TAPT1 family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Eukaryotic membrane protein family - putative

Species:

Leishmania infantum

UniProt:

A4HT53_LEIIN

TriTrypDb:

LINF_070006500

Length:

617

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4HT53

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HT53

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	1
GO:0032507	maintenance of protein location in cell	3	1
GO:0035437	maintenance of protein localization in endoplasmic reticulum	5	1
GO:0045185	maintenance of protein location	3	1
GO:0051179	localization	1	1
GO:0051235	maintenance of location	2	1
GO:0051651	maintenance of location in cell	2	1
GO:0072595	maintenance of protein localization in organelle	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	123	125	PF00675	0.556
CLV_NRD_NRD_1	162	164	PF00675	0.248
CLV_NRD_NRD_1	209	211	PF00675	0.313
CLV_NRD_NRD_1	532	534	PF00675	0.453
CLV_NRD_NRD_1	69	71	PF00675	0.551
CLV_NRD_NRD_1	79	81	PF00675	0.359
CLV_NRD_NRD_1	9	11	PF00675	0.471
CLV_PCSK_KEX2_1	123	125	PF00082	0.570
CLV_PCSK_KEX2_1	162	164	PF00082	0.248
CLV_PCSK_KEX2_1	208	210	PF00082	0.313
CLV_PCSK_KEX2_1	222	224	PF00082	0.326
CLV_PCSK_KEX2_1	437	439	PF00082	0.247
CLV_PCSK_KEX2_1	532	534	PF00082	0.453
CLV_PCSK_KEX2_1	614	616	PF00082	0.507
CLV_PCSK_KEX2_1	69	71	PF00082	0.551
CLV_PCSK_KEX2_1	9	11	PF00082	0.505
CLV_PCSK_PC1ET2_1	222	224	PF00082	0.358
CLV_PCSK_PC1ET2_1	437	439	PF00082	0.290
CLV_PCSK_PC1ET2_1	614	616	PF00082	0.507
CLV_PCSK_PC7_1	205	211	PF00082	0.292
CLV_PCSK_SKI1_1	117	121	PF00082	0.630
CLV_PCSK_SKI1_1	223	227	PF00082	0.289
CLV_PCSK_SKI1_1	249	253	PF00082	0.318
CLV_PCSK_SKI1_1	365	369	PF00082	0.248
CLV_PCSK_SKI1_1	434	438	PF00082	0.324
CLV_PCSK_SKI1_1	480	484	PF00082	0.397
DEG_APCC_DBOX_1	123	131	PF00400	0.318
DEG_APCC_DBOX_1	492	500	PF00400	0.605
DEG_APCC_DBOX_1	9	17	PF00400	0.554
DEG_Nend_UBRbox_1	1	4	PF02207	0.583
DEG_SCF_FBW7_1	553	560	PF00400	0.711
DEG_SPOP_SBC_1	572	576	PF00917	0.663
DOC_CDC14_PxL_1	397	405	PF14671	0.518
DOC_CKS1_1	243	248	PF01111	0.518
DOC_CKS1_1	424	429	PF01111	0.518
DOC_CKS1_1	554	559	PF01111	0.637
DOC_CYCLIN_RxL_1	244	255	PF00134	0.524
DOC_CYCLIN_yCln2_LP_2	112	118	PF00134	0.410
DOC_MAPK_DCC_7	588	598	PF00069	0.547
DOC_MAPK_gen_1	162	169	PF00069	0.448
DOC_MAPK_gen_1	9	15	PF00069	0.674
DOC_MAPK_MEF2A_6	128	135	PF00069	0.237
DOC_MAPK_MEF2A_6	162	171	PF00069	0.434
DOC_MAPK_MEF2A_6	592	600	PF00069	0.554
DOC_MAPK_MEF2A_6	85	93	PF00069	0.491
DOC_MAPK_NFAT4_5	128	136	PF00069	0.318
DOC_PP2B_LxvP_1	112	115	PF13499	0.297
DOC_USP7_MATH_1	225	229	PF00917	0.439
DOC_USP7_MATH_1	51	55	PF00917	0.762
DOC_USP7_MATH_1	510	514	PF00917	0.756
DOC_USP7_MATH_1	572	576	PF00917	0.632
DOC_USP7_MATH_1	58	62	PF00917	0.682
DOC_WW_Pin1_4	216	221	PF00397	0.509
DOC_WW_Pin1_4	242	247	PF00397	0.561
DOC_WW_Pin1_4	306	311	PF00397	0.318
DOC_WW_Pin1_4	423	428	PF00397	0.496
DOC_WW_Pin1_4	499	504	PF00397	0.638
DOC_WW_Pin1_4	549	554	PF00397	0.578
DOC_WW_Pin1_4	557	562	PF00397	0.658
DOC_WW_Pin1_4	580	585	PF00397	0.591
DOC_WW_Pin1_4	591	596	PF00397	0.628
LIG_14-3-3_CanoR_1	162	167	PF00244	0.447
LIG_14-3-3_CanoR_1	342	348	PF00244	0.318
LIG_14-3-3_CanoR_1	381	389	PF00244	0.466
LIG_14-3-3_CanoR_1	493	497	PF00244	0.586
LIG_14-3-3_CanoR_1	532	538	PF00244	0.686
LIG_14-3-3_CanoR_1	9	14	PF00244	0.606
LIG_Actin_WH2_2	112	130	PF00022	0.461
LIG_Actin_WH2_2	285	303	PF00022	0.324
LIG_DLG_GKlike_1	533	541	PF00625	0.629
LIG_EH1_1	106	114	PF00400	0.395
LIG_eIF4E_1	383	389	PF01652	0.524
LIG_EVH1_1	506	510	PF00568	0.603
LIG_EVH1_2	376	380	PF00568	0.473
LIG_FHA_1	10	16	PF00498	0.657
LIG_FHA_1	130	136	PF00498	0.399
LIG_FHA_1	148	154	PF00498	0.169
LIG_FHA_1	162	168	PF00498	0.437
LIG_FHA_1	274	280	PF00498	0.256
LIG_FHA_1	496	502	PF00498	0.611
LIG_FHA_1	536	542	PF00498	0.722
LIG_FHA_1	592	598	PF00498	0.562
LIG_FHA_2	414	420	PF00498	0.548
LIG_GBD_Chelix_1	178	186	PF00786	0.203
LIG_HCF-1_HBM_1	73	76	PF13415	0.590
LIG_LIR_Gen_1	164	173	PF02991	0.460
LIG_LIR_Gen_1	192	203	PF02991	0.518
LIG_LIR_Gen_1	341	351	PF02991	0.256
LIG_LIR_Gen_1	38	48	PF02991	0.662
LIG_LIR_Gen_1	73	83	PF02991	0.579
LIG_LIR_Gen_1	88	98	PF02991	0.424
LIG_LIR_LC3C_4	498	501	PF02991	0.595
LIG_LIR_Nem_3	151	157	PF02991	0.490
LIG_LIR_Nem_3	164	169	PF02991	0.460
LIG_LIR_Nem_3	192	198	PF02991	0.529
LIG_LIR_Nem_3	341	346	PF02991	0.249
LIG_LIR_Nem_3	350	355	PF02991	0.297
LIG_LIR_Nem_3	378	383	PF02991	0.472
LIG_LIR_Nem_3	4	8	PF02991	0.659
LIG_LIR_Nem_3	505	509	PF02991	0.657
LIG_LIR_Nem_3	73	79	PF02991	0.607
LIG_LIR_Nem_3	88	93	PF02991	0.445
LIG_LIR_Nem_3	94	99	PF02991	0.322
LIG_LYPXL_S_1	153	157	PF13949	0.148
LIG_LYPXL_yS_3	154	157	PF13949	0.348
LIG_MYND_3	400	404	PF01753	0.518
LIG_NRBOX	107	113	PF00104	0.299
LIG_NRBOX	267	273	PF00104	0.395
LIG_NRBOX	287	293	PF00104	0.125
LIG_NRBOX	596	602	PF00104	0.538
LIG_Pex14_2	368	372	PF04695	0.434
LIG_Rb_LxCxE_1	350	362	PF01857	0.395
LIG_SH2_CRK	158	162	PF00017	0.436
LIG_SH2_CRK	383	387	PF00017	0.448
LIG_SH2_CRK	446	450	PF00017	0.334
LIG_SH2_CRK	76	80	PF00017	0.632
LIG_SH2_NCK_1	195	199	PF00017	0.518
LIG_SH2_SRC	156	159	PF00017	0.448
LIG_SH2_STAP1	37	41	PF00017	0.652
LIG_SH2_STAP1	383	387	PF00017	0.490
LIG_SH2_STAP1	446	450	PF00017	0.327
LIG_SH2_STAT5	156	159	PF00017	0.474
LIG_SH2_STAT5	327	330	PF00017	0.346
LIG_SH2_STAT5	460	463	PF00017	0.346
LIG_SH2_STAT5	96	99	PF00017	0.349
LIG_SH3_3	497	503	PF00018	0.628
LIG_SH3_3	504	510	PF00018	0.696
LIG_SH3_3	512	518	PF00018	0.700
LIG_SUMO_SIM_anti_2	12	17	PF11976	0.658
LIG_SUMO_SIM_anti_2	129	135	PF11976	0.286
LIG_SUMO_SIM_anti_2	189	195	PF11976	0.466
LIG_SUMO_SIM_anti_2	267	272	PF11976	0.403
LIG_SUMO_SIM_anti_2	287	293	PF11976	0.125
LIG_SUMO_SIM_anti_2	384	390	PF11976	0.466
LIG_SUMO_SIM_anti_2	402	408	PF11976	0.466
LIG_SUMO_SIM_par_1	131	137	PF11976	0.360
LIG_SUMO_SIM_par_1	168	174	PF11976	0.452
LIG_SUMO_SIM_par_1	387	392	PF11976	0.530
LIG_SUMO_SIM_par_1	497	502	PF11976	0.569
LIG_TYR_ITIM	193	198	PF00017	0.518
LIG_TYR_ITIM	444	449	PF00017	0.297
LIG_UBA3_1	111	117	PF00899	0.325
LIG_UBA3_1	172	181	PF00899	0.518
LIG_UBA3_1	471	480	PF00899	0.415
LIG_UBA3_1	596	602	PF00899	0.590
LIG_WW_2	507	510	PF00397	0.604
MOD_CDK_SPK_2	553	558	PF00069	0.703
MOD_CDK_SPxK_1	216	222	PF00069	0.439
MOD_CDK_SPxxK_3	216	223	PF00069	0.495
MOD_CDK_SPxxK_3	242	249	PF00069	0.518
MOD_CK1_1	184	190	PF00069	0.435
MOD_CK1_1	264	270	PF00069	0.323
MOD_CK1_1	312	318	PF00069	0.363
MOD_CK1_1	502	508	PF00069	0.656
MOD_CK1_1	513	519	PF00069	0.683
MOD_CK1_1	527	533	PF00069	0.689
MOD_CK1_1	536	542	PF00069	0.671
MOD_CK1_1	54	60	PF00069	0.757
MOD_CK1_1	552	558	PF00069	0.651
MOD_CK1_1	571	577	PF00069	0.576
MOD_CK1_1	580	586	PF00069	0.585
MOD_CK2_1	305	311	PF00069	0.330
MOD_CK2_1	413	419	PF00069	0.538
MOD_CK2_1	520	526	PF00069	0.762
MOD_Cter_Amidation	67	70	PF01082	0.463
MOD_GlcNHglycan	227	230	PF01048	0.357
MOD_GlcNHglycan	237	240	PF01048	0.303
MOD_GlcNHglycan	254	257	PF01048	0.300
MOD_GlcNHglycan	407	410	PF01048	0.340
MOD_GlcNHglycan	411	414	PF01048	0.324
MOD_GlcNHglycan	43	46	PF01048	0.490
MOD_GlcNHglycan	512	515	PF01048	0.508
MOD_GlcNHglycan	526	529	PF01048	0.541
MOD_GlcNHglycan	53	56	PF01048	0.569
MOD_GlcNHglycan	533	536	PF01048	0.535
MOD_GlcNHglycan	564	567	PF01048	0.459
MOD_GlcNHglycan	570	573	PF01048	0.474
MOD_GlcNHglycan	60	63	PF01048	0.464
MOD_GSK3_1	260	267	PF00069	0.341
MOD_GSK3_1	273	280	PF00069	0.205
MOD_GSK3_1	295	302	PF00069	0.285
MOD_GSK3_1	305	312	PF00069	0.322
MOD_GSK3_1	405	412	PF00069	0.526
MOD_GSK3_1	495	502	PF00069	0.656
MOD_GSK3_1	520	527	PF00069	0.768
MOD_GSK3_1	531	538	PF00069	0.710
MOD_GSK3_1	54	61	PF00069	0.729
MOD_GSK3_1	549	556	PF00069	0.521
MOD_GSK3_1	568	575	PF00069	0.662
MOD_N-GLC_1	277	282	PF02516	0.543
MOD_N-GLC_1	295	300	PF02516	0.432
MOD_NEK2_1	134	139	PF00069	0.384
MOD_NEK2_1	148	153	PF00069	0.224
MOD_NEK2_1	171	176	PF00069	0.493
MOD_NEK2_1	252	257	PF00069	0.334
MOD_NEK2_1	277	282	PF00069	0.235
MOD_NEK2_1	305	310	PF00069	0.275
MOD_NEK2_1	41	46	PF00069	0.663
MOD_NEK2_1	481	486	PF00069	0.338
MOD_NEK2_1	537	542	PF00069	0.682
MOD_NEK2_1	97	102	PF00069	0.297
MOD_NEK2_2	492	497	PF00069	0.585
MOD_OFUCOSY	260	265	PF10250	0.395
MOD_PIKK_1	117	123	PF00454	0.340
MOD_PIKK_1	148	154	PF00454	0.355
MOD_PIKK_1	184	190	PF00454	0.466
MOD_PIKK_1	25	31	PF00454	0.704
MOD_PIKK_1	381	387	PF00454	0.466
MOD_PIKK_1	527	533	PF00454	0.770
MOD_PKA_1	162	168	PF00069	0.448
MOD_PKA_1	209	215	PF00069	0.393
MOD_PKA_1	9	15	PF00069	0.599
MOD_PKA_2	161	167	PF00069	0.448
MOD_PKA_2	204	210	PF00069	0.393
MOD_PKA_2	341	347	PF00069	0.318
MOD_PKA_2	492	498	PF00069	0.587
MOD_PKA_2	531	537	PF00069	0.736
MOD_PKA_2	9	15	PF00069	0.645
MOD_Plk_1	277	283	PF00069	0.216
MOD_Plk_4	139	145	PF00069	0.301
MOD_Plk_4	162	168	PF00069	0.403
MOD_Plk_4	266	272	PF00069	0.306
MOD_Plk_4	284	290	PF00069	0.223
MOD_Plk_4	299	305	PF00069	0.202
MOD_Plk_4	375	381	PF00069	0.432
MOD_Plk_4	482	488	PF00069	0.382
MOD_Plk_4	537	543	PF00069	0.580
MOD_ProDKin_1	216	222	PF00069	0.509
MOD_ProDKin_1	242	248	PF00069	0.561
MOD_ProDKin_1	306	312	PF00069	0.318
MOD_ProDKin_1	423	429	PF00069	0.496
MOD_ProDKin_1	499	505	PF00069	0.648
MOD_ProDKin_1	549	555	PF00069	0.581
MOD_ProDKin_1	557	563	PF00069	0.659
MOD_ProDKin_1	580	586	PF00069	0.585
MOD_ProDKin_1	591	597	PF00069	0.623
MOD_SUMO_rev_2	28	36	PF00179	0.678
TRG_DiLeu_BaEn_1	284	289	PF01217	0.248
TRG_DiLeu_BaEn_1	420	425	PF01217	0.518
TRG_DiLeu_BaLyEn_6	592	597	PF01217	0.604
TRG_ENDOCYTIC_2	154	157	PF00928	0.524
TRG_ENDOCYTIC_2	158	161	PF00928	0.434
TRG_ENDOCYTIC_2	195	198	PF00928	0.518
TRG_ENDOCYTIC_2	327	330	PF00928	0.360
TRG_ENDOCYTIC_2	37	40	PF00928	0.654
TRG_ENDOCYTIC_2	383	386	PF00928	0.436
TRG_ENDOCYTIC_2	446	449	PF00928	0.294
TRG_ENDOCYTIC_2	76	79	PF00928	0.631
TRG_ENDOCYTIC_2	96	99	PF00928	0.125
TRG_ER_diArg_1	122	124	PF00400	0.404
TRG_ER_diArg_1	161	163	PF00400	0.448
TRG_ER_diArg_1	208	210	PF00400	0.510
TRG_ER_diArg_1	69	72	PF00400	0.749
TRG_ER_diArg_1	8	10	PF00400	0.598
TRG_ER_diLys_1	612	617	PF00400	0.709

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JBJ3	Bodo saltans	33%	100%
A0A1X0NLV9	Trypanosomatidae	39%	100%
A0A3S7WPS5	Leishmania donovani	100%	100%
A0A422NTF0	Trypanosoma rangeli	41%	100%
A4H4V9	Leishmania braziliensis	78%	99%
C9ZUV5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	98%
E9AL25	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	97%
Q4QIS9	Leishmania major	93%	100%
Q4VBD2	Mus musculus	25%	100%
Q5EAY8	Xenopus laevis	24%	100%
V5D9E0	Trypanosoma cruzi	36%	100%