LeishMANIAdb
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Paraflagellar_rod_protein_-_putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Paraflagellar_rod_protein_-_putative
Gene product:
Paraflagellar rod protein - putative
Species:
Leishmania infantum
UniProt:
A4HT49_LEIIN
TriTrypDb:
LINF_070008300
Length:
809

Annotations

Annotations by Jardim et al.

Flagella, paraflagellar rod

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 6
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005929 cilium 4 11
GO:0031514 motile cilium 5 11
GO:0042995 cell projection 2 11
GO:0043226 organelle 2 11
GO:0043227 membrane-bounded organelle 3 11
GO:0110165 cellular anatomical entity 1 11
GO:0120025 plasma membrane bounded cell projection 3 11

Expansion

Sequence features

A4HT49
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HT49

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005488 binding 1 11
GO:0005515 protein binding 2 11
GO:0005516 calmodulin binding 3 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 340 344 PF00656 0.582
CLV_C14_Caspase3-7 549 553 PF00656 0.380
CLV_C14_Caspase3-7 687 691 PF00656 0.754
CLV_NRD_NRD_1 210 212 PF00675 0.474
CLV_NRD_NRD_1 265 267 PF00675 0.693
CLV_NRD_NRD_1 386 388 PF00675 0.551
CLV_NRD_NRD_1 5 7 PF00675 0.597
CLV_NRD_NRD_1 640 642 PF00675 0.322
CLV_PCSK_FUR_1 578 582 PF00082 0.420
CLV_PCSK_KEX2_1 210 212 PF00082 0.472
CLV_PCSK_KEX2_1 335 337 PF00082 0.563
CLV_PCSK_KEX2_1 386 388 PF00082 0.565
CLV_PCSK_KEX2_1 5 7 PF00082 0.597
CLV_PCSK_KEX2_1 580 582 PF00082 0.382
CLV_PCSK_PC1ET2_1 335 337 PF00082 0.627
CLV_PCSK_PC1ET2_1 580 582 PF00082 0.420
CLV_PCSK_SKI1_1 210 214 PF00082 0.481
CLV_PCSK_SKI1_1 28 32 PF00082 0.625
CLV_PCSK_SKI1_1 315 319 PF00082 0.572
CLV_PCSK_SKI1_1 371 375 PF00082 0.491
CLV_PCSK_SKI1_1 408 412 PF00082 0.480
CLV_PCSK_SKI1_1 419 423 PF00082 0.465
CLV_PCSK_SKI1_1 540 544 PF00082 0.347
CLV_PCSK_SKI1_1 650 654 PF00082 0.398
CLV_PCSK_SKI1_1 801 805 PF00082 0.567
CLV_Separin_Metazoa 423 427 PF03568 0.247
DEG_APCC_DBOX_1 209 217 PF00400 0.402
DEG_APCC_DBOX_1 370 378 PF00400 0.396
DEG_APCC_DBOX_1 407 415 PF00400 0.331
DEG_APCC_DBOX_1 446 454 PF00400 0.427
DEG_APCC_DBOX_1 783 791 PF00400 0.590
DEG_ODPH_VHL_1 223 235 PF01847 0.548
DEG_SCF_FBW7_2 188 194 PF00400 0.591
DEG_SPOP_SBC_1 70 74 PF00917 0.519
DEG_SPOP_SBC_1 723 727 PF00917 0.734
DOC_CKS1_1 176 181 PF01111 0.557
DOC_CKS1_1 188 193 PF01111 0.592
DOC_CKS1_1 674 679 PF01111 0.713
DOC_CYCLIN_RxL_1 78 89 PF00134 0.644
DOC_CYCLIN_yCln2_LP_2 217 223 PF00134 0.562
DOC_CYCLIN_yCln2_LP_2 99 105 PF00134 0.626
DOC_MAPK_DCC_7 189 197 PF00069 0.532
DOC_MAPK_gen_1 369 377 PF00069 0.400
DOC_MAPK_gen_1 383 392 PF00069 0.431
DOC_MAPK_MEF2A_6 189 197 PF00069 0.532
DOC_MAPK_MEF2A_6 622 631 PF00069 0.435
DOC_PP1_RVXF_1 456 462 PF00149 0.307
DOC_PP2B_LxvP_1 222 225 PF13499 0.568
DOC_PP2B_LxvP_1 99 102 PF13499 0.627
DOC_PP2B_PxIxI_1 192 198 PF00149 0.477
DOC_USP7_MATH_1 148 152 PF00917 0.582
DOC_USP7_MATH_1 373 377 PF00917 0.466
DOC_USP7_MATH_1 410 414 PF00917 0.464
DOC_USP7_MATH_1 65 69 PF00917 0.728
DOC_USP7_MATH_1 684 688 PF00917 0.773
DOC_USP7_MATH_1 696 700 PF00917 0.778
DOC_USP7_MATH_1 70 74 PF00917 0.753
DOC_USP7_MATH_1 704 708 PF00917 0.635
DOC_USP7_MATH_1 753 757 PF00917 0.544
DOC_USP7_MATH_2 102 108 PF00917 0.623
DOC_WW_Pin1_4 175 180 PF00397 0.576
DOC_WW_Pin1_4 187 192 PF00397 0.494
DOC_WW_Pin1_4 216 221 PF00397 0.551
DOC_WW_Pin1_4 673 678 PF00397 0.748
DOC_WW_Pin1_4 691 696 PF00397 0.586
LIG_14-3-3_CanoR_1 170 177 PF00244 0.532
LIG_14-3-3_CanoR_1 426 433 PF00244 0.307
LIG_14-3-3_CanoR_1 581 588 PF00244 0.386
LIG_14-3-3_CanoR_1 593 597 PF00244 0.375
LIG_14-3-3_CanoR_1 601 608 PF00244 0.289
LIG_14-3-3_CanoR_1 655 662 PF00244 0.549
LIG_14-3-3_CanoR_1 88 94 PF00244 0.584
LIG_Actin_WH2_2 617 634 PF00022 0.271
LIG_Actin_WH2_2 766 783 PF00022 0.615
LIG_APCC_ABBA_1 375 380 PF00400 0.464
LIG_BIR_III_2 690 694 PF00653 0.772
LIG_Clathr_ClatBox_1 803 807 PF01394 0.611
LIG_CtBP_PxDLS_1 733 737 PF00389 0.625
LIG_FHA_1 154 160 PF00498 0.597
LIG_FHA_1 275 281 PF00498 0.682
LIG_FHA_1 420 426 PF00498 0.380
LIG_FHA_1 744 750 PF00498 0.542
LIG_FHA_2 176 182 PF00498 0.550
LIG_FHA_2 268 274 PF00498 0.730
LIG_FHA_2 581 587 PF00498 0.435
LIG_FHA_2 661 667 PF00498 0.687
LIG_FHA_2 698 704 PF00498 0.848
LIG_LIR_Nem_3 528 533 PF02991 0.296
LIG_LIR_Nem_3 561 566 PF02991 0.396
LIG_LIR_Nem_3 774 780 PF02991 0.609
LIG_NRBOX 139 145 PF00104 0.515
LIG_NRBOX 212 218 PF00104 0.418
LIG_SH2_SRC 533 536 PF00017 0.317
LIG_SH2_STAP1 406 410 PF00017 0.435
LIG_SH2_STAP1 567 571 PF00017 0.380
LIG_SH2_STAP1 8 12 PF00017 0.582
LIG_SH2_STAT3 566 569 PF00017 0.295
LIG_SH2_STAT3 758 761 PF00017 0.550
LIG_SH2_STAT5 165 168 PF00017 0.492
LIG_SH2_STAT5 221 224 PF00017 0.498
LIG_SH2_STAT5 533 536 PF00017 0.279
LIG_SH2_STAT5 563 566 PF00017 0.304
LIG_SH2_STAT5 63 66 PF00017 0.687
LIG_SH2_STAT5 630 633 PF00017 0.322
LIG_SH2_STAT5 758 761 PF00017 0.605
LIG_SH3_1 18 24 PF00018 0.722
LIG_SH3_1 692 698 PF00018 0.598
LIG_SH3_3 18 24 PF00018 0.589
LIG_SH3_3 199 205 PF00018 0.598
LIG_SH3_3 247 253 PF00018 0.803
LIG_SH3_3 692 698 PF00018 0.598
LIG_SH3_3 737 743 PF00018 0.570
LIG_SH3_3 803 809 PF00018 0.515
LIG_SH3_4 257 264 PF00018 0.706
LIG_SUMO_SIM_anti_2 194 199 PF11976 0.522
LIG_SUMO_SIM_anti_2 363 368 PF11976 0.370
LIG_SUMO_SIM_anti_2 388 396 PF11976 0.480
LIG_SUMO_SIM_par_1 373 382 PF11976 0.473
LIG_SUMO_SIM_par_1 388 396 PF11976 0.509
LIG_TRAF2_1 287 290 PF00917 0.777
LIG_TRAF2_1 547 550 PF00917 0.380
LIG_TRAF2_1 573 576 PF00917 0.304
LIG_TRAF2_1 664 667 PF00917 0.619
LIG_TRAF2_1 783 786 PF00917 0.599
LIG_TRAF2_1 789 792 PF00917 0.648
LIG_TRFH_1 221 225 PF08558 0.581
LIG_TYR_ITIM 38 43 PF00017 0.717
MOD_CK1_1 274 280 PF00069 0.632
MOD_CK1_1 376 382 PF00069 0.467
MOD_CK1_1 396 402 PF00069 0.331
MOD_CK1_1 45 51 PF00069 0.676
MOD_CK1_1 69 75 PF00069 0.726
MOD_CK1_1 694 700 PF00069 0.780
MOD_CK1_1 702 708 PF00069 0.724
MOD_CK2_1 175 181 PF00069 0.663
MOD_CK2_1 267 273 PF00069 0.651
MOD_CK2_1 484 490 PF00069 0.435
MOD_CK2_1 632 638 PF00069 0.465
MOD_CK2_1 660 666 PF00069 0.686
MOD_CK2_1 697 703 PF00069 0.770
MOD_CK2_1 780 786 PF00069 0.660
MOD_GlcNHglycan 133 136 PF01048 0.617
MOD_GlcNHglycan 14 17 PF01048 0.639
MOD_GlcNHglycan 150 153 PF01048 0.668
MOD_GlcNHglycan 244 247 PF01048 0.686
MOD_GlcNHglycan 44 47 PF01048 0.640
MOD_GlcNHglycan 506 509 PF01048 0.422
MOD_GlcNHglycan 56 59 PF01048 0.563
MOD_GlcNHglycan 68 71 PF01048 0.608
MOD_GlcNHglycan 686 689 PF01048 0.711
MOD_GSK3_1 142 149 PF00069 0.582
MOD_GSK3_1 248 255 PF00069 0.724
MOD_GSK3_1 267 274 PF00069 0.644
MOD_GSK3_1 50 57 PF00069 0.667
MOD_GSK3_1 65 72 PF00069 0.513
MOD_GSK3_1 723 730 PF00069 0.703
MOD_GSK3_1 732 739 PF00069 0.566
MOD_GSK3_1 753 760 PF00069 0.571
MOD_GSK3_1 8 15 PF00069 0.590
MOD_GSK3_1 83 90 PF00069 0.513
MOD_LATS_1 129 135 PF00433 0.585
MOD_N-GLC_1 271 276 PF02516 0.607
MOD_NEK2_1 153 158 PF00069 0.611
MOD_NEK2_1 33 38 PF00069 0.592
MOD_NEK2_1 54 59 PF00069 0.652
MOD_NEK2_1 591 596 PF00069 0.324
MOD_NEK2_1 71 76 PF00069 0.539
MOD_NEK2_1 736 741 PF00069 0.605
MOD_NEK2_2 205 210 PF00069 0.456
MOD_NEK2_2 373 378 PF00069 0.460
MOD_PIKK_1 196 202 PF00454 0.581
MOD_PIKK_1 425 431 PF00454 0.358
MOD_PIKK_1 580 586 PF00454 0.453
MOD_PIKK_1 654 660 PF00454 0.519
MOD_PIKK_1 71 77 PF00454 0.675
MOD_PIKK_1 757 763 PF00454 0.549
MOD_PIKK_1 87 93 PF00454 0.698
MOD_PKA_1 580 586 PF00069 0.435
MOD_PKA_2 169 175 PF00069 0.506
MOD_PKA_2 425 431 PF00069 0.373
MOD_PKA_2 580 586 PF00069 0.338
MOD_PKA_2 592 598 PF00069 0.403
MOD_PKA_2 600 606 PF00069 0.229
MOD_PKA_2 654 660 PF00069 0.631
MOD_PKA_2 780 786 PF00069 0.604
MOD_PKA_2 87 93 PF00069 0.746
MOD_Plk_1 248 254 PF00069 0.543
MOD_Plk_1 267 273 PF00069 0.642
MOD_Plk_4 104 110 PF00069 0.719
MOD_Plk_4 161 167 PF00069 0.570
MOD_Plk_4 231 237 PF00069 0.525
MOD_Plk_4 50 56 PF00069 0.664
MOD_Plk_4 592 598 PF00069 0.380
MOD_ProDKin_1 175 181 PF00069 0.576
MOD_ProDKin_1 187 193 PF00069 0.499
MOD_ProDKin_1 216 222 PF00069 0.553
MOD_ProDKin_1 673 679 PF00069 0.747
MOD_ProDKin_1 691 697 PF00069 0.588
MOD_SUMO_rev_2 311 320 PF00179 0.570
MOD_SUMO_rev_2 635 643 PF00179 0.355
MOD_SUMO_rev_2 687 694 PF00179 0.769
MOD_SUMO_rev_2 769 778 PF00179 0.545
TRG_DiLeu_BaEn_1 139 144 PF01217 0.515
TRG_DiLeu_BaEn_1 463 468 PF01217 0.381
TRG_DiLeu_BaLyEn_6 586 591 PF01217 0.435
TRG_DiLeu_BaLyEn_6 745 750 PF01217 0.529
TRG_ENDOCYTIC_2 40 43 PF00928 0.719
TRG_ENDOCYTIC_2 567 570 PF00928 0.307
TRG_ER_diArg_1 209 211 PF00400 0.478
TRG_ER_diArg_1 368 371 PF00400 0.379
TRG_ER_diArg_1 385 387 PF00400 0.373
TRG_ER_diArg_1 478 481 PF00400 0.331
TRG_ER_diArg_1 5 7 PF00400 0.597
TRG_ER_diArg_1 587 590 PF00400 0.435
TRG_NLS_MonoCore_2 255 260 PF00514 0.655
TRG_NLS_MonoExtN_4 253 260 PF00514 0.648
TRG_Pf-PMV_PEXEL_1 211 215 PF00026 0.560
TRG_Pf-PMV_PEXEL_1 325 329 PF00026 0.590
TRG_Pf-PMV_PEXEL_1 352 357 PF00026 0.472
TRG_Pf-PMV_PEXEL_1 419 423 PF00026 0.440
TRG_Pf-PMV_PEXEL_1 458 462 PF00026 0.394
TRG_Pf-PMV_PEXEL_1 622 626 PF00026 0.371

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PCV3 Leptomonas seymouri 54% 100%
A0A1X0NP77 Trypanosomatidae 30% 99%
A0A3R7K8M9 Trypanosoma rangeli 33% 100%
A0A3S7WPT1 Leishmania donovani 100% 100%
A4H4X6 Leishmania braziliensis 79% 100%
C9ZUS6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 100%
E9AL41 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
Q4QIR3 Leishmania major 95% 100%
V5ASS7 Trypanosoma cruzi 32% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS