Calcium-transporting ATPase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

vacuolar-type Ca2+-ATPase - putative

Species:

Leishmania infantum

UniProt:

A4HT82_LEIIN

TriTrypDb:

LINF_070012100

Length:

863

Annotations

LeishMANIAdb annotations

Homologous to other eukaryotic P-type Ca2+ ATPases.. For some reason, this group has heavily expanded in Kinetoplastida.. Localization: Endosomal (by homology) / ER (by homology)

Annotations by Jardim et al.

Transporters, Calcium-transporting ATPase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	17
GO:0110165	cellular anatomical entity	1	17
GO:0005886	plasma membrane	3	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2

Expansion

Sequence features

A4HT82

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HT82

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	17
GO:0003824	catalytic activity	1	17
GO:0005215	transporter activity	1	15
GO:0005388	P-type calcium transporter activity	4	15
GO:0005488	binding	1	17
GO:0005524	ATP binding	5	17
GO:0008324	monoatomic cation transmembrane transporter activity	4	15
GO:0015075	monoatomic ion transmembrane transporter activity	3	15
GO:0015085	calcium ion transmembrane transporter activity	6	15
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	15
GO:0015399	primary active transmembrane transporter activity	4	15
GO:0015662	P-type ion transporter activity	4	15
GO:0016462	pyrophosphatase activity	5	17
GO:0016787	hydrolase activity	2	17
GO:0016817	hydrolase activity, acting on acid anhydrides	3	17
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	17
GO:0016887	ATP hydrolysis activity	7	17
GO:0017076	purine nucleotide binding	4	17
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	17
GO:0019829	ATPase-coupled monoatomic cation transmembrane transporter activity	3	15
GO:0022804	active transmembrane transporter activity	3	15
GO:0022853	active monoatomic ion transmembrane transporter activity	4	15
GO:0022857	transmembrane transporter activity	2	15
GO:0022890	inorganic cation transmembrane transporter activity	4	15
GO:0030554	adenyl nucleotide binding	5	17
GO:0032553	ribonucleotide binding	3	17
GO:0032555	purine ribonucleotide binding	4	17
GO:0032559	adenyl ribonucleotide binding	5	17
GO:0035639	purine ribonucleoside triphosphate binding	4	17
GO:0036094	small molecule binding	2	17
GO:0042626	ATPase-coupled transmembrane transporter activity	2	15
GO:0043167	ion binding	2	17
GO:0043168	anion binding	3	17
GO:0046873	metal ion transmembrane transporter activity	5	15
GO:0097159	organic cyclic compound binding	2	17
GO:0097367	carbohydrate derivative binding	2	17
GO:0140358	P-type transmembrane transporter activity	3	15
GO:0140657	ATP-dependent activity	1	15
GO:1901265	nucleoside phosphate binding	3	17
GO:1901363	heterocyclic compound binding	2	17

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	273	277	PF00656	0.511
CLV_C14_Caspase3-7	407	411	PF00656	0.554
CLV_NRD_NRD_1	157	159	PF00675	0.362
CLV_NRD_NRD_1	305	307	PF00675	0.271
CLV_NRD_NRD_1	565	567	PF00675	0.283
CLV_NRD_NRD_1	633	635	PF00675	0.260
CLV_NRD_NRD_1	641	643	PF00675	0.236
CLV_NRD_NRD_1	698	700	PF00675	0.262
CLV_NRD_NRD_1	821	823	PF00675	0.361
CLV_NRD_NRD_1	849	851	PF00675	0.386
CLV_PCSK_FUR_1	847	851	PF00082	0.410
CLV_PCSK_KEX2_1	157	159	PF00082	0.362
CLV_PCSK_KEX2_1	199	201	PF00082	0.462
CLV_PCSK_KEX2_1	307	309	PF00082	0.320
CLV_PCSK_KEX2_1	628	630	PF00082	0.316
CLV_PCSK_KEX2_1	641	643	PF00082	0.208
CLV_PCSK_KEX2_1	821	823	PF00082	0.420
CLV_PCSK_KEX2_1	847	849	PF00082	0.395
CLV_PCSK_PC1ET2_1	199	201	PF00082	0.433
CLV_PCSK_PC1ET2_1	307	309	PF00082	0.318
CLV_PCSK_PC1ET2_1	628	630	PF00082	0.311
CLV_PCSK_SKI1_1	113	117	PF00082	0.266
CLV_PCSK_SKI1_1	295	299	PF00082	0.356
CLV_PCSK_SKI1_1	470	474	PF00082	0.420
CLV_PCSK_SKI1_1	492	496	PF00082	0.276
CLV_PCSK_SKI1_1	566	570	PF00082	0.289
CLV_PCSK_SKI1_1	791	795	PF00082	0.448
DEG_SCF_FBW7_2	64	71	PF00400	0.473
DEG_SPOP_SBC_1	234	238	PF00917	0.625
DOC_CYCLIN_RxL_1	564	574	PF00134	0.478
DOC_CYCLIN_yCln2_LP_2	204	210	PF00134	0.637
DOC_MAPK_DCC_7	200	210	PF00069	0.633
DOC_MAPK_gen_1	566	573	PF00069	0.479
DOC_MAPK_gen_1	641	647	PF00069	0.488
DOC_MAPK_gen_1	699	707	PF00069	0.494
DOC_MAPK_MEF2A_6	492	499	PF00069	0.485
DOC_MAPK_MEF2A_6	566	575	PF00069	0.464
DOC_MAPK_MEF2A_6	714	721	PF00069	0.456
DOC_MAPK_NFAT4_5	492	500	PF00069	0.485
DOC_MAPK_NFAT4_5	566	574	PF00069	0.464
DOC_PP1_RVXF_1	551	558	PF00149	0.478
DOC_PP2B_PxIxI_1	716	722	PF00149	0.277
DOC_USP7_MATH_1	226	230	PF00917	0.592
DOC_USP7_MATH_1	301	305	PF00917	0.456
DOC_USP7_MATH_1	388	392	PF00917	0.607
DOC_USP7_MATH_1	535	539	PF00917	0.498
DOC_USP7_MATH_1	637	641	PF00917	0.478
DOC_USP7_MATH_1	744	748	PF00917	0.340
DOC_WW_Pin1_4	592	597	PF00397	0.319
DOC_WW_Pin1_4	64	69	PF00397	0.454
LIG_14-3-3_CanoR_1	214	219	PF00244	0.582
LIG_AP2alpha_1	115	119	PF02296	0.473
LIG_APCC_ABBAyCdc20_2	812	818	PF00400	0.497
LIG_BIR_II_1	1	5	PF00653	0.443
LIG_BIR_III_4	463	467	PF00653	0.600
LIG_BRCT_BRCA1_1	722	726	PF00533	0.337
LIG_DLG_GKlike_1	214	221	PF00625	0.573
LIG_FHA_1	137	143	PF00498	0.506
LIG_FHA_1	174	180	PF00498	0.493
LIG_FHA_1	26	32	PF00498	0.480
LIG_FHA_1	368	374	PF00498	0.533
LIG_FHA_1	387	393	PF00498	0.561
LIG_FHA_1	597	603	PF00498	0.287
LIG_FHA_1	656	662	PF00498	0.313
LIG_FHA_1	756	762	PF00498	0.408
LIG_FHA_2	236	242	PF00498	0.666
LIG_FHA_2	271	277	PF00498	0.527
LIG_FHA_2	32	38	PF00498	0.468
LIG_FHA_2	451	457	PF00498	0.512
LIG_FHA_2	499	505	PF00498	0.583
LIG_IBAR_NPY_1	444	446	PF08397	0.501
LIG_KLC1_Yacidic_2	813	818	PF13176	0.492
LIG_LIR_Gen_1	391	400	PF02991	0.547
LIG_LIR_Gen_1	574	585	PF02991	0.369
LIG_LIR_Gen_1	681	692	PF02991	0.298
LIG_LIR_Gen_1	723	732	PF02991	0.392
LIG_LIR_Nem_3	117	121	PF02991	0.508
LIG_LIR_Nem_3	391	397	PF02991	0.551
LIG_LIR_Nem_3	456	460	PF02991	0.500
LIG_LIR_Nem_3	545	551	PF02991	0.488
LIG_LIR_Nem_3	574	580	PF02991	0.369
LIG_LIR_Nem_3	681	687	PF02991	0.298
LIG_LIR_Nem_3	723	727	PF02991	0.384
LIG_LIR_Nem_3	99	104	PF02991	0.463
LIG_NRBOX	90	96	PF00104	0.491
LIG_PCNA_TLS_4	113	120	PF02747	0.485
LIG_PCNA_yPIPBox_3	559	569	PF02747	0.472
LIG_Pex14_2	115	119	PF04695	0.473
LIG_Pex14_2	724	728	PF04695	0.333
LIG_Pex14_2	777	781	PF04695	0.643
LIG_PTB_Apo_2	441	448	PF02174	0.489
LIG_PTB_Apo_2	456	463	PF02174	0.554
LIG_PTB_Apo_2	520	527	PF02174	0.507
LIG_PTB_Phospho_1	441	447	PF10480	0.492
LIG_PTB_Phospho_1	456	462	PF10480	0.554
LIG_SH2_CRK	375	379	PF00017	0.616
LIG_SH2_GRB2like	338	341	PF00017	0.606
LIG_SH2_PTP2	577	580	PF00017	0.424
LIG_SH2_SRC	664	667	PF00017	0.335
LIG_SH2_STAP1	664	668	PF00017	0.335
LIG_SH2_STAT5	118	121	PF00017	0.505
LIG_SH2_STAT5	190	193	PF00017	0.495
LIG_SH2_STAT5	338	341	PF00017	0.569
LIG_SH2_STAT5	577	580	PF00017	0.424
LIG_SH2_STAT5	816	819	PF00017	0.486
LIG_SH3_3	125	131	PF00018	0.448
LIG_SH3_3	195	201	PF00018	0.547
LIG_SH3_3	400	406	PF00018	0.556
LIG_SH3_3	769	775	PF00018	0.542
LIG_SUMO_SIM_anti_2	540	546	PF11976	0.482
LIG_SUMO_SIM_par_1	126	132	PF11976	0.448
LIG_SUMO_SIM_par_1	134	139	PF11976	0.448
LIG_SUMO_SIM_par_1	23	28	PF11976	0.467
LIG_SUMO_SIM_par_1	495	501	PF11976	0.503
LIG_SUMO_SIM_par_1	504	509	PF11976	0.452
LIG_SUMO_SIM_par_1	540	546	PF11976	0.482
LIG_SUMO_SIM_par_1	93	99	PF11976	0.476
LIG_TRAF2_1	618	621	PF00917	0.358
LIG_TRAF2_1	622	625	PF00917	0.496
LIG_TRAF2_1	68	71	PF00917	0.481
LIG_TYR_ITIM	116	121	PF00017	0.383
LIG_TYR_ITIM	373	378	PF00017	0.417
LIG_TYR_ITIM	575	580	PF00017	0.424
LIG_WRC_WIRS_1	721	726	PF05994	0.343
MOD_CK1_1	108	114	PF00069	0.456
MOD_CK1_1	173	179	PF00069	0.370
MOD_CK1_1	595	601	PF00069	0.391
MOD_CK1_1	799	805	PF00069	0.466
MOD_CK1_1	8	14	PF00069	0.297
MOD_CK2_1	226	232	PF00069	0.417
MOD_CK2_1	235	241	PF00069	0.491
MOD_CK2_1	498	504	PF00069	0.477
MOD_CK2_1	93	99	PF00069	0.306
MOD_GlcNHglycan	107	110	PF01048	0.243
MOD_GlcNHglycan	210	213	PF01048	0.588
MOD_GlcNHglycan	309	312	PF01048	0.366
MOD_GlcNHglycan	529	532	PF01048	0.377
MOD_GlcNHglycan	537	540	PF01048	0.350
MOD_GlcNHglycan	714	717	PF01048	0.243
MOD_GlcNHglycan	798	801	PF01048	0.443
MOD_GSK3_1	166	173	PF00069	0.350
MOD_GSK3_1	27	34	PF00069	0.313
MOD_GSK3_1	506	513	PF00069	0.366
MOD_GSK3_1	576	583	PF00069	0.347
MOD_GSK3_1	591	598	PF00069	0.407
MOD_GSK3_1	616	623	PF00069	0.298
MOD_GSK3_1	740	747	PF00069	0.407
MOD_GSK3_1	760	767	PF00069	0.279
MOD_GSK3_1	777	784	PF00069	0.554
MOD_LATS_1	323	329	PF00433	0.333
MOD_N-GLC_1	166	171	PF02516	0.395
MOD_N-GLC_1	227	232	PF02516	0.400
MOD_N-GLC_1	256	261	PF02516	0.290
MOD_N-GLC_1	367	372	PF02516	0.387
MOD_N-GLC_1	837	842	PF02516	0.411
MOD_NEK2_1	136	141	PF00069	0.341
MOD_NEK2_1	142	147	PF00069	0.295
MOD_NEK2_1	213	218	PF00069	0.521
MOD_NEK2_1	27	32	PF00069	0.293
MOD_NEK2_1	450	455	PF00069	0.434
MOD_NEK2_1	484	489	PF00069	0.384
MOD_NEK2_1	498	503	PF00069	0.360
MOD_NEK2_1	55	60	PF00069	0.326
MOD_NEK2_1	571	576	PF00069	0.311
MOD_NEK2_1	584	589	PF00069	0.311
MOD_NEK2_1	643	648	PF00069	0.301
MOD_NEK2_1	655	660	PF00069	0.282
MOD_NEK2_1	740	745	PF00069	0.334
MOD_NEK2_1	781	786	PF00069	0.422
MOD_NEK2_1	837	842	PF00069	0.588
MOD_NEK2_2	418	423	PF00069	0.362
MOD_PIKK_1	142	148	PF00454	0.306
MOD_PIKK_1	166	172	PF00454	0.378
MOD_PIKK_1	177	183	PF00454	0.400
MOD_PIKK_1	484	490	PF00454	0.380
MOD_PKA_1	307	313	PF00069	0.389
MOD_PKA_2	213	219	PF00069	0.392
MOD_PKA_2	307	313	PF00069	0.389
MOD_PKB_1	293	301	PF00069	0.363
MOD_Plk_1	166	172	PF00069	0.389
MOD_Plk_1	367	373	PF00069	0.384
MOD_Plk_1	46	52	PF00069	0.326
MOD_Plk_1	5	11	PF00069	0.306
MOD_Plk_1	677	683	PF00069	0.379
MOD_Plk_1	777	783	PF00069	0.401
MOD_Plk_1	837	843	PF00069	0.536
MOD_Plk_2-3	620	626	PF00069	0.389
MOD_Plk_4	182	188	PF00069	0.371
MOD_Plk_4	27	33	PF00069	0.313
MOD_Plk_4	316	322	PF00069	0.479
MOD_Plk_4	388	394	PF00069	0.495
MOD_Plk_4	479	485	PF00069	0.491
MOD_Plk_4	580	586	PF00069	0.340
MOD_Plk_4	643	649	PF00069	0.261
MOD_Plk_4	678	684	PF00069	0.305
MOD_Plk_4	688	694	PF00069	0.291
MOD_Plk_4	781	787	PF00069	0.557
MOD_Plk_4	855	861	PF00069	0.422
MOD_Plk_4	93	99	PF00069	0.334
MOD_ProDKin_1	592	598	PF00069	0.298
MOD_ProDKin_1	64	70	PF00069	0.298
MOD_SUMO_rev_2	304	309	PF00179	0.313
MOD_SUMO_rev_2	784	793	PF00179	0.491
TRG_DiLeu_BaEn_1	316	321	PF01217	0.424
TRG_DiLeu_BaEn_1	75	80	PF01217	0.383
TRG_DiLeu_BaEn_1	855	860	PF01217	0.417
TRG_DiLeu_BaEn_4	855	861	PF01217	0.445
TRG_DiLeu_BaLyEn_6	765	770	PF01217	0.351
TRG_ENDOCYTIC_2	118	121	PF00928	0.367
TRG_ENDOCYTIC_2	190	193	PF00928	0.357
TRG_ENDOCYTIC_2	375	378	PF00928	0.411
TRG_ENDOCYTIC_2	447	450	PF00928	0.354
TRG_ENDOCYTIC_2	577	580	PF00928	0.424
TRG_ENDOCYTIC_2	664	667	PF00928	0.340
TRG_ENDOCYTIC_2	702	705	PF00928	0.345
TRG_ER_diArg_1	156	158	PF00400	0.428
TRG_ER_diArg_1	306	309	PF00400	0.434
TRG_ER_diArg_1	353	356	PF00400	0.510
TRG_ER_diArg_1	641	643	PF00400	0.308
TRG_ER_diArg_1	821	824	PF00400	0.525
TRG_ER_diArg_1	846	849	PF00400	0.511
TRG_NES_CRM1_1	390	402	PF08389	0.464
TRG_NES_CRM1_1	488	504	PF08389	0.378
TRG_NLS_MonoExtN_4	16	21	PF00514	0.351
TRG_Pf-PMV_PEXEL_1	102	107	PF00026	0.368
TRG_Pf-PMV_PEXEL_1	219	223	PF00026	0.456
TRG_Pf-PMV_PEXEL_1	458	463	PF00026	0.384
TRG_Pf-PMV_PEXEL_1	53	57	PF00026	0.326
TRG_Pf-PMV_PEXEL_1	699	703	PF00026	0.330
TRG_Pf-PMV_PEXEL_1	826	831	PF00026	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Y1	Leptomonas seymouri	31%	85%
A0A0N1HWG6	Leptomonas seymouri	40%	77%
A0A0N1PFH3	Leptomonas seymouri	26%	71%
A0A0S4J5A1	Bodo saltans	29%	81%
A0A0S4J6U4	Bodo saltans	38%	79%
A0A0S4JA92	Bodo saltans	43%	85%
A0A0S4JRV4	Bodo saltans	41%	85%
A0A0S4KIG5	Bodo saltans	29%	85%
A0A0S4KNQ6	Bodo saltans	62%	77%
A0A1X0NNY6	Trypanosomatidae	30%	86%
A0A1X0NPD9	Trypanosomatidae	67%	78%
A0A1X0NTI6	Trypanosomatidae	40%	76%
A0A1X0P0Y8	Trypanosomatidae	37%	79%
A0A1X0P689	Trypanosomatidae	26%	83%
A0A381MFJ0	Leishmania infantum	24%	89%
A0A3R7KM63	Trypanosoma rangeli	67%	83%
A0A3R7MRX8	Trypanosoma rangeli	28%	83%
A0A3S5H5Y9	Leishmania donovani	87%	78%
A0A3S5ISK9	Trypanosoma rangeli	36%	81%
A0A3S7WPW0	Leishmania donovani	100%	77%
A0A3S7WUG2	Leishmania donovani	38%	76%
A0A3S7WV68	Leishmania donovani	24%	89%
A0A3S7X978	Leishmania donovani	26%	78%
A0A422NTS7	Trypanosoma rangeli	31%	86%
A0A451EJU6	Leishmania donovani	31%	84%
A0R3Y2	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	25%	100%
A2VDL6	Bos taurus	28%	85%
A4H3S2	Leishmania braziliensis	29%	84%
A4H514	Leishmania braziliensis	82%	100%
A4H516	Leishmania braziliensis	89%	100%
A4H903	Leishmania braziliensis	39%	100%
A4H9Q5	Leishmania braziliensis	24%	93%
A4HMM8	Leishmania braziliensis	26%	100%
A4HRZ6	Leishmania infantum	31%	84%
A4HTF0	Leishmania infantum	97%	93%
A4HXD4	Leishmania infantum	38%	76%
A4HY23	Leishmania infantum	24%	89%
A4IBA6	Leishmania infantum	26%	78%
A7L9Z8	Mus musculus	29%	91%
C9ZPL1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	85%
C9ZUN6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	80%
C9ZZN4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	83%
D0A4V8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	78%
D0A564	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	95%
D0ZTB2	Salmonella typhimurium (strain 14028s / SGSC 2262)	26%	96%
D2WKD8	Sus scrofa	28%	85%
D3K0R6	Bos taurus	36%	71%
E9AF31	Leishmania major	27%	100%
E9AJY3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	85%
E9AL76	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
E9AL78	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9AR29	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9ART6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	89%
E9B686	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	70%
G5E829	Mus musculus	38%	71%
O14983	Homo sapiens	27%	86%
O22218	Arabidopsis thaliana	38%	84%
O23087	Arabidopsis thaliana	28%	82%
O34431	Bacillus subtilis (strain 168)	30%	97%
O43108	Yarrowia lipolytica (strain CLIB 122 / E 150)	29%	93%
O46674	Canis lupus familiaris	27%	87%
O55143	Mus musculus	27%	83%
O59868	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	96%
O64806	Arabidopsis thaliana	39%	85%
O75185	Homo sapiens	29%	91%
O77696	Sus scrofa	30%	86%
O81108	Arabidopsis thaliana	40%	85%
P04074	Ovis aries	26%	85%
P04191	Oryctolagus cuniculus	27%	86%
P05023	Homo sapiens	27%	84%
P05024	Sus scrofa	27%	85%
P05025	Tetronarce californica	27%	84%
P05030	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	94%
P06685	Rattus norvegicus	27%	84%
P06686	Rattus norvegicus	29%	85%
P06687	Rattus norvegicus	27%	85%
P09572	Gallus gallus	27%	85%
P09626	Rattus norvegicus	27%	84%
P09627	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	94%
P0ABB8	Escherichia coli (strain K12)	26%	96%
P0ABB9	Escherichia coli O157:H7	26%	96%
P11505	Rattus norvegicus	38%	71%
P11506	Rattus norvegicus	38%	69%
P11507	Rattus norvegicus	27%	83%
P11607	Sus scrofa	27%	83%
P12522	Leishmania donovani	24%	89%
P13585	Gallus gallus	28%	87%
P13586	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	91%
P13587	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	79%
P13607	Drosophila melanogaster	27%	83%
P13637	Homo sapiens	27%	85%
P16615	Homo sapiens	27%	83%
P17326	Artemia franciscana	29%	87%
P18596	Rattus norvegicus	29%	86%
P18907	Equus caballus	27%	85%
P19156	Sus scrofa	27%	83%
P19657	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	91%
P20020	Homo sapiens	38%	71%
P20647	Oryctolagus cuniculus	27%	83%
P20648	Homo sapiens	26%	83%
P22036	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	26%	95%
P22189	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	83%
P22700	Drosophila melanogaster	27%	85%
P23220	Sus scrofa	38%	71%
P23634	Homo sapiens	41%	70%
P24797	Gallus gallus	28%	85%
P24798	Gallus gallus	29%	85%
P25489	Catostomus commersonii	29%	84%
P27112	Oryctolagus cuniculus	27%	83%
P28774	Artemia franciscana	28%	86%
P30714	Rhinella marina	27%	84%
P35315	Trypanosoma brucei brucei	31%	85%
P35316	Artemia franciscana	27%	86%
P35317	Hydra vulgaris	29%	84%
P36640	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	26%	96%
P37278	Synechococcus elongatus (strain PCC 7942 / FACHB-805)	33%	93%
P38929	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	74%
P47317	Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)	28%	99%
P49380	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	24%	96%
P50993	Homo sapiens	29%	85%
P50996	Canis lupus familiaris	27%	83%
P50997	Canis lupus familiaris	26%	85%
P54209	Dunaliella bioculata	31%	83%
P54210	Dunaliella acidophila	22%	78%
P54211	Dunaliella bioculata	23%	76%
P54678	Dictyostelium discoideum	42%	77%
P54707	Homo sapiens	28%	83%
P54708	Rattus norvegicus	27%	83%
P57709	Bos taurus	28%	91%
P58165	Oreochromis mossambicus	40%	78%
P58312	Oreochromis mossambicus	27%	85%
P63688	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	30%	95%
P70083	Makaira nigricans	29%	87%
P78036	Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1)	28%	99%
P92939	Arabidopsis thaliana	28%	81%
P98194	Homo sapiens	28%	94%
P9WPS8	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	30%	95%
P9WPS9	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	30%	95%
Q00779	Felis catus	27%	87%
Q00804	Oryctolagus cuniculus	38%	71%
Q01814	Homo sapiens	38%	69%
Q01896	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	79%
Q03194	Nicotiana plumbaginifolia	23%	91%
Q03669	Gallus gallus	26%	83%
Q07421	Ajellomyces capsulatus	24%	94%
Q08435	Nicotiana plumbaginifolia	23%	90%
Q08436	Nicotiana plumbaginifolia	23%	90%
Q08DA1	Bos taurus	26%	85%
Q0VCY0	Bos taurus	29%	87%
Q12691	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	79%
Q13733	Homo sapiens	28%	84%
Q16720	Homo sapiens	39%	71%
Q21286	Caenorhabditis elegans	20%	72%
Q292Q0	Drosophila pseudoobscura pseudoobscura	27%	86%
Q2QMX9	Oryza sativa subsp. japonica	38%	85%
Q2QY12	Oryza sativa subsp. japonica	38%	83%
Q2RAS0	Oryza sativa subsp. japonica	38%	85%
Q37145	Arabidopsis thaliana	38%	85%
Q42883	Solanum lycopersicum	27%	82%
Q4QED4	Leishmania major	39%	100%
Q4QIM6	Leishmania major	97%	100%
Q4QIM8	Leishmania major	86%	100%
Q4VNC1	Homo sapiens	21%	72%
Q58623	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	24%	100%
Q5R5K5	Pongo abelii	28%	94%
Q5RCD8	Pongo abelii	29%	85%
Q5RDR3	Pongo abelii	27%	84%
Q64392	Cavia porcellus	28%	84%
Q64436	Mus musculus	27%	83%
Q64518	Mus musculus	29%	86%
Q64541	Rattus norvegicus	27%	84%
Q64542	Rattus norvegicus	38%	72%
Q64566	Rattus norvegicus	27%	94%
Q64568	Rattus norvegicus	41%	69%
Q64578	Rattus norvegicus	27%	87%
Q65X71	Oryza sativa subsp. japonica	38%	85%
Q6ATV4	Oryza sativa subsp. japonica	40%	84%
Q6DFW5	Mus musculus	21%	73%
Q6PIC6	Mus musculus	27%	85%
Q6PIE5	Mus musculus	29%	85%
Q6Q477	Mus musculus	41%	72%
Q6RWA9	Taenia solium	29%	85%
Q73E41	Bacillus cereus (strain ATCC 10987 / NRS 248)	31%	97%
Q7PPA5	Anopheles gambiae	27%	85%
Q7X8B5	Oryza sativa subsp. japonica	38%	79%
Q7XEK4	Oryza sativa subsp. japonica	37%	83%
Q80XR2	Mus musculus	27%	94%
Q8R429	Mus musculus	27%	87%
Q8R4C1	Rattus norvegicus	29%	91%
Q8RUN1	Oryza sativa subsp. japonica	38%	83%
Q8VDN2	Mus musculus	27%	84%
Q8Y8Q5	Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)	32%	98%
Q92030	Anguilla anguilla	28%	84%
Q92036	Rhinella marina	26%	83%
Q92105	Pelophylax lessonae	27%	87%
Q92123	Xenopus laevis	28%	84%
Q92126	Xenopus laevis	27%	84%
Q93084	Homo sapiens	29%	86%
Q95Z93	Leishmania major	31%	84%
Q98SH2	Gallus gallus	37%	72%
Q9CFU9	Lactococcus lactis subsp. lactis (strain IL1403)	29%	98%
Q9CTG6	Mus musculus	23%	74%
Q9HDW7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	67%
Q9LF79	Arabidopsis thaliana	39%	80%
Q9LIK7	Arabidopsis thaliana	36%	85%
Q9LU41	Arabidopsis thaliana	36%	79%
Q9LY77	Arabidopsis thaliana	38%	84%
Q9M2A0	Arabidopsis thaliana	23%	91%
Q9M2L4	Arabidopsis thaliana	40%	84%
Q9N0Z6	Oryctolagus cuniculus	27%	84%
Q9NQ11	Homo sapiens	24%	73%
Q9R0K7	Mus musculus	37%	72%
Q9SJB3	Arabidopsis thaliana	22%	91%
Q9SU58	Arabidopsis thaliana	23%	90%
Q9SY55	Arabidopsis thaliana	30%	86%
Q9SZR1	Arabidopsis thaliana	37%	81%
Q9TV52	Oryctolagus cuniculus	29%	79%
Q9WV27	Mus musculus	27%	84%
Q9XES1	Arabidopsis thaliana	28%	81%
Q9YGL9	Gallus gallus	28%	86%
Q9YH26	Oreochromis mossambicus	29%	84%
Q9Z1W8	Mus musculus	28%	83%
V5B873	Trypanosoma cruzi	66%	78%
V5BHZ2	Trypanosoma cruzi	27%	83%
V5BLM1	Trypanosoma cruzi	31%	86%
V5BPC6	Trypanosoma cruzi	36%	81%