60S ribosomal protein L7a

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S ribosomal protein L7a - putative

Species:

Leishmania infantum

UniProt:

A4HT78_LEIIN

TriTrypDb:

LINF_070010500

Length:

348

Annotations

Annotations by Jardim et al.

Ribosomal Protein, 60S ribosomal L7a

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 24

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0015934	large ribosomal subunit	4	12
GO:0016020	membrane	2	2
GO:0022625	cytosolic large ribosomal subunit	5	12
GO:0032991	protein-containing complex	1	12
GO:0044391	ribosomal subunit	3	12
GO:0110165	cellular anatomical entity	1	3
GO:1990904	ribonucleoprotein complex	2	12
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

A4HT78

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HT78

Function

Biological processes
Term	Name	Level	Count
GO:0000470	maturation of LSU-rRNA	9	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	144	146	PF00675	0.430
CLV_NRD_NRD_1	152	154	PF00675	0.441
CLV_NRD_NRD_1	186	188	PF00675	0.474
CLV_NRD_NRD_1	190	192	PF00675	0.482
CLV_NRD_NRD_1	276	278	PF00675	0.344
CLV_NRD_NRD_1	315	317	PF00675	0.416
CLV_NRD_NRD_1	331	333	PF00675	0.446
CLV_NRD_NRD_1	79	81	PF00675	0.462
CLV_PCSK_FUR_1	145	149	PF00082	0.432
CLV_PCSK_KEX2_1	147	149	PF00082	0.433
CLV_PCSK_KEX2_1	152	154	PF00082	0.441
CLV_PCSK_KEX2_1	190	192	PF00082	0.548
CLV_PCSK_KEX2_1	315	317	PF00082	0.416
CLV_PCSK_KEX2_1	79	81	PF00082	0.474
CLV_PCSK_PC1ET2_1	147	149	PF00082	0.433
CLV_PCSK_PC7_1	148	154	PF00082	0.441
CLV_PCSK_SKI1_1	147	151	PF00082	0.438
CLV_PCSK_SKI1_1	152	156	PF00082	0.432
CLV_PCSK_SKI1_1	177	181	PF00082	0.426
CLV_PCSK_SKI1_1	278	282	PF00082	0.310
CLV_PCSK_SKI1_1	63	67	PF00082	0.393
CLV_PCSK_SKI1_1	88	92	PF00082	0.610
DEG_APCC_DBOX_1	211	219	PF00400	0.322
DOC_CYCLIN_yCln2_LP_2	64	70	PF00134	0.395
DOC_MAPK_gen_1	169	178	PF00069	0.408
DOC_MAPK_gen_1	230	238	PF00069	0.485
DOC_MAPK_gen_1	277	285	PF00069	0.544
DOC_MAPK_gen_1	315	323	PF00069	0.408
DOC_MAPK_HePTP_8	313	325	PF00069	0.405
DOC_MAPK_MEF2A_6	316	325	PF00069	0.409
DOC_PP2B_LxvP_1	154	157	PF13499	0.427
DOC_PP2B_LxvP_1	249	252	PF13499	0.468
DOC_PP2B_LxvP_1	64	67	PF13499	0.389
DOC_USP7_MATH_1	107	111	PF00917	0.568
DOC_USP7_MATH_1	81	85	PF00917	0.452
DOC_USP7_UBL2_3	177	181	PF12436	0.406
DOC_USP7_UBL2_3	202	206	PF12436	0.547
DOC_USP7_UBL2_3	88	92	PF12436	0.589
DOC_WW_Pin1_4	22	27	PF00397	0.407
DOC_WW_Pin1_4	3	8	PF00397	0.396
DOC_WW_Pin1_4	98	103	PF00397	0.708
LIG_14-3-3_CanoR_1	277	285	PF00244	0.544
LIG_BIR_III_4	273	277	PF00653	0.510
LIG_CaM_IQ_9	218	234	PF13499	0.468
LIG_CSL_BTD_1	249	252	PF09270	0.468
LIG_CtBP_PxDLS_1	244	248	PF00389	0.468
LIG_eIF4E_1	12	18	PF01652	0.397
LIG_FHA_1	162	168	PF00498	0.406
LIG_FHA_1	223	229	PF00498	0.468
LIG_FHA_1	6	12	PF00498	0.389
LIG_LIR_Apic_2	101	106	PF02991	0.685
LIG_LIR_Gen_1	14	22	PF02991	0.393
LIG_LIR_Nem_3	14	18	PF02991	0.397
LIG_NRBOX	12	18	PF00104	0.397
LIG_NRBOX	60	66	PF00104	0.404
LIG_Pex14_2	47	51	PF04695	0.402
LIG_Pex14_2	69	73	PF04695	0.405
LIG_SH2_CRK	103	107	PF00017	0.634
LIG_SH2_CRK	262	266	PF00017	0.468
LIG_SH2_SRC	262	265	PF00017	0.468
LIG_SH2_STAP1	127	131	PF00017	0.429
LIG_SH2_STAT5	12	15	PF00017	0.398
LIG_SH2_STAT5	68	71	PF00017	0.399
LIG_SUMO_SIM_anti_2	243	249	PF11976	0.468
LIG_SUMO_SIM_par_1	213	219	PF11976	0.341
LIG_TRAF2_1	197	200	PF00917	0.486
LIG_TYR_ITIM	13	18	PF00017	0.397
LIG_TYR_ITIM	260	265	PF00017	0.468
MOD_CDC14_SPxK_1	101	104	PF00782	0.690
MOD_CDK_SPxK_1	98	104	PF00069	0.706
MOD_CDK_SPxxK_3	98	105	PF00069	0.656
MOD_CK1_1	324	330	PF00069	0.424
MOD_CK1_1	5	11	PF00069	0.389
MOD_CK1_1	71	77	PF00069	0.412
MOD_CK2_1	168	174	PF00069	0.414
MOD_CK2_1	324	330	PF00069	0.424
MOD_Cter_Amidation	275	278	PF01082	0.344
MOD_GlcNHglycan	73	76	PF01048	0.415
MOD_GSK3_1	28	35	PF00069	0.396
MOD_GSK3_1	69	76	PF00069	0.431
MOD_N-GLC_2	253	255	PF02516	0.380
MOD_NEK2_1	11	16	PF00069	0.403
MOD_NEK2_1	299	304	PF00069	0.383
MOD_NEK2_1	32	37	PF00069	0.398
MOD_NEK2_1	321	326	PF00069	0.420
MOD_NEK2_1	69	74	PF00069	0.411
MOD_PIKK_1	91	97	PF00454	0.716
MOD_PKA_1	91	97	PF00069	0.642
MOD_PKA_2	168	174	PF00069	0.414
MOD_PKA_2	276	282	PF00069	0.544
MOD_Plk_1	129	135	PF00069	0.421
MOD_Plk_1	292	298	PF00069	0.485
MOD_Plk_1	81	87	PF00069	0.455
MOD_Plk_4	11	17	PF00069	0.394
MOD_Plk_4	136	142	PF00069	0.415
MOD_Plk_4	28	34	PF00069	0.363
MOD_ProDKin_1	22	28	PF00069	0.406
MOD_ProDKin_1	3	9	PF00069	0.394
MOD_ProDKin_1	98	104	PF00069	0.706
MOD_SUMO_rev_2	199	208	PF00179	0.558
MOD_SUMO_rev_2	223	233	PF00179	0.468
MOD_SUMO_rev_2	84	93	PF00179	0.478
TRG_DiLeu_BaEn_1	174	179	PF01217	0.400
TRG_DiLeu_BaLyEn_6	60	65	PF01217	0.405
TRG_ENDOCYTIC_2	15	18	PF00928	0.397
TRG_ENDOCYTIC_2	262	265	PF00928	0.468
TRG_ER_diArg_1	152	154	PF00400	0.441
TRG_ER_diArg_1	314	316	PF00400	0.398
TRG_ER_diArg_1	325	328	PF00400	0.431
TRG_NLS_Bipartite_1	315	336	PF00514	0.423
TRG_NLS_MonoCore_2	144	149	PF00514	0.432
TRG_NLS_MonoExtC_3	186	191	PF00514	0.497
TRG_NLS_MonoExtN_4	145	150	PF00514	0.433
TRG_NLS_MonoExtN_4	184	191	PF00514	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NEX8	Trypanosomatidae	87%	100%
A0A1X0NPC4	Trypanosomatidae	87%	100%
A0A3S7WPW6	Leishmania donovani	100%	100%
A4H500	Leishmania braziliensis	94%	100%
A4HT77	Leishmania infantum	100%	100%
C9ZUQ0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	81%	100%
E9AL62	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
E9AL63	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
O57592	Takifugu rubripes	44%	100%
P12970	Mus musculus	46%	100%
P17076	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	43%	100%
P29453	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	43%	100%
P32429	Gallus gallus	46%	100%
P62424	Homo sapiens	46%	100%
P62425	Rattus norvegicus	46%	100%
Q2TBQ5	Bos taurus	46%	100%
Q4QIP1	Leishmania major	98%	100%
Q4R5C2	Macaca fascicularis	46%	100%
Q90YW2	Ictalurus punctatus	45%	100%
Q966C6	Caenorhabditis elegans	42%	100%
Q9LZH9	Arabidopsis thaliana	41%	100%
V5DPU1	Trypanosoma cruzi	84%	100%