Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Peptidase dimerisation domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4HT25_LEIIN

TriTrypDb:

LINF_070005300

Length:

228

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HT25

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HT25

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006520	amino acid metabolic process	3	1
GO:0006525	arginine metabolic process	6	1
GO:0006526	arginine biosynthetic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008652	amino acid biosynthetic process	4	1
GO:0009058	biosynthetic process	2	1
GO:0009064	glutamine family amino acid metabolic process	5	1
GO:0009084	glutamine family amino acid biosynthetic process	6	1
GO:0009987	cellular process	1	1
GO:0016053	organic acid biosynthetic process	4	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044283	small molecule biosynthetic process	3	1
GO:0046394	carboxylic acid biosynthetic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1
GO:1901605	alpha-amino acid metabolic process	4	1
GO:1901607	alpha-amino acid biosynthetic process	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008777	acetylornithine deacetylase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	1
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	4	1
GO:0019213	deacetylase activity	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	160	162	PF00675	0.492
CLV_NRD_NRD_1	214	216	PF00675	0.714
CLV_PCSK_KEX2_1	16	18	PF00082	0.474
CLV_PCSK_KEX2_1	208	210	PF00082	0.708
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.474
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.708
CLV_PCSK_SKI1_1	152	156	PF00082	0.543
CLV_PCSK_SKI1_1	39	43	PF00082	0.474
DEG_Nend_Nbox_1	1	3	PF02207	0.350
DOC_CDC14_PxL_1	132	140	PF14671	0.458
DOC_MAPK_gen_1	207	213	PF00069	0.536
DOC_PP1_RVXF_1	37	43	PF00149	0.474
DOC_PP2B_LxvP_1	133	136	PF13499	0.453
DOC_USP7_UBL2_3	12	16	PF12436	0.474
LIG_FHA_1	79	85	PF00498	0.524
LIG_FHA_1	8	14	PF00498	0.349
LIG_FHA_2	165	171	PF00498	0.621
LIG_LIR_Gen_1	170	180	PF02991	0.634
LIG_LIR_Gen_1	91	99	PF02991	0.274
LIG_LIR_Nem_3	170	175	PF02991	0.640
LIG_LIR_Nem_3	91	95	PF02991	0.274
LIG_Pex14_2	88	92	PF04695	0.349
LIG_PTB_Apo_2	86	93	PF02174	0.349
LIG_SH2_CRK	172	176	PF00017	0.650
LIG_SH2_NCK_1	172	176	PF00017	0.650
LIG_SH2_STAT5	110	113	PF00017	0.540
LIG_SH2_STAT5	172	175	PF00017	0.398
LIG_SH3_3	178	184	PF00018	0.494
LIG_SUMO_SIM_par_1	130	137	PF11976	0.499
LIG_TRAF2_1	190	193	PF00917	0.674
LIG_UBA3_1	210	216	PF00899	0.654
MOD_CK1_1	134	140	PF00069	0.562
MOD_CK1_1	62	68	PF00069	0.474
MOD_Cter_Amidation	205	208	PF01082	0.701
MOD_GlcNHglycan	121	125	PF01048	0.556
MOD_GlcNHglycan	147	150	PF01048	0.528
MOD_GlcNHglycan	22	25	PF01048	0.349
MOD_GlcNHglycan	61	64	PF01048	0.349
MOD_GSK3_1	116	123	PF00069	0.480
MOD_GSK3_1	20	27	PF00069	0.443
MOD_GSK3_1	59	66	PF00069	0.474
MOD_N-GLC_1	211	216	PF02516	0.653
MOD_N-GLC_2	203	205	PF02516	0.498
MOD_N-GLC_2	29	31	PF02516	0.349
MOD_NEK2_1	211	216	PF00069	0.653
MOD_NEK2_1	61	66	PF00069	0.474
MOD_NEK2_1	68	73	PF00069	0.407
MOD_NEK2_1	7	12	PF00069	0.349
MOD_PIKK_1	100	106	PF00454	0.535
MOD_Plk_4	170	176	PF00069	0.393
MOD_Plk_4	63	69	PF00069	0.474
MOD_SUMO_rev_2	137	147	PF00179	0.506
TRG_DiLeu_BaLyEn_6	175	180	PF01217	0.457
TRG_ENDOCYTIC_2	172	175	PF00928	0.649

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WPP6	Leishmania donovani	99%	80%
E9AL13	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	99%
Q4QIU1	Leishmania major	77%	100%