LeishMANIAdb
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Pitrilysin-like metalloprotease

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Pitrilysin-like metalloprotease
Gene product:
metallo-peptidase - Clan ME - Family M16C
Species:
Leishmania infantum
UniProt:
A4HT59_LEIIN
TriTrypDb:
LINF_070006000
Length:
1032

Annotations

Annotations by Jardim et al.

Proteases, Pitrilysin-like metalloprotease

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HT59
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HT59

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0019538 protein metabolic process 3 12
GO:0043170 macromolecule metabolic process 3 12
GO:0044238 primary metabolic process 2 12
GO:0071704 organic substance metabolic process 2 12
GO:1901564 organonitrogen compound metabolic process 3 12
GO:0016485 protein processing 5 1
GO:0051604 protein maturation 4 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0004175 endopeptidase activity 4 12
GO:0004222 metalloendopeptidase activity 5 12
GO:0005488 binding 1 12
GO:0008233 peptidase activity 3 12
GO:0008237 metallopeptidase activity 4 12
GO:0016787 hydrolase activity 2 12
GO:0043167 ion binding 2 12
GO:0043169 cation binding 3 12
GO:0046872 metal ion binding 4 12
GO:0140096 catalytic activity, acting on a protein 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 267 271 PF00656 0.206
CLV_C14_Caspase3-7 337 341 PF00656 0.307
CLV_C14_Caspase3-7 389 393 PF00656 0.373
CLV_C14_Caspase3-7 816 820 PF00656 0.504
CLV_C14_Caspase3-7 957 961 PF00656 0.480
CLV_MEL_PAP_1 692 698 PF00089 0.298
CLV_NRD_NRD_1 130 132 PF00675 0.420
CLV_NRD_NRD_1 15 17 PF00675 0.462
CLV_NRD_NRD_1 183 185 PF00675 0.434
CLV_NRD_NRD_1 244 246 PF00675 0.393
CLV_NRD_NRD_1 3 5 PF00675 0.528
CLV_NRD_NRD_1 312 314 PF00675 0.372
CLV_NRD_NRD_1 33 35 PF00675 0.147
CLV_NRD_NRD_1 416 418 PF00675 0.260
CLV_NRD_NRD_1 467 469 PF00675 0.395
CLV_NRD_NRD_1 740 742 PF00675 0.325
CLV_NRD_NRD_1 889 891 PF00675 0.376
CLV_NRD_NRD_1 939 941 PF00675 0.545
CLV_PCSK_FUR_1 181 185 PF00082 0.530
CLV_PCSK_FUR_1 313 317 PF00082 0.307
CLV_PCSK_KEX2_1 106 108 PF00082 0.273
CLV_PCSK_KEX2_1 15 17 PF00082 0.421
CLV_PCSK_KEX2_1 180 182 PF00082 0.511
CLV_PCSK_KEX2_1 183 185 PF00082 0.378
CLV_PCSK_KEX2_1 244 246 PF00082 0.330
CLV_PCSK_KEX2_1 3 5 PF00082 0.528
CLV_PCSK_KEX2_1 312 314 PF00082 0.295
CLV_PCSK_KEX2_1 315 317 PF00082 0.294
CLV_PCSK_KEX2_1 33 35 PF00082 0.147
CLV_PCSK_KEX2_1 416 418 PF00082 0.260
CLV_PCSK_KEX2_1 467 469 PF00082 0.371
CLV_PCSK_KEX2_1 740 742 PF00082 0.325
CLV_PCSK_KEX2_1 889 891 PF00082 0.376
CLV_PCSK_PC1ET2_1 106 108 PF00082 0.358
CLV_PCSK_PC1ET2_1 180 182 PF00082 0.553
CLV_PCSK_PC1ET2_1 315 317 PF00082 0.298
CLV_PCSK_SKI1_1 212 216 PF00082 0.331
CLV_PCSK_SKI1_1 812 816 PF00082 0.468
CLV_PCSK_SKI1_1 928 932 PF00082 0.439
CLV_PCSK_SKI1_1 941 945 PF00082 0.461
CLV_PCSK_SKI1_1 982 986 PF00082 0.382
DEG_APCC_DBOX_1 985 993 PF00400 0.372
DEG_APCC_KENBOX_2 324 328 PF00400 0.322
DEG_Kelch_actinfilin_1 280 284 PF01344 0.128
DEG_Nend_Nbox_1 1 3 PF02207 0.531
DEG_SPOP_SBC_1 1006 1010 PF00917 0.403
DEG_SPOP_SBC_1 125 129 PF00917 0.391
DOC_CDC14_PxL_1 460 468 PF14671 0.368
DOC_CKS1_1 1003 1008 PF01111 0.438
DOC_CKS1_1 70 75 PF01111 0.268
DOC_CYCLIN_yClb1_LxF_4 454 460 PF00134 0.352
DOC_CYCLIN_yCln2_LP_2 301 307 PF00134 0.358
DOC_MAPK_gen_1 12 21 PF00069 0.497
DOC_MAPK_gen_1 3 11 PF00069 0.606
DOC_MAPK_gen_1 31 40 PF00069 0.388
DOC_MAPK_gen_1 312 319 PF00069 0.214
DOC_MAPK_gen_1 416 423 PF00069 0.273
DOC_MAPK_gen_1 677 686 PF00069 0.400
DOC_MAPK_MEF2A_6 329 338 PF00069 0.343
DOC_MAPK_MEF2A_6 636 644 PF00069 0.470
DOC_PP1_RVXF_1 417 424 PF00149 0.430
DOC_PP1_RVXF_1 793 800 PF00149 0.381
DOC_PP1_RVXF_1 862 868 PF00149 0.508
DOC_PP1_SILK_1 1012 1017 PF00149 0.409
DOC_PP2B_LxvP_1 540 543 PF13499 0.498
DOC_PP2B_LxvP_1 832 835 PF13499 0.511
DOC_PP2B_LxvP_1 859 862 PF13499 0.478
DOC_PP4_FxxP_1 293 296 PF00568 0.339
DOC_PP4_FxxP_1 70 73 PF00568 0.282
DOC_PP4_FxxP_1 833 836 PF00568 0.486
DOC_USP7_MATH_1 1018 1022 PF00917 0.559
DOC_USP7_MATH_1 249 253 PF00917 0.273
DOC_USP7_MATH_1 268 272 PF00917 0.273
DOC_USP7_MATH_1 400 404 PF00917 0.393
DOC_USP7_MATH_1 492 496 PF00917 0.331
DOC_USP7_MATH_1 558 562 PF00917 0.445
DOC_USP7_MATH_1 567 571 PF00917 0.441
DOC_USP7_MATH_1 714 718 PF00917 0.483
DOC_USP7_MATH_1 755 759 PF00917 0.407
DOC_USP7_MATH_1 768 772 PF00917 0.512
DOC_USP7_MATH_1 791 795 PF00917 0.327
DOC_USP7_MATH_1 897 901 PF00917 0.377
DOC_USP7_MATH_1 964 968 PF00917 0.392
DOC_USP7_UBL2_3 325 329 PF12436 0.420
DOC_USP7_UBL2_3 632 636 PF12436 0.498
DOC_WW_Pin1_4 1002 1007 PF00397 0.482
DOC_WW_Pin1_4 1025 1030 PF00397 0.516
DOC_WW_Pin1_4 346 351 PF00397 0.273
DOC_WW_Pin1_4 373 378 PF00397 0.281
DOC_WW_Pin1_4 69 74 PF00397 0.268
DOC_WW_Pin1_4 764 769 PF00397 0.342
DOC_WW_Pin1_4 866 871 PF00397 0.429
DOC_WW_Pin1_4 919 924 PF00397 0.383
DOC_WW_Pin1_4 958 963 PF00397 0.485
LIG_14-3-3_CanoR_1 107 113 PF00244 0.292
LIG_14-3-3_CanoR_1 196 202 PF00244 0.348
LIG_14-3-3_CanoR_1 292 296 PF00244 0.354
LIG_14-3-3_CanoR_1 3 7 PF00244 0.616
LIG_14-3-3_CanoR_1 316 322 PF00244 0.323
LIG_14-3-3_CanoR_1 416 422 PF00244 0.273
LIG_14-3-3_CanoR_1 430 438 PF00244 0.355
LIG_14-3-3_CanoR_1 491 497 PF00244 0.374
LIG_14-3-3_CanoR_1 569 579 PF00244 0.500
LIG_14-3-3_CanoR_1 695 703 PF00244 0.430
LIG_14-3-3_CanoR_1 837 843 PF00244 0.459
LIG_14-3-3_CanoR_1 876 882 PF00244 0.456
LIG_14-3-3_CanoR_1 940 948 PF00244 0.496
LIG_14-3-3_CanoR_1 954 963 PF00244 0.403
LIG_Actin_WH2_2 970 988 PF00022 0.466
LIG_AP2alpha_1 817 821 PF02296 0.472
LIG_AP2alpha_2 99 101 PF02296 0.273
LIG_APCC_ABBA_1 138 143 PF00400 0.273
LIG_APCC_ABBAyCdc20_2 419 425 PF00400 0.437
LIG_BIR_III_2 819 823 PF00653 0.449
LIG_BIR_III_4 306 310 PF00653 0.393
LIG_BRCT_BRCA1_1 202 206 PF00533 0.490
LIG_BRCT_BRCA1_1 251 255 PF00533 0.330
LIG_BRCT_BRCA1_1 348 352 PF00533 0.420
LIG_BRCT_BRCA1_1 419 423 PF00533 0.353
LIG_BRCT_BRCA1_1 669 673 PF00533 0.481
LIG_Clathr_ClatBox_1 298 302 PF01394 0.420
LIG_EH1_1 204 212 PF00400 0.413
LIG_FHA_1 1007 1013 PF00498 0.422
LIG_FHA_1 180 186 PF00498 0.575
LIG_FHA_1 378 384 PF00498 0.358
LIG_FHA_1 48 54 PF00498 0.376
LIG_FHA_1 481 487 PF00498 0.430
LIG_FHA_1 549 555 PF00498 0.443
LIG_FHA_1 557 563 PF00498 0.431
LIG_FHA_1 584 590 PF00498 0.420
LIG_FHA_1 63 69 PF00498 0.309
LIG_FHA_1 78 84 PF00498 0.273
LIG_FHA_1 852 858 PF00498 0.360
LIG_FHA_1 901 907 PF00498 0.414
LIG_FHA_2 115 121 PF00498 0.273
LIG_FHA_2 284 290 PF00498 0.434
LIG_FHA_2 520 526 PF00498 0.467
LIG_FHA_2 673 679 PF00498 0.420
LIG_FHA_2 688 694 PF00498 0.420
LIG_FHA_2 70 76 PF00498 0.358
LIG_FHA_2 799 805 PF00498 0.432
LIG_FHA_2 991 997 PF00498 0.454
LIG_KLC1_Yacidic_2 139 143 PF13176 0.288
LIG_LIR_Apic_2 290 296 PF02991 0.294
LIG_LIR_Apic_2 320 324 PF02991 0.358
LIG_LIR_Apic_2 830 836 PF02991 0.469
LIG_LIR_Apic_2 916 921 PF02991 0.359
LIG_LIR_Gen_1 133 142 PF02991 0.275
LIG_LIR_Gen_1 218 228 PF02991 0.324
LIG_LIR_Gen_1 235 242 PF02991 0.282
LIG_LIR_Gen_1 270 281 PF02991 0.307
LIG_LIR_Gen_1 99 109 PF02991 0.273
LIG_LIR_Nem_3 119 124 PF02991 0.089
LIG_LIR_Nem_3 133 137 PF02991 0.251
LIG_LIR_Nem_3 218 223 PF02991 0.330
LIG_LIR_Nem_3 235 239 PF02991 0.282
LIG_LIR_Nem_3 254 260 PF02991 0.245
LIG_LIR_Nem_3 270 276 PF02991 0.175
LIG_LIR_Nem_3 349 355 PF02991 0.272
LIG_LIR_Nem_3 669 674 PF02991 0.432
LIG_LIR_Nem_3 746 751 PF02991 0.420
LIG_LIR_Nem_3 853 859 PF02991 0.320
LIG_LIR_Nem_3 99 105 PF02991 0.330
LIG_NRBOX 338 344 PF00104 0.273
LIG_PCNA_PIPBox_1 266 275 PF02747 0.288
LIG_PCNA_yPIPBox_3 325 334 PF02747 0.420
LIG_Pex14_2 66 70 PF04695 0.273
LIG_Pex14_2 817 821 PF04695 0.352
LIG_PTB_Apo_2 653 660 PF02174 0.461
LIG_PTB_Phospho_1 653 659 PF10480 0.461
LIG_Rb_LxCxE_1 880 894 PF01857 0.436
LIG_RPA_C_Fungi 723 735 PF08784 0.420
LIG_SH2_CRK 220 224 PF00017 0.409
LIG_SH2_CRK 257 261 PF00017 0.420
LIG_SH2_CRK 321 325 PF00017 0.420
LIG_SH2_CRK 729 733 PF00017 0.420
LIG_SH2_GRB2like 502 505 PF00017 0.381
LIG_SH2_SRC 141 144 PF00017 0.288
LIG_SH2_SRC 591 594 PF00017 0.273
LIG_SH2_STAP1 236 240 PF00017 0.358
LIG_SH2_STAP1 370 374 PF00017 0.288
LIG_SH2_STAP1 704 708 PF00017 0.393
LIG_SH2_STAP1 782 786 PF00017 0.438
LIG_SH2_STAT5 1003 1006 PF00017 0.347
LIG_SH2_STAT5 121 124 PF00017 0.273
LIG_SH2_STAT5 141 144 PF00017 0.089
LIG_SH2_STAT5 220 223 PF00017 0.427
LIG_SH2_STAT5 272 275 PF00017 0.288
LIG_SH2_STAT5 373 376 PF00017 0.295
LIG_SH2_STAT5 502 505 PF00017 0.330
LIG_SH2_STAT5 580 583 PF00017 0.278
LIG_SH2_STAT5 591 594 PF00017 0.265
LIG_SH2_STAT5 674 677 PF00017 0.284
LIG_SH2_STAT5 886 889 PF00017 0.328
LIG_SH2_STAT5 972 975 PF00017 0.360
LIG_SH3_3 142 148 PF00018 0.273
LIG_SH3_3 196 202 PF00018 0.348
LIG_SH3_3 279 285 PF00018 0.307
LIG_SH3_3 344 350 PF00018 0.261
LIG_SH3_3 94 100 PF00018 0.273
LIG_SUMO_SIM_anti_2 1008 1016 PF11976 0.410
LIG_SUMO_SIM_anti_2 617 623 PF11976 0.391
LIG_SUMO_SIM_anti_2 681 688 PF11976 0.308
LIG_SUMO_SIM_par_1 280 286 PF11976 0.358
LIG_SUMO_SIM_par_1 331 337 PF11976 0.276
LIG_SUMO_SIM_par_1 492 497 PF11976 0.329
LIG_SUMO_SIM_par_1 685 690 PF11976 0.363
LIG_SUMO_SIM_par_1 987 993 PF11976 0.375
LIG_TRFH_1 121 125 PF08558 0.288
LIG_TYR_ITIM 234 239 PF00017 0.330
LIG_TYR_ITSM 216 223 PF00017 0.333
LIG_WRC_WIRS_1 109 114 PF05994 0.307
LIG_WRC_WIRS_1 239 244 PF05994 0.420
LIG_WW_3 834 838 PF00397 0.392
MOD_CDK_SPxxK_3 346 353 PF00069 0.358
MOD_CK1_1 10 16 PF00069 0.507
MOD_CK1_1 108 114 PF00069 0.307
MOD_CK1_1 119 125 PF00069 0.307
MOD_CK1_1 168 174 PF00069 0.342
MOD_CK1_1 200 206 PF00069 0.379
MOD_CK1_1 341 347 PF00069 0.288
MOD_CK1_1 570 576 PF00069 0.420
MOD_CK1_1 601 607 PF00069 0.307
MOD_CK1_1 660 666 PF00069 0.291
MOD_CK1_1 672 678 PF00069 0.350
MOD_CK1_1 771 777 PF00069 0.443
MOD_CK1_1 900 906 PF00069 0.478
MOD_CK1_1 914 920 PF00069 0.389
MOD_CK1_1 958 964 PF00069 0.414
MOD_CK2_1 11 17 PF00069 0.581
MOD_CK2_1 232 238 PF00069 0.320
MOD_CK2_1 261 267 PF00069 0.338
MOD_CK2_1 517 523 PF00069 0.335
MOD_CK2_1 558 564 PF00069 0.288
MOD_CK2_1 601 607 PF00069 0.395
MOD_CK2_1 672 678 PF00069 0.273
MOD_CK2_1 687 693 PF00069 0.273
MOD_CK2_1 69 75 PF00069 0.358
MOD_CK2_1 964 970 PF00069 0.344
MOD_GlcNHglycan 165 170 PF01048 0.263
MOD_GlcNHglycan 223 226 PF01048 0.327
MOD_GlcNHglycan 344 347 PF01048 0.288
MOD_GlcNHglycan 402 405 PF01048 0.364
MOD_GlcNHglycan 432 435 PF01048 0.475
MOD_GlcNHglycan 496 499 PF01048 0.362
MOD_GlcNHglycan 519 522 PF01048 0.408
MOD_GlcNHglycan 573 576 PF01048 0.323
MOD_GlcNHglycan 603 606 PF01048 0.354
MOD_GlcNHglycan 646 649 PF01048 0.326
MOD_GlcNHglycan 696 699 PF01048 0.336
MOD_GlcNHglycan 753 756 PF01048 0.315
MOD_GlcNHglycan 775 778 PF01048 0.391
MOD_GlcNHglycan 825 828 PF01048 0.464
MOD_GSK3_1 1002 1009 PF00069 0.447
MOD_GSK3_1 1025 1032 PF00069 0.556
MOD_GSK3_1 247 254 PF00069 0.273
MOD_GSK3_1 334 341 PF00069 0.277
MOD_GSK3_1 342 349 PF00069 0.273
MOD_GSK3_1 355 362 PF00069 0.247
MOD_GSK3_1 373 380 PF00069 0.287
MOD_GSK3_1 400 407 PF00069 0.364
MOD_GSK3_1 480 487 PF00069 0.476
MOD_GSK3_1 567 574 PF00069 0.436
MOD_GSK3_1 597 604 PF00069 0.348
MOD_GSK3_1 657 664 PF00069 0.311
MOD_GSK3_1 669 676 PF00069 0.329
MOD_GSK3_1 7 14 PF00069 0.626
MOD_GSK3_1 702 709 PF00069 0.320
MOD_GSK3_1 714 721 PF00069 0.260
MOD_GSK3_1 751 758 PF00069 0.340
MOD_GSK3_1 764 771 PF00069 0.378
MOD_GSK3_1 823 830 PF00069 0.450
MOD_GSK3_1 85 92 PF00069 0.338
MOD_GSK3_1 919 926 PF00069 0.379
MOD_GSK3_1 954 961 PF00069 0.437
MOD_N-GLC_1 517 522 PF02516 0.420
MOD_N-GLC_1 598 603 PF02516 0.422
MOD_N-GLC_1 62 67 PF02516 0.313
MOD_N-GLC_1 655 660 PF02516 0.273
MOD_N-GLC_1 900 905 PF02516 0.478
MOD_N-GLC_1 941 946 PF02516 0.378
MOD_N-GLC_2 439 441 PF02516 0.371
MOD_NEK2_1 105 110 PF00069 0.273
MOD_NEK2_1 11 16 PF00069 0.582
MOD_NEK2_1 126 131 PF00069 0.283
MOD_NEK2_1 2 7 PF00069 0.569
MOD_NEK2_1 206 211 PF00069 0.398
MOD_NEK2_1 342 347 PF00069 0.282
MOD_NEK2_1 355 360 PF00069 0.249
MOD_NEK2_1 372 377 PF00069 0.333
MOD_NEK2_1 598 603 PF00069 0.268
MOD_NEK2_1 620 625 PF00069 0.276
MOD_NEK2_1 644 649 PF00069 0.320
MOD_NEK2_1 655 660 PF00069 0.221
MOD_NEK2_1 687 692 PF00069 0.307
MOD_NEK2_1 713 718 PF00069 0.338
MOD_NEK2_1 751 756 PF00069 0.377
MOD_NEK2_1 793 798 PF00069 0.388
MOD_NEK2_1 84 89 PF00069 0.273
MOD_NEK2_2 902 907 PF00069 0.435
MOD_PIKK_1 355 361 PF00454 0.301
MOD_PIKK_1 749 755 PF00454 0.358
MOD_PK_1 417 423 PF00069 0.273
MOD_PK_1 636 642 PF00069 0.288
MOD_PKA_2 11 17 PF00069 0.510
MOD_PKA_2 2 8 PF00069 0.587
MOD_PKA_2 291 297 PF00069 0.346
MOD_PKA_2 568 574 PF00069 0.367
MOD_PKA_2 694 700 PF00069 0.333
MOD_PKA_2 771 777 PF00069 0.379
MOD_PKA_2 836 842 PF00069 0.448
MOD_PKA_2 946 952 PF00069 0.495
MOD_Plk_1 119 125 PF00069 0.273
MOD_Plk_1 598 604 PF00069 0.381
MOD_Plk_1 62 68 PF00069 0.314
MOD_Plk_1 636 642 PF00069 0.282
MOD_Plk_1 655 661 PF00069 0.296
MOD_Plk_1 84 90 PF00069 0.273
MOD_Plk_1 852 858 PF00069 0.339
MOD_Plk_4 1007 1013 PF00069 0.424
MOD_Plk_4 108 114 PF00069 0.290
MOD_Plk_4 119 125 PF00069 0.243
MOD_Plk_4 206 212 PF00069 0.379
MOD_Plk_4 218 224 PF00069 0.365
MOD_Plk_4 268 274 PF00069 0.339
MOD_Plk_4 334 340 PF00069 0.273
MOD_Plk_4 473 479 PF00069 0.424
MOD_Plk_4 614 620 PF00069 0.355
MOD_Plk_4 669 675 PF00069 0.396
MOD_Plk_4 687 693 PF00069 0.152
MOD_Plk_4 714 720 PF00069 0.402
MOD_Plk_4 852 858 PF00069 0.359
MOD_Plk_4 877 883 PF00069 0.452
MOD_ProDKin_1 1002 1008 PF00069 0.490
MOD_ProDKin_1 1025 1031 PF00069 0.515
MOD_ProDKin_1 346 352 PF00069 0.273
MOD_ProDKin_1 373 379 PF00069 0.281
MOD_ProDKin_1 69 75 PF00069 0.268
MOD_ProDKin_1 764 770 PF00069 0.340
MOD_ProDKin_1 866 872 PF00069 0.420
MOD_ProDKin_1 919 925 PF00069 0.385
MOD_ProDKin_1 958 964 PF00069 0.480
MOD_SUMO_for_1 155 158 PF00179 0.288
MOD_SUMO_for_1 498 501 PF00179 0.302
MOD_SUMO_for_1 865 868 PF00179 0.562
MOD_SUMO_rev_2 163 168 PF00179 0.366
MOD_SUMO_rev_2 935 943 PF00179 0.477
MOD_SUMO_rev_2 946 953 PF00179 0.318
MOD_SUMO_rev_2 976 984 PF00179 0.416
TRG_DiLeu_BaEn_1 682 687 PF01217 0.307
TRG_DiLeu_BaEn_3 808 814 PF01217 0.492
TRG_DiLeu_BaLyEn_6 145 150 PF01217 0.273
TRG_DiLeu_BaLyEn_6 181 186 PF01217 0.548
TRG_DiLeu_BaLyEn_6 650 655 PF01217 0.393
TRG_ENDOCYTIC_2 220 223 PF00928 0.336
TRG_ENDOCYTIC_2 236 239 PF00928 0.286
TRG_ENDOCYTIC_2 257 260 PF00928 0.393
TRG_ENDOCYTIC_2 364 367 PF00928 0.259
TRG_ENDOCYTIC_2 54 57 PF00928 0.316
TRG_ENDOCYTIC_2 729 732 PF00928 0.420
TRG_ENDOCYTIC_2 782 785 PF00928 0.379
TRG_ENDOCYTIC_2 974 977 PF00928 0.465
TRG_ER_diArg_1 181 184 PF00400 0.492
TRG_ER_diArg_1 2 4 PF00400 0.529
TRG_ER_diArg_1 311 313 PF00400 0.377
TRG_ER_diArg_1 32 34 PF00400 0.343
TRG_ER_diArg_1 416 419 PF00400 0.260
TRG_ER_diArg_1 466 468 PF00400 0.396
TRG_ER_diArg_1 874 877 PF00400 0.416
TRG_ER_diArg_1 889 892 PF00400 0.277
TRG_NES_CRM1_1 678 693 PF08389 0.273
TRG_NLS_MonoExtC_3 179 184 PF00514 0.610
TRG_NLS_MonoExtN_4 178 184 PF00514 0.543
TRG_Pf-PMV_PEXEL_1 33 37 PF00026 0.387
TRG_Pf-PMV_PEXEL_1 353 357 PF00026 0.358
TRG_Pf-PMV_PEXEL_1 467 471 PF00026 0.381
TRG_Pf-PMV_PEXEL_1 812 816 PF00026 0.501

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I980 Leptomonas seymouri 77% 100%
A0A0S4IK68 Bodo saltans 48% 100%
A0A1X0NK84 Trypanosomatidae 58% 100%
A0A3R7M459 Trypanosoma rangeli 58% 100%
A0A3S5H5V9 Leishmania donovani 100% 100%
A4H4V3 Leishmania braziliensis 89% 100%
C9ZUW1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 58% 100%
E9AL20 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
O42908 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 30% 100%
O51246 Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31) 22% 100%
P32898 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 29% 100%
Q28BR5 Xenopus tropicalis 30% 100%
Q2UGN1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 30% 100%
Q46205 Clostridium perfringens (strain 13 / Type A) 25% 100%
Q4IA56 Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) 30% 100%
Q4QIT4 Leishmania major 97% 100%
Q4WP38 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 31% 97%
Q5A301 Candida albicans (strain SC5314 / ATCC MYA-2876) 27% 100%
Q5B6H7 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 31% 98%
Q5JRX3 Homo sapiens 30% 100%
Q5RDG3 Pongo abelii 31% 100%
Q6BTC0 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 29% 97%
Q6C0U8 Yarrowia lipolytica (strain CLIB 122 / E 150) 30% 100%
Q6CWW6 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 29% 100%
Q6FUI7 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 28% 100%
Q6PF24 Xenopus laevis 30% 100%
Q759T9 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 28% 100%
Q7S7C0 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 31% 100%
Q7ZVZ6 Danio rerio 30% 100%
Q8K411 Mus musculus 31% 100%
Q8VY06 Arabidopsis thaliana 27% 96%
Q9LJL3 Arabidopsis thaliana 27% 96%
Q9V9E3 Drosophila melanogaster 29% 100%
V5BHV5 Trypanosoma cruzi 58% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS