Cysteine peptidase B (CPB)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HT73_LEIIN

TriTrypDb:

LINF_070011000

Length:

1904

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

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Expansion

Sequence features

A4HT73

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HT73

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016787	hydrolase activity	2	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1180	1184	PF00656	0.685
CLV_C14_Caspase3-7	1262	1266	PF00656	0.696
CLV_C14_Caspase3-7	1380	1384	PF00656	0.669
CLV_C14_Caspase3-7	1436	1440	PF00656	0.729
CLV_C14_Caspase3-7	351	355	PF00656	0.691
CLV_C14_Caspase3-7	510	514	PF00656	0.705
CLV_C14_Caspase3-7	854	858	PF00656	0.718
CLV_NRD_NRD_1	1095	1097	PF00675	0.531
CLV_NRD_NRD_1	1280	1282	PF00675	0.461
CLV_NRD_NRD_1	1341	1343	PF00675	0.548

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WPW5	Leishmania donovani	99%	100%
A4H505	Leishmania braziliensis	59%	97%
E9AL67	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QIN7	Leishmania major	88%	100%

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