Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase - putative

Species:

Leishmania infantum

UniProt:

A4HT34_LEIIN

TriTrypDb:

LINF_070006700

Length:

848

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HT34

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HT34

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004672	protein kinase activity	3	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	195	197	PF00675	0.323
CLV_NRD_NRD_1	326	328	PF00675	0.710
CLV_NRD_NRD_1	483	485	PF00675	0.683
CLV_NRD_NRD_1	490	492	PF00675	0.700
CLV_NRD_NRD_1	536	538	PF00675	0.624
CLV_NRD_NRD_1	653	655	PF00675	0.566
CLV_NRD_NRD_1	679	681	PF00675	0.672
CLV_NRD_NRD_1	818	820	PF00675	0.552
CLV_NRD_NRD_1	821	823	PF00675	0.549
CLV_PCSK_FUR_1	793	797	PF00082	0.549
CLV_PCSK_KEX2_1	34	36	PF00082	0.342
CLV_PCSK_KEX2_1	490	492	PF00082	0.683
CLV_PCSK_KEX2_1	536	538	PF00082	0.620
CLV_PCSK_KEX2_1	566	568	PF00082	0.790
CLV_PCSK_KEX2_1	653	655	PF00082	0.566
CLV_PCSK_KEX2_1	678	680	PF00082	0.665
CLV_PCSK_KEX2_1	795	797	PF00082	0.544
CLV_PCSK_KEX2_1	818	820	PF00082	0.561
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.342
CLV_PCSK_PC1ET2_1	490	492	PF00082	0.669
CLV_PCSK_PC1ET2_1	566	568	PF00082	0.790
CLV_PCSK_PC1ET2_1	795	797	PF00082	0.531
CLV_PCSK_PC1ET2_1	818	820	PF00082	0.561
CLV_PCSK_SKI1_1	123	127	PF00082	0.346
CLV_PCSK_SKI1_1	246	250	PF00082	0.379
CLV_PCSK_SKI1_1	253	257	PF00082	0.411
CLV_PCSK_SKI1_1	443	447	PF00082	0.664
CLV_PCSK_SKI1_1	566	570	PF00082	0.789
CLV_PCSK_SKI1_1	599	603	PF00082	0.674
DEG_SCF_FBW7_1	338	345	PF00400	0.673
DEG_SCF_FBW7_1	370	375	PF00400	0.799
DEG_SPOP_SBC_1	320	324	PF00917	0.608
DEG_SPOP_SBC_1	348	352	PF00917	0.691
DOC_CKS1_1	339	344	PF01111	0.673
DOC_CKS1_1	697	702	PF01111	0.802
DOC_CYCLIN_yCln2_LP_2	195	201	PF00134	0.342
DOC_MAPK_gen_1	123	132	PF00069	0.342
DOC_MAPK_gen_1	51	60	PF00069	0.342
DOC_MAPK_gen_1	772	779	PF00069	0.687
DOC_MAPK_gen_1	818	829	PF00069	0.694
DOC_MAPK_MEF2A_6	464	473	PF00069	0.691
DOC_MAPK_MEF2A_6	595	604	PF00069	0.672
DOC_MAPK_MEF2A_6	822	831	PF00069	0.599
DOC_PP2B_LxvP_1	463	466	PF13499	0.732
DOC_PP2B_LxvP_1	541	544	PF13499	0.705
DOC_PP2B_LxvP_1	602	605	PF13499	0.667
DOC_PP4_FxxP_1	199	202	PF00568	0.342
DOC_PP4_FxxP_1	478	481	PF00568	0.606
DOC_PP4_FxxP_1	686	689	PF00568	0.712
DOC_PP4_MxPP_1	424	427	PF00568	0.598
DOC_PP4_MxPP_1	698	701	PF00568	0.637
DOC_USP7_MATH_1	276	280	PF00917	0.635
DOC_USP7_MATH_1	313	317	PF00917	0.751
DOC_USP7_MATH_1	318	322	PF00917	0.648
DOC_USP7_MATH_1	340	344	PF00917	0.704
DOC_USP7_MATH_1	348	352	PF00917	0.613
DOC_USP7_MATH_1	395	399	PF00917	0.673
DOC_USP7_MATH_1	749	753	PF00917	0.684
DOC_USP7_MATH_1	775	779	PF00917	0.619
DOC_USP7_UBL2_3	486	490	PF12436	0.733
DOC_USP7_UBL2_3	553	557	PF12436	0.665
DOC_USP7_UBL2_3	595	599	PF12436	0.714
DOC_WW_Pin1_4	159	164	PF00397	0.342
DOC_WW_Pin1_4	214	219	PF00397	0.474
DOC_WW_Pin1_4	263	268	PF00397	0.571
DOC_WW_Pin1_4	287	292	PF00397	0.789
DOC_WW_Pin1_4	299	304	PF00397	0.752
DOC_WW_Pin1_4	321	326	PF00397	0.669
DOC_WW_Pin1_4	338	343	PF00397	0.579
DOC_WW_Pin1_4	368	373	PF00397	0.807
DOC_WW_Pin1_4	396	401	PF00397	0.742
DOC_WW_Pin1_4	407	412	PF00397	0.728
DOC_WW_Pin1_4	453	458	PF00397	0.702
DOC_WW_Pin1_4	513	518	PF00397	0.622
DOC_WW_Pin1_4	582	587	PF00397	0.674
DOC_WW_Pin1_4	662	667	PF00397	0.640
DOC_WW_Pin1_4	678	683	PF00397	0.650
DOC_WW_Pin1_4	685	690	PF00397	0.731
DOC_WW_Pin1_4	696	701	PF00397	0.744
DOC_WW_Pin1_4	730	735	PF00397	0.608
DOC_WW_Pin1_4	92	97	PF00397	0.329
LIG_14-3-3_CanoR_1	196	202	PF00244	0.323
LIG_14-3-3_CanoR_1	242	249	PF00244	0.342
LIG_14-3-3_CanoR_1	287	291	PF00244	0.694
LIG_14-3-3_CanoR_1	394	400	PF00244	0.705
LIG_14-3-3_CanoR_1	526	533	PF00244	0.745
LIG_14-3-3_CanoR_1	704	713	PF00244	0.719
LIG_14-3-3_CanoR_1	737	742	PF00244	0.752
LIG_14-3-3_CanoR_1	755	760	PF00244	0.525
LIG_14-3-3_CanoR_1	774	780	PF00244	0.483
LIG_14-3-3_CanoR_1	94	104	PF00244	0.397
LIG_BIR_III_2	614	618	PF00653	0.701
LIG_BRCT_BRCA1_1	759	763	PF00533	0.703
LIG_deltaCOP1_diTrp_1	181	189	PF00928	0.342
LIG_FHA_1	134	140	PF00498	0.513
LIG_FHA_1	150	156	PF00498	0.441
LIG_FHA_1	38	44	PF00498	0.474
LIG_FHA_1	528	534	PF00498	0.695
LIG_FHA_1	550	556	PF00498	0.760
LIG_FHA_1	96	102	PF00498	0.342
LIG_FHA_2	339	345	PF00498	0.712
LIG_FHA_2	350	356	PF00498	0.586
LIG_FHA_2	444	450	PF00498	0.628
LIG_Integrin_isoDGR_2	764	766	PF01839	0.622
LIG_LIR_Apic_2	162	168	PF02991	0.342
LIG_LIR_Apic_2	475	481	PF02991	0.603
LIG_LIR_Apic_2	684	689	PF02991	0.641
LIG_LIR_Gen_1	203	211	PF02991	0.342
LIG_LIR_Gen_1	4	12	PF02991	0.454
LIG_LIR_Gen_1	69	76	PF02991	0.474
LIG_LIR_LC3C_4	28	32	PF02991	0.323
LIG_LIR_LC3C_4	355	360	PF02991	0.684
LIG_LIR_Nem_3	203	207	PF02991	0.342
LIG_LIR_Nem_3	212	216	PF02991	0.342
LIG_LIR_Nem_3	4	9	PF02991	0.452
LIG_LIR_Nem_3	83	89	PF02991	0.342
LIG_MAD2	553	561	PF02301	0.783
LIG_PALB2_WD40_1	100	108	PF16756	0.342
LIG_Pex14_2	60	64	PF04695	0.345
LIG_SH2_CRK	6	10	PF00017	0.441
LIG_SH2_NCK_1	190	194	PF00017	0.474
LIG_SH2_STAP1	178	182	PF00017	0.347
LIG_SH2_STAT3	635	638	PF00017	0.532
LIG_SH2_STAT3	741	744	PF00017	0.653
LIG_SH2_STAT3	88	91	PF00017	0.474
LIG_SH2_STAT5	114	117	PF00017	0.486
LIG_SH2_STAT5	140	143	PF00017	0.353
LIG_SH2_STAT5	6	9	PF00017	0.451
LIG_SH2_STAT5	635	638	PF00017	0.558
LIG_SH2_STAT5	741	744	PF00017	0.638
LIG_SH2_STAT5	88	91	PF00017	0.479
LIG_SH3_1	300	306	PF00018	0.702
LIG_SH3_3	157	163	PF00018	0.329
LIG_SH3_3	233	239	PF00018	0.485
LIG_SH3_3	266	272	PF00018	0.620
LIG_SH3_3	300	306	PF00018	0.708
LIG_SH3_3	307	313	PF00018	0.651
LIG_SH3_3	334	340	PF00018	0.711
LIG_SH3_3	350	356	PF00018	0.533
LIG_SH3_3	410	416	PF00018	0.643
LIG_SH3_3	433	439	PF00018	0.772
LIG_SH3_3	506	512	PF00018	0.745
LIG_SH3_3	576	582	PF00018	0.749
LIG_SH3_3	594	600	PF00018	0.532
LIG_SH3_3	602	608	PF00018	0.640
LIG_SH3_3	686	692	PF00018	0.689
LIG_SH3_3	694	700	PF00018	0.630
LIG_SH3_3	708	714	PF00018	0.703
LIG_SH3_4	599	606	PF00018	0.754
LIG_Sin3_3	428	435	PF02671	0.670
LIG_SUMO_SIM_anti_2	28	34	PF11976	0.323
LIG_SUMO_SIM_anti_2	354	363	PF11976	0.685
LIG_SUMO_SIM_par_1	233	238	PF11976	0.367
LIG_SUMO_SIM_par_1	354	363	PF11976	0.709
LIG_TRAF2_1	778	781	PF00917	0.553
LIG_WRC_WIRS_1	61	66	PF05994	0.342
LIG_WW_3	284	288	PF00397	0.698
LIG_WW_3	324	328	PF00397	0.703
LIG_WW_3	577	581	PF00397	0.803
LIG_WW_3	699	703	PF00397	0.798
MOD_CDC14_SPxK_1	268	271	PF00782	0.737
MOD_CDC14_SPxK_1	585	588	PF00782	0.672
MOD_CDK_SPxK_1	265	271	PF00069	0.603
MOD_CDK_SPxK_1	321	327	PF00069	0.696
MOD_CDK_SPxK_1	582	588	PF00069	0.674
MOD_CDK_SPxK_1	696	702	PF00069	0.824
MOD_CDK_SPxxK_3	321	328	PF00069	0.698
MOD_CDK_SPxxK_3	662	669	PF00069	0.647
MOD_CDK_SPxxK_3	678	685	PF00069	0.630
MOD_CDK_SPxxK_3	730	737	PF00069	0.688
MOD_CK1_1	133	139	PF00069	0.342
MOD_CK1_1	146	152	PF00069	0.342
MOD_CK1_1	153	159	PF00069	0.342
MOD_CK1_1	200	206	PF00069	0.342
MOD_CK1_1	277	283	PF00069	0.620
MOD_CK1_1	316	322	PF00069	0.783
MOD_CK1_1	343	349	PF00069	0.775
MOD_CK1_1	351	357	PF00069	0.647
MOD_CK1_1	375	381	PF00069	0.798
MOD_CK1_1	399	405	PF00069	0.670
MOD_CK1_1	516	522	PF00069	0.657
MOD_CK1_1	529	535	PF00069	0.790
MOD_CK1_1	545	551	PF00069	0.766
MOD_CK1_1	681	687	PF00069	0.670
MOD_CK1_1	75	81	PF00069	0.419
MOD_CK1_1	754	760	PF00069	0.667
MOD_CK1_1	92	98	PF00069	0.226
MOD_CK2_1	287	293	PF00069	0.697
MOD_CK2_1	399	405	PF00069	0.692
MOD_CK2_1	775	781	PF00069	0.573
MOD_GlcNHglycan	145	148	PF01048	0.342
MOD_GlcNHglycan	199	202	PF01048	0.346
MOD_GlcNHglycan	279	282	PF01048	0.616
MOD_GlcNHglycan	318	321	PF01048	0.710
MOD_GlcNHglycan	377	380	PF01048	0.704
MOD_GlcNHglycan	548	551	PF01048	0.606
MOD_GlcNHglycan	662	665	PF01048	0.634
MOD_GlcNHglycan	77	80	PF01048	0.474
MOD_GlcNHglycan	807	810	PF01048	0.644
MOD_GlcNHglycan	842	845	PF01048	0.653
MOD_GSK3_1	146	153	PF00069	0.342
MOD_GSK3_1	155	162	PF00069	0.351
MOD_GSK3_1	226	233	PF00069	0.490
MOD_GSK3_1	276	283	PF00069	0.696
MOD_GSK3_1	304	311	PF00069	0.644
MOD_GSK3_1	312	319	PF00069	0.710
MOD_GSK3_1	338	345	PF00069	0.765
MOD_GSK3_1	347	354	PF00069	0.615
MOD_GSK3_1	368	375	PF00069	0.802
MOD_GSK3_1	395	402	PF00069	0.671
MOD_GSK3_1	405	412	PF00069	0.633
MOD_GSK3_1	472	479	PF00069	0.696
MOD_GSK3_1	512	519	PF00069	0.659
MOD_GSK3_1	527	534	PF00069	0.547
MOD_GSK3_1	542	549	PF00069	0.701
MOD_GSK3_1	681	688	PF00069	0.662
MOD_GSK3_1	751	758	PF00069	0.644
MOD_N-GLC_1	153	158	PF02516	0.342
MOD_N-GLC_1	46	51	PF02516	0.342
MOD_N-GLC_1	66	71	PF02516	0.397
MOD_NEK2_1	12	17	PF00069	0.486
MOD_NEK2_1	150	155	PF00069	0.351
MOD_NEK2_1	171	176	PF00069	0.343
MOD_NEK2_1	331	336	PF00069	0.782
MOD_NEK2_1	46	51	PF00069	0.345
MOD_NEK2_1	471	476	PF00069	0.612
MOD_NEK2_1	60	65	PF00069	0.353
MOD_NEK2_1	759	764	PF00069	0.618
MOD_NEK2_1	89	94	PF00069	0.404
MOD_NEK2_2	66	71	PF00069	0.474
MOD_PIKK_1	308	314	PF00454	0.700
MOD_PIKK_1	329	335	PF00454	0.690
MOD_PIKK_1	37	43	PF00454	0.343
MOD_PIKK_1	383	389	PF00454	0.707
MOD_PIKK_1	87	93	PF00454	0.474
MOD_PK_1	507	513	PF00069	0.790
MOD_PKA_2	241	247	PF00069	0.342
MOD_PKA_2	286	292	PF00069	0.724
MOD_PKA_2	545	551	PF00069	0.727
MOD_PKA_2	754	760	PF00069	0.707
MOD_PKA_2	775	781	PF00069	0.706
MOD_PKB_1	505	513	PF00069	0.790
MOD_PKB_1	702	710	PF00069	0.727
MOD_Plk_1	443	449	PF00069	0.622
MOD_Plk_1	46	52	PF00069	0.342
MOD_Plk_4	155	161	PF00069	0.342
MOD_Plk_4	230	236	PF00069	0.339
MOD_Plk_4	399	405	PF00069	0.603
MOD_Plk_4	60	66	PF00069	0.342
MOD_Plk_4	737	743	PF00069	0.642
MOD_Plk_4	97	103	PF00069	0.342
MOD_ProDKin_1	159	165	PF00069	0.342
MOD_ProDKin_1	214	220	PF00069	0.474
MOD_ProDKin_1	263	269	PF00069	0.580
MOD_ProDKin_1	287	293	PF00069	0.666
MOD_ProDKin_1	299	305	PF00069	0.746
MOD_ProDKin_1	321	327	PF00069	0.704
MOD_ProDKin_1	338	344	PF00069	0.583
MOD_ProDKin_1	368	374	PF00069	0.806
MOD_ProDKin_1	396	402	PF00069	0.742
MOD_ProDKin_1	407	413	PF00069	0.726
MOD_ProDKin_1	453	459	PF00069	0.700
MOD_ProDKin_1	513	519	PF00069	0.623
MOD_ProDKin_1	582	588	PF00069	0.674
MOD_ProDKin_1	662	668	PF00069	0.643
MOD_ProDKin_1	678	684	PF00069	0.650
MOD_ProDKin_1	685	691	PF00069	0.731
MOD_ProDKin_1	696	702	PF00069	0.747
MOD_ProDKin_1	730	736	PF00069	0.606
MOD_ProDKin_1	92	98	PF00069	0.329
MOD_SUMO_for_1	441	444	PF00179	0.662
MOD_SUMO_for_1	783	786	PF00179	0.528
MOD_SUMO_rev_2	118	128	PF00179	0.431
MOD_SUMO_rev_2	133	139	PF00179	0.287
MOD_SUMO_rev_2	362	366	PF00179	0.727
MOD_SUMO_rev_2	642	647	PF00179	0.652
TRG_DiLeu_BaEn_2	519	525	PF01217	0.788
TRG_DiLeu_BaLyEn_6	353	358	PF01217	0.777
TRG_ENDOCYTIC_2	6	9	PF00928	0.451
TRG_ER_diArg_1	50	53	PF00400	0.342
TRG_ER_diArg_1	504	507	PF00400	0.786
TRG_ER_diArg_1	678	680	PF00400	0.623
TRG_ER_diArg_1	701	704	PF00400	0.802
TRG_ER_diArg_1	774	777	PF00400	0.691
TRG_ER_diArg_1	800	803	PF00400	0.536
TRG_NLS_MonoExtC_3	817	822	PF00514	0.567
TRG_NLS_MonoExtN_4	481	488	PF00514	0.685
TRG_NLS_MonoExtN_4	489	494	PF00514	0.689
TRG_NLS_MonoExtN_4	815	822	PF00514	0.540
TRG_Pf-PMV_PEXEL_1	526	531	PF00026	0.710
TRG_Pf-PMV_PEXEL_1	704	708	PF00026	0.804

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD87	Leptomonas seymouri	49%	100%
A0A3S7WPQ0	Leishmania donovani	100%	100%
A4H4W0	Leishmania braziliensis	65%	95%
E9AL26	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QIS8	Leishmania major	92%	100%