Uncharacterized protein

Quick info Localization Phosphorylation Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HT71_LEIIN

TriTrypDb:

LINF_070011200

Length:

466

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Phosphorylation

Promastigote: 286, 288

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HT71

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HT71

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	284	288	PF00656	0.648
CLV_NRD_NRD_1	104	106	PF00675	0.580
CLV_NRD_NRD_1	23	25	PF00675	0.279
CLV_NRD_NRD_1	31	33	PF00675	0.409
CLV_NRD_NRD_1	311	313	PF00675	0.609
CLV_NRD_NRD_1	39	41	PF00675	0.416
CLV_NRD_NRD_1	413	415	PF00675	0.452
CLV_NRD_NRD_1	416	418	PF00675	0.448
CLV_NRD_NRD_1	6	8	PF00675	0.485
CLV_NRD_NRD_1	61	63	PF00675	0.544
CLV_NRD_NRD_1	96	98	PF00675	0.689
CLV_PCSK_FUR_1	37	41	PF00082	0.590
CLV_PCSK_KEX2_1	313	315	PF00082	0.603
CLV_PCSK_KEX2_1	39	41	PF00082	0.483
CLV_PCSK_KEX2_1	434	436	PF00082	0.512
CLV_PCSK_KEX2_1	63	65	PF00082	0.459
CLV_PCSK_PC1ET2_1	313	315	PF00082	0.603
CLV_PCSK_PC1ET2_1	434	436	PF00082	0.427
CLV_PCSK_PC1ET2_1	63	65	PF00082	0.469
CLV_PCSK_PC7_1	35	41	PF00082	0.554
CLV_PCSK_SKI1_1	146	150	PF00082	0.341
CLV_PCSK_SKI1_1	185	189	PF00082	0.382
CLV_PCSK_SKI1_1	192	196	PF00082	0.407
CLV_PCSK_SKI1_1	257	261	PF00082	0.439
CLV_PCSK_SKI1_1	298	302	PF00082	0.653
CLV_PCSK_SKI1_1	336	340	PF00082	0.557
CLV_PCSK_SKI1_1	395	399	PF00082	0.491
CLV_PCSK_SKI1_1	435	439	PF00082	0.452
DEG_COP1_1	128	138	PF00400	0.519
DEG_SCF_FBW7_1	446	451	PF00400	0.449
DEG_SPOP_SBC_1	126	130	PF00917	0.640
DOC_CKS1_1	445	450	PF01111	0.444
DOC_CYCLIN_RxL_1	235	247	PF00134	0.422
DOC_CYCLIN_RxL_1	432	442	PF00134	0.493
DOC_MAPK_gen_1	145	153	PF00069	0.294
DOC_MAPK_gen_1	182	188	PF00069	0.313
DOC_MAPK_gen_1	235	244	PF00069	0.442
DOC_MAPK_gen_1	245	254	PF00069	0.457
DOC_MAPK_gen_1	62	69	PF00069	0.502
DOC_MAPK_MEF2A_6	146	155	PF00069	0.320
DOC_PP1_RVXF_1	238	245	PF00149	0.401
DOC_PP1_RVXF_1	457	464	PF00149	0.491
DOC_PP2B_LxvP_1	186	189	PF13499	0.318
DOC_SPAK_OSR1_1	243	247	PF12202	0.451
DOC_USP7_MATH_1	112	116	PF00917	0.585
DOC_USP7_MATH_1	119	123	PF00917	0.609
DOC_USP7_MATH_1	126	130	PF00917	0.507
DOC_USP7_MATH_1	353	357	PF00917	0.600
DOC_USP7_MATH_1	439	443	PF00917	0.560
DOC_USP7_MATH_1	454	458	PF00917	0.582
DOC_USP7_MATH_1	56	60	PF00917	0.619
DOC_USP7_MATH_1	85	89	PF00917	0.651
DOC_USP7_UBL2_3	301	305	PF12436	0.630
DOC_USP7_UBL2_3	357	361	PF12436	0.660
DOC_USP7_UBL2_3	418	422	PF12436	0.426
DOC_WW_Pin1_4	107	112	PF00397	0.630
DOC_WW_Pin1_4	261	266	PF00397	0.542
DOC_WW_Pin1_4	305	310	PF00397	0.707
DOC_WW_Pin1_4	323	328	PF00397	0.591
DOC_WW_Pin1_4	345	350	PF00397	0.584
DOC_WW_Pin1_4	444	449	PF00397	0.528
DOC_WW_Pin1_4	91	96	PF00397	0.588
LIG_14-3-3_CanoR_1	440	444	PF00244	0.643
LIG_14-3-3_CanoR_1	453	463	PF00244	0.558
LIG_FHA_1	168	174	PF00498	0.363
LIG_FHA_1	262	268	PF00498	0.451
LIG_FHA_1	328	334	PF00498	0.666
LIG_FHA_1	408	414	PF00498	0.483
LIG_FHA_2	284	290	PF00498	0.652
LIG_Integrin_RGD_1	282	284	PF01839	0.530
LIG_LIR_Gen_1	425	430	PF02991	0.411
LIG_LIR_LC3C_4	170	175	PF02991	0.346
LIG_LIR_Nem_3	181	187	PF02991	0.394
LIG_LIR_Nem_3	425	429	PF02991	0.415
LIG_SH2_CRK	184	188	PF00017	0.371
LIG_SH3_4	357	364	PF00018	0.590
LIG_TRAF2_1	403	406	PF00917	0.499
LIG_TRAF2_2	159	164	PF00917	0.418
LIG_UBA3_1	232	240	PF00899	0.366
MOD_CDC14_SPxK_1	110	113	PF00782	0.528
MOD_CDC14_SPxK_1	94	97	PF00782	0.546
MOD_CDK_SPK_2	305	310	PF00069	0.698
MOD_CDK_SPK_2	345	350	PF00069	0.493
MOD_CDK_SPK_2	444	449	PF00069	0.473
MOD_CDK_SPxK_1	107	113	PF00069	0.532
MOD_CDK_SPxK_1	91	97	PF00069	0.549
MOD_CDK_SPxxK_3	107	114	PF00069	0.543
MOD_CDK_SPxxK_3	305	312	PF00069	0.603
MOD_CDK_SPxxK_3	91	98	PF00069	0.548
MOD_CK1_1	122	128	PF00069	0.609
MOD_CK1_1	129	135	PF00069	0.432
MOD_CK1_1	308	314	PF00069	0.634
MOD_CK1_1	360	366	PF00069	0.505
MOD_CK1_1	87	93	PF00069	0.605
MOD_CK2_1	285	291	PF00069	0.650
MOD_CK2_1	345	351	PF00069	0.608
MOD_CK2_1	360	366	PF00069	0.564
MOD_CK2_1	386	392	PF00069	0.485
MOD_CK2_1	400	406	PF00069	0.448
MOD_GlcNHglycan	114	117	PF01048	0.601
MOD_GlcNHglycan	124	127	PF01048	0.722
MOD_GlcNHglycan	333	336	PF01048	0.732
MOD_GlcNHglycan	456	459	PF01048	0.612
MOD_GlcNHglycan	58	61	PF01048	0.576
MOD_GlcNHglycan	87	90	PF01048	0.611
MOD_GSK3_1	122	129	PF00069	0.536
MOD_GSK3_1	130	137	PF00069	0.417
MOD_GSK3_1	163	170	PF00069	0.407
MOD_GSK3_1	174	181	PF00069	0.291
MOD_GSK3_1	308	315	PF00069	0.672
MOD_GSK3_1	323	330	PF00069	0.717
MOD_GSK3_1	353	360	PF00069	0.575
MOD_GSK3_1	444	451	PF00069	0.450
MOD_GSK3_1	52	59	PF00069	0.573
MOD_GSK3_1	87	94	PF00069	0.724
MOD_N-GLC_1	122	127	PF02516	0.676
MOD_N-GLC_1	345	350	PF02516	0.493
MOD_N-GLC_1	454	459	PF02516	0.510
MOD_NEK2_2	250	255	PF00069	0.528
MOD_PIKK_1	259	265	PF00454	0.535
MOD_PKA_1	312	318	PF00069	0.657
MOD_PKA_2	244	250	PF00069	0.436
MOD_PKA_2	439	445	PF00069	0.637
MOD_PKA_2	448	454	PF00069	0.692
MOD_PKA_2	96	102	PF00069	0.681
MOD_Plk_1	250	256	PF00069	0.533
MOD_Plk_2-3	285	291	PF00069	0.525
MOD_Plk_4	130	136	PF00069	0.556
MOD_ProDKin_1	107	113	PF00069	0.631
MOD_ProDKin_1	261	267	PF00069	0.540
MOD_ProDKin_1	305	311	PF00069	0.704
MOD_ProDKin_1	323	329	PF00069	0.591
MOD_ProDKin_1	345	351	PF00069	0.584
MOD_ProDKin_1	444	450	PF00069	0.529
MOD_ProDKin_1	91	97	PF00069	0.587
MOD_SUMO_for_1	368	371	PF00179	0.391
MOD_SUMO_rev_2	317	326	PF00179	0.730
MOD_SUMO_rev_2	363	370	PF00179	0.443
MOD_SUMO_rev_2	90	99	PF00179	0.488
TRG_ENDOCYTIC_2	184	187	PF00928	0.343
TRG_ER_diArg_1	254	257	PF00400	0.425
TRG_ER_diArg_1	61	64	PF00400	0.554
TRG_ER_diArg_1	76	79	PF00400	0.353
TRG_NLS_MonoExtC_3	311	316	PF00514	0.689
TRG_NLS_MonoExtC_3	360	365	PF00514	0.646
TRG_NLS_MonoExtN_4	309	316	PF00514	0.655
TRG_NLS_MonoExtN_4	358	365	PF00514	0.640
TRG_Pf-PMV_PEXEL_1	411	416	PF00026	0.620
TRG_Pf-PMV_PEXEL_1	428	432	PF00026	0.407

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB51	Leptomonas seymouri	60%	100%
A0A0S4IW25	Bodo saltans	32%	100%
A0A3R7ME95	Trypanosoma rangeli	39%	100%
A0A3S7WPV8	Leishmania donovani	98%	100%
A4H507	Leishmania braziliensis	72%	100%
C9ZUP3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	83%
E9AL69	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QIN5	Leishmania major	92%	100%
V5BY30	Trypanosoma cruzi	41%	97%