CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatidylglycerolphosphate synthase - mitochondrial - putative

Species:

Leishmania infantum

UniProt:

A4HT38_LEIIN

TriTrypDb:

LINF_070007200

Length:

755

Annotations

LeishMANIAdb annotations

Overall very similar to animal mitochondrial PGS1 enzymes, with one key difference: instead a a transit signal, the Kinetoplastid variant has membrane anchor.

Annotations by Jardim et al.

Phospholipid biosynthesis, phosphatidylglycerophosphate synthase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0043229	intracellular organelle	3	8
GO:0043231	intracellular membrane-bounded organelle	4	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4HT38

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HT38

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	8
GO:0006644	phospholipid metabolic process	4	8
GO:0006650	glycerophospholipid metabolic process	5	8
GO:0006655	phosphatidylglycerol biosynthetic process	6	8
GO:0006793	phosphorus metabolic process	3	8
GO:0006796	phosphate-containing compound metabolic process	4	8
GO:0008152	metabolic process	1	8
GO:0008610	lipid biosynthetic process	4	8
GO:0008654	phospholipid biosynthetic process	5	8
GO:0009058	biosynthetic process	2	8
GO:0009987	cellular process	1	8
GO:0019637	organophosphate metabolic process	3	8
GO:0032048	cardiolipin metabolic process	7	8
GO:0032049	cardiolipin biosynthetic process	7	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044249	cellular biosynthetic process	3	8
GO:0044255	cellular lipid metabolic process	3	8
GO:0045017	glycerolipid biosynthetic process	4	8
GO:0046471	phosphatidylglycerol metabolic process	6	8
GO:0046474	glycerophospholipid biosynthetic process	5	8
GO:0046486	glycerolipid metabolic process	4	8
GO:0071704	organic substance metabolic process	2	8
GO:0090407	organophosphate biosynthetic process	4	8
GO:1901576	organic substance biosynthetic process	3	8

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003824	catalytic activity	1	8
GO:0005488	binding	1	8
GO:0005524	ATP binding	5	8
GO:0008444	CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity	6	8
GO:0016740	transferase activity	2	8
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	8
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	4	8
GO:0017076	purine nucleotide binding	4	8
GO:0017169	CDP-alcohol phosphatidyltransferase activity	5	8
GO:0030554	adenyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032559	adenyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	257	261	PF00656	0.665
CLV_C14_Caspase3-7	704	708	PF00656	0.598
CLV_NRD_NRD_1	190	192	PF00675	0.417
CLV_NRD_NRD_1	367	369	PF00675	0.432
CLV_NRD_NRD_1	451	453	PF00675	0.449
CLV_NRD_NRD_1	490	492	PF00675	0.412
CLV_NRD_NRD_1	606	608	PF00675	0.443
CLV_NRD_NRD_1	630	632	PF00675	0.501
CLV_NRD_NRD_1	69	71	PF00675	0.548
CLV_PCSK_KEX2_1	134	136	PF00082	0.368
CLV_PCSK_KEX2_1	490	492	PF00082	0.393
CLV_PCSK_KEX2_1	606	608	PF00082	0.443
CLV_PCSK_KEX2_1	630	632	PF00082	0.504
CLV_PCSK_PC1ET2_1	134	136	PF00082	0.368
CLV_PCSK_SKI1_1	141	145	PF00082	0.367
CLV_PCSK_SKI1_1	280	284	PF00082	0.411
CLV_PCSK_SKI1_1	301	305	PF00082	0.383
CLV_PCSK_SKI1_1	349	353	PF00082	0.392
CLV_PCSK_SKI1_1	526	530	PF00082	0.354
CLV_PCSK_SKI1_1	616	620	PF00082	0.416
DEG_APCC_DBOX_1	190	198	PF00400	0.626
DEG_APCC_DBOX_1	582	590	PF00400	0.599
DEG_APCC_DBOX_1	713	721	PF00400	0.553
DEG_SPOP_SBC_1	264	268	PF00917	0.785
DOC_CYCLIN_RxL_1	520	533	PF00134	0.578
DOC_CYCLIN_yCln2_LP_2	122	128	PF00134	0.588
DOC_MAPK_FxFP_2	506	509	PF00069	0.563
DOC_MAPK_gen_1	191	197	PF00069	0.586
DOC_MAPK_gen_1	299	306	PF00069	0.592
DOC_MAPK_gen_1	452	459	PF00069	0.615
DOC_MAPK_MEF2A_6	739	746	PF00069	0.629
DOC_PP1_RVXF_1	164	170	PF00149	0.598
DOC_PP1_RVXF_1	495	501	PF00149	0.546
DOC_PP1_RVXF_1	614	621	PF00149	0.617
DOC_PP4_FxxP_1	506	509	PF00568	0.563
DOC_USP7_MATH_1	113	117	PF00917	0.546
DOC_USP7_MATH_1	139	143	PF00917	0.598
DOC_USP7_MATH_1	220	224	PF00917	0.729
DOC_USP7_MATH_1	271	275	PF00917	0.769
DOC_USP7_MATH_1	387	391	PF00917	0.721
DOC_USP7_MATH_1	410	414	PF00917	0.750
DOC_USP7_MATH_1	436	440	PF00917	0.759
DOC_USP7_MATH_1	44	48	PF00917	0.785
DOC_USP7_MATH_1	681	685	PF00917	0.522
DOC_USP7_MATH_1	69	73	PF00917	0.777
DOC_USP7_MATH_2	670	676	PF00917	0.627
DOC_WW_Pin1_4	223	228	PF00397	0.755
DOC_WW_Pin1_4	383	388	PF00397	0.787
DOC_WW_Pin1_4	40	45	PF00397	0.720
DOC_WW_Pin1_4	417	422	PF00397	0.758
DOC_WW_Pin1_4	431	436	PF00397	0.664
DOC_WW_Pin1_4	444	449	PF00397	0.602
DOC_WW_Pin1_4	539	544	PF00397	0.531
DOC_WW_Pin1_4	639	644	PF00397	0.759
LIG_14-3-3_CanoR_1	141	146	PF00244	0.530
LIG_14-3-3_CanoR_1	230	236	PF00244	0.791
LIG_14-3-3_CanoR_1	360	364	PF00244	0.616
LIG_14-3-3_CanoR_1	452	459	PF00244	0.571
LIG_14-3-3_CanoR_1	530	539	PF00244	0.546
LIG_14-3-3_CanoR_1	70	76	PF00244	0.728
LIG_Actin_WH2_2	591	608	PF00022	0.645
LIG_APCC_ABBA_1	19	24	PF00400	0.644
LIG_APCC_ABBAyCdc20_2	515	521	PF00400	0.542
LIG_BRCT_BRCA1_1	155	159	PF00533	0.535
LIG_BRCT_BRCA1_1	237	241	PF00533	0.731
LIG_BRCT_BRCA1_1	396	400	PF00533	0.643
LIG_CaM_NSCaTE_8	488	495	PF13499	0.521
LIG_deltaCOP1_diTrp_1	499	506	PF00928	0.591
LIG_EH1_1	176	184	PF00400	0.589
LIG_FHA_1	1	7	PF00498	0.344
LIG_FHA_1	116	122	PF00498	0.574
LIG_FHA_1	16	22	PF00498	0.356
LIG_FHA_1	178	184	PF00498	0.532
LIG_FHA_1	208	214	PF00498	0.754
LIG_FHA_1	350	356	PF00498	0.606
LIG_FHA_1	436	442	PF00498	0.791
LIG_FHA_1	49	55	PF00498	0.718
LIG_FHA_1	557	563	PF00498	0.577
LIG_FHA_1	564	570	PF00498	0.551
LIG_FHA_2	197	203	PF00498	0.603
LIG_FHA_2	331	337	PF00498	0.587
LIG_FHA_2	531	537	PF00498	0.586
LIG_FHA_2	60	66	PF00498	0.813
LIG_FHA_2	702	708	PF00498	0.599
LIG_Integrin_RGD_1	255	257	PF01839	0.485
LIG_LIR_Apic_2	504	509	PF02991	0.566
LIG_LIR_Gen_1	18	25	PF02991	0.575
LIG_LIR_Gen_1	184	190	PF02991	0.567
LIG_LIR_Gen_1	336	346	PF02991	0.541
LIG_LIR_Gen_1	542	552	PF02991	0.530
LIG_LIR_Nem_3	18	22	PF02991	0.432
LIG_LIR_Nem_3	288	293	PF02991	0.610
LIG_LIR_Nem_3	336	341	PF02991	0.515
LIG_LIR_Nem_3	499	503	PF02991	0.574
LIG_LIR_Nem_3	505	511	PF02991	0.510
LIG_LIR_Nem_3	592	598	PF02991	0.550
LIG_NRBOX	716	722	PF00104	0.558
LIG_OCRL_FandH_1	313	325	PF00620	0.556
LIG_PALB2_WD40_1	346	354	PF16756	0.580
LIG_PCNA_PIPBox_1	98	107	PF02747	0.591
LIG_PCNA_yPIPBox_3	337	351	PF02747	0.554
LIG_PCNA_yPIPBox_3	91	105	PF02747	0.640
LIG_PDZ_Class_3	750	755	PF00595	0.677
LIG_Pex14_1	290	294	PF04695	0.639
LIG_RPA_C_Fungi	486	498	PF08784	0.383
LIG_RPA_C_Fungi	626	638	PF08784	0.433
LIG_SH2_CRK	284	288	PF00017	0.466
LIG_SH2_CRK	338	342	PF00017	0.326
LIG_SH2_CRK	602	606	PF00017	0.501
LIG_SH2_CRK	689	693	PF00017	0.487
LIG_SH2_GRB2like	284	287	PF00017	0.465
LIG_SH2_GRB2like	544	547	PF00017	0.422
LIG_SH2_SRC	284	287	PF00017	0.465
LIG_SH2_STAP1	503	507	PF00017	0.451
LIG_SH2_STAT5	149	152	PF00017	0.403
LIG_SH2_STAT5	330	333	PF00017	0.430
LIG_SH2_STAT5	544	547	PF00017	0.422
LIG_SH2_STAT5	561	564	PF00017	0.405
LIG_SH2_STAT5	588	591	PF00017	0.430
LIG_SH2_STAT5	597	600	PF00017	0.433
LIG_SH2_STAT5	678	681	PF00017	0.455
LIG_SH2_STAT5	7	10	PF00017	0.515
LIG_SH3_3	290	296	PF00018	0.422
LIG_SH3_3	430	436	PF00018	0.592
LIG_SH3_3	665	671	PF00018	0.613
LIG_SUMO_SIM_anti_2	178	184	PF11976	0.416
LIG_SUMO_SIM_anti_2	454	460	PF11976	0.406
LIG_SUMO_SIM_par_1	178	184	PF11976	0.469
LIG_SUMO_SIM_par_1	193	199	PF11976	0.514
LIG_TYR_ITIM	127	132	PF00017	0.457
LIG_TYR_ITIM	5	10	PF00017	0.501
LIG_TYR_ITIM	586	591	PF00017	0.481
LIG_WRC_WIRS_1	101	106	PF05994	0.464
LIG_WRC_WIRS_1	503	508	PF05994	0.449
MOD_CDC14_SPxK_1	420	423	PF00782	0.617
MOD_CDK_SPxK_1	383	389	PF00069	0.772
MOD_CDK_SPxK_1	417	423	PF00069	0.628
MOD_CDK_SPxxK_3	223	230	PF00069	0.614
MOD_CDK_SPxxK_3	639	646	PF00069	0.650
MOD_CK1_1	196	202	PF00069	0.561
MOD_CK1_1	223	229	PF00069	0.750
MOD_CK1_1	231	237	PF00069	0.756
MOD_CK1_1	263	269	PF00069	0.796
MOD_CK1_1	439	445	PF00069	0.674
MOD_CK1_1	468	474	PF00069	0.516
MOD_CK1_1	47	53	PF00069	0.754
MOD_CK1_1	568	574	PF00069	0.471
MOD_CK2_1	196	202	PF00069	0.502
MOD_CK2_1	410	416	PF00069	0.704
MOD_CK2_1	439	445	PF00069	0.707
MOD_CK2_1	529	535	PF00069	0.431
MOD_Cter_Amidation	628	631	PF01082	0.576
MOD_DYRK1A_RPxSP_1	431	435	PF00069	0.737
MOD_GlcNHglycan	145	148	PF01048	0.381
MOD_GlcNHglycan	222	225	PF01048	0.708
MOD_GlcNHglycan	257	260	PF01048	0.814
MOD_GlcNHglycan	262	265	PF01048	0.769
MOD_GlcNHglycan	376	379	PF01048	0.505
MOD_GlcNHglycan	389	392	PF01048	0.594
MOD_GlcNHglycan	396	399	PF01048	0.616
MOD_GlcNHglycan	412	415	PF01048	0.537
MOD_GlcNHglycan	46	49	PF01048	0.669
MOD_GlcNHglycan	633	636	PF01048	0.646
MOD_GlcNHglycan	674	677	PF01048	0.458
MOD_GlcNHglycan	78	82	PF01048	0.605
MOD_GSK3_1	139	146	PF00069	0.478
MOD_GSK3_1	222	229	PF00069	0.795
MOD_GSK3_1	230	237	PF00069	0.766
MOD_GSK3_1	260	267	PF00069	0.751
MOD_GSK3_1	374	381	PF00069	0.547
MOD_GSK3_1	38	45	PF00069	0.597
MOD_GSK3_1	383	390	PF00069	0.612
MOD_GSK3_1	406	413	PF00069	0.689
MOD_GSK3_1	431	438	PF00069	0.675
MOD_GSK3_1	50	57	PF00069	0.735
MOD_GSK3_1	721	728	PF00069	0.429
MOD_LATS_1	609	615	PF00433	0.415
MOD_N-GLC_1	324	329	PF02516	0.376
MOD_N-GLC_1	387	392	PF02516	0.567
MOD_N-GLC_1	410	415	PF02516	0.714
MOD_NEK2_1	177	182	PF00069	0.415
MOD_NEK2_1	235	240	PF00069	0.767
MOD_NEK2_1	354	359	PF00069	0.468
MOD_NEK2_1	38	43	PF00069	0.518
MOD_NEK2_1	393	398	PF00069	0.697
MOD_NEK2_1	400	405	PF00069	0.600
MOD_NEK2_1	529	534	PF00069	0.467
MOD_NEK2_1	547	552	PF00069	0.268
MOD_NEK2_1	556	561	PF00069	0.380
MOD_NEK2_1	591	596	PF00069	0.416
MOD_NEK2_1	701	706	PF00069	0.424
MOD_NEK2_1	709	714	PF00069	0.430
MOD_NEK2_1	721	726	PF00069	0.246
MOD_NEK2_1	732	737	PF00069	0.599
MOD_NEK2_2	236	241	PF00069	0.662
MOD_NEK2_2	688	693	PF00069	0.432
MOD_PIKK_1	349	355	PF00454	0.484
MOD_PIKK_1	439	445	PF00454	0.707
MOD_PK_1	611	617	PF00069	0.494
MOD_PKA_2	316	322	PF00069	0.430
MOD_PKA_2	359	365	PF00069	0.490
MOD_PKA_2	451	457	PF00069	0.523
MOD_PKA_2	529	535	PF00069	0.441
MOD_PKA_2	69	75	PF00069	0.683
MOD_PKA_2	709	715	PF00069	0.522
MOD_Plk_1	591	597	PF00069	0.419
MOD_Plk_1	611	617	PF00069	0.235
MOD_Plk_4	196	202	PF00069	0.499
MOD_Plk_4	236	242	PF00069	0.760
MOD_Plk_4	316	322	PF00069	0.430
MOD_Plk_4	436	442	PF00069	0.751
MOD_Plk_4	502	508	PF00069	0.404
MOD_Plk_4	519	525	PF00069	0.399
MOD_Plk_4	547	553	PF00069	0.476
MOD_Plk_4	557	563	PF00069	0.478
MOD_Plk_4	84	90	PF00069	0.498
MOD_ProDKin_1	223	229	PF00069	0.710
MOD_ProDKin_1	383	389	PF00069	0.753
MOD_ProDKin_1	40	46	PF00069	0.669
MOD_ProDKin_1	417	423	PF00069	0.711
MOD_ProDKin_1	431	437	PF00069	0.588
MOD_ProDKin_1	444	450	PF00069	0.484
MOD_ProDKin_1	539	545	PF00069	0.398
MOD_ProDKin_1	639	645	PF00069	0.716
MOD_SUMO_rev_2	184	194	PF00179	0.511
MOD_SUMO_rev_2	53	62	PF00179	0.610
TRG_DiLeu_BaEn_1	716	721	PF01217	0.423
TRG_DiLeu_BaEn_2	534	540	PF01217	0.464
TRG_DiLeu_BaEn_2	696	702	PF01217	0.410
TRG_DiLeu_BaEn_2	99	105	PF01217	0.476
TRG_ENDOCYTIC_2	129	132	PF00928	0.426
TRG_ENDOCYTIC_2	185	188	PF00928	0.434
TRG_ENDOCYTIC_2	338	341	PF00928	0.393
TRG_ENDOCYTIC_2	503	506	PF00928	0.454
TRG_ENDOCYTIC_2	544	547	PF00928	0.386
TRG_ENDOCYTIC_2	588	591	PF00928	0.430
TRG_ENDOCYTIC_2	596	599	PF00928	0.421
TRG_ENDOCYTIC_2	602	605	PF00928	0.439
TRG_ENDOCYTIC_2	689	692	PF00928	0.489
TRG_ENDOCYTIC_2	7	10	PF00928	0.447
TRG_ER_diArg_1	166	169	PF00400	0.575
TRG_ER_diArg_1	277	280	PF00400	0.534
TRG_ER_diArg_1	490	492	PF00400	0.480
TRG_ER_diArg_1	605	607	PF00400	0.564
TRG_NES_CRM1_1	455	466	PF08389	0.438
TRG_NES_CRM1_1	715	729	PF08389	0.480
TRG_Pf-PMV_PEXEL_1	198	202	PF00026	0.460

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILX1	Leptomonas seymouri	62%	100%
A0A0S4JQL9	Bodo saltans	36%	100%
A0A3S5H5W5	Leishmania donovani	99%	100%
A4H4W4	Leishmania braziliensis	78%	99%
E9AL30	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	99%
Q4QIS4	Leishmania major	92%	100%