LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HT42_LEIIN
TriTrypDb:
LINF_070007600
Length:
607

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 4
GO:0016020 membrane 2 3

Expansion

Sequence features

A4HT42
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HT42

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 243 247 PF00656 0.388
CLV_NRD_NRD_1 231 233 PF00675 0.672
CLV_NRD_NRD_1 236 238 PF00675 0.625
CLV_NRD_NRD_1 271 273 PF00675 0.599
CLV_NRD_NRD_1 290 292 PF00675 0.598
CLV_NRD_NRD_1 303 305 PF00675 0.633
CLV_NRD_NRD_1 315 317 PF00675 0.568
CLV_NRD_NRD_1 33 35 PF00675 0.398
CLV_NRD_NRD_1 365 367 PF00675 0.691
CLV_NRD_NRD_1 394 396 PF00675 0.710
CLV_NRD_NRD_1 40 42 PF00675 0.509
CLV_NRD_NRD_1 427 429 PF00675 0.795
CLV_NRD_NRD_1 447 449 PF00675 0.553
CLV_NRD_NRD_1 6 8 PF00675 0.439
CLV_PCSK_FUR_1 301 305 PF00082 0.704
CLV_PCSK_FUR_1 445 449 PF00082 0.687
CLV_PCSK_KEX2_1 231 233 PF00082 0.675
CLV_PCSK_KEX2_1 236 238 PF00082 0.628
CLV_PCSK_KEX2_1 271 273 PF00082 0.599
CLV_PCSK_KEX2_1 290 292 PF00082 0.483
CLV_PCSK_KEX2_1 303 305 PF00082 0.552
CLV_PCSK_KEX2_1 315 317 PF00082 0.568
CLV_PCSK_KEX2_1 33 35 PF00082 0.394
CLV_PCSK_KEX2_1 364 366 PF00082 0.689
CLV_PCSK_KEX2_1 39 41 PF00082 0.515
CLV_PCSK_KEX2_1 394 396 PF00082 0.710
CLV_PCSK_KEX2_1 427 429 PF00082 0.795
CLV_PCSK_KEX2_1 447 449 PF00082 0.553
CLV_PCSK_KEX2_1 6 8 PF00082 0.464
CLV_PCSK_PC7_1 232 238 PF00082 0.645
CLV_PCSK_SKI1_1 271 275 PF00082 0.604
CLV_PCSK_SKI1_1 455 459 PF00082 0.711
CLV_PCSK_SKI1_1 46 50 PF00082 0.409
CLV_PCSK_SKI1_1 503 507 PF00082 0.722
DEG_Nend_Nbox_1 1 3 PF02207 0.709
DOC_CKS1_1 178 183 PF01111 0.507
DOC_CKS1_1 411 416 PF01111 0.523
DOC_CYCLIN_RxL_1 268 277 PF00134 0.405
DOC_CYCLIN_yCln2_LP_2 321 327 PF00134 0.433
DOC_MAPK_gen_1 236 242 PF00069 0.397
DOC_MAPK_gen_1 364 372 PF00069 0.425
DOC_MAPK_gen_1 424 434 PF00069 0.564
DOC_MAPK_MEF2A_6 132 140 PF00069 0.365
DOC_MAPK_RevD_3 352 366 PF00069 0.463
DOC_PP2B_LxvP_1 79 82 PF13499 0.504
DOC_PP4_FxxP_1 125 128 PF00568 0.410
DOC_PP4_FxxP_1 327 330 PF00568 0.508
DOC_USP7_MATH_1 205 209 PF00917 0.499
DOC_USP7_MATH_1 459 463 PF00917 0.490
DOC_USP7_MATH_1 572 576 PF00917 0.510
DOC_USP7_MATH_1 581 585 PF00917 0.396
DOC_WW_Pin1_4 168 173 PF00397 0.565
DOC_WW_Pin1_4 17 22 PF00397 0.695
DOC_WW_Pin1_4 177 182 PF00397 0.545
DOC_WW_Pin1_4 210 215 PF00397 0.502
DOC_WW_Pin1_4 274 279 PF00397 0.426
DOC_WW_Pin1_4 295 300 PF00397 0.434
DOC_WW_Pin1_4 410 415 PF00397 0.500
LIG_14-3-3_CanoR_1 132 140 PF00244 0.333
LIG_14-3-3_CanoR_1 271 277 PF00244 0.410
LIG_14-3-3_CanoR_1 331 339 PF00244 0.480
LIG_14-3-3_CanoR_1 427 433 PF00244 0.493
LIG_14-3-3_CanoR_1 476 484 PF00244 0.472
LIG_Actin_WH2_2 116 134 PF00022 0.396
LIG_Actin_WH2_2 524 539 PF00022 0.559
LIG_APCC_ABBA_1 354 359 PF00400 0.385
LIG_BRCT_BRCA1_1 188 192 PF00533 0.505
LIG_BRCT_BRCA1_1 26 30 PF00533 0.664
LIG_DLG_GKlike_1 40 47 PF00625 0.621
LIG_EH1_1 60 68 PF00400 0.299
LIG_eIF4E_1 61 67 PF01652 0.402
LIG_FHA_1 107 113 PF00498 0.418
LIG_FHA_1 213 219 PF00498 0.471
LIG_FHA_1 261 267 PF00498 0.421
LIG_FHA_1 3 9 PF00498 0.756
LIG_FHA_1 342 348 PF00498 0.478
LIG_FHA_1 386 392 PF00498 0.531
LIG_FHA_1 459 465 PF00498 0.539
LIG_FHA_1 62 68 PF00498 0.389
LIG_FHA_2 417 423 PF00498 0.537
LIG_FHA_2 85 91 PF00498 0.457
LIG_Integrin_isoDGR_2 407 409 PF01839 0.740
LIG_LIR_Apic_2 124 128 PF02991 0.404
LIG_LIR_Gen_1 249 255 PF02991 0.396
LIG_LIR_Gen_1 355 363 PF02991 0.385
LIG_LIR_Gen_1 487 494 PF02991 0.458
LIG_LIR_LC3C_4 64 68 PF02991 0.375
LIG_LIR_Nem_3 249 253 PF02991 0.403
LIG_LIR_Nem_3 355 360 PF02991 0.384
LIG_LIR_Nem_3 43 47 PF02991 0.536
LIG_LIR_Nem_3 436 442 PF02991 0.494
LIG_LIR_Nem_3 487 491 PF02991 0.455
LIG_LIR_Nem_3 89 94 PF02991 0.394
LIG_MLH1_MIPbox_1 26 30 PF16413 0.595
LIG_MYND_1 96 100 PF01753 0.407
LIG_PCNA_PIPBox_1 494 503 PF02747 0.388
LIG_PCNA_PIPBox_1 73 82 PF02747 0.424
LIG_PCNA_yPIPBox_3 69 80 PF02747 0.414
LIG_Pex14_2 121 125 PF04695 0.391
LIG_PTB_Apo_2 244 251 PF02174 0.413
LIG_PTB_Phospho_1 244 250 PF10480 0.408
LIG_REV1ctd_RIR_1 123 127 PF16727 0.396
LIG_REV1ctd_RIR_1 27 38 PF16727 0.655
LIG_SH2_NCK_1 133 137 PF00017 0.362
LIG_SH2_NCK_1 250 254 PF00017 0.417
LIG_SH2_SRC 435 438 PF00017 0.480
LIG_SH2_SRC 556 559 PF00017 0.500
LIG_SH2_STAP1 133 137 PF00017 0.362
LIG_SH2_STAP1 435 439 PF00017 0.451
LIG_SH2_STAT3 550 553 PF00017 0.415
LIG_SH2_STAT5 286 289 PF00017 0.380
LIG_SH2_STAT5 61 64 PF00017 0.411
LIG_SH2_STAT5 86 89 PF00017 0.459
LIG_SH3_1 368 374 PF00018 0.493
LIG_SH3_1 453 459 PF00018 0.549
LIG_SH3_2 211 216 PF14604 0.474
LIG_SH3_3 136 142 PF00018 0.371
LIG_SH3_3 15 21 PF00018 0.782
LIG_SH3_3 208 214 PF00018 0.524
LIG_SH3_3 368 374 PF00018 0.461
LIG_SH3_3 376 382 PF00018 0.579
LIG_SH3_3 408 414 PF00018 0.593
LIG_SH3_3 453 459 PF00018 0.549
LIG_SH3_5 82 86 PF00018 0.558
LIG_SUMO_SIM_anti_2 102 107 PF11976 0.372
LIG_SUMO_SIM_anti_2 134 140 PF11976 0.355
LIG_SUMO_SIM_par_1 272 277 PF11976 0.422
LIG_TRAF2_1 603 606 PF00917 0.615
LIG_TYR_ITIM 131 136 PF00017 0.440
LIG_UBA3_1 241 248 PF00899 0.446
LIG_ULM_U2AF65_1 364 370 PF00076 0.609
LIG_WRC_WIRS_1 122 127 PF05994 0.489
MOD_CDC14_SPxK_1 171 174 PF00782 0.682
MOD_CDC14_SPxK_1 213 216 PF00782 0.650
MOD_CDK_SPxK_1 168 174 PF00069 0.691
MOD_CDK_SPxK_1 210 216 PF00069 0.672
MOD_CDK_SPxK_1 295 301 PF00069 0.532
MOD_CDK_SPxxK_3 17 24 PF00069 0.664
MOD_CDK_SPxxK_3 177 184 PF00069 0.637
MOD_CK1_1 176 182 PF00069 0.608
MOD_CK1_1 385 391 PF00069 0.639
MOD_CK1_1 560 566 PF00069 0.484
MOD_CK2_1 345 351 PF00069 0.483
MOD_CK2_1 459 465 PF00069 0.655
MOD_Cter_Amidation 313 316 PF01082 0.525
MOD_GlcNHglycan 14 17 PF01048 0.633
MOD_GlcNHglycan 175 178 PF01048 0.710
MOD_GlcNHglycan 200 203 PF01048 0.726
MOD_GlcNHglycan 278 281 PF01048 0.643
MOD_GlcNHglycan 384 387 PF01048 0.714
MOD_GlcNHglycan 399 402 PF01048 0.711
MOD_GlcNHglycan 56 59 PF01048 0.371
MOD_GSK3_1 106 113 PF00069 0.492
MOD_GSK3_1 173 180 PF00069 0.712
MOD_GSK3_1 272 279 PF00069 0.622
MOD_GSK3_1 341 348 PF00069 0.617
MOD_GSK3_1 381 388 PF00069 0.772
MOD_GSK3_1 556 563 PF00069 0.609
MOD_N-GLC_1 186 191 PF02516 0.534
MOD_N-GLC_1 257 262 PF02516 0.627
MOD_N-GLC_1 581 586 PF02516 0.544
MOD_NEK2_1 106 111 PF00069 0.449
MOD_NEK2_1 121 126 PF00069 0.340
MOD_NEK2_1 131 136 PF00069 0.418
MOD_NEK2_1 173 178 PF00069 0.716
MOD_NEK2_1 2 7 PF00069 0.614
MOD_NEK2_1 317 322 PF00069 0.535
MOD_NEK2_1 477 482 PF00069 0.629
MOD_PIKK_1 331 337 PF00454 0.583
MOD_PK_1 272 278 PF00069 0.557
MOD_PKA_1 24 30 PF00069 0.493
MOD_PKA_1 40 46 PF00069 0.515
MOD_PKA_2 106 112 PF00069 0.444
MOD_PKA_2 131 137 PF00069 0.438
MOD_PKA_2 193 199 PF00069 0.697
MOD_PKA_2 2 8 PF00069 0.612
MOD_PKA_2 40 46 PF00069 0.515
MOD_PKA_2 426 432 PF00069 0.733
MOD_PKA_2 477 483 PF00069 0.628
MOD_PKB_1 184 192 PF00069 0.568
MOD_Plk_1 317 323 PF00069 0.633
MOD_Plk_1 459 465 PF00069 0.655
MOD_Plk_1 556 562 PF00069 0.517
MOD_Plk_1 581 587 PF00069 0.548
MOD_Plk_1 84 90 PF00069 0.590
MOD_Plk_4 121 127 PF00069 0.505
MOD_Plk_4 317 323 PF00069 0.531
MOD_Plk_4 459 465 PF00069 0.655
MOD_Plk_4 572 578 PF00069 0.633
MOD_ProDKin_1 168 174 PF00069 0.713
MOD_ProDKin_1 17 23 PF00069 0.619
MOD_ProDKin_1 177 183 PF00069 0.676
MOD_ProDKin_1 210 216 PF00069 0.627
MOD_ProDKin_1 274 280 PF00069 0.524
MOD_ProDKin_1 295 301 PF00069 0.532
MOD_ProDKin_1 410 416 PF00069 0.624
TRG_DiLeu_BaLyEn_6 269 274 PF01217 0.594
TRG_DiLeu_BaLyEn_6 453 458 PF01217 0.758
TRG_ENDOCYTIC_2 133 136 PF00928 0.435
TRG_ENDOCYTIC_2 250 253 PF00928 0.485
TRG_ENDOCYTIC_2 284 287 PF00928 0.476
TRG_ENDOCYTIC_2 357 360 PF00928 0.463
TRG_ENDOCYTIC_2 439 442 PF00928 0.644
TRG_ER_diArg_1 183 186 PF00400 0.651
TRG_ER_diArg_1 231 233 PF00400 0.597
TRG_ER_diArg_1 235 237 PF00400 0.554
TRG_ER_diArg_1 271 273 PF00400 0.486
TRG_ER_diArg_1 289 291 PF00400 0.476
TRG_ER_diArg_1 303 305 PF00400 0.533
TRG_ER_diArg_1 315 317 PF00400 0.419
TRG_ER_diArg_1 33 35 PF00400 0.506
TRG_ER_diArg_1 363 366 PF00400 0.596
TRG_ER_diArg_1 38 41 PF00400 0.638
TRG_ER_diArg_1 427 430 PF00400 0.758
TRG_ER_diArg_1 445 448 PF00400 0.615
TRG_ER_diArg_1 475 478 PF00400 0.650
TRG_ER_diArg_1 481 484 PF00400 0.635
TRG_ER_diArg_1 6 8 PF00400 0.542
TRG_Pf-PMV_PEXEL_1 186 190 PF00026 0.581
TRG_Pf-PMV_PEXEL_1 455 460 PF00026 0.796
TRG_Pf-PMV_PEXEL_1 503 508 PF00026 0.581
TRG_Pf-PMV_PEXEL_1 6 10 PF00026 0.597
TRG_Pf-PMV_PEXEL_1 69 73 PF00026 0.473

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PE68 Leptomonas seymouri 54% 100%
A0A3S5H5W8 Leishmania donovani 100% 100%
A4H4W9 Leishmania braziliensis 80% 98%
E9AL34 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4QIS0 Leishmania major 94% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS