Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HT11_LEIIN

TriTrypDb:

LINF_060018000

Length:

394

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HT11

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HT11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	281	285	PF00656	0.739
CLV_NRD_NRD_1	143	145	PF00675	0.597
CLV_NRD_NRD_1	163	165	PF00675	0.705
CLV_NRD_NRD_1	325	327	PF00675	0.697
CLV_NRD_NRD_1	359	361	PF00675	0.707
CLV_NRD_NRD_1	386	388	PF00675	0.619
CLV_PCSK_KEX2_1	163	165	PF00082	0.802
CLV_PCSK_KEX2_1	308	310	PF00082	0.654
CLV_PCSK_KEX2_1	325	327	PF00082	0.697
CLV_PCSK_KEX2_1	359	361	PF00082	0.752
CLV_PCSK_KEX2_1	386	388	PF00082	0.619
CLV_PCSK_KEX2_1	63	65	PF00082	0.491
CLV_PCSK_PC1ET2_1	308	310	PF00082	0.656
CLV_PCSK_PC1ET2_1	63	65	PF00082	0.491
CLV_PCSK_PC7_1	304	310	PF00082	0.713
CLV_PCSK_PC7_1	59	65	PF00082	0.522
CLV_PCSK_SKI1_1	154	158	PF00082	0.740
DEG_APCC_DBOX_1	386	394	PF00400	0.592
DEG_Nend_Nbox_1	1	3	PF02207	0.591
DOC_ANK_TNKS_1	21	28	PF00023	0.530
DOC_CYCLIN_RxL_1	330	341	PF00134	0.654
DOC_MAPK_FxFP_2	2	5	PF00069	0.588
DOC_PP1_RVXF_1	331	338	PF00149	0.630
DOC_PP1_RVXF_1	377	383	PF00149	0.545
DOC_PP2B_LxvP_1	41	44	PF13499	0.613
DOC_PP4_FxxP_1	2	5	PF00568	0.652
DOC_USP7_MATH_1	166	170	PF00917	0.680
DOC_USP7_MATH_1	175	179	PF00917	0.572
DOC_USP7_MATH_1	78	82	PF00917	0.551
DOC_USP7_MATH_1	98	102	PF00917	0.353
DOC_WW_Pin1_4	162	167	PF00397	0.656
DOC_WW_Pin1_4	176	181	PF00397	0.579
DOC_WW_Pin1_4	198	203	PF00397	0.605
DOC_WW_Pin1_4	230	235	PF00397	0.742
DOC_WW_Pin1_4	286	291	PF00397	0.663
DOC_WW_Pin1_4	296	301	PF00397	0.628
DOC_WW_Pin1_4	347	352	PF00397	0.723
DOC_WW_Pin1_4	359	364	PF00397	0.781
DOC_WW_Pin1_4	47	52	PF00397	0.626
LIG_14-3-3_CanoR_1	386	391	PF00244	0.600
LIG_APCC_ABBA_1	276	281	PF00400	0.741
LIG_APCC_ABBAyCdc20_2	333	339	PF00400	0.606
LIG_BRCT_BRCA1_1	217	221	PF00533	0.613
LIG_Clathr_ClatBox_1	219	223	PF01394	0.556
LIG_CtBP_PxDLS_1	365	369	PF00389	0.606
LIG_DLG_GKlike_1	386	393	PF00625	0.587
LIG_FHA_1	107	113	PF00498	0.534
LIG_FHA_2	241	247	PF00498	0.763
LIG_FHA_2	313	319	PF00498	0.679
LIG_FHA_2	348	354	PF00498	0.657
LIG_FHA_2	369	375	PF00498	0.601
LIG_Integrin_RGD_1	296	298	PF01839	0.697
LIG_Integrin_RGD_1	311	313	PF01839	0.630
LIG_IRF3_LxIS_1	41	46	PF10401	0.670
LIG_LIR_Gen_1	389	394	PF02991	0.594
LIG_LIR_Nem_3	109	114	PF02991	0.525
LIG_LIR_Nem_3	389	394	PF02991	0.571
LIG_LYPXL_yS_3	4	7	PF13949	0.598
LIG_PDZ_Class_1	389	394	PF00595	0.549
LIG_Pex14_2	217	221	PF04695	0.470
LIG_SH2_CRK	99	103	PF00017	0.495
LIG_SH2_PTP2	6	9	PF00017	0.581
LIG_SH2_SRC	6	9	PF00017	0.502
LIG_SH2_STAT5	207	210	PF00017	0.495
LIG_SH2_STAT5	230	233	PF00017	0.738
LIG_SH2_STAT5	6	9	PF00017	0.581
LIG_SH3_1	360	366	PF00018	0.605
LIG_SH3_3	174	180	PF00018	0.632
LIG_SH3_3	233	239	PF00018	0.663
LIG_SH3_3	360	366	PF00018	0.685
LIG_SH3_3	50	56	PF00018	0.654
LIG_TRAF2_1	351	354	PF00917	0.800
LIG_TRAF2_2	21	26	PF00917	0.586
LIG_TYR_ITIM	112	117	PF00017	0.494
MOD_CDK_SPK_2	347	352	PF00069	0.723
MOD_CK1_1	178	184	PF00069	0.724
MOD_CK1_1	262	268	PF00069	0.605
MOD_CK1_1	341	347	PF00069	0.647
MOD_CK1_1	46	52	PF00069	0.588
MOD_CK2_1	207	213	PF00069	0.545
MOD_CK2_1	312	318	PF00069	0.680
MOD_CK2_1	32	38	PF00069	0.515
MOD_CK2_1	347	353	PF00069	0.762
MOD_CK2_1	368	374	PF00069	0.605
MOD_Cter_Amidation	323	326	PF01082	0.780
MOD_GlcNHglycan	300	303	PF01048	0.723
MOD_GlcNHglycan	353	357	PF01048	0.675
MOD_GlcNHglycan	368	371	PF01048	0.612
MOD_GlcNHglycan	80	83	PF01048	0.532
MOD_GSK3_1	162	169	PF00069	0.758
MOD_GSK3_1	198	205	PF00069	0.583
MOD_GSK3_1	230	237	PF00069	0.778
MOD_GSK3_1	241	248	PF00069	0.644
MOD_GSK3_1	282	289	PF00069	0.641
MOD_GSK3_1	338	345	PF00069	0.657
MOD_GSK3_1	364	371	PF00069	0.656
MOD_GSK3_1	43	50	PF00069	0.632
MOD_N-GLC_1	228	233	PF02516	0.668
MOD_NEK2_1	189	194	PF00069	0.743
MOD_NEK2_1	253	258	PF00069	0.714
MOD_NEK2_1	267	272	PF00069	0.693
MOD_NEK2_1	340	345	PF00069	0.805
MOD_NEK2_1	368	373	PF00069	0.605
MOD_PIKK_1	245	251	PF00454	0.710
MOD_PIKK_1	343	349	PF00454	0.795
MOD_PIKK_1	43	49	PF00454	0.639
MOD_PKA_1	386	392	PF00069	0.616
MOD_PKA_2	122	128	PF00069	0.583
MOD_PKA_2	386	392	PF00069	0.662
MOD_PKB_1	309	317	PF00069	0.774
MOD_Plk_1	16	22	PF00069	0.570
MOD_Plk_1	166	172	PF00069	0.622
MOD_Plk_1	222	228	PF00069	0.600
MOD_Plk_1	37	43	PF00069	0.606
MOD_Plk_4	368	374	PF00069	0.759
MOD_Plk_4	386	392	PF00069	0.646
MOD_ProDKin_1	162	168	PF00069	0.658
MOD_ProDKin_1	176	182	PF00069	0.580
MOD_ProDKin_1	198	204	PF00069	0.604
MOD_ProDKin_1	230	236	PF00069	0.741
MOD_ProDKin_1	286	292	PF00069	0.665
MOD_ProDKin_1	296	302	PF00069	0.628
MOD_ProDKin_1	347	353	PF00069	0.726
MOD_ProDKin_1	359	365	PF00069	0.777
MOD_ProDKin_1	47	53	PF00069	0.623
TRG_ENDOCYTIC_2	114	117	PF00928	0.525
TRG_ENDOCYTIC_2	4	7	PF00928	0.598
TRG_ENDOCYTIC_2	99	102	PF00928	0.498
TRG_ER_diArg_1	385	387	PF00400	0.619
TRG_NLS_MonoExtC_3	307	313	PF00514	0.634
TRG_Pf-PMV_PEXEL_1	120	124	PF00026	0.641
TRG_Pf-PMV_PEXEL_1	29	34	PF00026	0.615
TRG_Pf-PMV_PEXEL_1	333	338	PF00026	0.747

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4J6	Leptomonas seymouri	40%	100%
A0A3S5H5U8	Leishmania donovani	99%	100%
A4H4T2	Leishmania braziliensis	70%	100%
E9AKZ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QIV6	Leishmania major	89%	100%