LeishMANIAdb
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Putative cytochrome c1, heme protein, mitochondrial

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative cytochrome c1, heme protein, mitochondrial
Gene product:
cytochrome c1 - heme protein - mitochondrial - putative
Species:
Leishmania infantum
UniProt:
A4HT63_LEIIN
TriTrypDb:
LINF_070005600
Length:
258

Annotations

Annotations by Jardim et al.

Electron Transport Chain (see tricarboxylic acid section for Complex II), cytochrome c1, Complex III heme , mitochondrial

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
TermNameLevelCount
GO:0005739 mitochondrion 5 1
GO:0005750 mitochondrial respiratory chain complex III 4 1
GO:0016020 membrane 2 9
GO:0032991 protein-containing complex 1 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0045275 respiratory chain complex III 4 1
GO:0070069 cytochrome complex 3 1
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Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HT63
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HT63

Function

Biological processes
TermNameLevelCount
GO:0006091 generation of precursor metabolites and energy 3 1
GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c 7 1
GO:0008152 metabolic process 1 1
GO:0009060 aerobic respiration 6 1
GO:0009987 cellular process 1 1
GO:0015980 energy derivation by oxidation of organic compounds 4 1
GO:0019646 aerobic electron transport chain 6 1
GO:0022900 electron transport chain 4 1
GO:0022904 respiratory electron transport chain 5 1
GO:0044237 cellular metabolic process 2 1
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Molecular functions
TermNameLevelCount
GO:0003824 catalytic activity 1 12
GO:0005488 binding 1 12
GO:0009055 electron transfer activity 3 12
GO:0016491 oxidoreductase activity 2 12
GO:0020037 heme binding 4 12
GO:0046906 tetrapyrrole binding 3 12
GO:0097159 organic cyclic compound binding 2 12
GO:1901363 heterocyclic compound binding 2 12
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 74 78 PF00656 0.281
CLV_NRD_NRD_1 215 217 PF00675 0.278
CLV_NRD_NRD_1 33 35 PF00675 0.278
CLV_NRD_NRD_1 88 90 PF00675 0.398
CLV_PCSK_KEX2_1 10 12 PF00082 0.417
CLV_PCSK_KEX2_1 215 217 PF00082 0.278
CLV_PCSK_KEX2_1 33 35 PF00082 0.278
CLV_PCSK_KEX2_1 88 90 PF00082 0.363
CLV_PCSK_PC1ET2_1 10 12 PF00082 0.417
CLV_PCSK_SKI1_1 216 220 PF00082 0.279
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1PDF2 Leptomonas seymouri 96% 100%
A0A0S4IRH2 Bodo saltans 83% 100%
A0A1X0NKV6 Trypanosomatidae 90% 100%
A0A3S7WPP0 Leishmania donovani 100% 100%
A0A422NTC0 Trypanosoma rangeli 90% 100%
A4H4U9 Leishmania braziliensis 97% 100%
C9ZUW4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 91% 85%
D5ANZ4 Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003) 29% 92%
E9AL16 Leishmania mexicana (strain MHOM/GT/2001/U1103) 100% 100%
O59680 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 45% 84%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS