Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Thioredoxin - putative

Species:

Leishmania infantum

UniProt:

A4HT10_LEIIN

TriTrypDb:

LINF_060017700

Length:

147

Annotations

Annotations by Jardim et al.

Redox homeostasis, thioredoxin, putative

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 13, no: 3
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0016020	membrane	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	3
GO:0005783	endoplasmic reticulum	5	1

Expansion

Sequence features

A4HT10

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HT10

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0009987	cellular process	1	1

Molecular functions
Term	Name	Level	Count
GO:0003756	protein disulfide isomerase activity	3	7
GO:0003824	catalytic activity	1	9
GO:0016853	isomerase activity	2	9
GO:0016860	intramolecular oxidoreductase activity	3	7
GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	4	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	107	109	PF00082	0.312
CLV_PCSK_PC1ET2_1	107	109	PF00082	0.260
CLV_PCSK_SKI1_1	89	93	PF00082	0.318
DEG_Nend_UBRbox_1	1	4	PF02207	0.529
DEG_SCF_FBW7_1	118	125	PF00400	0.204
DOC_CKS1_1	119	124	PF01111	0.376
DOC_MAPK_DCC_7	8	17	PF00069	0.379
DOC_MAPK_gen_1	67	75	PF00069	0.354
DOC_MAPK_MEF2A_6	8	17	PF00069	0.473
DOC_PP4_FxxP_1	119	122	PF00568	0.376
DOC_USP7_MATH_1	133	137	PF00917	0.384
DOC_USP7_MATH_1	33	37	PF00917	0.417
DOC_WW_Pin1_4	118	123	PF00397	0.334
LIG_14-3-3_CanoR_1	67	76	PF00244	0.285
LIG_14-3-3_CanoR_1	78	88	PF00244	0.356
LIG_BRCT_BRCA1_1	140	144	PF00533	0.260
LIG_FHA_1	123	129	PF00498	0.348
LIG_FHA_1	55	61	PF00498	0.327
LIG_FHA_1	7	13	PF00498	0.609
LIG_GBD_Chelix_1	15	23	PF00786	0.491
LIG_IRF3_LxIS_1	75	82	PF10401	0.279
LIG_LIR_Apic_2	116	122	PF02991	0.392
LIG_LIR_Apic_2	129	133	PF02991	0.441
LIG_LIR_Gen_1	54	63	PF02991	0.307
LIG_LIR_Nem_3	100	105	PF02991	0.345
LIG_LIR_Nem_3	44	49	PF02991	0.212
LIG_LIR_Nem_3	54	59	PF02991	0.235
LIG_LYPXL_yS_3	102	105	PF13949	0.264
LIG_NRBOX	18	24	PF00104	0.536
LIG_PCNA_yPIPBox_3	78	92	PF02747	0.219
LIG_Pex14_2	142	146	PF04695	0.427
LIG_SH2_CRK	120	124	PF00017	0.313
LIG_SH2_CRK	130	134	PF00017	0.236
LIG_SH2_CRK	56	60	PF00017	0.250
LIG_SH2_SRC	96	99	PF00017	0.376
LIG_SH2_STAP1	56	60	PF00017	0.250
LIG_SH2_STAT5	120	123	PF00017	0.312
LIG_SH2_STAT5	137	140	PF00017	0.354
LIG_SH2_STAT5	49	52	PF00017	0.239
LIG_SH2_STAT5	56	59	PF00017	0.328
LIG_SH2_STAT5	61	64	PF00017	0.160
LIG_SH2_STAT5	96	99	PF00017	0.376
LIG_SH3_3	47	53	PF00018	0.274
LIG_SUMO_SIM_par_1	36	42	PF11976	0.316
LIG_TYR_ITIM	118	123	PF00017	0.347
LIG_WRC_WIRS_1	139	144	PF05994	0.242
MOD_CK2_1	81	87	PF00069	0.392
MOD_GSK3_1	118	125	PF00069	0.322
MOD_GSK3_1	77	84	PF00069	0.336
MOD_NEK2_1	1	6	PF00069	0.480
MOD_NEK2_1	138	143	PF00069	0.275
MOD_NEK2_1	79	84	PF00069	0.262
MOD_PIKK_1	79	85	PF00454	0.237
MOD_PKA_2	1	7	PF00069	0.560
MOD_PKA_2	133	139	PF00069	0.219
MOD_PKA_2	42	48	PF00069	0.344
MOD_PKA_2	77	83	PF00069	0.324
MOD_Plk_1	33	39	PF00069	0.410
MOD_Plk_4	113	119	PF00069	0.287
MOD_Plk_4	133	139	PF00069	0.287
MOD_Plk_4	54	60	PF00069	0.279
MOD_ProDKin_1	118	124	PF00069	0.334
TRG_DiLeu_BaLyEn_6	10	15	PF01217	0.380
TRG_ENDOCYTIC_2	102	105	PF00928	0.342
TRG_ENDOCYTIC_2	120	123	PF00928	0.309
TRG_ENDOCYTIC_2	56	59	PF00928	0.301

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I216	Leptomonas seymouri	64%	100%
A0A0N1I5T9	Leptomonas seymouri	31%	100%
A0A0S4JA26	Bodo saltans	28%	89%
A0A1X0NGQ4	Trypanosomatidae	53%	99%
A0A3R7NHA8	Trypanosoma rangeli	34%	80%
A0A3S5H5U6	Leishmania donovani	100%	70%
A0A422NM49	Trypanosoma rangeli	50%	99%
A4H4R8	Leishmania braziliensis	28%	100%
A4H4T0	Leishmania braziliensis	83%	100%
A4HSZ7	Leishmania infantum	31%	100%
C9ZTP4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	97%
C9ZTP5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AKY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9AKZ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q10N04	Oryza sativa subsp. japonica	30%	100%
Q4QIV7	Leishmania major	90%	100%
Q4QIX1	Leishmania major	30%	100%
Q8GYD1	Arabidopsis thaliana	30%	100%
Q8I7Z7	Leishmania donovani	31%	100%