Putative 3-hydroxyacyl-ACP dehydratase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

3-hydroxyacyl-ACP dehydratase - putative

Species:

Leishmania infantum

UniProt:

A4HT65_LEIIN

TriTrypDb:

LINF_070009700

Length:

157

Annotations

Annotations by Jardim et al.

Fatty acid metabolism, 3-hydroxyacyl-ACP dehydratase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 32

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HT65

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HT65

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	2
GO:0006629	lipid metabolic process	3	2
GO:0006631	fatty acid metabolic process	4	2
GO:0006633	fatty acid biosynthetic process	5	2
GO:0008152	metabolic process	1	2
GO:0008610	lipid biosynthetic process	4	2
GO:0009058	biosynthetic process	2	2
GO:0009987	cellular process	1	2
GO:0016053	organic acid biosynthetic process	4	2
GO:0019752	carboxylic acid metabolic process	5	2
GO:0032787	monocarboxylic acid metabolic process	6	2
GO:0043436	oxoacid metabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044255	cellular lipid metabolic process	3	2
GO:0044281	small molecule metabolic process	2	2
GO:0044283	small molecule biosynthetic process	3	2
GO:0046394	carboxylic acid biosynthetic process	5	2
GO:0071704	organic substance metabolic process	2	2
GO:0072330	monocarboxylic acid biosynthetic process	6	2
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0016829	lyase activity	2	8
GO:0016835	carbon-oxygen lyase activity	3	2
GO:0016836	hydro-lyase activity	4	2
GO:0019171	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity	5	2
GO:0004312	fatty acid synthase activity	5	1
GO:0016740	transferase activity	2	1
GO:0016746	acyltransferase activity	3	1
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	8	14	PF00089	0.488
CLV_NRD_NRD_1	107	109	PF00675	0.362
DOC_CYCLIN_RxL_1	140	151	PF00134	0.430
DOC_MAPK_gen_1	108	116	PF00069	0.353
DOC_PP1_RVXF_1	141	148	PF00149	0.410
DOC_PP4_FxxP_1	88	91	PF00568	0.316
DOC_USP7_MATH_1	39	43	PF00917	0.409
LIG_14-3-3_CanoR_1	15	21	PF00244	0.333
LIG_14-3-3_CanoR_1	87	91	PF00244	0.325
LIG_BIR_II_1	1	5	PF00653	0.612
LIG_FHA_1	129	135	PF00498	0.418
LIG_FHA_1	15	21	PF00498	0.371
LIG_FHA_1	3	9	PF00498	0.557
LIG_FHA_1	77	83	PF00498	0.409
LIG_FHA_1	87	93	PF00498	0.379
LIG_FHA_2	27	33	PF00498	0.388
LIG_LIR_Nem_3	29	33	PF02991	0.407
LIG_LIR_Nem_3	55	61	PF02991	0.348
LIG_LIR_Nem_3	64	69	PF02991	0.329
LIG_SH2_STAT3	81	84	PF00017	0.316
LIG_SH2_STAT5	81	84	PF00017	0.331
LIG_SUMO_SIM_anti_2	96	103	PF11976	0.407
LIG_SUMO_SIM_par_1	112	117	PF11976	0.266
LIG_SUMO_SIM_par_1	99	106	PF11976	0.284
LIG_UBA3_1	65	72	PF00899	0.284
LIG_WRC_WIRS_1	27	32	PF05994	0.459
MOD_CK1_1	14	20	PF00069	0.315
MOD_CK1_1	151	157	PF00069	0.504
MOD_CK1_1	2	8	PF00069	0.578
MOD_CK1_1	64	70	PF00069	0.316
MOD_CK2_1	39	45	PF00069	0.345
MOD_GlcNHglycan	135	139	PF01048	0.523
MOD_GlcNHglycan	66	69	PF01048	0.331
MOD_GSK3_1	120	127	PF00069	0.429
MOD_GSK3_1	16	23	PF00069	0.456
MOD_GSK3_1	76	83	PF00069	0.357
MOD_N-GLC_1	141	146	PF02516	0.343
MOD_NEK2_1	141	146	PF00069	0.354
MOD_NEK2_1	86	91	PF00069	0.338
MOD_NEK2_2	16	21	PF00069	0.406
MOD_NEK2_2	61	66	PF00069	0.492
MOD_PIKK_1	20	26	PF00454	0.349
MOD_PIKK_1	80	86	PF00454	0.331
MOD_PKA_2	14	20	PF00069	0.413
MOD_PKA_2	86	92	PF00069	0.388
MOD_Plk_1	141	147	PF00069	0.354
MOD_Plk_1	151	157	PF00069	0.386
MOD_Plk_4	61	67	PF00069	0.333
MOD_Plk_4	76	82	PF00069	0.316

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7R8	Leptomonas seymouri	79%	100%
A0A0N1I7V2	Leptomonas seymouri	66%	100%
A0A0S4J3A3	Bodo saltans	48%	96%
A0A1X0NPA8	Trypanosomatidae	55%	97%
A0A3S5H5X9	Leishmania donovani	100%	100%
A0A3S7WPU4	Leishmania donovani	63%	100%
A0A422NAR2	Trypanosoma rangeli	56%	100%
A4H4Z0	Leishmania braziliensis	61%	100%
A4HT66	Leishmania infantum	63%	100%
C9ZUR2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	97%
E9AL54	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E9AL55	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	100%
O32472	Aeromonas caviae	37%	100%
P86397	Homo sapiens	36%	93%
P9WNP2	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	38%	100%
P9WNP3	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	38%	100%
Q2RQ36	Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIMB 8255 / S1)	32%	100%
Q4QIP9	Leishmania major	63%	100%
Q4QIQ0	Leishmania major	99%	100%
Q7U2S5	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	38%	100%