LeishMANIAdb
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Putative acyl-CoA dehydrogenase, mitochondrial

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative acyl-CoA dehydrogenase, mitochondrial
Gene product:
acyl-CoA dehydrogenase - mitochondrial precursor - putative
Species:
Leishmania infantum
UniProt:
A4HT68_LEIIN
TriTrypDb:
LINF_070010000
Length:
519

Annotations

Annotations by Jardim et al.

Fatty acid metabolism, acyl-CoA dehydrogenase, mitochondrial

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HT68
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HT68

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 1
GO:0006629 lipid metabolic process 3 1
GO:0006631 fatty acid metabolic process 4 1
GO:0006635 fatty acid beta-oxidation 6 1
GO:0008152 metabolic process 1 1
GO:0009056 catabolic process 2 1
GO:0009062 fatty acid catabolic process 5 1
GO:0009987 cellular process 1 1
GO:0016042 lipid catabolic process 4 1
GO:0016054 organic acid catabolic process 4 1
GO:0019395 fatty acid oxidation 5 1
GO:0019605 butyrate metabolic process 6 1
GO:0019626 short-chain fatty acid catabolic process 6 1
GO:0019752 carboxylic acid metabolic process 5 1
GO:0030258 lipid modification 4 1
GO:0032787 monocarboxylic acid metabolic process 6 1
GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase 7 1
GO:0034440 lipid oxidation 5 1
GO:0043436 oxoacid metabolic process 4 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044242 cellular lipid catabolic process 4 1
GO:0044248 cellular catabolic process 3 1
GO:0044255 cellular lipid metabolic process 3 1
GO:0044281 small molecule metabolic process 2 1
GO:0044282 small molecule catabolic process 3 1
GO:0046359 butyrate catabolic process 7 1
GO:0046395 carboxylic acid catabolic process 5 1
GO:0046459 short-chain fatty acid metabolic process 5 1
GO:0071704 organic substance metabolic process 2 1
GO:0072329 monocarboxylic acid catabolic process 6 1
GO:1901575 organic substance catabolic process 3 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 12
GO:0003824 catalytic activity 1 12
GO:0005488 binding 1 12
GO:0016491 oxidoreductase activity 2 12
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 3 12
GO:0036094 small molecule binding 2 12
GO:0043167 ion binding 2 12
GO:0043168 anion binding 3 12
GO:0050660 flavin adenine dinucleotide binding 4 12
GO:0097159 organic cyclic compound binding 2 12
GO:1901265 nucleoside phosphate binding 3 12
GO:1901363 heterocyclic compound binding 2 12
GO:0003995 acyl-CoA dehydrogenase activity 5 1
GO:0004085 butyryl-CoA dehydrogenase activity 6 1
GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 266 270 PF00656 0.492
CLV_C14_Caspase3-7 407 411 PF00656 0.439
CLV_C14_Caspase3-7 92 96 PF00656 0.387
CLV_NRD_NRD_1 10 12 PF00675 0.518
CLV_NRD_NRD_1 2 4 PF00675 0.523
CLV_NRD_NRD_1 37 39 PF00675 0.362
CLV_PCSK_KEX2_1 10 12 PF00082 0.518
CLV_PCSK_KEX2_1 168 170 PF00082 0.298
CLV_PCSK_KEX2_1 2 4 PF00082 0.523
CLV_PCSK_KEX2_1 261 263 PF00082 0.291
CLV_PCSK_KEX2_1 464 466 PF00082 0.506
CLV_PCSK_KEX2_1 506 508 PF00082 0.351
CLV_PCSK_PC1ET2_1 168 170 PF00082 0.298
CLV_PCSK_PC1ET2_1 261 263 PF00082 0.306
CLV_PCSK_PC1ET2_1 464 466 PF00082 0.506
CLV_PCSK_PC1ET2_1 506 508 PF00082 0.366
CLV_PCSK_SKI1_1 118 122 PF00082 0.257
CLV_PCSK_SKI1_1 123 127 PF00082 0.257
CLV_PCSK_SKI1_1 161 165 PF00082 0.429
CLV_PCSK_SKI1_1 184 188 PF00082 0.383
CLV_PCSK_SKI1_1 2 6 PF00082 0.600
CLV_PCSK_SKI1_1 208 212 PF00082 0.473
CLV_PCSK_SKI1_1 241 245 PF00082 0.421
CLV_PCSK_SKI1_1 348 352 PF00082 0.348
CLV_PCSK_SKI1_1 68 72 PF00082 0.330
DEG_APCC_DBOX_1 347 355 PF00400 0.426
DEG_Nend_UBRbox_1 1 4 PF02207 0.572
DEG_SPOP_SBC_1 319 323 PF00917 0.330
DOC_MAPK_FxFP_2 33 36 PF00069 0.326
DOC_PP2B_LxvP_1 301 304 PF13499 0.427
DOC_PP4_FxxP_1 33 36 PF00568 0.326
DOC_USP7_MATH_1 152 156 PF00917 0.541
DOC_USP7_MATH_1 289 293 PF00917 0.261
DOC_USP7_MATH_1 313 317 PF00917 0.374
DOC_USP7_MATH_1 34 38 PF00917 0.450
DOC_USP7_MATH_1 408 412 PF00917 0.404
DOC_USP7_MATH_1 451 455 PF00917 0.265
DOC_USP7_MATH_1 501 505 PF00917 0.487
DOC_WW_Pin1_4 222 227 PF00397 0.354
DOC_WW_Pin1_4 331 336 PF00397 0.450
LIG_14-3-3_CanoR_1 14 19 PF00244 0.307
LIG_14-3-3_CanoR_1 2 12 PF00244 0.542
LIG_14-3-3_CanoR_1 200 204 PF00244 0.330
LIG_14-3-3_CanoR_1 241 246 PF00244 0.422
LIG_14-3-3_CanoR_1 348 354 PF00244 0.395
LIG_14-3-3_CanoR_1 378 383 PF00244 0.432
LIG_14-3-3_CanoR_1 388 394 PF00244 0.389
LIG_14-3-3_CanoR_1 56 64 PF00244 0.307
LIG_14-3-3_CanoR_1 68 76 PF00244 0.121
LIG_Actin_WH2_2 252 270 PF00022 0.442
LIG_APCC_ABBA_1 243 248 PF00400 0.287
LIG_BRCT_BRCA1_1 355 359 PF00533 0.355
LIG_DLG_GKlike_1 14 22 PF00625 0.348
LIG_FHA_1 175 181 PF00498 0.298
LIG_FHA_1 200 206 PF00498 0.399
LIG_FHA_1 296 302 PF00498 0.439
LIG_FHA_1 377 383 PF00498 0.399
LIG_FHA_2 187 193 PF00498 0.450
LIG_FHA_2 469 475 PF00498 0.510
LIG_FHA_2 498 504 PF00498 0.393
LIG_FHA_2 90 96 PF00498 0.387
LIG_LIR_Apic_2 30 36 PF02991 0.320
LIG_LIR_Gen_1 177 186 PF02991 0.282
LIG_LIR_Gen_1 323 333 PF02991 0.471
LIG_LIR_Gen_1 477 487 PF02991 0.365
LIG_LIR_Nem_3 177 182 PF02991 0.286
LIG_LIR_Nem_3 202 206 PF02991 0.360
LIG_LIR_Nem_3 323 329 PF02991 0.461
LIG_LIR_Nem_3 370 375 PF02991 0.350
LIG_LIR_Nem_3 502 508 PF02991 0.361
LIG_LIR_Nem_3 71 76 PF02991 0.258
LIG_MAD2 26 34 PF02301 0.373
LIG_SH2_CRK 372 376 PF00017 0.452
LIG_SH2_CRK 505 509 PF00017 0.386
LIG_SH2_CRK 73 77 PF00017 0.257
LIG_SH2_SRC 250 253 PF00017 0.286
LIG_SH2_STAP1 252 256 PF00017 0.259
LIG_SH2_STAP1 295 299 PF00017 0.266
LIG_SH2_STAP1 361 365 PF00017 0.297
LIG_SH2_STAP1 449 453 PF00017 0.259
LIG_SH2_STAT5 110 113 PF00017 0.278
LIG_SH2_STAT5 12 15 PF00017 0.516
LIG_SH2_STAT5 124 127 PF00017 0.189
LIG_SH2_STAT5 162 165 PF00017 0.324
LIG_SH2_STAT5 179 182 PF00017 0.296
LIG_SH2_STAT5 250 253 PF00017 0.267
LIG_Sin3_3 347 354 PF02671 0.409
LIG_SUMO_SIM_anti_2 325 332 PF11976 0.459
LIG_SUMO_SIM_par_1 240 248 PF11976 0.273
LIG_UBA3_1 256 261 PF00899 0.295
LIG_UBA3_1 51 60 PF00899 0.379
MOD_CK1_1 148 154 PF00069 0.359
MOD_CK1_1 155 161 PF00069 0.409
MOD_CK1_1 199 205 PF00069 0.419
MOD_CK1_1 328 334 PF00069 0.385
MOD_CK1_1 42 48 PF00069 0.448
MOD_CK1_1 491 497 PF00069 0.475
MOD_CK1_1 93 99 PF00069 0.320
MOD_CK2_1 186 192 PF00069 0.479
MOD_CK2_1 267 273 PF00069 0.535
MOD_CK2_1 305 311 PF00069 0.296
MOD_CK2_1 319 325 PF00069 0.275
MOD_CK2_1 349 355 PF00069 0.369
MOD_CK2_1 468 474 PF00069 0.506
MOD_GlcNHglycan 362 365 PF01048 0.420
MOD_GlcNHglycan 405 409 PF01048 0.473
MOD_GlcNHglycan 410 413 PF01048 0.458
MOD_GlcNHglycan 451 454 PF01048 0.273
MOD_GlcNHglycan 476 479 PF01048 0.324
MOD_GlcNHglycan 6 9 PF01048 0.624
MOD_GlcNHglycan 92 95 PF01048 0.273
MOD_GSK3_1 106 113 PF00069 0.167
MOD_GSK3_1 148 155 PF00069 0.369
MOD_GSK3_1 184 191 PF00069 0.403
MOD_GSK3_1 218 225 PF00069 0.419
MOD_GSK3_1 325 332 PF00069 0.375
MOD_GSK3_1 349 356 PF00069 0.386
MOD_GSK3_1 404 411 PF00069 0.422
MOD_GSK3_1 449 456 PF00069 0.275
MOD_GSK3_1 497 504 PF00069 0.504
MOD_GSK3_1 89 96 PF00069 0.324
MOD_N-GLC_1 426 431 PF02516 0.397
MOD_NEK2_1 111 116 PF00069 0.226
MOD_NEK2_1 186 191 PF00069 0.391
MOD_NEK2_1 196 201 PF00069 0.416
MOD_NEK2_1 257 262 PF00069 0.310
MOD_NEK2_1 267 272 PF00069 0.408
MOD_NEK2_1 290 295 PF00069 0.280
MOD_NEK2_1 318 323 PF00069 0.342
MOD_NEK2_1 349 354 PF00069 0.363
MOD_NEK2_1 359 364 PF00069 0.264
MOD_NEK2_1 376 381 PF00069 0.324
MOD_NEK2_1 404 409 PF00069 0.450
MOD_NEK2_1 460 465 PF00069 0.411
MOD_NEK2_1 482 487 PF00069 0.377
MOD_NEK2_1 78 83 PF00069 0.242
MOD_NEK2_1 98 103 PF00069 0.283
MOD_NEK2_2 313 318 PF00069 0.432
MOD_PIKK_1 184 190 PF00454 0.355
MOD_PIKK_1 426 432 PF00454 0.373
MOD_PK_1 211 217 PF00069 0.484
MOD_PKA_2 199 205 PF00069 0.321
MOD_PKA_2 267 273 PF00069 0.535
MOD_PKA_2 377 383 PF00069 0.438
MOD_PKA_2 55 61 PF00069 0.307
MOD_Plk_1 145 151 PF00069 0.373
MOD_Plk_1 290 296 PF00069 0.269
MOD_Plk_1 305 311 PF00069 0.347
MOD_Plk_1 404 410 PF00069 0.354
MOD_Plk_1 420 426 PF00069 0.346
MOD_Plk_1 491 497 PF00069 0.521
MOD_Plk_1 501 507 PF00069 0.457
MOD_Plk_2-3 302 308 PF00069 0.435
MOD_Plk_4 106 112 PF00069 0.332
MOD_Plk_4 199 205 PF00069 0.308
MOD_Plk_4 290 296 PF00069 0.268
MOD_Plk_4 305 311 PF00069 0.300
MOD_Plk_4 313 319 PF00069 0.259
MOD_Plk_4 325 331 PF00069 0.203
MOD_Plk_4 349 355 PF00069 0.341
MOD_Plk_4 420 426 PF00069 0.303
MOD_Plk_4 443 449 PF00069 0.297
MOD_ProDKin_1 222 228 PF00069 0.354
MOD_ProDKin_1 331 337 PF00069 0.445
MOD_SUMO_for_1 469 472 PF00179 0.385
MOD_SUMO_rev_2 129 134 PF00179 0.455
MOD_SUMO_rev_2 89 99 PF00179 0.336
TRG_DiLeu_BaEn_1 370 375 PF01217 0.450
TRG_DiLeu_BaEn_1 443 448 PF01217 0.279
TRG_DiLeu_BaEn_2 354 360 PF01217 0.285
TRG_DiLeu_BaLyEn_6 345 350 PF01217 0.359
TRG_ENDOCYTIC_2 179 182 PF00928 0.407
TRG_ENDOCYTIC_2 372 375 PF00928 0.355
TRG_ENDOCYTIC_2 505 508 PF00928 0.387
TRG_ENDOCYTIC_2 73 76 PF00928 0.242
TRG_ER_diArg_1 1 3 PF00400 0.535
TRG_ER_diArg_1 9 11 PF00400 0.520
TRG_NES_CRM1_1 386 397 PF08389 0.439
TRG_Pf-PMV_PEXEL_1 38 43 PF00026 0.453

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I163 Leptomonas seymouri 84% 100%
A0A0S4JAW1 Bodo saltans 38% 81%
A0A1X0NP97 Trypanosomatidae 57% 99%
A0A3S5H5Y0 Leishmania donovani 99% 100%
A0A422NAN1 Trypanosoma rangeli 57% 99%
A4H4Z2 Leishmania braziliensis 89% 100%
B1WC61 Rattus norvegicus 26% 83%
C9ZUR0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 54% 100%
E9AL57 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
P45953 Rattus norvegicus 25% 79%
P48818 Bos taurus 25% 79%
P49748 Homo sapiens 24% 79%
P50544 Mus musculus 24% 79%
Q4QIP7 Leishmania major 97% 100%
Q8HXY7 Macaca fascicularis 24% 79%
Q8JZN5 Mus musculus 25% 83%
Q9H845 Homo sapiens 26% 84%
V5BCS4 Trypanosoma cruzi 55% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS