WW domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HT79_LEIIN

TriTrypDb:

LINF_070010400

Length:

284

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4HT79

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HT79

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	67	71	PF00656	0.560
CLV_NRD_NRD_1	187	189	PF00675	0.510
CLV_NRD_NRD_1	35	37	PF00675	0.552
CLV_NRD_NRD_1	99	101	PF00675	0.524
CLV_PCSK_KEX2_1	112	114	PF00082	0.337
CLV_PCSK_KEX2_1	187	189	PF00082	0.487
CLV_PCSK_KEX2_1	35	37	PF00082	0.552
CLV_PCSK_KEX2_1	99	101	PF00082	0.507
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.516
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.524
CLV_PCSK_SKI1_1	187	191	PF00082	0.487
DEG_Nend_UBRbox_1	1	4	PF02207	0.440
DEG_SPOP_SBC_1	270	274	PF00917	0.615
DOC_MAPK_FxFP_2	93	96	PF00069	0.569
DOC_MAPK_gen_1	199	207	PF00069	0.569
DOC_MAPK_gen_1	48	58	PF00069	0.475
DOC_MAPK_MEF2A_6	42	49	PF00069	0.485
DOC_PP4_FxxP_1	93	96	PF00568	0.457
DOC_USP7_MATH_1	117	121	PF00917	0.599
DOC_USP7_MATH_1	138	142	PF00917	0.733
DOC_USP7_MATH_1	208	212	PF00917	0.632
DOC_USP7_MATH_1	222	226	PF00917	0.650
DOC_USP7_MATH_1	256	260	PF00917	0.724
DOC_USP7_UBL2_3	99	103	PF12436	0.546
DOC_WW_Pin1_4	134	139	PF00397	0.721
DOC_WW_Pin1_4	162	167	PF00397	0.723
LIG_14-3-3_CanoR_1	121	127	PF00244	0.622
LIG_14-3-3_CanoR_1	187	193	PF00244	0.627
LIG_14-3-3_CanoR_1	261	267	PF00244	0.689
LIG_14-3-3_CanoR_1	269	276	PF00244	0.566
LIG_14-3-3_CanoR_1	42	46	PF00244	0.447
LIG_14-3-3_CanoR_1	61	69	PF00244	0.455
LIG_14-3-3_CanoR_1	76	84	PF00244	0.332
LIG_BRCT_BRCA1_1	182	186	PF00533	0.655
LIG_BRCT_BRCA1_1	224	228	PF00533	0.693
LIG_FHA_1	265	271	PF00498	0.614
LIG_FHA_1	87	93	PF00498	0.444
LIG_FHA_2	65	71	PF00498	0.564
LIG_LIR_Apic_2	91	97	PF02991	0.467
LIG_LIR_Nem_3	183	189	PF02991	0.501
LIG_LIR_Nem_3	265	271	PF02991	0.657
LIG_LIR_Nem_3	70	75	PF02991	0.456
LIG_Pex14_2	186	190	PF04695	0.492
LIG_SH2_CRK	268	272	PF00017	0.618
LIG_SH2_STAT5	192	195	PF00017	0.504
MOD_CDC14_SPxK_1	137	140	PF00782	0.784
MOD_CDK_SPxK_1	134	140	PF00069	0.780
MOD_CK1_1	134	140	PF00069	0.695
MOD_CK1_1	149	155	PF00069	0.586
MOD_CK1_1	259	265	PF00069	0.741
MOD_CK1_1	272	278	PF00069	0.540
MOD_CK2_1	149	155	PF00069	0.789
MOD_CK2_1	207	213	PF00069	0.666
MOD_GlcNHglycan	151	154	PF01048	0.781
MOD_GlcNHglycan	220	223	PF01048	0.716
MOD_GlcNHglycan	225	228	PF01048	0.665
MOD_GlcNHglycan	233	236	PF01048	0.559
MOD_GlcNHglycan	237	240	PF01048	0.516
MOD_GlcNHglycan	245	248	PF01048	0.528
MOD_GlcNHglycan	262	265	PF01048	0.606
MOD_GlcNHglycan	280	283	PF01048	0.496
MOD_GlcNHglycan	77	80	PF01048	0.490
MOD_GSK3_1	130	137	PF00069	0.662
MOD_GSK3_1	145	152	PF00069	0.608
MOD_GSK3_1	208	215	PF00069	0.682
MOD_GSK3_1	218	225	PF00069	0.691
MOD_GSK3_1	231	238	PF00069	0.608
MOD_GSK3_1	256	263	PF00069	0.750
MOD_N-GLC_1	122	127	PF02516	0.643
MOD_N-GLC_1	131	136	PF02516	0.650
MOD_N-GLC_1	162	167	PF02516	0.685
MOD_NEK2_1	131	136	PF00069	0.690
MOD_NEK2_1	146	151	PF00069	0.611
MOD_NEK2_1	182	187	PF00069	0.653
MOD_NEK2_1	207	212	PF00069	0.665
MOD_NEK2_1	229	234	PF00069	0.568
MOD_NEK2_1	41	46	PF00069	0.427
MOD_NEK2_1	64	69	PF00069	0.512
MOD_NEK2_1	74	79	PF00069	0.375
MOD_PIKK_1	140	146	PF00454	0.706
MOD_PIKK_1	86	92	PF00454	0.453
MOD_PK_1	212	218	PF00069	0.705
MOD_PKA_2	208	214	PF00069	0.635
MOD_PKA_2	260	266	PF00069	0.765
MOD_PKA_2	41	47	PF00069	0.435
MOD_PKA_2	75	81	PF00069	0.438
MOD_Plk_1	122	128	PF00069	0.646
MOD_Plk_1	131	137	PF00069	0.652
MOD_Plk_1	28	34	PF00069	0.557
MOD_Plk_4	212	218	PF00069	0.673
MOD_ProDKin_1	134	140	PF00069	0.724
MOD_ProDKin_1	162	168	PF00069	0.720
MOD_SUMO_rev_2	191	201	PF00179	0.552
TRG_ENDOCYTIC_2	268	271	PF00928	0.621
TRG_ER_diArg_1	186	188	PF00400	0.547
TRG_NES_CRM1_1	53	66	PF08389	0.446
TRG_NLS_Bipartite_1	99	115	PF00514	0.521
TRG_NLS_MonoExtC_3	110	115	PF00514	0.565
TRG_Pf-PMV_PEXEL_1	103	107	PF00026	0.574
TRG_Pf-PMV_PEXEL_1	61	66	PF00026	0.555

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSU4	Leptomonas seymouri	73%	72%
A0A1X0NPE0	Trypanosomatidae	47%	74%
A0A3S7WPV5	Leishmania donovani	100%	71%
A4H4Z9	Leishmania braziliensis	88%	100%
C9ZUQ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	78%
E9AL61	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4QIP3	Leishmania major	97%	100%
V5B859	Trypanosoma cruzi	44%	87%