DNAJ-domain transmembrane-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNAJ-domain transmembrane-like protein

Species:

Leishmania infantum

UniProt:

A4HTA3_LEIIN

TriTrypDb:

LINF_070013600

Length:

608

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HTA3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HTA3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	233	237	PF00656	0.698
CLV_C14_Caspase3-7	309	313	PF00656	0.768
CLV_C14_Caspase3-7	406	410	PF00656	0.687
CLV_C14_Caspase3-7	43	47	PF00656	0.446
CLV_C14_Caspase3-7	585	589	PF00656	0.644
CLV_C14_Caspase3-7	80	84	PF00656	0.657
CLV_NRD_NRD_1	142	144	PF00675	0.508
CLV_NRD_NRD_1	175	177	PF00675	0.493
CLV_NRD_NRD_1	255	257	PF00675	0.597
CLV_NRD_NRD_1	601	603	PF00675	0.481
CLV_NRD_NRD_1	68	70	PF00675	0.470
CLV_NRD_NRD_1	78	80	PF00675	0.476
CLV_PCSK_KEX2_1	142	144	PF00082	0.508
CLV_PCSK_KEX2_1	175	177	PF00082	0.493
CLV_PCSK_KEX2_1	255	257	PF00082	0.597
CLV_PCSK_KEX2_1	600	602	PF00082	0.494
CLV_PCSK_KEX2_1	77	79	PF00082	0.508
CLV_PCSK_PC1ET2_1	600	602	PF00082	0.494
CLV_PCSK_SKI1_1	133	137	PF00082	0.508
CLV_PCSK_SKI1_1	2	6	PF00082	0.451
CLV_PCSK_SKI1_1	558	562	PF00082	0.406
CLV_PCSK_SKI1_1	69	73	PF00082	0.430
DEG_COP1_1	329	339	PF00400	0.715
DEG_SCF_FBW7_1	244	250	PF00400	0.703
DEG_SCF_FBW7_1	85	92	PF00400	0.678
DEG_SPOP_SBC_1	121	125	PF00917	0.637
DEG_SPOP_SBC_1	235	239	PF00917	0.824
DEG_SPOP_SBC_1	311	315	PF00917	0.791
DEG_SPOP_SBC_1	39	43	PF00917	0.467
DOC_CKS1_1	244	249	PF01111	0.705
DOC_CYCLIN_RxL_1	344	355	PF00134	0.649
DOC_MAPK_MEF2A_6	558	567	PF00069	0.406
DOC_MAPK_RevD_3	128	143	PF00069	0.673
DOC_PP2B_LxvP_1	511	514	PF13499	0.520
DOC_PP2B_LxvP_1	538	541	PF13499	0.578
DOC_USP7_MATH_1	10	14	PF00917	0.631
DOC_USP7_MATH_1	112	116	PF00917	0.614
DOC_USP7_MATH_1	214	218	PF00917	0.675
DOC_USP7_MATH_1	222	226	PF00917	0.713
DOC_USP7_MATH_1	231	235	PF00917	0.692
DOC_USP7_MATH_1	247	251	PF00917	0.757
DOC_USP7_MATH_1	272	276	PF00917	0.792
DOC_USP7_MATH_1	288	292	PF00917	0.725
DOC_USP7_MATH_1	296	300	PF00917	0.667
DOC_USP7_MATH_1	310	314	PF00917	0.710
DOC_USP7_MATH_1	335	339	PF00917	0.670
DOC_USP7_MATH_1	49	53	PF00917	0.295
DOC_USP7_MATH_1	518	522	PF00917	0.549
DOC_USP7_MATH_1	89	93	PF00917	0.743
DOC_WW_Pin1_4	203	208	PF00397	0.770
DOC_WW_Pin1_4	212	217	PF00397	0.708
DOC_WW_Pin1_4	243	248	PF00397	0.737
DOC_WW_Pin1_4	274	279	PF00397	0.762
DOC_WW_Pin1_4	469	474	PF00397	0.517
DOC_WW_Pin1_4	85	90	PF00397	0.718
DOC_WW_Pin1_4	93	98	PF00397	0.676
LIG_14-3-3_CanoR_1	106	113	PF00244	0.638
LIG_14-3-3_CanoR_1	133	141	PF00244	0.678
LIG_14-3-3_CanoR_1	17	25	PF00244	0.525
LIG_14-3-3_CanoR_1	438	444	PF00244	0.732
LIG_14-3-3_CanoR_1	510	514	PF00244	0.575
LIG_14-3-3_CanoR_1	515	521	PF00244	0.510
LIG_14-3-3_CanoR_1	69	76	PF00244	0.644
LIG_14-3-3_CanoR_1	77	82	PF00244	0.641
LIG_Actin_WH2_2	400	418	PF00022	0.562
LIG_CSL_BTD_1	538	541	PF09270	0.535
LIG_EH1_1	545	553	PF00400	0.475
LIG_FHA_1	134	140	PF00498	0.662
LIG_FHA_1	204	210	PF00498	0.786
LIG_FHA_1	275	281	PF00498	0.705
LIG_FHA_1	33	39	PF00498	0.586
LIG_FHA_1	331	337	PF00498	0.720
LIG_FHA_1	346	352	PF00498	0.626
LIG_FHA_1	43	49	PF00498	0.228
LIG_FHA_1	469	475	PF00498	0.549
LIG_FHA_1	479	485	PF00498	0.423
LIG_FHA_1	571	577	PF00498	0.470
LIG_FHA_2	231	237	PF00498	0.696
LIG_FHA_2	320	326	PF00498	0.798
LIG_FHA_2	393	399	PF00498	0.652
LIG_FHA_2	41	47	PF00498	0.453
LIG_FHA_2	415	421	PF00498	0.651
LIG_FHA_2	438	444	PF00498	0.736
LIG_GBD_Chelix_1	563	571	PF00786	0.470
LIG_LIR_Apic_2	536	542	PF02991	0.537
LIG_LIR_Gen_1	206	216	PF02991	0.661
LIG_LIR_Gen_1	338	346	PF02991	0.670
LIG_LIR_Gen_1	395	405	PF02991	0.682
LIG_LIR_Gen_1	545	552	PF02991	0.563
LIG_LIR_Nem_3	206	211	PF02991	0.668
LIG_LIR_Nem_3	338	342	PF02991	0.679
LIG_LIR_Nem_3	395	400	PF02991	0.677
LIG_LIR_Nem_3	457	462	PF02991	0.406
LIG_LIR_Nem_3	545	549	PF02991	0.564
LIG_Pex14_1	465	469	PF04695	0.516
LIG_RPA_C_Fungi	25	37	PF08784	0.295
LIG_SH2_CRK	147	151	PF00017	0.534
LIG_SH2_CRK	371	375	PF00017	0.601
LIG_SH2_CRK	397	401	PF00017	0.642
LIG_SH2_CRK	528	532	PF00017	0.669
LIG_SH2_NCK_1	258	262	PF00017	0.690
LIG_SH2_STAP1	258	262	PF00017	0.690
LIG_SH2_STAP1	397	401	PF00017	0.588
LIG_SH2_STAP1	559	563	PF00017	0.470
LIG_SH2_STAT5	87	90	PF00017	0.591
LIG_SH3_3	241	247	PF00018	0.713
LIG_SH3_3	92	98	PF00018	0.571
LIG_SxIP_EBH_1	51	63	PF03271	0.247
LIG_TRAF2_1	322	325	PF00917	0.780
LIG_TYR_ITIM	526	531	PF00017	0.677
LIG_WRC_WIRS_1	336	341	PF05994	0.559
MOD_CK1_1	117	123	PF00069	0.658
MOD_CK1_1	225	231	PF00069	0.687
MOD_CK1_1	234	240	PF00069	0.678
MOD_CK1_1	250	256	PF00069	0.791
MOD_CK1_1	260	266	PF00069	0.672
MOD_CK1_1	313	319	PF00069	0.741
MOD_CK1_1	437	443	PF00069	0.681
MOD_CK1_1	487	493	PF00069	0.585
MOD_CK2_1	313	319	PF00069	0.797
MOD_CK2_1	335	341	PF00069	0.580
MOD_CK2_1	414	420	PF00069	0.568
MOD_CK2_1	437	443	PF00069	0.681
MOD_Cter_Amidation	598	601	PF01082	0.599
MOD_GlcNHglycan	153	156	PF01048	0.678
MOD_GlcNHglycan	183	186	PF01048	0.516
MOD_GlcNHglycan	212	215	PF01048	0.653
MOD_GlcNHglycan	227	230	PF01048	0.649
MOD_GlcNHglycan	233	236	PF01048	0.731
MOD_GlcNHglycan	259	262	PF01048	0.686
MOD_GlcNHglycan	27	30	PF01048	0.333
MOD_GlcNHglycan	274	277	PF01048	0.824
MOD_GlcNHglycan	290	293	PF01048	0.559
MOD_GlcNHglycan	307	311	PF01048	0.714
MOD_GlcNHglycan	315	318	PF01048	0.583
MOD_GlcNHglycan	403	406	PF01048	0.607
MOD_GlcNHglycan	456	459	PF01048	0.492
MOD_GlcNHglycan	486	489	PF01048	0.720
MOD_GlcNHglycan	51	54	PF01048	0.314
MOD_GlcNHglycan	535	538	PF01048	0.694
MOD_GlcNHglycan	584	587	PF01048	0.560
MOD_GSK3_1	117	124	PF00069	0.676
MOD_GSK3_1	210	217	PF00069	0.747
MOD_GSK3_1	227	234	PF00069	0.537
MOD_GSK3_1	243	250	PF00069	0.736
MOD_GSK3_1	25	32	PF00069	0.348
MOD_GSK3_1	256	263	PF00069	0.661
MOD_GSK3_1	268	275	PF00069	0.681
MOD_GSK3_1	306	313	PF00069	0.737
MOD_GSK3_1	38	45	PF00069	0.513
MOD_GSK3_1	434	441	PF00069	0.623
MOD_GSK3_1	474	481	PF00069	0.690
MOD_GSK3_1	49	56	PF00069	0.274
MOD_GSK3_1	529	536	PF00069	0.705
MOD_GSK3_1	83	90	PF00069	0.661
MOD_LATS_1	75	81	PF00433	0.562
MOD_N-GLC_1	393	398	PF02516	0.591
MOD_NEK2_1	210	215	PF00069	0.791
MOD_NEK2_1	25	30	PF00069	0.295
MOD_NEK2_1	434	439	PF00069	0.692
MOD_NEK2_1	468	473	PF00069	0.723
MOD_NEK2_1	551	556	PF00069	0.585
MOD_NEK2_1	71	76	PF00069	0.630
MOD_NEK2_2	247	252	PF00069	0.692
MOD_PIKK_1	122	128	PF00454	0.555
MOD_PIKK_1	133	139	PF00454	0.570
MOD_PIKK_1	198	204	PF00454	0.727
MOD_PIKK_1	490	496	PF00454	0.563
MOD_PK_1	77	83	PF00069	0.563
MOD_PKA_1	69	75	PF00069	0.540
MOD_PKA_1	77	83	PF00069	0.538
MOD_PKA_2	105	111	PF00069	0.538
MOD_PKA_2	11	17	PF00069	0.622
MOD_PKA_2	29	35	PF00069	0.228
MOD_PKA_2	319	325	PF00069	0.690
MOD_PKA_2	437	443	PF00069	0.681
MOD_PKA_2	509	515	PF00069	0.733
MOD_PKA_2	593	599	PF00069	0.597
MOD_PKA_2	77	83	PF00069	0.563
MOD_PKB_1	15	23	PF00069	0.590
MOD_Plk_1	393	399	PF00069	0.592
MOD_Plk_2-3	319	325	PF00069	0.754
MOD_Plk_4	222	228	PF00069	0.690
MOD_Plk_4	570	576	PF00069	0.486
MOD_ProDKin_1	203	209	PF00069	0.717
MOD_ProDKin_1	212	218	PF00069	0.630
MOD_ProDKin_1	243	249	PF00069	0.670
MOD_ProDKin_1	274	280	PF00069	0.705
MOD_ProDKin_1	469	475	PF00069	0.647
MOD_ProDKin_1	85	91	PF00069	0.646
MOD_ProDKin_1	93	99	PF00069	0.585
MOD_SUMO_rev_2	319	327	PF00179	0.783
TRG_DiLeu_BaEn_1	443	448	PF01217	0.635
TRG_ENDOCYTIC_2	343	346	PF00928	0.571
TRG_ENDOCYTIC_2	371	374	PF00928	0.603
TRG_ENDOCYTIC_2	397	400	PF00928	0.641
TRG_ENDOCYTIC_2	528	531	PF00928	0.681
TRG_ER_diArg_1	141	143	PF00400	0.630
TRG_ER_diArg_1	76	79	PF00400	0.621
TRG_NES_CRM1_1	341	355	PF08389	0.603
TRG_Pf-PMV_PEXEL_1	133	137	PF00026	0.628
TRG_Pf-PMV_PEXEL_1	372	377	PF00026	0.686
TRG_Pf-PMV_PEXEL_1	69	73	PF00026	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WPX9	Leishmania donovani	100%	100%
A4H529	Leishmania braziliensis	71%	100%
E9AL92	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QIL2	Leishmania major	90%	100%