Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial calcium uptake 1 - putative

Species:

Leishmania infantum

UniProt:

A4HT58_LEIIN

TriTrypDb:

LINF_070006100

Length:

345

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0032991	protein-containing complex	1	1
GO:0034702	monoatomic ion channel complex	4	1
GO:0034703	cation channel complex	5	1
GO:0034704	calcium channel complex	6	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098800	inner mitochondrial membrane protein complex	3	1
GO:0110165	cellular anatomical entity	1	4
GO:1902495	transmembrane transporter complex	3	1
GO:1990246	uniplex complex	4	1
GO:1990351	transporter complex	2	1
GO:0016020	membrane	2	3

Expansion

Sequence features

A4HT58

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HT58

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0006811	monoatomic ion transport	4	12
GO:0006812	monoatomic cation transport	5	12
GO:0006816	calcium ion transport	7	12
GO:0006851	mitochondrial calcium ion transmembrane transport	4	12
GO:0009987	cellular process	1	12
GO:0030001	metal ion transport	6	12
GO:0034220	monoatomic ion transmembrane transport	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0055085	transmembrane transport	2	12
GO:0070588	calcium ion transmembrane transport	6	12
GO:0098655	monoatomic cation transmembrane transport	4	12
GO:0098660	inorganic ion transmembrane transport	4	12
GO:0098662	inorganic cation transmembrane transport	5	12
GO:1990542	mitochondrial transmembrane transport	3	12
GO:0006873	intracellular monoatomic ion homeostasis	4	1
GO:0006874	intracellular calcium ion homeostasis	7	1
GO:0006875	obsolete intracellular metal ion homeostasis	6	1
GO:0019725	cellular homeostasis	2	1
GO:0030003	intracellular monoatomic cation homeostasis	5	1
GO:0036444	calcium import into the mitochondrion	5	1
GO:0042592	homeostatic process	3	1
GO:0048878	chemical homeostasis	4	1
GO:0050801	monoatomic ion homeostasis	5	1
GO:0051560	mitochondrial calcium ion homeostasis	8	1
GO:0055065	obsolete metal ion homeostasis	7	1
GO:0055074	calcium ion homeostasis	8	1
GO:0055080	monoatomic cation homeostasis	6	1
GO:0055082	intracellular chemical homeostasis	3	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0072503	obsolete cellular divalent inorganic cation homeostasis	6	1
GO:0072507	obsolete divalent inorganic cation homeostasis	7	1
GO:0098771	inorganic ion homeostasis	6	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005509	calcium ion binding	5	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	74	78	PF00656	0.313
CLV_NRD_NRD_1	146	148	PF00675	0.438
CLV_NRD_NRD_1	162	164	PF00675	0.442
CLV_NRD_NRD_1	223	225	PF00675	0.235
CLV_NRD_NRD_1	270	272	PF00675	0.284
CLV_NRD_NRD_1	310	312	PF00675	0.416
CLV_NRD_NRD_1	324	326	PF00675	0.605
CLV_NRD_NRD_1	33	35	PF00675	0.347
CLV_NRD_NRD_1	330	332	PF00675	0.536
CLV_PCSK_KEX2_1	146	148	PF00082	0.416
CLV_PCSK_KEX2_1	162	164	PF00082	0.452
CLV_PCSK_KEX2_1	192	194	PF00082	0.323
CLV_PCSK_KEX2_1	223	225	PF00082	0.325
CLV_PCSK_KEX2_1	266	268	PF00082	0.311
CLV_PCSK_KEX2_1	270	272	PF00082	0.311
CLV_PCSK_KEX2_1	330	332	PF00082	0.560
CLV_PCSK_KEX2_1	35	37	PF00082	0.429
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.323
CLV_PCSK_PC1ET2_1	266	268	PF00082	0.348
CLV_PCSK_PC1ET2_1	35	37	PF00082	0.429
CLV_PCSK_SKI1_1	138	142	PF00082	0.425
CLV_PCSK_SKI1_1	152	156	PF00082	0.290
CLV_PCSK_SKI1_1	207	211	PF00082	0.386
CLV_PCSK_SKI1_1	312	316	PF00082	0.339
CLV_PCSK_SKI1_1	330	334	PF00082	0.504
DOC_CDC14_PxL_1	275	283	PF14671	0.282
DOC_CKS1_1	9	14	PF01111	0.444
DOC_CYCLIN_RxL_1	132	145	PF00134	0.495
DOC_CYCLIN_RxL_1	146	159	PF00134	0.360
DOC_USP7_MATH_2	322	328	PF00917	0.485
DOC_WW_Pin1_4	52	57	PF00397	0.462
DOC_WW_Pin1_4	8	13	PF00397	0.492
LIG_14-3-3_CanoR_1	162	167	PF00244	0.337
LIG_14-3-3_CanoR_1	193	201	PF00244	0.318
LIG_14-3-3_CanoR_1	270	276	PF00244	0.398
LIG_14-3-3_CanoR_1	325	329	PF00244	0.517
LIG_14-3-3_CanoR_1	90	96	PF00244	0.397
LIG_APCC_ABBA_1	243	248	PF00400	0.338
LIG_BIR_III_4	77	81	PF00653	0.269
LIG_deltaCOP1_diTrp_1	179	185	PF00928	0.256
LIG_DLG_GKlike_1	162	169	PF00625	0.474
LIG_FHA_1	11	17	PF00498	0.582
LIG_FHA_1	115	121	PF00498	0.411
LIG_FHA_1	283	289	PF00498	0.397
LIG_FHA_2	128	134	PF00498	0.482
LIG_FHA_2	195	201	PF00498	0.397
LIG_FHA_2	263	269	PF00498	0.427
LIG_FHA_2	42	48	PF00498	0.291
LIG_LIR_Apic_2	13	17	PF02991	0.370
LIG_LIR_Apic_2	8	12	PF02991	0.467
LIG_LIR_Gen_1	121	127	PF02991	0.368
LIG_LIR_Gen_1	199	209	PF02991	0.397
LIG_LIR_Gen_1	287	294	PF02991	0.335
LIG_LIR_Gen_1	304	314	PF02991	0.177
LIG_LIR_Gen_1	81	91	PF02991	0.286
LIG_LIR_Nem_3	104	110	PF02991	0.283
LIG_LIR_Nem_3	121	126	PF02991	0.157
LIG_LIR_Nem_3	165	169	PF02991	0.344
LIG_LIR_Nem_3	184	188	PF02991	0.257
LIG_LIR_Nem_3	199	204	PF02991	0.254
LIG_LIR_Nem_3	235	240	PF02991	0.274
LIG_LIR_Nem_3	25	30	PF02991	0.303
LIG_LIR_Nem_3	268	272	PF02991	0.350
LIG_LIR_Nem_3	287	293	PF02991	0.339
LIG_LIR_Nem_3	304	309	PF02991	0.177
LIG_LIR_Nem_3	81	86	PF02991	0.298
LIG_LIR_Nem_3	88	92	PF02991	0.316
LIG_NRBOX	91	97	PF00104	0.254
LIG_PCNA_yPIPBox_3	142	155	PF02747	0.417
LIG_Pex14_1	181	185	PF04695	0.254
LIG_SH2_CRK	30	34	PF00017	0.372
LIG_SH2_CRK	318	322	PF00017	0.573
LIG_SH2_NCK_1	318	322	PF00017	0.573
LIG_SH2_NCK_1	9	13	PF00017	0.526
LIG_SH2_SRC	14	17	PF00017	0.402
LIG_SH2_STAP1	246	250	PF00017	0.389
LIG_SH2_STAT3	246	249	PF00017	0.306
LIG_SH2_STAT5	108	111	PF00017	0.464
LIG_SH2_STAT5	14	17	PF00017	0.398
LIG_SH2_STAT5	19	22	PF00017	0.364
LIG_SH2_STAT5	217	220	PF00017	0.351
LIG_SH2_STAT5	83	86	PF00017	0.275
LIG_SH3_3	276	282	PF00018	0.383
LIG_SUMO_SIM_par_1	115	122	PF11976	0.397
LIG_SUMO_SIM_par_1	230	235	PF11976	0.291
LIG_TRAF2_1	119	122	PF00917	0.330
LIG_TRAF2_1	197	200	PF00917	0.397
LIG_TYR_ITIM	214	219	PF00017	0.397
LIG_TYR_ITIM	28	33	PF00017	0.388
LIG_UBA3_1	106	114	PF00899	0.343
LIG_UBA3_1	307	315	PF00899	0.366
MOD_CDC14_SPxK_1	55	58	PF00782	0.496
MOD_CDK_SPxK_1	52	58	PF00069	0.468
MOD_CK1_1	175	181	PF00069	0.489
MOD_CK1_1	260	266	PF00069	0.348
MOD_CK1_1	8	14	PF00069	0.641
MOD_CK1_1	94	100	PF00069	0.379
MOD_CK2_1	116	122	PF00069	0.337
MOD_CK2_1	128	134	PF00069	0.411
MOD_CK2_1	162	168	PF00069	0.351
MOD_CK2_1	194	200	PF00069	0.421
MOD_CK2_1	82	88	PF00069	0.269
MOD_GlcNHglycan	113	117	PF01048	0.404
MOD_GlcNHglycan	227	230	PF01048	0.313
MOD_GlcNHglycan	259	262	PF01048	0.290
MOD_GlcNHglycan	318	321	PF01048	0.474
MOD_GSK3_1	112	119	PF00069	0.372
MOD_GSK3_1	256	263	PF00069	0.374
MOD_GSK3_1	91	98	PF00069	0.359
MOD_NEK2_1	127	132	PF00069	0.366
MOD_NEK2_1	172	177	PF00069	0.437
MOD_NEK2_1	256	261	PF00069	0.287
MOD_NEK2_1	262	267	PF00069	0.276
MOD_NEK2_1	91	96	PF00069	0.288
MOD_PKA_1	162	168	PF00069	0.430
MOD_PKA_2	127	133	PF00069	0.287
MOD_PKA_2	162	168	PF00069	0.393
MOD_PKA_2	194	200	PF00069	0.380
MOD_PKA_2	324	330	PF00069	0.578
MOD_Plk_2-3	230	236	PF00069	0.265
MOD_Plk_4	10	16	PF00069	0.500
MOD_Plk_4	91	97	PF00069	0.298
MOD_ProDKin_1	52	58	PF00069	0.468
MOD_ProDKin_1	8	14	PF00069	0.487
MOD_SUMO_rev_2	319	328	PF00179	0.515
TRG_DiLeu_BaEn_1	168	173	PF01217	0.325
TRG_DiLeu_BaEn_1	200	205	PF01217	0.348
TRG_DiLeu_BaEn_1	88	93	PF01217	0.254
TRG_DiLeu_BaEn_2	301	307	PF01217	0.258
TRG_ENDOCYTIC_2	216	219	PF00928	0.397
TRG_ENDOCYTIC_2	30	33	PF00928	0.344
TRG_ENDOCYTIC_2	42	45	PF00928	0.225
TRG_ENDOCYTIC_2	83	86	PF00928	0.275
TRG_ER_diArg_1	161	163	PF00400	0.492
TRG_ER_diArg_1	193	196	PF00400	0.197
TRG_ER_diArg_1	222	224	PF00400	0.325
TRG_ER_diArg_1	23	26	PF00400	0.401
TRG_ER_diArg_1	269	271	PF00400	0.335
TRG_ER_diArg_1	329	331	PF00400	0.533
TRG_ER_diArg_1	33	36	PF00400	0.356
TRG_NES_CRM1_1	235	248	PF08389	0.368
TRG_NLS_MonoCore_2	33	38	PF00514	0.497
TRG_NLS_MonoExtC_3	310	315	PF00514	0.332
TRG_NLS_MonoExtN_4	311	316	PF00514	0.339
TRG_NLS_MonoExtN_4	34	39	PF00514	0.494
TRG_Pf-PMV_PEXEL_1	152	157	PF00026	0.357

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P773	Leptomonas seymouri	75%	79%
A0A0S4IPF8	Bodo saltans	43%	87%
A0A1X0NK53	Trypanosomatidae	49%	86%
A0A3S5H5W0	Leishmania donovani	100%	100%
A0A422NT64	Trypanosoma rangeli	47%	86%
A4H4V4	Leishmania braziliensis	87%	100%
A4IG32	Danio rerio	22%	71%
C9ZUW0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	72%
E9AL21	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QIT3	Leishmania major	97%	100%
Q4R518	Macaca fascicularis	20%	72%
Q8CD10	Mus musculus	21%	80%
Q8IYU8	Homo sapiens	22%	79%
Q99P63	Rattus norvegicus	21%	80%
Q9BPX6	Homo sapiens	20%	72%
Q9SZ45	Arabidopsis thaliana	26%	69%
V5B8U7	Trypanosoma cruzi	49%	74%
V5BRA1	Trypanosoma cruzi	24%	74%