Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HT17_LEIIN

TriTrypDb:

LINF_060018600

Length:

238

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4HT17

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HT17

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	111	117	PF00089	0.272
CLV_NRD_NRD_1	20	22	PF00675	0.402
CLV_NRD_NRD_1	24	26	PF00675	0.400
CLV_PCSK_KEX2_1	11	13	PF00082	0.407
CLV_PCSK_KEX2_1	167	169	PF00082	0.514
CLV_PCSK_KEX2_1	19	21	PF00082	0.372
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.459
CLV_PCSK_PC1ET2_1	167	169	PF00082	0.553
CLV_PCSK_PC1ET2_1	19	21	PF00082	0.422
DOC_MAPK_DCC_7	125	134	PF00069	0.416
DOC_MAPK_MEF2A_6	125	134	PF00069	0.440
DOC_MAPK_MEF2A_6	199	208	PF00069	0.539
DOC_MAPK_MEF2A_6	53	62	PF00069	0.516
DOC_MAPK_NFAT4_5	199	207	PF00069	0.551
DOC_PP1_RVXF_1	154	161	PF00149	0.705
DOC_PP2B_PxIxI_1	55	61	PF00149	0.369
DOC_PP4_FxxP_1	93	96	PF00568	0.652
DOC_USP7_MATH_2	96	102	PF00917	0.536
DOC_WW_Pin1_4	151	156	PF00397	0.627
DOC_WW_Pin1_4	47	52	PF00397	0.665
LIG_14-3-3_CanoR_1	114	123	PF00244	0.529
LIG_14-3-3_CanoR_1	159	165	PF00244	0.703
LIG_Actin_WH2_2	146	161	PF00022	0.612
LIG_BIR_II_1	1	5	PF00653	0.627
LIG_BRCT_BRCA1_1	153	157	PF00533	0.644
LIG_deltaCOP1_diTrp_1	75	82	PF00928	0.292
LIG_eIF4E_1	137	143	PF01652	0.485
LIG_FAT_LD_1	200	208	PF03623	0.561
LIG_FHA_1	103	109	PF00498	0.357
LIG_FHA_1	37	43	PF00498	0.687
LIG_FHA_1	50	56	PF00498	0.614
LIG_LIR_Apic_2	117	123	PF02991	0.441
LIG_LIR_Gen_1	154	164	PF02991	0.710
LIG_LIR_Gen_1	181	192	PF02991	0.641
LIG_LIR_Gen_1	31	42	PF02991	0.656
LIG_LIR_Gen_1	97	107	PF02991	0.510
LIG_LIR_Nem_3	154	160	PF02991	0.691
LIG_LIR_Nem_3	181	187	PF02991	0.645
LIG_LIR_Nem_3	31	37	PF02991	0.643
LIG_LIR_Nem_3	75	79	PF02991	0.331
LIG_LIR_Nem_3	97	102	PF02991	0.504
LIG_NRBOX	199	205	PF00104	0.561
LIG_NRBOX	58	64	PF00104	0.485
LIG_NRBOX	84	90	PF00104	0.424
LIG_SH2_CRK	120	124	PF00017	0.476
LIG_SH2_NCK_1	120	124	PF00017	0.446
LIG_SH2_PTP2	137	140	PF00017	0.432
LIG_SH2_PTP2	152	155	PF00017	0.461
LIG_SH2_SRC	34	37	PF00017	0.654
LIG_SH2_STAT5	137	140	PF00017	0.389
LIG_SH2_STAT5	149	152	PF00017	0.311
LIG_SH2_STAT5	217	220	PF00017	0.444
LIG_SH2_STAT5	34	37	PF00017	0.653
LIG_SH2_STAT5	77	80	PF00017	0.374
LIG_SH3_3	124	130	PF00018	0.403
LIG_SH3_3	62	68	PF00018	0.396
LIG_SUMO_SIM_anti_2	198	204	PF11976	0.597
LIG_SUMO_SIM_anti_2	33	39	PF11976	0.653
LIG_TYR_ITIM	135	140	PF00017	0.420
LIG_TYR_ITIM	215	220	PF00017	0.444
MOD_CDC14_SPxK_1	50	53	PF00782	0.654
MOD_CDK_SPK_2	151	156	PF00069	0.627
MOD_CDK_SPxK_1	47	53	PF00069	0.671
MOD_CK1_1	101	107	PF00069	0.429
MOD_CK1_1	2	8	PF00069	0.677
MOD_CK2_1	2	8	PF00069	0.644
MOD_Cter_Amidation	165	168	PF01082	0.489
MOD_GlcNHglycan	172	175	PF01048	0.498
MOD_GSK3_1	45	52	PF00069	0.660
MOD_GSK3_1	63	70	PF00069	0.195
MOD_GSK3_1	94	101	PF00069	0.648
MOD_NEK2_1	158	163	PF00069	0.689
MOD_NEK2_1	63	68	PF00069	0.401
MOD_NEK2_1	91	96	PF00069	0.482
MOD_PKA_2	113	119	PF00069	0.499
MOD_PKA_2	158	164	PF00069	0.702
MOD_PKA_2	169	175	PF00069	0.652
MOD_PKA_2	45	51	PF00069	0.722
MOD_PKB_1	168	176	PF00069	0.725
MOD_Plk_4	102	108	PF00069	0.221
MOD_Plk_4	54	60	PF00069	0.377
MOD_Plk_4	84	90	PF00069	0.389
MOD_ProDKin_1	151	157	PF00069	0.630
MOD_ProDKin_1	47	53	PF00069	0.663
TRG_DiLeu_BaEn_1	198	203	PF01217	0.631
TRG_DiLeu_BaEn_4	195	201	PF01217	0.659
TRG_DiLeu_BaLyEn_6	127	132	PF01217	0.467
TRG_DiLeu_BaLyEn_6	232	237	PF01217	0.462
TRG_ENDOCYTIC_2	137	140	PF00928	0.389
TRG_ENDOCYTIC_2	184	187	PF00928	0.646
TRG_ENDOCYTIC_2	217	220	PF00928	0.412
TRG_ENDOCYTIC_2	34	37	PF00928	0.630
TRG_Pf-PMV_PEXEL_1	40	44	PF00026	0.481

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBC2	Leptomonas seymouri	68%	100%
A0A0S4JA41	Bodo saltans	29%	100%
A0A1X0NGU0	Trypanosomatidae	38%	100%
A0A3S5H5V0	Leishmania donovani	100%	100%
A4H4T7	Leishmania braziliensis	85%	100%
C9ZTQ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AL05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QIV0	Leishmania major	95%	100%