NPL domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HT85_LEIIN

TriTrypDb:

LINF_070011600

Length:

195

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HT85

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HT85

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	130	132	PF00675	0.682
CLV_PCSK_KEX2_1	130	132	PF00082	0.678
DEG_Nend_Nbox_1	1	3	PF02207	0.583
DOC_MAPK_HePTP_8	54	66	PF00069	0.535
DOC_MAPK_MEF2A_6	11	19	PF00069	0.511
DOC_MAPK_MEF2A_6	57	66	PF00069	0.504
DOC_PP1_RVXF_1	95	102	PF00149	0.390
DOC_PP4_FxxP_1	19	22	PF00568	0.531
DOC_PP4_FxxP_1	95	98	PF00568	0.481
DOC_SPAK_OSR1_1	74	78	PF12202	0.486
DOC_USP7_MATH_1	113	117	PF00917	0.735
DOC_USP7_MATH_1	179	183	PF00917	0.595
DOC_USP7_MATH_1	33	37	PF00917	0.461
DOC_USP7_MATH_1	40	44	PF00917	0.647
DOC_USP7_MATH_1	46	50	PF00917	0.751
DOC_USP7_MATH_1	76	80	PF00917	0.483
DOC_WW_Pin1_4	115	120	PF00397	0.743
DOC_WW_Pin1_4	48	53	PF00397	0.741
DOC_WW_Pin1_4	57	62	PF00397	0.522
DOC_WW_Pin1_4	78	83	PF00397	0.420
LIG_eIF4E_1	88	94	PF01652	0.419
LIG_FHA_1	153	159	PF00498	0.441
LIG_FHA_1	23	29	PF00498	0.423
LIG_FHA_1	33	39	PF00498	0.388
LIG_FHA_1	61	67	PF00498	0.416
LIG_LIR_Apic_2	18	22	PF02991	0.538
LIG_LIR_Gen_1	100	105	PF02991	0.381
LIG_LIR_Nem_3	100	104	PF02991	0.373
LIG_LIR_Nem_3	150	156	PF02991	0.529
LIG_LIR_Nem_3	87	91	PF02991	0.423
LIG_LYPXL_yS_3	153	156	PF13949	0.468
LIG_SH2_CRK	59	63	PF00017	0.493
LIG_SH2_CRK	88	92	PF00017	0.448
LIG_SH2_NCK_1	162	166	PF00017	0.598
LIG_SH2_NCK_1	59	63	PF00017	0.493
LIG_SH2_STAP1	162	166	PF00017	0.583
LIG_SH2_STAT5	88	91	PF00017	0.416
LIG_SH3_3	34	40	PF00018	0.546
LIG_SH3_3	99	105	PF00018	0.498
LIG_SUMO_SIM_par_1	25	30	PF11976	0.467
LIG_TRAF2_2	40	45	PF00917	0.617
LIG_TRFH_1	101	105	PF08558	0.457
LIG_TYR_ITIM	86	91	PF00017	0.398
MOD_CK1_1	117	123	PF00069	0.768
MOD_CK1_1	60	66	PF00069	0.516
MOD_CK2_1	189	195	PF00069	0.654
MOD_Cter_Amidation	125	128	PF01082	0.697
MOD_GSK3_1	113	120	PF00069	0.453
MOD_GSK3_1	152	159	PF00069	0.447
MOD_GSK3_1	23	30	PF00069	0.377
MOD_GSK3_1	93	100	PF00069	0.385
MOD_N-GLC_1	135	140	PF02516	0.650
MOD_NEK2_1	27	32	PF00069	0.350
MOD_NEK2_1	93	98	PF00069	0.416
MOD_PIKK_1	27	33	PF00454	0.444
MOD_Plk_2-3	189	195	PF00069	0.659
MOD_Plk_4	23	29	PF00069	0.365
MOD_Plk_4	33	39	PF00069	0.405
MOD_Plk_4	97	103	PF00069	0.456
MOD_ProDKin_1	115	121	PF00069	0.743
MOD_ProDKin_1	48	54	PF00069	0.736
MOD_ProDKin_1	57	63	PF00069	0.518
MOD_ProDKin_1	78	84	PF00069	0.427
TRG_ENDOCYTIC_2	153	156	PF00928	0.468
TRG_ENDOCYTIC_2	59	62	PF00928	0.495
TRG_ENDOCYTIC_2	88	91	PF00928	0.396
TRG_NLS_MonoExtC_3	126	131	PF00514	0.547
TRG_NLS_MonoExtN_4	125	131	PF00514	0.550

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4E4	Leptomonas seymouri	62%	98%
A0A0S4JAK6	Bodo saltans	34%	100%
A0A1X0NPD6	Trypanosomatidae	34%	100%
A0A3S7WPW4	Leishmania donovani	100%	100%
A0A422N682	Trypanosoma rangeli	40%	93%
A4H511	Leishmania braziliensis	80%	100%
C9ZUN9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AL73	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QIN1	Leishmania major	94%	100%
V5B8I1	Trypanosoma cruzi	36%	71%