RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ring finger domain/Zinc finger - C3HC4 type (RING finger) containing protein - putative

Species:

Leishmania infantum

UniProt:

A4HT31_LEIIN

TriTrypDb:

LINF_070009100

Length:

922

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HT31

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HT31

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0008270	zinc ion binding	6	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0046914	transition metal ion binding	5	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	493	497	PF00656	0.635
CLV_NRD_NRD_1	249	251	PF00675	0.823
CLV_NRD_NRD_1	266	268	PF00675	0.540
CLV_NRD_NRD_1	420	422	PF00675	0.530
CLV_NRD_NRD_1	507	509	PF00675	0.591
CLV_NRD_NRD_1	58	60	PF00675	0.791
CLV_NRD_NRD_1	714	716	PF00675	0.820
CLV_PCSK_FUR_1	247	251	PF00082	0.763
CLV_PCSK_FUR_1	505	509	PF00082	0.562
CLV_PCSK_KEX2_1	247	249	PF00082	0.847
CLV_PCSK_KEX2_1	266	268	PF00082	0.511
CLV_PCSK_KEX2_1	420	422	PF00082	0.530
CLV_PCSK_KEX2_1	507	509	PF00082	0.591
CLV_PCSK_KEX2_1	540	542	PF00082	0.474
CLV_PCSK_KEX2_1	58	60	PF00082	0.791
CLV_PCSK_KEX2_1	714	716	PF00082	0.825
CLV_PCSK_PC1ET2_1	540	542	PF00082	0.474
CLV_PCSK_SKI1_1	249	253	PF00082	0.757
CLV_PCSK_SKI1_1	275	279	PF00082	0.732
CLV_PCSK_SKI1_1	431	435	PF00082	0.452
CLV_PCSK_SKI1_1	61	65	PF00082	0.694
CLV_PCSK_SKI1_1	823	827	PF00082	0.513
CLV_PCSK_SKI1_1	861	865	PF00082	0.585
CLV_Separin_Metazoa	546	550	PF03568	0.593
CLV_Separin_Metazoa	586	590	PF03568	0.663
DEG_Nend_UBRbox_1	1	4	PF02207	0.768
DEG_SPOP_SBC_1	124	128	PF00917	0.716
DEG_SPOP_SBC_1	141	145	PF00917	0.540
DEG_SPOP_SBC_1	147	151	PF00917	0.564
DEG_SPOP_SBC_1	351	355	PF00917	0.729
DEG_SPOP_SBC_1	39	43	PF00917	0.736
DOC_CYCLIN_yClb3_PxF_3	331	337	PF00134	0.600
DOC_MAPK_MEF2A_6	439	446	PF00069	0.509
DOC_MAPK_MEF2A_6	527	534	PF00069	0.519
DOC_PP1_RVXF_1	855	861	PF00149	0.624
DOC_PP2B_LxvP_1	251	254	PF13499	0.835
DOC_PP2B_PxIxI_1	529	535	PF00149	0.588
DOC_PP4_FxxP_1	753	756	PF00568	0.697
DOC_PP4_FxxP_1	772	775	PF00568	0.801
DOC_USP7_MATH_1	10	14	PF00917	0.757
DOC_USP7_MATH_1	104	108	PF00917	0.742
DOC_USP7_MATH_1	124	128	PF00917	0.851
DOC_USP7_MATH_1	140	144	PF00917	0.534
DOC_USP7_MATH_1	148	152	PF00917	0.587
DOC_USP7_MATH_1	169	173	PF00917	0.607
DOC_USP7_MATH_1	216	220	PF00917	0.737
DOC_USP7_MATH_1	228	232	PF00917	0.616
DOC_USP7_MATH_1	255	259	PF00917	0.842
DOC_USP7_MATH_1	261	265	PF00917	0.726
DOC_USP7_MATH_1	319	323	PF00917	0.659
DOC_USP7_MATH_1	350	354	PF00917	0.780
DOC_USP7_MATH_1	366	370	PF00917	0.686
DOC_USP7_MATH_1	614	618	PF00917	0.756
DOC_WW_Pin1_4	126	131	PF00397	0.756
DOC_WW_Pin1_4	177	182	PF00397	0.690
DOC_WW_Pin1_4	199	204	PF00397	0.732
DOC_WW_Pin1_4	217	222	PF00397	0.636
DOC_WW_Pin1_4	284	289	PF00397	0.756
DOC_WW_Pin1_4	295	300	PF00397	0.631
DOC_WW_Pin1_4	314	319	PF00397	0.633
DOC_WW_Pin1_4	343	348	PF00397	0.651
DOC_WW_Pin1_4	390	395	PF00397	0.552
DOC_WW_Pin1_4	437	442	PF00397	0.649
DOC_WW_Pin1_4	6	11	PF00397	0.671
DOC_WW_Pin1_4	647	652	PF00397	0.785
DOC_WW_Pin1_4	659	664	PF00397	0.633
DOC_WW_Pin1_4	747	752	PF00397	0.673
LIG_14-3-3_CanoR_1	266	272	PF00244	0.817
LIG_14-3-3_CanoR_1	275	284	PF00244	0.668
LIG_14-3-3_CanoR_1	310	318	PF00244	0.762
LIG_14-3-3_CanoR_1	38	46	PF00244	0.778
LIG_14-3-3_CanoR_1	421	427	PF00244	0.355
LIG_14-3-3_CanoR_1	431	436	PF00244	0.365
LIG_14-3-3_CanoR_1	463	469	PF00244	0.553
LIG_14-3-3_CanoR_1	470	476	PF00244	0.540
LIG_14-3-3_CanoR_1	512	516	PF00244	0.602
LIG_14-3-3_CanoR_1	541	550	PF00244	0.456
LIG_14-3-3_CanoR_1	715	725	PF00244	0.765
LIG_14-3-3_CanoR_1	823	833	PF00244	0.533
LIG_14-3-3_CanoR_1	897	901	PF00244	0.513
LIG_APCC_ABBA_1	847	852	PF00400	0.601
LIG_APCC_ABBA_1	862	867	PF00400	0.506
LIG_APCC_ABBAyCdc20_2	861	867	PF00400	0.513
LIG_BIR_III_4	499	503	PF00653	0.706
LIG_BRCT_BRCA1_1	749	753	PF00533	0.600
LIG_BRCT_BRCA1_1	821	825	PF00533	0.619
LIG_BRCT_MDC1_1	918	922	PF00533	0.647
LIG_FHA_1	289	295	PF00498	0.690
LIG_FHA_1	356	362	PF00498	0.756
LIG_FHA_1	432	438	PF00498	0.377
LIG_FHA_1	667	673	PF00498	0.759
LIG_FHA_1	742	748	PF00498	0.735
LIG_FHA_1	769	775	PF00498	0.803
LIG_FHA_2	276	282	PF00498	0.734
LIG_FHA_2	355	361	PF00498	0.811
LIG_FHA_2	391	397	PF00498	0.532
LIG_Integrin_RGD_1	501	503	PF01839	0.788
LIG_LIR_Apic_2	684	688	PF02991	0.792
LIG_LIR_Apic_2	750	756	PF02991	0.597
LIG_LIR_Apic_2	771	775	PF02991	0.803
LIG_LIR_Gen_1	291	299	PF02991	0.691
LIG_LIR_Gen_1	804	814	PF02991	0.498
LIG_LIR_Nem_3	291	295	PF02991	0.692
LIG_LIR_Nem_3	336	340	PF02991	0.798
LIG_LIR_Nem_3	575	581	PF02991	0.458
LIG_LIR_Nem_3	684	690	PF02991	0.720
LIG_LIR_Nem_3	804	809	PF02991	0.495
LIG_LIR_Nem_3	831	836	PF02991	0.558
LIG_LIR_Nem_3	859	863	PF02991	0.588
LIG_Pex14_1	880	884	PF04695	0.715
LIG_Pex14_2	894	898	PF04695	0.613
LIG_SH2_CRK	292	296	PF00017	0.735
LIG_SH2_CRK	578	582	PF00017	0.484
LIG_SH2_NCK_1	292	296	PF00017	0.697
LIG_SH2_PTP2	531	534	PF00017	0.505
LIG_SH2_PTP2	833	836	PF00017	0.401
LIG_SH2_SRC	531	534	PF00017	0.505
LIG_SH2_STAP1	292	296	PF00017	0.697
LIG_SH2_STAP1	619	623	PF00017	0.710
LIG_SH2_STAP1	821	825	PF00017	0.541
LIG_SH2_STAT5	292	295	PF00017	0.735
LIG_SH2_STAT5	531	534	PF00017	0.505
LIG_SH2_STAT5	833	836	PF00017	0.576
LIG_SH2_STAT5	848	851	PF00017	0.588
LIG_SH2_STAT5	884	887	PF00017	0.632
LIG_SH3_3	117	123	PF00018	0.758
LIG_SH3_3	302	308	PF00018	0.726
LIG_SH3_3	315	321	PF00018	0.663
LIG_SH3_3	323	329	PF00018	0.775
LIG_SH3_3	595	601	PF00018	0.700
LIG_SH3_3	668	674	PF00018	0.750
LIG_SH3_3	680	686	PF00018	0.663
LIG_SH3_3	692	698	PF00018	0.702
LIG_SH3_3	915	921	PF00018	0.485
LIG_SUMO_SIM_anti_2	562	568	PF11976	0.625
LIG_SUMO_SIM_anti_2	584	589	PF11976	0.658
LIG_SUMO_SIM_par_1	384	389	PF11976	0.582
LIG_SUMO_SIM_par_1	562	568	PF11976	0.496
LIG_SUMO_SIM_par_1	596	602	PF11976	0.671
LIG_SUMO_SIM_par_1	650	655	PF11976	0.703
LIG_TRAF2_2	390	395	PF00917	0.649
LIG_WRC_WIRS_1	112	117	PF05994	0.628
LIG_WW_3	789	793	PF00397	0.647
MOD_CDC14_SPxK_1	667	670	PF00782	0.762
MOD_CDK_SPK_2	295	300	PF00069	0.696
MOD_CDK_SPxK_1	437	443	PF00069	0.518
MOD_CDK_SPxK_1	664	670	PF00069	0.714
MOD_CK1_1	107	113	PF00069	0.753
MOD_CK1_1	129	135	PF00069	0.678
MOD_CK1_1	177	183	PF00069	0.667
MOD_CK1_1	209	215	PF00069	0.731
MOD_CK1_1	219	225	PF00069	0.681
MOD_CK1_1	231	237	PF00069	0.575
MOD_CK1_1	24	30	PF00069	0.810
MOD_CK1_1	270	276	PF00069	0.763
MOD_CK1_1	314	320	PF00069	0.825
MOD_CK1_1	346	352	PF00069	0.747
MOD_CK1_1	355	361	PF00069	0.634
MOD_CK1_1	364	370	PF00069	0.639
MOD_CK1_1	375	381	PF00069	0.301
MOD_CK1_1	469	475	PF00069	0.628
MOD_CK1_1	617	623	PF00069	0.769
MOD_CK1_1	647	653	PF00069	0.776
MOD_CK1_1	662	668	PF00069	0.814
MOD_CK1_1	73	79	PF00069	0.672
MOD_CK1_1	824	830	PF00069	0.564
MOD_CK2_1	275	281	PF00069	0.696
MOD_CK2_1	354	360	PF00069	0.811
MOD_CK2_1	517	523	PF00069	0.385
MOD_Cter_Amidation	264	267	PF01082	0.749
MOD_DYRK1A_RPxSP_1	6	10	PF00069	0.673
MOD_GlcNHglycan	144	147	PF01048	0.685
MOD_GlcNHglycan	160	163	PF01048	0.600
MOD_GlcNHglycan	166	169	PF01048	0.698
MOD_GlcNHglycan	171	174	PF01048	0.628
MOD_GlcNHglycan	197	200	PF01048	0.826
MOD_GlcNHglycan	211	215	PF01048	0.593
MOD_GlcNHglycan	261	264	PF01048	0.749
MOD_GlcNHglycan	275	278	PF01048	0.566
MOD_GlcNHglycan	29	32	PF01048	0.665
MOD_GlcNHglycan	313	316	PF01048	0.770
MOD_GlcNHglycan	348	351	PF01048	0.787
MOD_GlcNHglycan	354	357	PF01048	0.606
MOD_GlcNHglycan	368	371	PF01048	0.520
MOD_GlcNHglycan	480	483	PF01048	0.751
MOD_GlcNHglycan	543	546	PF01048	0.549
MOD_GlcNHglycan	557	560	PF01048	0.409
MOD_GlcNHglycan	646	649	PF01048	0.653
MOD_GlcNHglycan	664	667	PF01048	0.749
MOD_GlcNHglycan	679	682	PF01048	0.717
MOD_GlcNHglycan	731	734	PF01048	0.648
MOD_GlcNHglycan	760	763	PF01048	0.608
MOD_GlcNHglycan	787	790	PF01048	0.748
MOD_GlcNHglycan	798	801	PF01048	0.562
MOD_GlcNHglycan	907	910	PF01048	0.559
MOD_GlcNHglycan	918	921	PF01048	0.516
MOD_GSK3_1	104	111	PF00069	0.725
MOD_GSK3_1	124	131	PF00069	0.685
MOD_GSK3_1	142	149	PF00069	0.489
MOD_GSK3_1	177	184	PF00069	0.756
MOD_GSK3_1	195	202	PF00069	0.631
MOD_GSK3_1	206	213	PF00069	0.638
MOD_GSK3_1	216	223	PF00069	0.719
MOD_GSK3_1	229	236	PF00069	0.681
MOD_GSK3_1	255	262	PF00069	0.792
MOD_GSK3_1	267	274	PF00069	0.663
MOD_GSK3_1	280	287	PF00069	0.594
MOD_GSK3_1	342	349	PF00069	0.773
MOD_GSK3_1	350	357	PF00069	0.673
MOD_GSK3_1	362	369	PF00069	0.529
MOD_GSK3_1	6	13	PF00069	0.715
MOD_GSK3_1	643	650	PF00069	0.630
MOD_GSK3_1	662	669	PF00069	0.651
MOD_GSK3_1	70	77	PF00069	0.690
MOD_GSK3_1	702	709	PF00069	0.679
MOD_GSK3_1	742	749	PF00069	0.780
MOD_GSK3_1	758	765	PF00069	0.655
MOD_GSK3_1	808	815	PF00069	0.618
MOD_GSK3_1	819	826	PF00069	0.472
MOD_N-GLC_1	104	109	PF02516	0.649
MOD_N-GLC_1	39	44	PF02516	0.776
MOD_N-GLC_1	429	434	PF02516	0.355
MOD_N-GLC_2	26	28	PF02516	0.763
MOD_NEK2_1	1	6	PF00069	0.713
MOD_NEK2_1	226	231	PF00069	0.744
MOD_NEK2_1	342	347	PF00069	0.728
MOD_NEK2_1	361	366	PF00069	0.811
MOD_NEK2_1	565	570	PF00069	0.608
MOD_NEK2_1	690	695	PF00069	0.773
MOD_NEK2_1	905	910	PF00069	0.490
MOD_NEK2_2	308	313	PF00069	0.762
MOD_NEK2_2	614	619	PF00069	0.711
MOD_PIKK_1	129	135	PF00454	0.780
MOD_PIKK_1	171	177	PF00454	0.755
MOD_PIKK_1	469	475	PF00454	0.628
MOD_PIKK_1	565	571	PF00454	0.628
MOD_PIKK_1	63	69	PF00454	0.684
MOD_PIKK_1	690	696	PF00454	0.617
MOD_PIKK_1	706	712	PF00454	0.637
MOD_PKA_2	1	7	PF00069	0.774
MOD_PKA_2	141	147	PF00069	0.726
MOD_PKA_2	209	215	PF00069	0.779
MOD_PKA_2	265	271	PF00069	0.743
MOD_PKA_2	469	475	PF00069	0.628
MOD_PKA_2	511	517	PF00069	0.604
MOD_PKA_2	728	734	PF00069	0.619
MOD_PKA_2	74	80	PF00069	0.740
MOD_PKA_2	896	902	PF00069	0.518
MOD_PKB_1	59	67	PF00069	0.691
MOD_Plk_1	280	286	PF00069	0.733
MOD_Plk_1	734	740	PF00069	0.744
MOD_Plk_1	742	748	PF00069	0.630
MOD_Plk_4	290	296	PF00069	0.692
MOD_Plk_4	372	378	PF00069	0.663
MOD_Plk_4	422	428	PF00069	0.398
MOD_Plk_4	614	620	PF00069	0.656
MOD_Plk_4	828	834	PF00069	0.397
MOD_ProDKin_1	126	132	PF00069	0.757
MOD_ProDKin_1	177	183	PF00069	0.690
MOD_ProDKin_1	199	205	PF00069	0.732
MOD_ProDKin_1	217	223	PF00069	0.635
MOD_ProDKin_1	284	290	PF00069	0.757
MOD_ProDKin_1	295	301	PF00069	0.632
MOD_ProDKin_1	314	320	PF00069	0.634
MOD_ProDKin_1	343	349	PF00069	0.651
MOD_ProDKin_1	390	396	PF00069	0.548
MOD_ProDKin_1	437	443	PF00069	0.654
MOD_ProDKin_1	6	12	PF00069	0.671
MOD_ProDKin_1	647	653	PF00069	0.787
MOD_ProDKin_1	659	665	PF00069	0.635
MOD_ProDKin_1	747	753	PF00069	0.676
MOD_SUMO_rev_2	355	364	PF00179	0.600
TRG_DiLeu_BaEn_2	900	906	PF01217	0.607
TRG_ENDOCYTIC_2	292	295	PF00928	0.735
TRG_ENDOCYTIC_2	531	534	PF00928	0.505
TRG_ENDOCYTIC_2	578	581	PF00928	0.459
TRG_ENDOCYTIC_2	833	836	PF00928	0.576
TRG_ER_diArg_1	247	250	PF00400	0.766
TRG_ER_diArg_1	46	49	PF00400	0.777
TRG_ER_diArg_1	460	463	PF00400	0.393
TRG_ER_diArg_1	505	508	PF00400	0.570
TRG_ER_diArg_1	57	59	PF00400	0.653
TRG_ER_diArg_1	588	591	PF00400	0.676
TRG_ER_diArg_1	713	715	PF00400	0.664
TRG_Pf-PMV_PEXEL_1	579	584	PF00026	0.657

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WPU3	Leishmania donovani	100%	100%
A4H4Y3	Leishmania braziliensis	66%	100%
E9AL48	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	99%
Q4QIQ6	Leishmania major	90%	100%