LeishMANIAdb
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Serine/threonine-protein phosphatase 2A activator

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Serine/threonine-protein phosphatase 2A activator
Gene product:
protein phosphatase 2A - regulatory subunit B - putative
Species:
Leishmania infantum
UniProt:
A4HT37_LEIIN
TriTrypDb:
LINF_070007100
Length:
393

Annotations

Annotations by Jardim et al.

Phosphatase, Serine/threonine- phosphatase 2A activator

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 12
GO:0110165 cellular anatomical entity 1 12
GO:0000159 protein phosphatase type 2A complex 5 1
GO:0005634 nucleus 5 1
GO:0008287 protein serine/threonine phosphatase complex 4 1
GO:0032991 protein-containing complex 1 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:1902494 catalytic complex 2 1
GO:1903293 phosphatase complex 3 1

Expansion

Sequence features

A4HT37
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HT37

Function

Biological processes
Term Name Level Count
GO:0000226 microtubule cytoskeleton organization 3 1
GO:0006996 organelle organization 4 1
GO:0007010 cytoskeleton organization 5 1
GO:0007017 microtubule-based process 2 1
GO:0007051 spindle organization 3 1
GO:0007052 mitotic spindle organization 4 1
GO:0009987 cellular process 1 1
GO:0016043 cellular component organization 3 1
GO:0022402 cell cycle process 2 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:1902850 microtubule cytoskeleton organization involved in mitosis 4 1
GO:1903047 mitotic cell cycle process 3 1
Molecular functions
Term Name Level Count
GO:0003755 peptidyl-prolyl cis-trans isomerase activity 3 12
GO:0003824 catalytic activity 1 12
GO:0008047 enzyme activator activity 3 12
GO:0016853 isomerase activity 2 12
GO:0016859 cis-trans isomerase activity 3 12
GO:0019208 phosphatase regulator activity 3 12
GO:0019211 phosphatase activator activity 4 12
GO:0030234 enzyme regulator activity 2 12
GO:0098772 molecular function regulator activity 1 12
GO:0140096 catalytic activity, acting on a protein 2 12
GO:0140677 molecular function activator activity 2 12
GO:0008160 protein tyrosine phosphatase activator activity 6 1
GO:0019888 protein phosphatase regulator activity 4 1
GO:0072542 protein phosphatase activator activity 5 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 197 201 PF00656 0.463
CLV_C14_Caspase3-7 2 6 PF00656 0.512
CLV_NRD_NRD_1 23 25 PF00675 0.621
CLV_NRD_NRD_1 231 233 PF00675 0.333
CLV_NRD_NRD_1 234 236 PF00675 0.172
CLV_NRD_NRD_1 251 253 PF00675 0.175
CLV_NRD_NRD_1 51 53 PF00675 0.303
CLV_PCSK_FUR_1 121 125 PF00082 0.354
CLV_PCSK_FUR_1 232 236 PF00082 0.338
CLV_PCSK_KEX2_1 123 125 PF00082 0.311
CLV_PCSK_KEX2_1 233 235 PF00082 0.294
CLV_PCSK_KEX2_1 251 253 PF00082 0.255
CLV_PCSK_KEX2_1 255 257 PF00082 0.354
CLV_PCSK_KEX2_1 51 53 PF00082 0.335
CLV_PCSK_PC1ET2_1 123 125 PF00082 0.321
CLV_PCSK_PC1ET2_1 233 235 PF00082 0.317
CLV_PCSK_PC1ET2_1 255 257 PF00082 0.354
CLV_PCSK_PC7_1 251 257 PF00082 0.354
CLV_PCSK_SKI1_1 123 127 PF00082 0.354
CLV_PCSK_SKI1_1 38 42 PF00082 0.319
DOC_MAPK_MEF2A_6 206 215 PF00069 0.540
DOC_MAPK_RevD_3 221 235 PF00069 0.547
DOC_PP2B_LxvP_1 215 218 PF13499 0.535
DOC_USP7_MATH_1 149 153 PF00917 0.501
DOC_USP7_MATH_1 261 265 PF00917 0.440
DOC_USP7_MATH_1 69 73 PF00917 0.554
DOC_WW_Pin1_4 70 75 PF00397 0.490
LIG_14-3-3_CanoR_1 24 33 PF00244 0.600
LIG_14-3-3_CanoR_1 256 260 PF00244 0.554
LIG_14-3-3_CanoR_1 51 59 PF00244 0.461
LIG_14-3-3_CanoR_1 78 84 PF00244 0.554
LIG_14-3-3_CanoR_1 91 101 PF00244 0.499
LIG_APCC_ABBA_1 240 245 PF00400 0.535
LIG_BIR_II_1 1 5 PF00653 0.659
LIG_BRCT_BRCA1_1 52 56 PF00533 0.440
LIG_Clathr_ClatBox_1 212 216 PF01394 0.554
LIG_EH1_1 186 194 PF00400 0.474
LIG_FHA_1 93 99 PF00498 0.499
LIG_FHA_2 173 179 PF00498 0.459
LIG_FHA_2 80 86 PF00498 0.510
LIG_LIR_Gen_1 245 253 PF02991 0.478
LIG_LIR_Gen_1 271 280 PF02991 0.440
LIG_LIR_Gen_1 320 329 PF02991 0.474
LIG_LIR_Gen_1 353 363 PF02991 0.490
LIG_LIR_Gen_1 53 63 PF02991 0.449
LIG_LIR_Nem_3 184 190 PF02991 0.444
LIG_LIR_Nem_3 237 243 PF02991 0.462
LIG_LIR_Nem_3 245 249 PF02991 0.430
LIG_LIR_Nem_3 271 276 PF02991 0.440
LIG_LIR_Nem_3 320 325 PF02991 0.449
LIG_LIR_Nem_3 353 358 PF02991 0.461
LIG_LIR_Nem_3 53 59 PF02991 0.449
LIG_Pex14_1 355 359 PF04695 0.461
LIG_SH2_CRK 246 250 PF00017 0.554
LIG_SH2_STAT5 166 169 PF00017 0.449
LIG_SH2_STAT5 238 241 PF00017 0.483
LIG_SH2_STAT5 278 281 PF00017 0.535
LIG_SH2_STAT5 322 325 PF00017 0.451
LIG_SH2_STAT5 62 65 PF00017 0.449
LIG_SH2_STAT5 92 95 PF00017 0.535
LIG_SH2_STAT5 97 100 PF00017 0.535
LIG_SH3_2 33 38 PF14604 0.462
LIG_SH3_3 208 214 PF00018 0.480
LIG_SH3_3 215 221 PF00018 0.468
LIG_SH3_3 289 295 PF00018 0.535
LIG_SH3_3 30 36 PF00018 0.433
LIG_SH3_3 300 306 PF00018 0.493
LIG_TRAF2_1 297 300 PF00917 0.499
LIG_TRFH_1 257 261 PF08558 0.302
LIG_UBA3_1 327 335 PF00899 0.422
LIG_WRC_WIRS_1 168 173 PF05994 0.449
MOD_CK1_1 27 33 PF00069 0.593
MOD_CK2_1 178 184 PF00069 0.302
MOD_CK2_1 347 353 PF00069 0.328
MOD_CK2_1 42 48 PF00069 0.422
MOD_GlcNHglycan 1 4 PF01048 0.518
MOD_GlcNHglycan 147 150 PF01048 0.359
MOD_GlcNHglycan 180 183 PF01048 0.422
MOD_GlcNHglycan 349 352 PF01048 0.301
MOD_GlcNHglycan 359 362 PF01048 0.118
MOD_GlcNHglycan 52 55 PF01048 0.323
MOD_GlcNHglycan 79 82 PF01048 0.332
MOD_GSK3_1 141 148 PF00069 0.365
MOD_GSK3_1 154 161 PF00069 0.405
MOD_GSK3_1 353 360 PF00069 0.343
MOD_N-GLC_1 172 177 PF02516 0.359
MOD_N-GLC_1 333 338 PF02516 0.359
MOD_N-GLC_1 347 352 PF02516 0.302
MOD_N-GLC_1 374 379 PF02516 0.422
MOD_NEK2_1 130 135 PF00069 0.395
MOD_NEK2_1 141 146 PF00069 0.317
MOD_NEK2_1 318 323 PF00069 0.421
MOD_NEK2_1 374 379 PF00069 0.352
MOD_NEK2_1 50 55 PF00069 0.313
MOD_NEK2_2 201 206 PF00069 0.422
MOD_NEK2_2 86 91 PF00069 0.449
MOD_PIKK_1 14 20 PF00454 0.592
MOD_PIKK_1 374 380 PF00454 0.420
MOD_PKA_1 24 30 PF00069 0.640
MOD_PKA_1 255 261 PF00069 0.449
MOD_PKA_2 14 20 PF00069 0.635
MOD_PKA_2 255 261 PF00069 0.449
MOD_PKA_2 50 56 PF00069 0.317
MOD_PKA_2 77 83 PF00069 0.409
MOD_Plk_1 130 136 PF00069 0.405
MOD_Plk_1 172 178 PF00069 0.359
MOD_Plk_1 42 48 PF00069 0.422
MOD_Plk_1 86 92 PF00069 0.449
MOD_Plk_2-3 42 48 PF00069 0.422
MOD_Plk_4 130 136 PF00069 0.382
MOD_Plk_4 318 324 PF00069 0.332
MOD_Plk_4 42 48 PF00069 0.404
MOD_ProDKin_1 70 76 PF00069 0.359
MOD_SUMO_for_1 205 208 PF00179 0.371
MOD_SUMO_for_1 313 316 PF00179 0.371
TRG_DiLeu_BaEn_1 208 213 PF01217 0.371
TRG_DiLeu_BaEn_1 245 250 PF01217 0.399
TRG_DiLeu_BaEn_1 42 47 PF01217 0.287
TRG_DiLeu_BaEn_2 183 189 PF01217 0.302
TRG_ENDOCYTIC_2 246 249 PF00928 0.298
TRG_ENDOCYTIC_2 273 276 PF00928 0.302
TRG_ENDOCYTIC_2 322 325 PF00928 0.302
TRG_ENDOCYTIC_2 359 362 PF00928 0.317
TRG_ER_diArg_1 231 234 PF00400 0.420
TRG_ER_diArg_1 250 252 PF00400 0.309
TRG_ER_diArg_1 50 52 PF00400 0.422
TRG_NLS_MonoCore_2 231 236 PF00514 0.449
TRG_NLS_MonoExtC_3 231 237 PF00514 0.449
TRG_Pf-PMV_PEXEL_1 91 96 PF00026 0.371

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PFC2 Leptomonas seymouri 75% 100%
A0A0S4JLT6 Bodo saltans 41% 100%
A0A1X0NL05 Trypanosomatidae 55% 99%
A0A3R7M448 Trypanosoma rangeli 54% 100%
A0A3S5H5W4 Leishmania donovani 100% 100%
A4H4W3 Leishmania braziliensis 84% 100%
C9ZUU4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 46% 97%
E9AL29 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
O36016 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 34% 100%
P0C153 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 31% 94%
P0CQ00 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) 27% 100%
P0CQ01 Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) 27% 100%
P0CQ02 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) 33% 100%
P0CQ03 Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) 33% 100%
P40454 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 32% 100%
P58389 Mus musculus 33% 100%
Q12461 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 31% 100%
Q15257 Homo sapiens 37% 100%
Q28717 Oryctolagus cuniculus 33% 100%
Q2KJ44 Bos taurus 34% 100%
Q2UCL6 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 34% 93%
Q2UN27 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 35% 82%
Q4I0M9 Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) 38% 88%
Q4INW6 Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) 31% 91%
Q4P4W3 Ustilago maydis (strain 521 / FGSC 9021) 34% 81%
Q4PCR0 Ustilago maydis (strain 521 / FGSC 9021) 32% 86%
Q4QIS5 Leishmania major 97% 100%
Q4WMU5 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 32% 83%
Q4WSA8 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 32% 93%
Q54WH6 Dictyostelium discoideum 33% 84%
Q55CJ3 Dictyostelium discoideum 35% 100%
Q59ST6 Candida albicans (strain SC5314 / ATCC MYA-2876) 34% 100%
Q5ADP9 Candida albicans (strain SC5314 / ATCC MYA-2876) 35% 93%
Q5B6C5 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 34% 91%
Q6BNW4 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 39% 89%
Q6BU97 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 32% 100%
Q6C712 Yarrowia lipolytica (strain CLIB 122 / E 150) 35% 100%
Q6CFX5 Yarrowia lipolytica (strain CLIB 122 / E 150) 36% 91%
Q6CKF0 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 30% 100%
Q6CYH1 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 30% 100%
Q6FK00 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 33% 100%
Q6FRQ9 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 33% 93%
Q753L9 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 31% 100%
Q75BY1 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 33% 100%
Q7SEF9 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 32% 88%
Q9P7H4 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 32% 100%
V5D9E5 Trypanosoma cruzi 55% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS