbox_1	1	4	PF02207	0.616
DEG_SPOP_SBC_1	112	116	PF00917	0.415
DOC_ANK_TNKS_1	238	245	PF00023	0.476
DOC_ANK_TNKS_1	319	326	PF00023	0.337
DOC_MAPK_DCC_7	95	105	PF00069	0.417
DOC_MAPK_gen_1	95	105	PF00069	0.417
DOC_MAPK_MEF2A_6	98	105	PF00069	0.412
DOC_PP4_FxxP_1	321	324	PF00568	0.343
DOC_PP4_FxxP_1	464	467	PF00568	0.540
DOC_USP7_MATH_1	112	116	PF00917	0.544
DOC_USP7_MATH_1	303	307	PF00917	0.414
DOC_USP7_MATH_1	345	349	PF00917	0.362
DOC_USP7_MATH_1	516	520	PF00917	0.679
DOC_USP7_MATH_1	522	526	PF00917	0.695
DOC_USP7_MATH_1	533	537	PF00917	0.648
DOC_USP7_MATH_1	542	546	PF00917	0.468
DOC_USP7_MATH_1	69	73	PF00917	0.411
DOC_USP7_MATH_1	94	98	PF00917	0.445
DOC_USP7_UBL2_3	172	176	PF12436	0.253
DOC_USP7_UBL2_3	218	222	PF12436	0.335
DOC_WW_Pin1_4	10	15	PF00397	0.661
DOC_WW_Pin1_4	238	243	PF00397	0.453
DOC_WW_Pin1_4	305	310	PF00397	0.376
DOC_WW_Pin1_4	406	411	PF00397	0.664
DOC_WW_Pin1_4	491	496	PF00397	0.704
DOC_WW_Pin1_4	75	80	PF00397	0.520
LIG_14-3-3_CanoR_1	142	151	PF00244	0.404
LIG_14-3-3_CanoR_1	198	202	PF00244	0.226
LIG_14-3-3_CanoR_1	30	38	PF00244	0.715
LIG_14-3-3_CanoR_1	307	313	PF00244	0.406
LIG_14-3-3_CanoR_1	488	496	PF00244	0.678
LIG_14-3-3_CanoR_1	56	60	PF00244	0.272
LIG_14-3-3_CanoR_1	88	96	PF00244	0.524
LIG_14-3-3_CterR_2	561	565	PF00244	0.658
LIG_APCC_ABBA_1	68	73	PF00400	0.333
LIG_BIR_III_4	188	192	PF00653	0.222
LIG_BRCT_BRCA1_1	295	299	PF00533	0.455
LIG_BRCT_BRCA1_1	338	342	PF00533	0.387
LIG_BRCT_BRCA1_1	4	8	PF00533	0.656
LIG_CtBP_PxDLS_1	102	106	PF00389	0.358
LIG_deltaCOP1_diTrp_1	351	358	PF00928	0.516
LIG_EH_1	301	305	PF12763	0.392
LIG_EVH1_2	242	246	PF00568	0.475
LIG_FHA_1	104	110	PF00498	0.476
LIG_FHA_1	338	344	PF00498	0.454
LIG_FHA_2	150	156	PF00498	0.313
LIG_FHA_2	208	214	PF00498	0.324
LIG_LIR_Gen_1	152	160	PF02991	0.318
LIG_LIR_Gen_1	200	209	PF02991	0.248
LIG_LIR_Nem_3	152	156	PF02991	0.326
LIG_LIR_Nem_3	200	206	PF02991	0.248
LIG_LIR_Nem_3	308	313	PF02991	0.480
LIG_SH2_GRB2like	286	289	PF00017	0.420
LIG_SH2_NCK_1	248	252	PF00017	0.513
LIG_SH2_NCK_1	313	317	PF00017	0.406
LIG_SH2_SRC	415	418	PF00017	0.552
LIG_SH2_STAT3	266	269	PF00017	0.402
LIG_SH2_STAT3	417	420	PF00017	0.637
LIG_SH2_STAT5	335	338	PF00017	0.259
LIG_SH2_STAT5	405	408	PF00017	0.689
LIG_SH3_1	237	243	PF00018	0.559
LIG_SH3_1	248	254	PF00018	0.428
LIG_SH3_2	4	9	PF14604	0.567
LIG_SH3_3	1	7	PF00018	0.654
LIG_SH3_3	237	243	PF00018	0.559
LIG_SH3_3	248	254	PF00018	0.428
LIG_SH3_3	525	531	PF00018	0.742
LIG_SH3_3	536	542	PF00018	0.658
LIG_SH3_3	54	60	PF00018	0.432
LIG_SH3_3	78	84	PF00018	0.491
LIG_SUMO_SIM_par_1	101	108	PF11976	0.358
LIG_SUMO_SIM_par_1	161	166	PF11976	0.278
LIG_TRAF2_1	545	548	PF00917	0.637
LIG_TYR_ITIM	201	206	PF00017	0.222
LIG_TYR_ITIM	333	338	PF00017	0.278
LIG_UBA3_1	556	562	PF00899	0.605
MOD_CDC14_SPxK_1	83	86	PF00782	0.422
MOD_CDK_SPxK_1	80	86	PF00069	0.421
MOD_CDK_SPxxK_3	406	413	PF00069	0.658
MOD_CK1_1	104	110	PF00069	0.487
MOD_CK1_1	113	119	PF00069	0.499
MOD_CK1_1	15	21	PF00069	0.593
MOD_CK1_1	207	213	PF00069	0.253
MOD_CK1_1	228	234	PF00069	0.460
MOD_CK1_1	308	314	PF00069	0.409
MOD_CK1_1	399	405	PF00069	0.696
MOD_CK1_1	484	490	PF00069	0.712
MOD_CK1_1	491	497	PF00069	0.674
MOD_CK2_1	149	155	PF00069	0.347
MOD_CK2_1	207	213	PF00069	0.232
MOD_CK2_1	487	493	PF00069	0.691
MOD_CK2_1	542	548	PF00069	0.650
MOD_Cter_Amidation	147	150	PF01082	0.626
MOD_GlcNHglycan	115	118	PF01048	0.675
MOD_GlcNHglycan	128	131	PF01048	0.705
MOD_GlcNHglycan	132	135	PF01048	0.666
MOD_GlcNHglycan	14	17	PF01048	0.483
MOD_GlcNHglycan	225	228	PF01048	0.638
MOD_GlcNHglycan	231	234	PF01048	0.644
MOD_GlcNHglycan	295	298	PF01048	0.662
MOD_GlcNHglycan	458	462	PF01048	0.407
MOD_GlcNHglycan	483	486	PF01048	0.472
MOD_GlcNHglycan	524	528	PF01048	0.531
MOD_GlcNHglycan	92	95	PF01048	0.733
MOD_GSK3_1	101	108	PF00069	0.437
MOD_GSK3_1	12	19	PF00069	0.626
MOD_GSK3_1	126	133	PF00069	0.508
MOD_GSK3_1	225	232	PF00069	0.405
MOD_GSK3_1	484	491	PF00069	0.745
MOD_GSK3_1	69	76	PF00069	0.481
MOD_GSK3_1	90	97	PF00069	0.543
MOD_LATS_1	27	33	PF00433	0.544
MOD_LATS_1	291	297	PF00433	0.453
MOD_N-GLC_1	491	496	PF02516	0.418
MOD_N-GLC_1	533	538	PF02516	0.480
MOD_NEK2_1	103	108	PF00069	0.413
MOD_NEK2_1	126	131	PF00069	0.525
MOD_NEK2_1	223	228	PF00069	0.431
MOD_NEK2_1	336	341	PF00069	0.311
MOD_NEK2_1	360	365	PF00069	0.524
MOD_NEK2_1	38	43	PF00069	0.621
MOD_PKA_1	149	155	PF00069	0.371
MOD_PKA_1	29	35	PF00069	0.590
MOD_PKA_1	481	487	PF00069	0.683
MOD_PKA_2	149	155	PF00069	0.376
MOD_PKA_2	197	203	PF00069	0.226
MOD_PKA_2	204	210	PF00069	0.216
MOD_PKA_2	29	35	PF00069	0.651
MOD_PKA_2	358	364	PF00069	0.623
MOD_PKA_2	481	487	PF00069	0.686
MOD_PKA_2	55	61	PF00069	0.354
MOD_PKA_2	94	100	PF00069	0.557
MOD_PKB_1	86	94	PF00069	0.424
MOD_Plk_1	163	169	PF00069	0.278
MOD_Plk_1	192	198	PF00069	0.296
MOD_Plk_1	533	539	PF00069	0.680
MOD_Plk_4	323	329	PF00069	0.222
MOD_Plk_4	337	343	PF00069	0.297
MOD_Plk_4	534	540	PF00069	0.744
MOD_ProDKin_1	10	16	PF00069	0.661
MOD_ProDKin_1	238	244	PF00069	0.453
MOD_ProDKin_1	305	311	PF00069	0.369
MOD_ProDKin_1	406	412	PF00069	0.660
MOD_ProDKin_1	491	497	PF00069	0.706
MOD_ProDKin_1	75	81	PF00069	0.521
MOD_SUMO_rev_2	164	174	PF00179	0.262
MOD_SUMO_rev_2	213	219	PF00179	0.391
TRG_DiLeu_BaLyEn_6	60	65	PF01217	0.664
TRG_ENDOCYTIC_2	178	181	PF00928	0.249
TRG_ENDOCYTIC_2	203	206	PF00928	0.249
TRG_ENDOCYTIC_2	335	338	PF00928	0.259
TRG_ER_diArg_1	149	151	PF00400	0.402
TRG_ER_diArg_1	236	238	PF00400	0.525
TRG_ER_diArg_1	318	321	PF00400	0.371
TRG_ER_diArg_1	400	403	PF00400	0.735
TRG_ER_diArg_1	419	422	PF00400	0.500
TRG_ER_diArg_1	473	475	PF00400	0.659
TRG_NES_CRM1_1	155	168	PF08389	0.334
TRG_NLS_MonoExtC_3	174	179	PF00514	0.315
TRG_NLS_MonoExtN_4	172	179	PF00514	0.315

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYH8	Leptomonas seymouri	63%	100%
A0A1X0NR65	Trypanosomatidae	44%	100%
A0A3R7NAN2	Trypanosoma rangeli	44%	100%
A4H530	Leishmania braziliensis	78%	100%
C9ZUL9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
V5BTE7	Trypanosoma cruzi	37%	100%