60S ribosomal protein L7a

Quick info Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S ribosomal protein L7a - putative

Species:

Leishmania infantum

UniProt:

A4HT77_LEIIN

TriTrypDb:

LINF_070010500

Length:

333

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 2
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 24

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 1, no: 11
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0015934	large ribosomal subunit	4	13
GO:0022625	cytosolic large ribosomal subunit	5	13
GO:0032991	protein-containing complex	1	13
GO:0044391	ribosomal subunit	3	13
GO:1990904	ribonucleoprotein complex	2	13
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HT77

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HT77

Function

Biological processes
Term	Name	Level	Count
GO:0000470	maturation of LSU-rRNA	9	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	13
GO:0003723	RNA binding	4	13
GO:0005488	binding	1	13
GO:0097159	organic cyclic compound binding	2	13
GO:1901363	heterocyclic compound binding	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	129	131	PF00675	0.441
CLV_NRD_NRD_1	137	139	PF00675	0.453
CLV_NRD_NRD_1	171	173	PF00675	0.467
CLV_NRD_NRD_1	175	177	PF00675	0.477
CLV_NRD_NRD_1	261	263	PF00675	0.346
CLV_NRD_NRD_1	300	302	PF00675	0.419
CLV_NRD_NRD_1	316	318	PF00675	0.442
CLV_PCSK_FUR_1	130	134	PF00082	0.446
CLV_PCSK_KEX2_1	132	134	PF00082	0.449
CLV_PCSK_KEX2_1	137	139	PF00082	0.453
CLV_PCSK_KEX2_1	175	177	PF00082	0.556
CLV_PCSK_KEX2_1	300	302	PF00082	0.419
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.449
CLV_PCSK_PC7_1	133	139	PF00082	0.454
CLV_PCSK_SKI1_1	132	136	PF00082	0.440
CLV_PCSK_SKI1_1	137	141	PF00082	0.423
CLV_PCSK_SKI1_1	162	166	PF00082	0.428
CLV_PCSK_SKI1_1	263	267	PF00082	0.318
CLV_PCSK_SKI1_1	73	77	PF00082	0.583
DEG_APCC_DBOX_1	196	204	PF00400	0.309
DEG_SCF_FBW7_1	44	51	PF00400	0.398
DOC_CKS1_1	43	48	PF01111	0.390
DOC_MAPK_gen_1	154	163	PF00069	0.409
DOC_MAPK_gen_1	215	223	PF00069	0.478
DOC_MAPK_gen_1	262	270	PF00069	0.546
DOC_MAPK_gen_1	300	308	PF00069	0.430
DOC_MAPK_gen_1	4	12	PF00069	0.363
DOC_MAPK_HePTP_8	298	310	PF00069	0.424
DOC_MAPK_MEF2A_6	301	310	PF00069	0.430
DOC_MAPK_MEF2A_6	6	14	PF00069	0.363
DOC_PP2B_LxvP_1	139	142	PF13499	0.437
DOC_PP2B_LxvP_1	234	237	PF13499	0.466
DOC_PP4_FxxP_1	43	46	PF00568	0.390
DOC_USP7_MATH_1	92	96	PF00917	0.594
DOC_USP7_UBL2_3	162	166	PF12436	0.407
DOC_USP7_UBL2_3	187	191	PF12436	0.570
DOC_USP7_UBL2_3	73	77	PF12436	0.562
DOC_WW_Pin1_4	22	27	PF00397	0.385
DOC_WW_Pin1_4	42	47	PF00397	0.415
DOC_WW_Pin1_4	83	88	PF00397	0.709
LIG_14-3-3_CanoR_1	262	270	PF00244	0.527
LIG_14-3-3_CanoR_1	59	67	PF00244	0.447
LIG_BIR_II_1	1	5	PF00653	0.370
LIG_BIR_III_4	258	262	PF00653	0.496
LIG_CaM_IQ_9	203	219	PF13499	0.466
LIG_CSL_BTD_1	234	237	PF09270	0.466
LIG_CtBP_PxDLS_1	229	233	PF00389	0.454
LIG_FHA_1	147	153	PF00498	0.403
LIG_FHA_1	208	214	PF00498	0.455
LIG_FHA_1	60	66	PF00498	0.453
LIG_LIR_Apic_2	27	32	PF02991	0.366
LIG_LIR_Apic_2	40	46	PF02991	0.390
LIG_LIR_Apic_2	86	91	PF02991	0.695
LIG_MYND_1	20	24	PF01753	0.345
LIG_SH2_CRK	247	251	PF00017	0.466
LIG_SH2_CRK	88	92	PF00017	0.664
LIG_SH2_SRC	247	250	PF00017	0.466
LIG_SH2_STAP1	112	116	PF00017	0.442
LIG_SH2_STAT5	29	32	PF00017	0.529
LIG_SH3_3	18	24	PF00018	0.351
LIG_SUMO_SIM_anti_2	228	234	PF11976	0.466
LIG_SUMO_SIM_par_1	198	204	PF11976	0.338
LIG_TRAF2_1	182	185	PF00917	0.616
LIG_TYR_ITIM	245	250	PF00017	0.466
MOD_CDC14_SPxK_1	86	89	PF00782	0.695
MOD_CDK_SPxK_1	83	89	PF00069	0.707
MOD_CDK_SPxxK_3	46	53	PF00069	0.411
MOD_CDK_SPxxK_3	83	90	PF00069	0.659
MOD_CK1_1	309	315	PF00069	0.421
MOD_CK2_1	153	159	PF00069	0.417
MOD_CK2_1	309	315	PF00069	0.440
MOD_Cter_Amidation	260	263	PF01082	0.346
MOD_GSK3_1	42	49	PF00069	0.416
MOD_GSK3_1	55	62	PF00069	0.464
MOD_N-GLC_2	238	240	PF02516	0.367
MOD_NEK2_1	14	19	PF00069	0.641
MOD_NEK2_1	284	289	PF00069	0.401
MOD_NEK2_1	306	311	PF00069	0.443
MOD_NEK2_1	37	42	PF00069	0.398
MOD_PIKK_1	59	65	PF00454	0.484
MOD_PIKK_1	76	82	PF00454	0.695
MOD_PKA_1	76	82	PF00069	0.621
MOD_PKA_2	153	159	PF00069	0.417
MOD_PKA_2	261	267	PF00069	0.546
MOD_PKA_2	52	58	PF00069	0.465
MOD_Plk_1	114	120	PF00069	0.439
MOD_Plk_1	277	283	PF00069	0.475
MOD_Plk_4	121	127	PF00069	0.424
MOD_ProDKin_1	22	28	PF00069	0.385
MOD_ProDKin_1	42	48	PF00069	0.414
MOD_ProDKin_1	83	89	PF00069	0.707
MOD_SUMO_rev_2	184	193	PF00179	0.659
MOD_SUMO_rev_2	208	218	PF00179	0.466
MOD_SUMO_rev_2	69	78	PF00179	0.441
TRG_DiLeu_BaEn_1	159	164	PF01217	0.404
TRG_ENDOCYTIC_2	247	250	PF00928	0.466
TRG_ER_diArg_1	137	139	PF00400	0.453
TRG_ER_diArg_1	299	301	PF00400	0.403
TRG_ER_diArg_1	3	6	PF00400	0.641
TRG_ER_diArg_1	310	313	PF00400	0.431
TRG_NLS_Bipartite_1	300	321	PF00514	0.442
TRG_NLS_MonoCore_2	129	134	PF00514	0.445
TRG_NLS_MonoExtC_3	171	176	PF00514	0.509
TRG_NLS_MonoExtN_4	130	135	PF00514	0.448
TRG_NLS_MonoExtN_4	169	176	PF00514	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IQB8	Bodo saltans	77%	100%
A0A1D8PF11	Candida albicans (strain SC5314 / ATCC MYA-2876)	45%	100%
A0A1X0NEX8	Trypanosomatidae	87%	100%
A0A1X0NPC4	Trypanosomatidae	87%	100%
A0A3S7WPW6	Leishmania donovani	100%	100%
A4H500	Leishmania braziliensis	94%	100%
A4HT78	Leishmania infantum	100%	96%
C9ZUQ0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	81%	100%
E9AL62	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
E9AL63	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O13672	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	43%	100%
O57592	Takifugu rubripes	44%	100%
O76732	Anopheles gambiae	45%	100%
P12970	Mus musculus	46%	100%
P17076	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	43%	100%
P29453	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	43%	100%
P32429	Gallus gallus	46%	100%
P46223	Drosophila melanogaster	48%	100%
P49692	Arabidopsis thaliana	43%	100%
P62424	Homo sapiens	46%	100%
P62425	Rattus norvegicus	46%	100%
Q2TBQ5	Bos taurus	46%	100%
Q4QIP1	Leishmania major	98%	100%
Q4R5C2	Macaca fascicularis	46%	100%
Q54ZD1	Dictyostelium discoideum	44%	100%
Q90YW2	Ictalurus punctatus	45%	100%
Q966C6	Caenorhabditis elegans	42%	100%
Q9LZH9	Arabidopsis thaliana	41%	100%
V5DPU1	Trypanosoma cruzi	84%	100%