LeishMANIAdb
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SEL1 protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
SEL1 protein
Gene product:
Sel1 repeat - putative
Species:
Leishmania infantum
UniProt:
A4HT83_LEIIN
TriTrypDb:
LINF_070011400
Length:
831

Annotations

LeishMANIAdb annotations

Fast evolving protein with mostly disordered structure. Possibly coat proteins.

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 2
NetGPI no yes: 0, no: 2
Cellular components
Term Name Level Count
GO:0005789 endoplasmic reticulum membrane 4 1
GO:0016020 membrane 2 1
GO:0031090 organelle membrane 3 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HT83
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HT83

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0006950 response to stress 2 1
GO:0008152 metabolic process 1 1
GO:0009056 catabolic process 2 1
GO:0009057 macromolecule catabolic process 4 1
GO:0009987 cellular process 1 1
GO:0010033 response to organic substance 3 1
GO:0010243 response to organonitrogen compound 4 1
GO:0010498 proteasomal protein catabolic process 5 1
GO:0019538 protein metabolic process 3 1
GO:0030163 protein catabolic process 4 1
GO:0033554 cellular response to stress 3 1
GO:0034976 response to endoplasmic reticulum stress 4 1
GO:0036503 ERAD pathway 5 1
GO:0042221 response to chemical 2 1
GO:0043170 macromolecule metabolic process 3 1
GO:0044238 primary metabolic process 2 1
GO:0050896 response to stimulus 1 1
GO:0051603 proteolysis involved in protein catabolic process 5 1
GO:0051716 cellular response to stimulus 2 1
GO:0071704 organic substance metabolic process 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
GO:1901565 organonitrogen compound catabolic process 4 1
GO:1901575 organic substance catabolic process 3 1
GO:1901698 response to nitrogen compound 3 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 218 222 PF00656 0.836
CLV_C14_Caspase3-7 393 397 PF00656 0.876
CLV_C14_Caspase3-7 402 406 PF00656 0.692
CLV_C14_Caspase3-7 41 45 PF00656 0.549
CLV_C14_Caspase3-7 462 466 PF00656 0.658
CLV_NRD_NRD_1 100 102 PF00675 0.648
CLV_NRD_NRD_1 138 140 PF00675 0.549
CLV_NRD_NRD_1 179 181 PF00675 0.549
CLV_NRD_NRD_1 274 276 PF00675 0.549
CLV_NRD_NRD_1 96 98 PF00675 0.722
CLV_PCSK_FUR_1 379 383 PF00082 0.856
CLV_PCSK_KEX2_1 100 102 PF00082 0.718
CLV_PCSK_KEX2_1 138 140 PF00082 0.549
CLV_PCSK_KEX2_1 179 181 PF00082 0.549
CLV_PCSK_KEX2_1 274 276 PF00082 0.549
CLV_PCSK_KEX2_1 381 383 PF00082 0.862
CLV_PCSK_KEX2_1 768 770 PF00082 0.844
CLV_PCSK_PC1ET2_1 381 383 PF00082 0.629
CLV_PCSK_PC1ET2_1 768 770 PF00082 0.844
CLV_PCSK_SKI1_1 179 183 PF00082 0.549
CLV_PCSK_SKI1_1 274 278 PF00082 0.549
CLV_PCSK_SKI1_1 279 283 PF00082 0.462
CLV_PCSK_SKI1_1 532 536 PF00082 0.644
CLV_PCSK_SKI1_1 769 773 PF00082 0.838
CLV_Separin_Metazoa 621 625 PF03568 0.775
DEG_APCC_DBOX_1 100 108 PF00400 0.679
DEG_Nend_Nbox_1 1 3 PF02207 0.437
DEG_SPOP_SBC_1 446 450 PF00917 0.773
DOC_CYCLIN_RxL_1 270 278 PF00134 0.549
DOC_CYCLIN_RxL_1 310 321 PF00134 0.639
DOC_CYCLIN_RxL_1 97 106 PF00134 0.699
DOC_CYCLIN_yCln2_LP_2 501 507 PF00134 0.466
DOC_MAPK_gen_1 21 28 PF00069 0.549
DOC_MAPK_gen_1 75 84 PF00069 0.811
DOC_MAPK_gen_1 97 107 PF00069 0.693
DOC_MAPK_MEF2A_6 21 28 PF00069 0.491
DOC_MAPK_MEF2A_6 692 699 PF00069 0.712
DOC_MAPK_NFAT4_5 21 29 PF00069 0.549
DOC_PP4_FxxP_1 410 413 PF00568 0.788
DOC_USP7_MATH_1 377 381 PF00917 0.616
DOC_USP7_MATH_1 403 407 PF00917 0.617
DOC_USP7_MATH_1 466 470 PF00917 0.620
DOC_USP7_MATH_1 493 497 PF00917 0.759
DOC_USP7_MATH_1 520 524 PF00917 0.430
DOC_USP7_MATH_1 54 58 PF00917 0.771
DOC_USP7_MATH_1 732 736 PF00917 0.842
DOC_USP7_MATH_1 91 95 PF00917 0.742
DOC_WW_Pin1_4 168 173 PF00397 0.549
DOC_WW_Pin1_4 482 487 PF00397 0.733
DOC_WW_Pin1_4 509 514 PF00397 0.510
DOC_WW_Pin1_4 557 562 PF00397 0.549
DOC_WW_Pin1_4 645 650 PF00397 0.790
DOC_WW_Pin1_4 724 729 PF00397 0.844
LIG_14-3-3_CanoR_1 320 325 PF00244 0.668
LIG_14-3-3_CanoR_1 412 421 PF00244 0.734
LIG_14-3-3_CanoR_1 664 670 PF00244 0.752
LIG_BIR_III_4 796 800 PF00653 0.765
LIG_BRCT_BRCA1_1 647 651 PF00533 0.782
LIG_BRCT_BRCA1_1 80 84 PF00533 0.794
LIG_CaM_IQ_9 703 719 PF13499 0.704
LIG_EH1_1 712 720 PF00400 0.520
LIG_eIF4E_1 254 260 PF01652 0.549
LIG_FHA_1 402 408 PF00498 0.616
LIG_FHA_1 446 452 PF00498 0.760
LIG_FHA_1 603 609 PF00498 0.749
LIG_FHA_1 682 688 PF00498 0.580
LIG_FHA_1 778 784 PF00498 0.531
LIG_FHA_2 216 222 PF00498 0.824
LIG_LIR_Apic_2 803 807 PF02991 0.511
LIG_LIR_Gen_1 121 131 PF02991 0.549
LIG_LIR_Gen_1 4 12 PF02991 0.639
LIG_LIR_Gen_1 416 427 PF02991 0.712
LIG_LIR_Gen_1 453 461 PF02991 0.656
LIG_LIR_Gen_1 469 476 PF02991 0.334
LIG_LIR_Gen_1 477 487 PF02991 0.563
LIG_LIR_Gen_1 524 535 PF02991 0.620
LIG_LIR_Nem_3 121 127 PF02991 0.549
LIG_LIR_Nem_3 130 134 PF02991 0.392
LIG_LIR_Nem_3 405 411 PF02991 0.706
LIG_LIR_Nem_3 416 422 PF02991 0.653
LIG_LIR_Nem_3 453 457 PF02991 0.671
LIG_LIR_Nem_3 469 473 PF02991 0.329
LIG_LIR_Nem_3 477 482 PF02991 0.527
LIG_LIR_Nem_3 524 530 PF02991 0.603
LIG_LIR_Nem_3 803 808 PF02991 0.510
LIG_LIR_Nem_3 81 87 PF02991 0.793
LIG_MYND_1 172 176 PF01753 0.549
LIG_NRBOX 121 127 PF00104 0.549
LIG_NRBOX 525 531 PF00104 0.610
LIG_PCNA_yPIPBox_3 282 296 PF02747 0.630
LIG_Pex14_2 588 592 PF04695 0.614
LIG_PTB_Apo_2 550 557 PF02174 0.549
LIG_PTB_Apo_2 586 593 PF02174 0.607
LIG_PTB_Phospho_1 550 556 PF10480 0.549
LIG_REV1ctd_RIR_1 82 92 PF16727 0.784
LIG_SH2_CRK 131 135 PF00017 0.549
LIG_SH2_CRK 408 412 PF00017 0.691
LIG_SH2_CRK 419 423 PF00017 0.647
LIG_SH2_CRK 527 531 PF00017 0.614
LIG_SH2_CRK 814 818 PF00017 0.719
LIG_SH2_GRB2like 626 629 PF00017 0.535
LIG_SH2_NCK_1 626 630 PF00017 0.777
LIG_SH2_SRC 479 482 PF00017 0.664
LIG_SH2_STAP1 3 7 PF00017 0.631
LIG_SH2_STAP1 683 687 PF00017 0.618
LIG_SH2_STAT3 208 211 PF00017 0.644
LIG_SH2_STAT5 124 127 PF00017 0.549
LIG_SH2_STAT5 143 146 PF00017 0.217
LIG_SH2_STAT5 208 211 PF00017 0.644
LIG_SH2_STAT5 243 246 PF00017 0.624
LIG_SH2_STAT5 475 478 PF00017 0.642
LIG_SH2_STAT5 479 482 PF00017 0.594
LIG_SH2_STAT5 515 518 PF00017 0.666
LIG_SH2_STAT5 548 551 PF00017 0.549
LIG_SH2_STAT5 626 629 PF00017 0.769
LIG_SH2_STAT5 644 647 PF00017 0.465
LIG_SH2_STAT5 677 680 PF00017 0.644
LIG_SH2_STAT5 683 686 PF00017 0.506
LIG_SH3_3 170 176 PF00018 0.549
LIG_SUMO_SIM_anti_2 453 459 PF11976 0.667
LIG_SUMO_SIM_anti_2 818 823 PF11976 0.724
LIG_SUMO_SIM_par_1 456 463 PF11976 0.652
LIG_TRAF2_1 432 435 PF00917 0.748
LIG_TRAF2_1 612 615 PF00917 0.762
LIG_TYR_ITIM 122 127 PF00017 0.549
LIG_TYR_ITIM 525 530 PF00017 0.604
LIG_TYR_ITIM 571 576 PF00017 0.549
LIG_TYR_ITIM 812 817 PF00017 0.715
LIG_UBA3_1 104 108 PF00899 0.663
LIG_WRC_WIRS_1 2 7 PF05994 0.639
LIG_WRC_WIRS_1 451 456 PF05994 0.695
LIG_WW_1 641 644 PF00397 0.771
MOD_CK1_1 297 303 PF00069 0.748
MOD_CK1_1 31 37 PF00069 0.549
MOD_CK1_1 323 329 PF00069 0.748
MOD_CK1_1 436 442 PF00069 0.811
MOD_CK1_1 450 456 PF00069 0.456
MOD_CK1_1 724 730 PF00069 0.844
MOD_CK1_1 735 741 PF00069 0.648
MOD_CK2_1 219 225 PF00069 0.622
MOD_CK2_1 386 392 PF00069 0.876
MOD_CK2_1 412 418 PF00069 0.741
MOD_CK2_1 436 442 PF00069 0.811
MOD_CK2_1 450 456 PF00069 0.456
MOD_CK2_1 609 615 PF00069 0.768
MOD_CK2_1 738 744 PF00069 0.837
MOD_Cter_Amidation 136 139 PF01082 0.549
MOD_Cter_Amidation 766 769 PF01082 0.610
MOD_GlcNHglycan 151 154 PF01048 0.639
MOD_GlcNHglycan 215 218 PF01048 0.789
MOD_GlcNHglycan 33 36 PF01048 0.549
MOD_GlcNHglycan 336 339 PF01048 0.636
MOD_GlcNHglycan 387 391 PF01048 0.865
MOD_GlcNHglycan 495 498 PF01048 0.725
MOD_GlcNHglycan 516 519 PF01048 0.550
MOD_GlcNHglycan 56 59 PF01048 0.799
MOD_GlcNHglycan 611 614 PF01048 0.760
MOD_GlcNHglycan 665 668 PF01048 0.747
MOD_GlcNHglycan 72 75 PF01048 0.563
MOD_GlcNHglycan 724 727 PF01048 0.829
MOD_GlcNHglycan 732 735 PF01048 0.692
MOD_GlcNHglycan 737 740 PF01048 0.604
MOD_GlcNHglycan 78 81 PF01048 0.712
MOD_GlcNHglycan 796 800 PF01048 0.532
MOD_GSK3_1 215 222 PF00069 0.584
MOD_GSK3_1 382 389 PF00069 0.870
MOD_GSK3_1 433 440 PF00069 0.779
MOD_GSK3_1 446 453 PF00069 0.524
MOD_GSK3_1 456 463 PF00069 0.477
MOD_GSK3_1 46 53 PF00069 0.678
MOD_GSK3_1 535 542 PF00069 0.684
MOD_GSK3_1 724 731 PF00069 0.846
MOD_GSK3_1 76 83 PF00069 0.811
MOD_GSK3_1 775 782 PF00069 0.757
MOD_LATS_1 489 495 PF00433 0.558
MOD_NEK2_1 1 6 PF00069 0.498
MOD_NEK2_1 244 249 PF00069 0.616
MOD_NEK2_1 375 380 PF00069 0.614
MOD_NEK2_1 530 535 PF00069 0.635
MOD_NEK2_1 651 656 PF00069 0.515
MOD_NEK2_1 713 718 PF00069 0.644
MOD_NEK2_1 722 727 PF00069 0.783
MOD_NEK2_1 779 784 PF00069 0.705
MOD_NEK2_2 403 408 PF00069 0.615
MOD_NEK2_2 683 688 PF00069 0.631
MOD_NEK2_2 80 85 PF00069 0.790
MOD_PK_1 282 288 PF00069 0.549
MOD_PKA_2 334 340 PF00069 0.639
MOD_PKA_2 602 608 PF00069 0.739
MOD_PKA_2 663 669 PF00069 0.753
MOD_PKA_2 691 697 PF00069 0.722
MOD_Plk_1 433 439 PF00069 0.775
MOD_Plk_1 750 756 PF00069 0.825
MOD_Plk_2-3 456 462 PF00069 0.647
MOD_Plk_4 282 288 PF00069 0.549
MOD_Plk_4 403 409 PF00069 0.615
MOD_Plk_4 433 439 PF00069 0.775
MOD_Plk_4 450 456 PF00069 0.404
MOD_Plk_4 466 472 PF00069 0.339
MOD_Plk_4 750 756 PF00069 0.825
MOD_Plk_4 797 803 PF00069 0.765
MOD_Plk_4 80 86 PF00069 0.789
MOD_ProDKin_1 168 174 PF00069 0.549
MOD_ProDKin_1 482 488 PF00069 0.743
MOD_ProDKin_1 509 515 PF00069 0.505
MOD_ProDKin_1 557 563 PF00069 0.549
MOD_ProDKin_1 645 651 PF00069 0.787
MOD_ProDKin_1 724 730 PF00069 0.844
TRG_DiLeu_BaEn_1 418 423 PF01217 0.711
TRG_DiLeu_BaLyEn_6 170 175 PF01217 0.549
TRG_DiLeu_BaLyEn_6 370 375 PF01217 0.615
TRG_DiLeu_BaLyEn_6 714 719 PF01217 0.757
TRG_ENDOCYTIC_2 124 127 PF00928 0.549
TRG_ENDOCYTIC_2 131 134 PF00928 0.427
TRG_ENDOCYTIC_2 2 5 PF00928 0.652
TRG_ENDOCYTIC_2 408 411 PF00928 0.693
TRG_ENDOCYTIC_2 419 422 PF00928 0.651
TRG_ENDOCYTIC_2 479 482 PF00928 0.664
TRG_ENDOCYTIC_2 527 530 PF00928 0.606
TRG_ENDOCYTIC_2 548 551 PF00928 0.549
TRG_ENDOCYTIC_2 573 576 PF00928 0.549
TRG_ENDOCYTIC_2 805 808 PF00928 0.739
TRG_ENDOCYTIC_2 814 817 PF00928 0.558
TRG_ER_diArg_1 100 102 PF00400 0.718
TRG_ER_diArg_1 178 180 PF00400 0.549
TRG_ER_diArg_1 274 276 PF00400 0.549
TRG_ER_diArg_1 411 414 PF00400 0.778
TRG_NES_CRM1_1 117 130 PF08389 0.549
TRG_NES_CRM1_1 177 191 PF08389 0.549
TRG_NLS_MonoExtC_3 96 101 PF00514 0.718
TRG_Pf-PMV_PEXEL_1 274 278 PF00026 0.549
TRG_Pf-PMV_PEXEL_1 717 721 PF00026 0.795

Homologs

Protein Taxonomy Sequence identity Coverage
Q4QIN3 Leishmania major 94% 66%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS