Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HT90_LEIIN

TriTrypDb:

LINF_070012200

Length:

519

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HT90

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HT90

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	333	337	PF00656	0.480
CLV_C14_Caspase3-7	52	56	PF00656	0.718
CLV_NRD_NRD_1	214	216	PF00675	0.329
CLV_PCSK_KEX2_1	214	216	PF00082	0.329
CLV_PCSK_KEX2_1	370	372	PF00082	0.405
CLV_PCSK_PC1ET2_1	370	372	PF00082	0.405
CLV_PCSK_PC7_1	210	216	PF00082	0.348
CLV_PCSK_SKI1_1	468	472	PF00082	0.459
CLV_PCSK_SKI1_1	75	79	PF00082	0.409
DEG_APCC_DBOX_1	463	471	PF00400	0.537
DEG_APCC_DBOX_1	74	82	PF00400	0.436
DEG_Nend_Nbox_1	1	3	PF02207	0.438
DEG_SPOP_SBC_1	56	60	PF00917	0.567
DOC_CDC14_PxL_1	147	155	PF14671	0.498
DOC_CYCLIN_RxL_1	464	475	PF00134	0.461
DOC_CYCLIN_yCln2_LP_2	42	45	PF00134	0.567
DOC_MAPK_DCC_7	370	380	PF00069	0.480
DOC_MAPK_DCC_7	75	83	PF00069	0.483
DOC_MAPK_gen_1	484	491	PF00069	0.595
DOC_MAPK_HePTP_8	367	379	PF00069	0.524
DOC_MAPK_MEF2A_6	370	379	PF00069	0.503
DOC_MAPK_MEF2A_6	405	413	PF00069	0.491
DOC_MAPK_RevD_3	356	371	PF00069	0.348
DOC_PP1_RVXF_1	486	492	PF00149	0.592
DOC_PP2B_LxvP_1	41	44	PF13499	0.536
DOC_USP7_MATH_1	101	105	PF00917	0.659
DOC_USP7_MATH_1	12	16	PF00917	0.440
DOC_USP7_MATH_1	229	233	PF00917	0.541
DOC_USP7_MATH_1	241	245	PF00917	0.643
DOC_USP7_MATH_1	307	311	PF00917	0.499
DOC_USP7_MATH_1	324	328	PF00917	0.542
DOC_USP7_MATH_1	33	37	PF00917	0.494
DOC_USP7_MATH_1	423	427	PF00917	0.684
DOC_USP7_MATH_1	56	60	PF00917	0.681
DOC_WW_Pin1_4	119	124	PF00397	0.651
DOC_WW_Pin1_4	249	254	PF00397	0.631
DOC_WW_Pin1_4	27	32	PF00397	0.609
DOC_WW_Pin1_4	320	325	PF00397	0.482
DOC_WW_Pin1_4	361	366	PF00397	0.550
DOC_WW_Pin1_4	397	402	PF00397	0.613
LIG_14-3-3_CanoR_1	230	234	PF00244	0.457
LIG_14-3-3_CanoR_1	238	247	PF00244	0.509
LIG_14-3-3_CanoR_1	26	33	PF00244	0.599
LIG_14-3-3_CanoR_1	305	315	PF00244	0.522
LIG_APCC_ABBA_1	412	417	PF00400	0.484
LIG_BIR_III_4	434	438	PF00653	0.421
LIG_CAP-Gly_1	516	519	PF01302	0.537
LIG_eIF4E_1	147	153	PF01652	0.396
LIG_eIF4E_1	37	43	PF01652	0.455
LIG_FHA_1	137	143	PF00498	0.478
LIG_FHA_1	249	255	PF00498	0.575
LIG_FHA_1	460	466	PF00498	0.484
LIG_FHA_1	58	64	PF00498	0.731
LIG_FHA_2	185	191	PF00498	0.442
LIG_FHA_2	331	337	PF00498	0.497
LIG_FHA_2	361	367	PF00498	0.549
LIG_FHA_2	427	433	PF00498	0.610
LIG_FHA_2	480	486	PF00498	0.481
LIG_FHA_2	60	66	PF00498	0.713
LIG_HP1_1	259	263	PF01393	0.474
LIG_IRF3_LxIS_1	391	398	PF10401	0.317
LIG_LIR_Gen_1	144	154	PF02991	0.373
LIG_LIR_Gen_1	285	295	PF02991	0.362
LIG_LIR_Gen_1	35	45	PF02991	0.538
LIG_LIR_Nem_3	138	143	PF02991	0.354
LIG_LIR_Nem_3	144	150	PF02991	0.395
LIG_LIR_Nem_3	34	40	PF02991	0.542
LIG_LIR_Nem_3	445	450	PF02991	0.428
LIG_LIR_Nem_3	475	481	PF02991	0.567
LIG_MYND_1	119	123	PF01753	0.624
LIG_NRBOX	390	396	PF00104	0.370
LIG_Pex14_1	283	287	PF04695	0.334
LIG_SH2_CRK	143	147	PF00017	0.377
LIG_SH2_CRK	308	312	PF00017	0.427
LIG_SH2_CRK	38	42	PF00017	0.514
LIG_SH2_CRK	447	451	PF00017	0.499
LIG_SH2_NCK_1	147	151	PF00017	0.400
LIG_SH2_NCK_1	223	227	PF00017	0.509
LIG_SH2_NCK_1	308	312	PF00017	0.476
LIG_SH2_SRC	147	150	PF00017	0.407
LIG_SH2_STAP1	143	147	PF00017	0.358
LIG_SH2_STAP1	223	227	PF00017	0.500
LIG_SH2_STAP1	284	288	PF00017	0.441
LIG_SH2_STAP1	38	42	PF00017	0.514
LIG_SH2_STAT5	284	287	PF00017	0.455
LIG_SH2_STAT5	308	311	PF00017	0.477
LIG_SH2_STAT5	481	484	PF00017	0.606
LIG_SH3_3	148	154	PF00018	0.502
LIG_SH3_3	301	307	PF00018	0.333
LIG_SH3_3	460	466	PF00018	0.504
LIG_SUMO_SIM_anti_2	39	44	PF11976	0.528
LIG_SUMO_SIM_par_1	257	264	PF11976	0.379
LIG_SUMO_SIM_par_1	376	383	PF11976	0.467
LIG_TRFH_1	76	80	PF08558	0.500
LIG_TYR_ITIM	145	150	PF00017	0.384
LIG_TYR_ITIM	306	311	PF00017	0.421
LIG_TYR_ITSM	443	450	PF00017	0.328
LIG_UBA3_1	1	8	PF00899	0.594
MOD_CK1_1	181	187	PF00069	0.533
MOD_CK1_1	193	199	PF00069	0.464
MOD_CK1_1	249	255	PF00069	0.632
MOD_CK1_1	310	316	PF00069	0.495
MOD_CK1_1	323	329	PF00069	0.465
MOD_CK1_1	36	42	PF00069	0.478
MOD_CK1_1	426	432	PF00069	0.617
MOD_CK1_1	46	52	PF00069	0.632
MOD_CK1_1	59	65	PF00069	0.729
MOD_CK1_1	99	105	PF00069	0.623
MOD_CK2_1	101	107	PF00069	0.538
MOD_CK2_1	119	125	PF00069	0.520
MOD_CK2_1	184	190	PF00069	0.678
MOD_CK2_1	360	366	PF00069	0.488
MOD_CK2_1	426	432	PF00069	0.667
MOD_CK2_1	446	452	PF00069	0.295
MOD_CK2_1	474	480	PF00069	0.528
MOD_CK2_1	59	65	PF00069	0.724
MOD_GlcNHglycan	104	107	PF01048	0.784
MOD_GlcNHglycan	207	210	PF01048	0.472
MOD_GlcNHglycan	224	227	PF01048	0.447
MOD_GlcNHglycan	243	246	PF01048	0.754
MOD_GlcNHglycan	248	251	PF01048	0.673
MOD_GlcNHglycan	326	329	PF01048	0.655
MOD_GlcNHglycan	387	390	PF01048	0.441
MOD_GlcNHglycan	397	400	PF01048	0.494
MOD_GlcNHglycan	429	432	PF01048	0.651
MOD_GlcNHglycan	439	442	PF01048	0.567
MOD_GlcNHglycan	48	51	PF01048	0.690
MOD_GSK3_1	119	126	PF00069	0.551
MOD_GSK3_1	177	184	PF00069	0.520
MOD_GSK3_1	186	193	PF00069	0.524
MOD_GSK3_1	217	224	PF00069	0.369
MOD_GSK3_1	248	255	PF00069	0.598
MOD_GSK3_1	27	34	PF00069	0.558
MOD_GSK3_1	306	313	PF00069	0.464
MOD_GSK3_1	316	323	PF00069	0.446
MOD_GSK3_1	423	430	PF00069	0.695
MOD_GSK3_1	44	51	PF00069	0.568
MOD_GSK3_1	442	449	PF00069	0.280
MOD_GSK3_1	55	62	PF00069	0.730
MOD_GSK3_1	92	99	PF00069	0.591
MOD_N-GLC_1	102	107	PF02516	0.537
MOD_N-GLC_2	490	492	PF02516	0.461
MOD_NEK2_1	205	210	PF00069	0.479
MOD_NEK2_1	25	30	PF00069	0.487
MOD_NEK2_1	360	365	PF00069	0.432
MOD_NEK2_1	395	400	PF00069	0.521
MOD_NEK2_2	459	464	PF00069	0.325
MOD_PIKK_1	12	18	PF00454	0.439
MOD_PIKK_1	442	448	PF00454	0.557
MOD_PKA_2	136	142	PF00069	0.418
MOD_PKA_2	229	235	PF00069	0.488
MOD_PKA_2	25	31	PF00069	0.488
MOD_PKA_2	65	71	PF00069	0.494
MOD_Plk_1	474	480	PF00069	0.595
MOD_Plk_2-3	474	480	PF00069	0.644
MOD_Plk_4	274	280	PF00069	0.458
MOD_Plk_4	291	297	PF00069	0.285
MOD_Plk_4	310	316	PF00069	0.228
MOD_Plk_4	33	39	PF00069	0.527
MOD_ProDKin_1	119	125	PF00069	0.650
MOD_ProDKin_1	249	255	PF00069	0.626
MOD_ProDKin_1	27	33	PF00069	0.605
MOD_ProDKin_1	320	326	PF00069	0.488
MOD_ProDKin_1	361	367	PF00069	0.547
MOD_ProDKin_1	397	403	PF00069	0.612
TRG_DiLeu_BaEn_2	339	345	PF01217	0.342
TRG_DiLeu_BaLyEn_6	148	153	PF01217	0.505
TRG_ENDOCYTIC_2	143	146	PF00928	0.365
TRG_ENDOCYTIC_2	147	150	PF00928	0.388
TRG_ENDOCYTIC_2	284	287	PF00928	0.363
TRG_ENDOCYTIC_2	308	311	PF00928	0.431
TRG_ENDOCYTIC_2	353	356	PF00928	0.470
TRG_ENDOCYTIC_2	37	40	PF00928	0.469
TRG_ENDOCYTIC_2	447	450	PF00928	0.499
TRG_ER_diArg_1	214	216	PF00400	0.329
TRG_ER_diArg_1	3	6	PF00400	0.456
TRG_ER_diArg_1	486	489	PF00400	0.598
TRG_NES_CRM1_1	347	361	PF08389	0.469
TRG_Pf-PMV_PEXEL_1	173	177	PF00026	0.507
TRG_Pf-PMV_PEXEL_1	61	65	PF00026	0.512

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHX1	Leptomonas seymouri	53%	100%
A0A1X0NPG1	Trypanosomatidae	26%	100%
A0A3S5H5Z0	Leishmania donovani	100%	100%
A0A422N3S3	Trypanosoma rangeli	31%	100%
A4H517	Leishmania braziliensis	67%	99%
C9ZUN4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AL79	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QIM5	Leishmania major	89%	100%
V5BTD2	Trypanosoma cruzi	28%	100%