LeishMANIAdb
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MPN domain-containing protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
MPN domain-containing protein
Gene product:
Uncharacterised protein family (UPF0172) - putative
Species:
Leishmania infantum
UniProt:
A4HT47_LEIIN
TriTrypDb:
LINF_070008100
Length:
254

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0032991 protein-containing complex 1 10
GO:0072546 EMC complex 3 10
GO:0098796 membrane protein complex 2 10
GO:0140534 endoplasmic reticulum protein-containing complex 2 10
GO:0005783 endoplasmic reticulum 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HT47
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HT47

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 252 254 PF00675 0.564
CLV_PCSK_KEX2_1 37 39 PF00082 0.235
CLV_PCSK_PC1ET2_1 37 39 PF00082 0.235
CLV_PCSK_SKI1_1 130 134 PF00082 0.352
CLV_PCSK_SKI1_1 17 21 PF00082 0.235
DEG_SPOP_SBC_1 3 7 PF00917 0.370
DOC_CYCLIN_yCln2_LP_2 243 249 PF00134 0.352
DOC_MAPK_RevD_3 238 254 PF00069 0.341
DOC_PP1_RVXF_1 143 150 PF00149 0.352
DOC_USP7_MATH_1 164 168 PF00917 0.310
DOC_USP7_MATH_1 205 209 PF00917 0.277
DOC_USP7_MATH_1 46 50 PF00917 0.308
DOC_USP7_MATH_1 56 60 PF00917 0.280
DOC_WW_Pin1_4 123 128 PF00397 0.260
DOC_WW_Pin1_4 155 160 PF00397 0.304
DOC_WW_Pin1_4 49 54 PF00397 0.381
DOC_WW_Pin1_4 8 13 PF00397 0.352
LIG_14-3-3_CanoR_1 119 127 PF00244 0.271
LIG_14-3-3_CanoR_1 139 149 PF00244 0.108
LIG_14-3-3_CanoR_1 172 179 PF00244 0.360
LIG_14-3-3_CanoR_1 190 194 PF00244 0.153
LIG_14-3-3_CanoR_1 195 203 PF00244 0.352
LIG_BIR_II_1 1 5 PF00653 0.453
LIG_BIR_III_2 75 79 PF00653 0.235
LIG_eIF4E_1 242 248 PF01652 0.308
LIG_FHA_1 14 20 PF00498 0.333
LIG_FHA_1 142 148 PF00498 0.306
LIG_FHA_1 176 182 PF00498 0.208
LIG_FHA_1 4 10 PF00498 0.471
LIG_FHA_1 68 74 PF00498 0.373
LIG_FHA_2 239 245 PF00498 0.286
LIG_LIR_Gen_1 93 103 PF02991 0.241
LIG_LIR_Nem_3 221 226 PF02991 0.314
LIG_LIR_Nem_3 93 99 PF02991 0.243
LIG_SH2_CRK 23 27 PF00017 0.352
LIG_SH2_NCK_1 96 100 PF00017 0.235
LIG_SH2_SRC 96 99 PF00017 0.308
LIG_SH2_STAP1 15 19 PF00017 0.295
LIG_SH2_STAT3 242 245 PF00017 0.235
LIG_SH2_STAT3 25 28 PF00017 0.235
LIG_SH2_STAT5 114 117 PF00017 0.235
LIG_SH2_STAT5 15 18 PF00017 0.293
LIG_SH2_STAT5 242 245 PF00017 0.235
LIG_SH2_STAT5 72 75 PF00017 0.308
LIG_SH3_1 23 29 PF00018 0.352
LIG_SH3_3 23 29 PF00018 0.352
LIG_SH3_3 50 56 PF00018 0.246
LIG_SH3_3 6 12 PF00018 0.352
LIG_SUMO_SIM_par_1 177 183 PF11976 0.376
LIG_TYR_ITIM 94 99 PF00017 0.235
LIG_UBA3_1 247 254 PF00899 0.476
MOD_CDK_SPxxK_3 123 130 PF00069 0.352
MOD_CK1_1 126 132 PF00069 0.255
MOD_CK1_1 158 164 PF00069 0.318
MOD_CK1_1 180 186 PF00069 0.331
MOD_CK1_1 2 8 PF00069 0.411
MOD_CK1_1 208 214 PF00069 0.417
MOD_CK1_1 49 55 PF00069 0.313
MOD_CK1_1 64 70 PF00069 0.409
MOD_CK2_1 183 189 PF00069 0.381
MOD_CK2_1 208 214 PF00069 0.364
MOD_CK2_1 238 244 PF00069 0.317
MOD_Cter_Amidation 35 38 PF01082 0.235
MOD_GlcNHglycan 1 4 PF01048 0.482
MOD_GlcNHglycan 185 188 PF01048 0.401
MOD_GlcNHglycan 207 210 PF01048 0.246
MOD_GlcNHglycan 49 52 PF01048 0.349
MOD_GlcNHglycan 63 66 PF01048 0.373
MOD_GSK3_1 102 109 PF00069 0.249
MOD_GSK3_1 154 161 PF00069 0.347
MOD_GSK3_1 171 178 PF00069 0.188
MOD_GSK3_1 208 215 PF00069 0.302
MOD_GSK3_1 4 11 PF00069 0.370
MOD_GSK3_1 47 54 PF00069 0.375
MOD_GSK3_1 61 68 PF00069 0.326
MOD_GSK3_1 79 86 PF00069 0.217
MOD_N-GLC_1 175 180 PF02516 0.208
MOD_N-GLC_2 153 155 PF02516 0.336
MOD_NEK2_1 163 168 PF00069 0.406
MOD_NEK2_1 4 9 PF00069 0.360
MOD_NEK2_1 79 84 PF00069 0.277
MOD_PIKK_1 180 186 PF00454 0.322
MOD_PKA_1 37 43 PF00069 0.219
MOD_PKA_2 118 124 PF00069 0.271
MOD_PKA_2 171 177 PF00069 0.325
MOD_PKA_2 189 195 PF00069 0.128
MOD_PKA_2 37 43 PF00069 0.219
MOD_Plk_1 175 181 PF00069 0.272
MOD_Plk_1 203 209 PF00069 0.308
MOD_Plk_4 106 112 PF00069 0.352
MOD_Plk_4 208 214 PF00069 0.271
MOD_Plk_4 4 10 PF00069 0.340
MOD_ProDKin_1 123 129 PF00069 0.260
MOD_ProDKin_1 155 161 PF00069 0.304
MOD_ProDKin_1 49 55 PF00069 0.381
MOD_ProDKin_1 8 14 PF00069 0.352
TRG_DiLeu_BaLyEn_6 142 147 PF01217 0.246
TRG_ENDOCYTIC_2 96 99 PF00928 0.235

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I7U5 Leptomonas seymouri 76% 100%
A0A1X0NP88 Trypanosomatidae 39% 95%
A0A3S7WPT3 Leishmania donovani 100% 100%
A0A422NDI1 Trypanosoma rangeli 46% 100%
A4H4X4 Leishmania braziliensis 85% 100%
C9ZUT0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 93%
E9AL39 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
Q4QIR5 Leishmania major 98% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS