CLN3 protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

CLN3 protein

Gene product:

CLN3 protein - putative

Species:

Leishmania infantum

UniProt:

A4HT21_LEIIN

TriTrypDb:

LINF_060019200

Length:

642

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005773	vacuole	5	13
GO:0016020	membrane	2	13
GO:0043226	organelle	2	13
GO:0043227	membrane-bounded organelle	3	13
GO:0043229	intracellular organelle	3	13
GO:0043231	intracellular membrane-bounded organelle	4	13
GO:0110165	cellular anatomical entity	1	13

Expansion

Sequence features

A4HT21

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HT21

Function

Biological processes
Term	Name	Level	Count
GO:0006873	intracellular monoatomic ion homeostasis	4	1
GO:0006885	regulation of pH	8	1
GO:0009987	cellular process	1	1
GO:0019725	cellular homeostasis	2	1
GO:0030003	intracellular monoatomic cation homeostasis	5	1
GO:0030004	obsolete cellular monovalent inorganic cation homeostasis	6	1
GO:0030641	regulation of cellular pH	7	1
GO:0042592	homeostatic process	3	1
GO:0048878	chemical homeostasis	4	1
GO:0050801	monoatomic ion homeostasis	5	1
GO:0051453	regulation of intracellular pH	8	1
GO:0055067	obsolete monovalent inorganic cation homeostasis	7	1
GO:0055080	monoatomic cation homeostasis	6	1
GO:0055082	intracellular chemical homeostasis	3	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0098771	inorganic ion homeostasis	6	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	330	334	PF00656	0.510
CLV_C14_Caspase3-7	401	405	PF00656	0.304
CLV_C14_Caspase3-7	586	590	PF00656	0.504
CLV_MEL_PAP_1	129	135	PF00089	0.263
CLV_NRD_NRD_1	254	256	PF00675	0.231
CLV_NRD_NRD_1	354	356	PF00675	0.318
CLV_NRD_NRD_1	536	538	PF00675	0.434
CLV_NRD_NRD_1	553	555	PF00675	0.379
CLV_NRD_NRD_1	605	607	PF00675	0.374
CLV_PCSK_FUR_1	54	58	PF00082	0.363
CLV_PCSK_KEX2_1	266	268	PF00082	0.219
CLV_PCSK_KEX2_1	354	356	PF00082	0.258
CLV_PCSK_KEX2_1	500	502	PF00082	0.323
CLV_PCSK_KEX2_1	56	58	PF00082	0.364
CLV_PCSK_KEX2_1	605	607	PF00082	0.281
CLV_PCSK_KEX2_1	67	69	PF00082	0.290
CLV_PCSK_PC1ET2_1	266	268	PF00082	0.219
CLV_PCSK_PC1ET2_1	500	502	PF00082	0.323
CLV_PCSK_PC1ET2_1	56	58	PF00082	0.355
CLV_PCSK_PC1ET2_1	67	69	PF00082	0.246
CLV_PCSK_PC7_1	262	268	PF00082	0.187
CLV_PCSK_SKI1_1	255	259	PF00082	0.289
CLV_PCSK_SKI1_1	57	61	PF00082	0.363
CLV_PCSK_SKI1_1	64	68	PF00082	0.316
DEG_APCC_DBOX_1	426	434	PF00400	0.409
DEG_Nend_UBRbox_1	1	4	PF02207	0.655
DOC_CKS1_1	155	160	PF01111	0.260
DOC_CKS1_1	235	240	PF01111	0.393
DOC_CYCLIN_yCln2_LP_2	390	396	PF00134	0.317
DOC_MAPK_gen_1	266	272	PF00069	0.419
DOC_MAPK_gen_1	466	474	PF00069	0.290
DOC_MAPK_gen_1	605	612	PF00069	0.486
DOC_MAPK_MEF2A_6	358	366	PF00069	0.473
DOC_MAPK_MEF2A_6	427	435	PF00069	0.409
DOC_MAPK_MEF2A_6	466	474	PF00069	0.263
DOC_MAPK_MEF2A_6	72	79	PF00069	0.463
DOC_PP1_RVXF_1	310	317	PF00149	0.509
DOC_PP2B_LxvP_1	390	393	PF13499	0.317
DOC_PP2B_LxvP_1	579	582	PF13499	0.483
DOC_PP4_FxxP_1	155	158	PF00568	0.322
DOC_USP7_MATH_1	143	147	PF00917	0.277
DOC_USP7_MATH_1	203	207	PF00917	0.352
DOC_USP7_MATH_1	531	535	PF00917	0.661
DOC_USP7_MATH_1	562	566	PF00917	0.790
DOC_USP7_MATH_1	94	98	PF00917	0.310
DOC_USP7_UBL2_3	462	466	PF12436	0.231
DOC_USP7_UBL2_3	551	555	PF12436	0.712
DOC_WW_Pin1_4	154	159	PF00397	0.260
DOC_WW_Pin1_4	234	239	PF00397	0.394
DOC_WW_Pin1_4	250	255	PF00397	0.233
DOC_WW_Pin1_4	316	321	PF00397	0.495
DOC_WW_Pin1_4	345	350	PF00397	0.490
LIG_14-3-3_CanoR_1	132	136	PF00244	0.441
LIG_14-3-3_CanoR_1	138	144	PF00244	0.255
LIG_14-3-3_CanoR_1	22	28	PF00244	0.575
LIG_14-3-3_CanoR_1	312	317	PF00244	0.512
LIG_14-3-3_CanoR_1	427	431	PF00244	0.409
LIG_14-3-3_CanoR_1	501	506	PF00244	0.510
LIG_14-3-3_CanoR_1	72	76	PF00244	0.443
LIG_Actin_WH2_2	122	140	PF00022	0.197
LIG_Actin_WH2_2	622	639	PF00022	0.395
LIG_BRCT_BRCA1_1	215	219	PF00533	0.269
LIG_deltaCOP1_diTrp_1	399	407	PF00928	0.261
LIG_EH1_1	302	310	PF00400	0.419
LIG_eIF4E_1	102	108	PF01652	0.263
LIG_eIF4E_1	419	425	PF01652	0.274
LIG_FHA_1	230	236	PF00498	0.292
LIG_FHA_1	616	622	PF00498	0.309
LIG_FHA_2	22	28	PF00498	0.607
LIG_FHA_2	502	508	PF00498	0.507
LIG_FHA_2	582	588	PF00498	0.606
LIG_FHA_2	602	608	PF00498	0.390
LIG_FHA_2	623	629	PF00498	0.395
LIG_GBD_Chelix_1	169	177	PF00786	0.322
LIG_LIR_Apic_2	154	158	PF02991	0.322
LIG_LIR_Apic_2	395	400	PF02991	0.323
LIG_LIR_Gen_1	112	121	PF02991	0.254
LIG_LIR_Gen_1	473	482	PF02991	0.308
LIG_LIR_Gen_1	490	499	PF02991	0.160
LIG_LIR_Gen_1	74	83	PF02991	0.322
LIG_LIR_Nem_3	112	116	PF02991	0.254
LIG_LIR_Nem_3	216	222	PF02991	0.246
LIG_LIR_Nem_3	370	376	PF02991	0.336
LIG_LIR_Nem_3	473	477	PF02991	0.308
LIG_LIR_Nem_3	490	494	PF02991	0.160
LIG_LIR_Nem_3	74	79	PF02991	0.304
LIG_NRBOX	143	149	PF00104	0.409
LIG_Pex14_1	113	117	PF04695	0.294
LIG_Pex14_1	402	406	PF04695	0.317
LIG_Pex14_1	78	82	PF04695	0.322
LIG_Pex14_2	117	121	PF04695	0.368
LIG_Pex14_2	151	155	PF04695	0.397
LIG_Pex14_2	82	86	PF04695	0.331
LIG_PTB_Apo_2	490	497	PF02174	0.259
LIG_PTB_Apo_2	70	77	PF02174	0.511
LIG_PTB_Apo_2	82	89	PF02174	0.191
LIG_PTB_Phospho_1	490	496	PF10480	0.274
LIG_PTB_Phospho_1	82	88	PF10480	0.255
LIG_Rb_LxCxE_1	268	288	PF01857	0.431
LIG_SH2_CRK	616	620	PF00017	0.270
LIG_SH2_CRK	88	92	PF00017	0.259
LIG_SH2_GRB2like	491	494	PF00017	0.246
LIG_SH2_NCK_1	616	620	PF00017	0.255
LIG_SH2_PTP2	437	440	PF00017	0.294
LIG_SH2_PTP2	491	494	PF00017	0.246
LIG_SH2_SRC	491	494	PF00017	0.246
LIG_SH2_STAP1	303	307	PF00017	0.489
LIG_SH2_STAP1	386	390	PF00017	0.259
LIG_SH2_STAT3	386	389	PF00017	0.246
LIG_SH2_STAT5	273	276	PF00017	0.514
LIG_SH2_STAT5	382	385	PF00017	0.270
LIG_SH2_STAT5	397	400	PF00017	0.225
LIG_SH2_STAT5	412	415	PF00017	0.398
LIG_SH2_STAT5	437	440	PF00017	0.294
LIG_SH2_STAT5	460	463	PF00017	0.317
LIG_SH2_STAT5	491	494	PF00017	0.246
LIG_SH2_STAT5	496	499	PF00017	0.409
LIG_SH2_STAT5	517	520	PF00017	0.613
LIG_SH2_STAT5	88	91	PF00017	0.273
LIG_SH3_3	232	238	PF00018	0.322
LIG_SH3_3	319	325	PF00018	0.487
LIG_SH3_3	430	436	PF00018	0.517
LIG_SUMO_SIM_anti_2	428	434	PF11976	0.463
LIG_SUMO_SIM_anti_2	625	632	PF11976	0.265
LIG_SUMO_SIM_par_1	106	112	PF11976	0.360
LIG_SUMO_SIM_par_1	174	180	PF11976	0.435
LIG_SUMO_SIM_par_1	295	302	PF11976	0.462
LIG_TRAF2_1	48	51	PF00917	0.654
LIG_TRAF2_1	584	587	PF00917	0.553
LIG_TYR_ITIM	435	440	PF00017	0.294
LIG_TYR_ITIM	494	499	PF00017	0.274
LIG_UBA3_1	248	256	PF00899	0.277
LIG_WRC_WIRS_1	152	157	PF05994	0.274
LIG_WRC_WIRS_1	189	194	PF05994	0.393
MOD_CDC14_SPxK_1	253	256	PF00782	0.322
MOD_CDK_SPK_2	250	255	PF00069	0.277
MOD_CDK_SPxK_1	250	256	PF00069	0.322
MOD_CK1_1	154	160	PF00069	0.382
MOD_CK1_1	205	211	PF00069	0.266
MOD_CK1_1	426	432	PF00069	0.246
MOD_CK2_1	295	301	PF00069	0.304
MOD_CK2_1	44	50	PF00069	0.621
MOD_CK2_1	501	507	PF00069	0.277
MOD_CK2_1	581	587	PF00069	0.483
MOD_CK2_1	601	607	PF00069	0.225
MOD_CK2_1	94	100	PF00069	0.397
MOD_Cter_Amidation	264	267	PF01082	0.260
MOD_GlcNHglycan	205	208	PF01048	0.246
MOD_GlcNHglycan	210	213	PF01048	0.246
MOD_GlcNHglycan	223	226	PF01048	0.246
MOD_GlcNHglycan	570	573	PF01048	0.518
MOD_GlcNHglycan	92	95	PF01048	0.277
MOD_GSK3_1	18	25	PF00069	0.733
MOD_GSK3_1	184	191	PF00069	0.290
MOD_GSK3_1	221	228	PF00069	0.309
MOD_GSK3_1	229	236	PF00069	0.294
MOD_GSK3_1	312	319	PF00069	0.365
MOD_GSK3_1	460	467	PF00069	0.412
MOD_GSK3_1	562	569	PF00069	0.770
MOD_GSK3_1	615	622	PF00069	0.274
MOD_GSK3_1	90	97	PF00069	0.360
MOD_N-GLC_1	35	40	PF02516	0.503
MOD_NEK2_1	137	142	PF00069	0.292
MOD_NEK2_1	151	156	PF00069	0.198
MOD_NEK2_1	177	182	PF00069	0.316
MOD_NEK2_1	220	225	PF00069	0.254
MOD_NEK2_1	233	238	PF00069	0.227
MOD_NEK2_1	258	263	PF00069	0.406
MOD_NEK2_1	367	372	PF00069	0.425
MOD_NEK2_1	499	504	PF00069	0.309
MOD_NEK2_1	615	620	PF00069	0.278
MOD_NEK2_1	629	634	PF00069	0.291
MOD_NEK2_1	636	641	PF00069	0.412
MOD_NEK2_1	66	71	PF00069	0.439
MOD_NEK2_1	90	95	PF00069	0.266
MOD_PIKK_1	225	231	PF00454	0.360
MOD_PIKK_1	562	568	PF00454	0.583
MOD_PIKK_1	581	587	PF00454	0.273
MOD_PKA_1	500	506	PF00069	0.322
MOD_PKA_2	131	137	PF00069	0.278
MOD_PKA_2	21	27	PF00069	0.479
MOD_PKA_2	426	432	PF00069	0.246
MOD_PKA_2	500	506	PF00069	0.322
MOD_PKA_2	71	77	PF00069	0.352
MOD_Plk_1	35	41	PF00069	0.460
MOD_Plk_1	57	63	PF00069	0.389
MOD_Plk_2-3	295	301	PF00069	0.304
MOD_Plk_2-3	45	51	PF00069	0.419
MOD_Plk_4	143	149	PF00069	0.283
MOD_Plk_4	184	190	PF00069	0.297
MOD_Plk_4	196	202	PF00069	0.262
MOD_Plk_4	213	219	PF00069	0.145
MOD_Plk_4	229	235	PF00069	0.240
MOD_Plk_4	35	41	PF00069	0.460
MOD_Plk_4	367	373	PF00069	0.370
MOD_Plk_4	408	414	PF00069	0.261
MOD_Plk_4	426	432	PF00069	0.147
MOD_Plk_4	470	476	PF00069	0.355
MOD_Plk_4	487	493	PF00069	0.148
MOD_Plk_4	622	628	PF00069	0.264
MOD_Plk_4	631	637	PF00069	0.414
MOD_Plk_4	71	77	PF00069	0.362
MOD_ProDKin_1	154	160	PF00069	0.260
MOD_ProDKin_1	234	240	PF00069	0.394
MOD_ProDKin_1	250	256	PF00069	0.233
MOD_ProDKin_1	316	322	PF00069	0.366
MOD_ProDKin_1	345	351	PF00069	0.360
MOD_SUMO_for_1	550	553	PF00179	0.554
MOD_SUMO_rev_2	298	308	PF00179	0.260
TRG_DiLeu_BaEn_4	330	336	PF01217	0.322
TRG_ENDOCYTIC_2	437	440	PF00928	0.294
TRG_ENDOCYTIC_2	491	494	PF00928	0.253
TRG_ENDOCYTIC_2	496	499	PF00928	0.256
TRG_ENDOCYTIC_2	616	619	PF00928	0.255
TRG_ENDOCYTIC_2	88	91	PF00928	0.258
TRG_ER_diArg_1	353	355	PF00400	0.419
TRG_ER_diArg_1	527	530	PF00400	0.627
TRG_NLS_MonoExtC_3	536	542	PF00514	0.534
TRG_NLS_MonoExtN_4	536	541	PF00514	0.452

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2N3	Leptomonas seymouri	43%	88%
A0A0S4IMH8	Bodo saltans	40%	100%
A0A1X0NL65	Trypanosomatidae	39%	100%
A0A1X0NM99	Trypanosomatidae	41%	100%
A0A3Q8IBB0	Leishmania donovani	98%	100%
A0A3R7MV96	Trypanosoma rangeli	40%	100%
A4HC54	Leishmania braziliensis	78%	100%
C9ZTE5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AVI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4HX89	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	25%	100%
Q4QBZ3	Leishmania major	91%	100%
Q4X0S3	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	26%	100%
V5DU41	Trypanosoma cruzi	41%	100%