Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HT12_LEIIN

TriTrypDb:

LINF_060018100

Length:

588

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 5
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HT12

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HT12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	555	559	PF00656	0.639
CLV_NRD_NRD_1	125	127	PF00675	0.589
CLV_NRD_NRD_1	380	382	PF00675	0.526
CLV_NRD_NRD_1	389	391	PF00675	0.610
CLV_NRD_NRD_1	481	483	PF00675	0.572
CLV_PCSK_FUR_1	479	483	PF00082	0.571
CLV_PCSK_KEX2_1	125	127	PF00082	0.589
CLV_PCSK_KEX2_1	377	379	PF00082	0.492
CLV_PCSK_KEX2_1	389	391	PF00082	0.586
CLV_PCSK_KEX2_1	457	459	PF00082	0.539
CLV_PCSK_KEX2_1	481	483	PF00082	0.572
CLV_PCSK_KEX2_1	575	577	PF00082	0.641
CLV_PCSK_PC1ET2_1	377	379	PF00082	0.445
CLV_PCSK_PC1ET2_1	457	459	PF00082	0.496
CLV_PCSK_PC1ET2_1	575	577	PF00082	0.604
CLV_PCSK_SKI1_1	152	156	PF00082	0.403
CLV_PCSK_SKI1_1	181	185	PF00082	0.331
CLV_PCSK_SKI1_1	392	396	PF00082	0.549
CLV_PCSK_SKI1_1	544	548	PF00082	0.622
CLV_PCSK_SKI1_1	572	576	PF00082	0.600
CLV_PCSK_SKI1_1	74	78	PF00082	0.583
CLV_Separin_Metazoa	160	164	PF03568	0.432
DEG_Nend_Nbox_1	1	3	PF02207	0.690
DEG_SPOP_SBC_1	164	168	PF00917	0.522
DEG_SPOP_SBC_1	37	41	PF00917	0.646
DOC_CDC14_PxL_1	563	571	PF14671	0.599
DOC_CKS1_1	348	353	PF01111	0.567
DOC_MAPK_gen_1	239	248	PF00069	0.543
DOC_MAPK_gen_1	502	509	PF00069	0.538
DOC_MAPK_MEF2A_6	192	199	PF00069	0.365
DOC_MAPK_MEF2A_6	239	248	PF00069	0.543
DOC_MAPK_MEF2A_6	462	470	PF00069	0.474
DOC_PP1_RVXF_1	55	61	PF00149	0.664
DOC_USP7_MATH_1	165	169	PF00917	0.539
DOC_USP7_MATH_1	290	294	PF00917	0.588
DOC_USP7_MATH_1	344	348	PF00917	0.590
DOC_USP7_MATH_1	425	429	PF00917	0.605
DOC_USP7_MATH_1	65	69	PF00917	0.569
DOC_USP7_UBL2_3	245	249	PF12436	0.429
DOC_WW_Pin1_4	347	352	PF00397	0.510
DOC_WW_Pin1_4	38	43	PF00397	0.625
LIG_14-3-3_CanoR_1	163	173	PF00244	0.525
LIG_14-3-3_CanoR_1	291	299	PF00244	0.577
LIG_14-3-3_CanoR_1	406	416	PF00244	0.636
LIG_14-3-3_CanoR_1	429	435	PF00244	0.538
LIG_14-3-3_CanoR_1	57	65	PF00244	0.654
LIG_14-3-3_CanoR_1	576	584	PF00244	0.628
LIG_APCC_ABBA_1	155	160	PF00400	0.398
LIG_APCC_ABBA_1	217	222	PF00400	0.450
LIG_APCC_ABBAyCdc20_2	325	331	PF00400	0.509
LIG_BIR_III_4	302	306	PF00653	0.601
LIG_BIR_III_4	319	323	PF00653	0.464
LIG_BRCT_BRCA1_1	363	367	PF00533	0.494
LIG_BRCT_BRCA1_1	536	540	PF00533	0.636
LIG_CaM_NSCaTE_8	283	290	PF13499	0.423
LIG_Clathr_ClatBox_1	105	109	PF01394	0.689
LIG_FAT_LD_1	334	342	PF03623	0.447
LIG_FHA_1	302	308	PF00498	0.617
LIG_FHA_1	371	377	PF00498	0.578
LIG_FHA_1	38	44	PF00498	0.613
LIG_FHA_1	433	439	PF00498	0.546
LIG_FHA_1	552	558	PF00498	0.717
LIG_FHA_1	568	574	PF00498	0.500
LIG_FHA_1	82	88	PF00498	0.630
LIG_FHA_2	204	210	PF00498	0.464
LIG_LIR_Apic_2	144	150	PF02991	0.526
LIG_LIR_Gen_1	251	261	PF02991	0.408
LIG_LIR_Gen_1	537	546	PF02991	0.637
LIG_LIR_LC3C_4	274	279	PF02991	0.382
LIG_LIR_Nem_3	172	178	PF02991	0.534
LIG_LIR_Nem_3	218	223	PF02991	0.496
LIG_LIR_Nem_3	251	257	PF02991	0.414
LIG_LIR_Nem_3	537	543	PF02991	0.637
LIG_LIR_Nem_3	560	566	PF02991	0.592
LIG_LYPXL_yS_3	566	569	PF13949	0.601
LIG_MLH1_MIPbox_1	363	367	PF16413	0.494
LIG_NRBOX	333	339	PF00104	0.447
LIG_PCNA_yPIPBox_3	192	203	PF02747	0.401
LIG_PCNA_yPIPBox_3	389	398	PF02747	0.519
LIG_Pex14_2	203	207	PF04695	0.493
LIG_SH2_CRK	147	151	PF00017	0.513
LIG_SH2_CRK	404	408	PF00017	0.561
LIG_SH2_NCK_1	329	333	PF00017	0.474
LIG_SH2_SRC	329	332	PF00017	0.475
LIG_SH2_STAP1	215	219	PF00017	0.486
LIG_SH2_STAP1	329	333	PF00017	0.474
LIG_SH2_STAT3	107	110	PF00017	0.619
LIG_SH2_STAT5	107	110	PF00017	0.680
LIG_SH2_STAT5	223	226	PF00017	0.544
LIG_SH2_STAT5	260	263	PF00017	0.460
LIG_SH2_STAT5	59	62	PF00017	0.583
LIG_SH2_STAT5	75	78	PF00017	0.601
LIG_SH3_3	199	205	PF00018	0.401
LIG_SH3_3	40	46	PF00018	0.542
LIG_SH3_3	468	474	PF00018	0.675
LIG_SH3_3	504	510	PF00018	0.553
LIG_SH3_3	92	98	PF00018	0.583
LIG_UBA3_1	539	547	PF00899	0.616
LIG_WRC_WIRS_1	204	209	PF05994	0.528
MOD_CDK_SPxK_1	347	353	PF00069	0.502
MOD_CK1_1	119	125	PF00069	0.675
MOD_CK1_1	168	174	PF00069	0.607
MOD_CK1_1	285	291	PF00069	0.547
MOD_CK1_1	293	299	PF00069	0.565
MOD_CK1_1	347	353	PF00069	0.641
MOD_CK1_1	36	42	PF00069	0.655
MOD_CK1_1	405	411	PF00069	0.683
MOD_CK1_1	464	470	PF00069	0.588
MOD_CK1_1	495	501	PF00069	0.539
MOD_CK1_1	524	530	PF00069	0.609
MOD_CK1_1	550	556	PF00069	0.549
MOD_CK1_1	580	586	PF00069	0.645
MOD_CK2_1	23	29	PF00069	0.580
MOD_CK2_1	430	436	PF00069	0.489
MOD_CK2_1	542	548	PF00069	0.578
MOD_Cter_Amidation	123	126	PF01082	0.602
MOD_GlcNHglycan	133	136	PF01048	0.594
MOD_GlcNHglycan	167	170	PF01048	0.556
MOD_GlcNHglycan	287	290	PF01048	0.567
MOD_GlcNHglycan	35	38	PF01048	0.685
MOD_GlcNHglycan	363	366	PF01048	0.506
MOD_GlcNHglycan	412	415	PF01048	0.579
MOD_GlcNHglycan	446	449	PF01048	0.518
MOD_GlcNHglycan	463	466	PF01048	0.637
MOD_GlcNHglycan	471	474	PF01048	0.659
MOD_GlcNHglycan	486	489	PF01048	0.497
MOD_GlcNHglycan	494	497	PF01048	0.569
MOD_GlcNHglycan	536	539	PF01048	0.548
MOD_GlcNHglycan	65	68	PF01048	0.534
MOD_GSK3_1	131	138	PF00069	0.633
MOD_GSK3_1	164	171	PF00069	0.656
MOD_GSK3_1	209	216	PF00069	0.468
MOD_GSK3_1	281	288	PF00069	0.450
MOD_GSK3_1	29	36	PF00069	0.673
MOD_GSK3_1	37	44	PF00069	0.620
MOD_GSK3_1	405	412	PF00069	0.588
MOD_GSK3_1	519	526	PF00069	0.638
MOD_GSK3_1	547	554	PF00069	0.623
MOD_N-GLC_1	551	556	PF02516	0.586
MOD_NEK2_1	272	277	PF00069	0.447
MOD_NEK2_1	33	38	PF00069	0.553
MOD_NEK2_1	372	377	PF00069	0.476
MOD_NEK2_1	407	412	PF00069	0.617
MOD_NEK2_1	444	449	PF00069	0.597
MOD_NEK2_1	456	461	PF00069	0.486
MOD_NEK2_1	525	530	PF00069	0.615
MOD_NEK2_1	534	539	PF00069	0.555
MOD_NEK2_1	551	556	PF00069	0.514
MOD_NEK2_1	577	582	PF00069	0.625
MOD_PIKK_1	109	115	PF00454	0.562
MOD_PIKK_1	119	125	PF00454	0.540
MOD_PIKK_1	135	141	PF00454	0.501
MOD_PIKK_1	260	266	PF00454	0.413
MOD_PIKK_1	293	299	PF00454	0.609
MOD_PIKK_1	525	531	PF00454	0.594
MOD_PIKK_1	577	583	PF00454	0.561
MOD_PKA_2	285	291	PF00069	0.507
MOD_PKA_2	405	411	PF00069	0.628
MOD_PKA_2	461	467	PF00069	0.658
MOD_PKA_2	529	535	PF00069	0.665
MOD_Plk_1	339	345	PF00069	0.460
MOD_Plk_1	547	553	PF00069	0.561
MOD_Plk_2-3	23	29	PF00069	0.543
MOD_Plk_4	529	535	PF00069	0.591
MOD_Plk_4	552	558	PF00069	0.585
MOD_ProDKin_1	347	353	PF00069	0.513
MOD_ProDKin_1	38	44	PF00069	0.625
MOD_SUMO_for_1	76	79	PF00179	0.568
TRG_DiLeu_BaLyEn_6	263	268	PF01217	0.426
TRG_DiLeu_BaLyEn_6	83	88	PF01217	0.633
TRG_ENDOCYTIC_2	404	407	PF00928	0.558
TRG_ENDOCYTIC_2	566	569	PF00928	0.601
TRG_ENDOCYTIC_2	75	78	PF00928	0.643
TRG_ER_diArg_1	388	390	PF00400	0.665
TRG_ER_diArg_1	478	481	PF00400	0.577
TRG_Pf-PMV_PEXEL_1	482	486	PF00026	0.585
TRG_Pf-PMV_PEXEL_1	544	548	PF00026	0.573
TRG_Pf-PMV_PEXEL_1	74	79	PF00026	0.699

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDF5	Leptomonas seymouri	33%	100%
A0A3S7WPN2	Leishmania donovani	99%	100%
A4H4T3	Leishmania braziliensis	69%	99%
E9AL00	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%
Q4QIV5	Leishmania major	90%	100%