LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
FAD binding domain containing protein - putative
Species:
Leishmania infantum
UniProt:
A4HT15_LEIIN
TriTrypDb:
LINF_060018400
Length:
494

Annotations

Annotations by Jardim et al.

Oxidoreductase, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005739 mitochondrion 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 2
GO:0016020 membrane 2 1

Expansion

Sequence features

A4HT15
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HT15

Function

Biological processes
Term Name Level Count
GO:0006743 ubiquinone metabolic process 5 1
GO:0006744 ubiquinone biosynthetic process 6 1
GO:0008152 metabolic process 1 1
GO:0009058 biosynthetic process 2 1
GO:0009987 cellular process 1 1
GO:0042180 cellular ketone metabolic process 3 1
GO:0042181 ketone biosynthetic process 4 1
GO:0044237 cellular metabolic process 2 1
GO:0044249 cellular biosynthetic process 3 1
GO:0044281 small molecule metabolic process 2 1
GO:0044283 small molecule biosynthetic process 3 1
GO:0071704 organic substance metabolic process 2 1
GO:1901576 organic substance biosynthetic process 3 1
GO:1901661 quinone metabolic process 4 1
GO:1901663 quinone biosynthetic process 5 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 11
GO:0003824 catalytic activity 1 9
GO:0004497 monooxygenase activity 3 9
GO:0005488 binding 1 11
GO:0016491 oxidoreductase activity 2 9
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 3 5
GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 4 5
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0050660 flavin adenine dinucleotide binding 4 11
GO:0071949 FAD binding 5 11
GO:0097159 organic cyclic compound binding 2 11
GO:1901265 nucleoside phosphate binding 3 11
GO:1901363 heterocyclic compound binding 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 344 348 PF00656 0.312
CLV_NRD_NRD_1 153 155 PF00675 0.517
CLV_NRD_NRD_1 3 5 PF00675 0.640
CLV_NRD_NRD_1 324 326 PF00675 0.325
CLV_NRD_NRD_1 67 69 PF00675 0.273
CLV_PCSK_KEX2_1 3 5 PF00082 0.640
CLV_PCSK_KEX2_1 324 326 PF00082 0.265
CLV_PCSK_KEX2_1 67 69 PF00082 0.478
CLV_PCSK_SKI1_1 242 246 PF00082 0.265
CLV_PCSK_SKI1_1 308 312 PF00082 0.380
CLV_PCSK_SKI1_1 371 375 PF00082 0.247
CLV_PCSK_SKI1_1 443 447 PF00082 0.495
CLV_PCSK_SKI1_1 59 63 PF00082 0.319
DEG_Nend_Nbox_1 1 3 PF02207 0.575
DEG_SCF_FBW7_1 83 90 PF00400 0.305
DEG_SPOP_SBC_1 299 303 PF00917 0.334
DEG_SPOP_SBC_1 341 345 PF00917 0.312
DOC_CKS1_1 182 187 PF01111 0.346
DOC_CKS1_1 245 250 PF01111 0.380
DOC_CYCLIN_RxL_1 305 314 PF00134 0.380
DOC_CYCLIN_yCln2_LP_2 153 159 PF00134 0.331
DOC_MAPK_gen_1 154 162 PF00069 0.371
DOC_MAPK_HePTP_8 138 150 PF00069 0.444
DOC_MAPK_MEF2A_6 141 150 PF00069 0.435
DOC_PP1_RVXF_1 153 160 PF00149 0.342
DOC_PP2B_LxvP_1 6 9 PF13499 0.451
DOC_USP7_MATH_1 353 357 PF00917 0.321
DOC_USP7_MATH_1 378 382 PF00917 0.235
DOC_USP7_MATH_1 399 403 PF00917 0.296
DOC_USP7_MATH_1 407 411 PF00917 0.233
DOC_USP7_MATH_1 459 463 PF00917 0.450
DOC_USP7_MATH_1 464 468 PF00917 0.432
DOC_USP7_MATH_1 52 56 PF00917 0.389
DOC_USP7_MATH_1 87 91 PF00917 0.358
DOC_WW_Pin1_4 117 122 PF00397 0.433
DOC_WW_Pin1_4 181 186 PF00397 0.347
DOC_WW_Pin1_4 244 249 PF00397 0.406
DOC_WW_Pin1_4 311 316 PF00397 0.379
DOC_WW_Pin1_4 342 347 PF00397 0.268
DOC_WW_Pin1_4 446 451 PF00397 0.522
DOC_WW_Pin1_4 83 88 PF00397 0.351
DOC_WW_Pin1_4 9 14 PF00397 0.619
LIG_14-3-3_CanoR_1 128 133 PF00244 0.496
LIG_14-3-3_CanoR_1 141 148 PF00244 0.445
LIG_14-3-3_CanoR_1 237 242 PF00244 0.444
LIG_14-3-3_CanoR_1 3 7 PF00244 0.572
LIG_14-3-3_CanoR_1 324 330 PF00244 0.268
LIG_14-3-3_CanoR_1 458 464 PF00244 0.397
LIG_14-3-3_CanoR_1 46 53 PF00244 0.600
LIG_BRCT_BRCA1_1 128 132 PF00533 0.497
LIG_BRCT_BRCA1_1 461 465 PF00533 0.604
LIG_Clathr_ClatBox_1 60 64 PF01394 0.346
LIG_CtBP_PxDLS_1 315 319 PF00389 0.191
LIG_FHA_1 133 139 PF00498 0.594
LIG_FHA_1 245 251 PF00498 0.287
LIG_FHA_1 255 261 PF00498 0.222
LIG_FHA_1 293 299 PF00498 0.243
LIG_FHA_1 399 405 PF00498 0.325
LIG_FHA_1 430 436 PF00498 0.521
LIG_FHA_1 447 453 PF00498 0.374
LIG_FHA_1 80 86 PF00498 0.351
LIG_FHA_2 140 146 PF00498 0.552
LIG_FHA_2 193 199 PF00498 0.286
LIG_FHA_2 220 226 PF00498 0.292
LIG_FHA_2 289 295 PF00498 0.314
LIG_FHA_2 312 318 PF00498 0.355
LIG_FHA_2 342 348 PF00498 0.246
LIG_FHA_2 435 441 PF00498 0.354
LIG_GBD_Chelix_1 318 326 PF00786 0.237
LIG_GBD_Chelix_1 53 61 PF00786 0.368
LIG_LIR_Gen_1 149 157 PF02991 0.358
LIG_LIR_Gen_1 275 280 PF02991 0.306
LIG_LIR_Nem_3 149 153 PF02991 0.389
LIG_LIR_Nem_3 225 231 PF02991 0.338
LIG_LIR_Nem_3 275 279 PF02991 0.306
LIG_MLH1_MIPbox_1 129 133 PF16413 0.616
LIG_PCNA_yPIPBox_3 167 179 PF02747 0.273
LIG_Pex14_2 276 280 PF04695 0.247
LIG_REV1ctd_RIR_1 277 285 PF16727 0.380
LIG_SH2_NCK_1 71 75 PF00017 0.515
LIG_SH2_STAP1 254 258 PF00017 0.265
LIG_SH2_STAP1 395 399 PF00017 0.247
LIG_SH3_3 179 185 PF00018 0.341
LIG_SH3_3 197 203 PF00018 0.395
LIG_SH3_3 364 370 PF00018 0.254
LIG_UBA3_1 435 444 PF00899 0.457
LIG_WRC_WIRS_1 273 278 PF05994 0.360
LIG_WRC_WIRS_1 326 331 PF05994 0.268
MOD_CDK_SPxxK_3 342 349 PF00069 0.268
MOD_CK1_1 204 210 PF00069 0.521
MOD_CK1_1 211 217 PF00069 0.447
MOD_CK1_1 219 225 PF00069 0.265
MOD_CK1_1 246 252 PF00069 0.306
MOD_CK1_1 292 298 PF00069 0.226
MOD_CK2_1 139 145 PF00069 0.586
MOD_CK2_1 192 198 PF00069 0.382
MOD_CK2_1 310 316 PF00069 0.352
MOD_CK2_1 399 405 PF00069 0.380
MOD_CK2_1 434 440 PF00069 0.349
MOD_Cter_Amidation 65 68 PF01082 0.418
MOD_GlcNHglycan 213 216 PF01048 0.415
MOD_GlcNHglycan 218 221 PF01048 0.383
MOD_GlcNHglycan 23 26 PF01048 0.349
MOD_GlcNHglycan 409 412 PF01048 0.406
MOD_GlcNHglycan 47 50 PF01048 0.645
MOD_GlcNHglycan 478 481 PF01048 0.294
MOD_GlcNHglycan 64 67 PF01048 0.411
MOD_GSK3_1 128 135 PF00069 0.507
MOD_GSK3_1 204 211 PF00069 0.491
MOD_GSK3_1 216 223 PF00069 0.443
MOD_GSK3_1 288 295 PF00069 0.259
MOD_GSK3_1 79 86 PF00069 0.374
MOD_N-GLC_1 139 144 PF02516 0.589
MOD_N-GLC_2 167 169 PF02516 0.398
MOD_N-GLC_2 272 274 PF02516 0.247
MOD_NEK2_1 132 137 PF00069 0.559
MOD_NEK2_1 2 7 PF00069 0.588
MOD_NEK2_1 208 213 PF00069 0.495
MOD_NEK2_1 259 264 PF00069 0.341
MOD_NEK2_1 300 305 PF00069 0.274
MOD_NEK2_1 310 315 PF00069 0.258
MOD_NEK2_1 33 38 PF00069 0.358
MOD_NEK2_1 429 434 PF00069 0.315
MOD_NEK2_1 44 49 PF00069 0.479
MOD_NEK2_1 465 470 PF00069 0.460
MOD_NEK2_1 475 480 PF00069 0.346
MOD_NEK2_1 62 67 PF00069 0.370
MOD_NEK2_1 76 81 PF00069 0.437
MOD_NEK2_2 378 383 PF00069 0.235
MOD_PIKK_1 201 207 PF00454 0.506
MOD_PIKK_1 300 306 PF00454 0.340
MOD_PKA_1 443 449 PF00069 0.513
MOD_PKA_2 127 133 PF00069 0.610
MOD_PKA_2 140 146 PF00069 0.580
MOD_PKA_2 2 8 PF00069 0.572
MOD_PKA_2 236 242 PF00069 0.444
MOD_PKA_2 45 51 PF00069 0.455
MOD_Plk_4 128 134 PF00069 0.488
MOD_Plk_4 399 405 PF00069 0.361
MOD_ProDKin_1 117 123 PF00069 0.436
MOD_ProDKin_1 181 187 PF00069 0.336
MOD_ProDKin_1 244 250 PF00069 0.406
MOD_ProDKin_1 311 317 PF00069 0.379
MOD_ProDKin_1 342 348 PF00069 0.268
MOD_ProDKin_1 446 452 PF00069 0.526
MOD_ProDKin_1 83 89 PF00069 0.347
MOD_ProDKin_1 9 15 PF00069 0.611
TRG_DiLeu_BaLyEn_6 143 148 PF01217 0.430
TRG_ENDOCYTIC_2 108 111 PF00928 0.338
TRG_ER_diArg_1 2 4 PF00400 0.594
TRG_ER_diArg_1 324 326 PF00400 0.325
TRG_ER_diArg_1 335 338 PF00400 0.325
TRG_ER_diArg_1 67 69 PF00400 0.273
TRG_Pf-PMV_PEXEL_1 179 183 PF00026 0.392

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I4M2 Leptomonas seymouri 74% 97%
A0A1X0NI75 Trypanosomatidae 57% 96%
A0A3R7KEW4 Trypanosoma rangeli 55% 99%
A0A3S7WPP5 Leishmania donovani 99% 100%
A4H4T6 Leishmania braziliensis 83% 100%
C9ZTQ2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 52% 96%
E9AL03 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 99%
F1RAX8 Danio rerio 28% 100%
O01884 Caenorhabditis elegans 26% 100%
P25535 Escherichia coli (strain K12) 27% 100%
P53318 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 24% 100%
P75728 Escherichia coli (strain K12) 24% 100%
Q2KIL4 Bos taurus 25% 100%
Q4QIV2 Leishmania major 96% 100%
Q68FU7 Rattus norvegicus 26% 100%
Q6DF46 Xenopus tropicalis 28% 100%
Q8R1S0 Mus musculus 27% 100%
Q9Y2Z9 Homo sapiens 26% 100%
Q9Y7Z9 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 24% 100%
V5B825 Trypanosoma cruzi 55% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS