DUF4379 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4379) - putative

Species:

Leishmania infantum

UniProt:

A4HT07_LEIIN

TriTrypDb:

LINF_060017300

Length:

521

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HT07

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HT07

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.691
CLV_C14_Caspase3-7	183	187	PF00656	0.573
CLV_NRD_NRD_1	14	16	PF00675	0.638
CLV_NRD_NRD_1	309	311	PF00675	0.545
CLV_NRD_NRD_1	324	326	PF00675	0.535
CLV_NRD_NRD_1	486	488	PF00675	0.476
CLV_PCSK_FUR_1	483	487	PF00082	0.477
CLV_PCSK_KEX2_1	14	16	PF00082	0.638
CLV_PCSK_KEX2_1	309	311	PF00082	0.529
CLV_PCSK_KEX2_1	324	326	PF00082	0.408
CLV_PCSK_KEX2_1	485	487	PF00082	0.474
CLV_PCSK_SKI1_1	15	19	PF00082	0.597
CLV_PCSK_SKI1_1	416	420	PF00082	0.398
CLV_PCSK_SKI1_1	456	460	PF00082	0.426
DEG_APCC_DBOX_1	411	419	PF00400	0.429
DEG_ODPH_VHL_1	8	21	PF01847	0.490
DEG_SPOP_SBC_1	237	241	PF00917	0.332
DEG_SPOP_SBC_1	48	52	PF00917	0.482
DOC_CKS1_1	127	132	PF01111	0.334
DOC_CKS1_1	179	184	PF01111	0.621
DOC_CYCLIN_RxL_1	11	23	PF00134	0.462
DOC_CYCLIN_RxL_1	485	498	PF00134	0.568
DOC_MAPK_gen_1	387	396	PF00069	0.467
DOC_MAPK_gen_1	412	420	PF00069	0.422
DOC_MAPK_gen_1	485	495	PF00069	0.555
DOC_PP1_RVXF_1	13	20	PF00149	0.462
DOC_PP4_FxxP_1	124	127	PF00568	0.420
DOC_USP7_MATH_1	149	153	PF00917	0.343
DOC_USP7_MATH_1	191	195	PF00917	0.750
DOC_USP7_MATH_1	312	316	PF00917	0.626
DOC_USP7_MATH_1	382	386	PF00917	0.389
DOC_USP7_MATH_1	452	456	PF00917	0.435
DOC_USP7_MATH_1	57	61	PF00917	0.680
DOC_USP7_MATH_1	66	70	PF00917	0.698
DOC_WW_Pin1_4	126	131	PF00397	0.369
DOC_WW_Pin1_4	175	180	PF00397	0.682
DOC_WW_Pin1_4	181	186	PF00397	0.692
DOC_WW_Pin1_4	251	256	PF00397	0.409
DOC_WW_Pin1_4	285	290	PF00397	0.782
DOC_WW_Pin1_4	316	321	PF00397	0.539
DOC_WW_Pin1_4	73	78	PF00397	0.572
LIG_14-3-3_CanoR_1	139	147	PF00244	0.387
LIG_14-3-3_CanoR_1	196	204	PF00244	0.703
LIG_14-3-3_CanoR_1	238	247	PF00244	0.476
LIG_14-3-3_CanoR_1	273	277	PF00244	0.514
LIG_14-3-3_CanoR_1	309	318	PF00244	0.568
LIG_14-3-3_CanoR_1	347	356	PF00244	0.413
LIG_14-3-3_CanoR_1	359	367	PF00244	0.259
LIG_14-3-3_CanoR_1	387	392	PF00244	0.442
LIG_14-3-3_CanoR_1	4	9	PF00244	0.665
LIG_14-3-3_CanoR_1	504	510	PF00244	0.571
LIG_14-3-3_CanoR_1	68	78	PF00244	0.517
LIG_Actin_WH2_2	403	418	PF00022	0.520
LIG_APCC_ABBA_1	339	344	PF00400	0.491
LIG_APCC_ABBA_1	418	423	PF00400	0.363
LIG_BIR_II_1	1	5	PF00653	0.560
LIG_BRCT_BRCA1_1	209	213	PF00533	0.312
LIG_BRCT_BRCA1_1	361	365	PF00533	0.332
LIG_BRCT_BRCA1_1	454	458	PF00533	0.481
LIG_BRCT_BRCA1_1	75	79	PF00533	0.419
LIG_Clathr_ClatBox_1	78	82	PF01394	0.477
LIG_DLG_GKlike_1	387	394	PF00625	0.482
LIG_FHA_1	28	34	PF00498	0.644
LIG_FHA_2	112	118	PF00498	0.660
LIG_FHA_2	181	187	PF00498	0.690
LIG_FHA_2	417	423	PF00498	0.357
LIG_FHA_2	506	512	PF00498	0.537
LIG_LIR_Nem_3	209	214	PF02991	0.393
LIG_LIR_Nem_3	432	437	PF02991	0.464
LIG_LYPXL_yS_3	211	214	PF13949	0.439
LIG_PCNA_PIPBox_1	100	109	PF02747	0.454
LIG_PCNA_yPIPBox_3	100	111	PF02747	0.566
LIG_SH2_PTP2	417	420	PF00017	0.477
LIG_SH2_STAP1	367	371	PF00017	0.393
LIG_SH2_STAT3	169	172	PF00017	0.510
LIG_SH2_STAT5	417	420	PF00017	0.477
LIG_SH3_2	320	325	PF14604	0.455
LIG_SH3_3	124	130	PF00018	0.404
LIG_SH3_3	176	182	PF00018	0.742
LIG_SH3_3	274	280	PF00018	0.518
LIG_SH3_3	290	296	PF00018	0.584
LIG_SH3_3	317	323	PF00018	0.608
LIG_SH3_3	394	400	PF00018	0.547
LIG_SH3_3	421	427	PF00018	0.413
LIG_SH3_3	43	49	PF00018	0.706
LIG_SUMO_SIM_anti_2	299	304	PF11976	0.410
LIG_TYR_ITIM	415	420	PF00017	0.489
MOD_CDC14_SPxK_1	322	325	PF00782	0.480
MOD_CDK_SPK_2	319	324	PF00069	0.525
MOD_CDK_SPxK_1	319	325	PF00069	0.516
MOD_CK1_1	145	151	PF00069	0.408
MOD_CK1_1	152	158	PF00069	0.388
MOD_CK1_1	178	184	PF00069	0.663
MOD_CK1_1	195	201	PF00069	0.592
MOD_CK1_1	240	246	PF00069	0.377
MOD_CK1_1	259	265	PF00069	0.265
MOD_CK1_1	275	281	PF00069	0.628
MOD_CK1_1	319	325	PF00069	0.403
MOD_CK1_1	349	355	PF00069	0.428
MOD_CK1_1	385	391	PF00069	0.508
MOD_CK1_1	51	57	PF00069	0.694
MOD_CK1_1	67	73	PF00069	0.629
MOD_CK2_1	230	236	PF00069	0.417
MOD_CK2_1	505	511	PF00069	0.544
MOD_GlcNHglycan	119	122	PF01048	0.678
MOD_GlcNHglycan	147	150	PF01048	0.307
MOD_GlcNHglycan	240	243	PF01048	0.345
MOD_GlcNHglycan	314	317	PF01048	0.612
MOD_GlcNHglycan	384	387	PF01048	0.455
MOD_GlcNHglycan	480	483	PF01048	0.525
MOD_GlcNHglycan	59	62	PF01048	0.668
MOD_GSK3_1	107	114	PF00069	0.584
MOD_GSK3_1	138	145	PF00069	0.403
MOD_GSK3_1	191	198	PF00069	0.773
MOD_GSK3_1	23	30	PF00069	0.711
MOD_GSK3_1	232	239	PF00069	0.388
MOD_GSK3_1	278	285	PF00069	0.778
MOD_GSK3_1	312	319	PF00069	0.435
MOD_GSK3_1	404	411	PF00069	0.454
MOD_GSK3_1	459	466	PF00069	0.444
MOD_GSK3_1	47	54	PF00069	0.676
MOD_GSK3_1	64	71	PF00069	0.649
MOD_NEK2_1	207	212	PF00069	0.340
MOD_NEK2_1	21	26	PF00069	0.668
MOD_NEK2_1	27	32	PF00069	0.653
MOD_NEK2_1	282	287	PF00069	0.603
MOD_NEK2_1	458	463	PF00069	0.540
MOD_NEK2_1	493	498	PF00069	0.554
MOD_NEK2_1	505	510	PF00069	0.593
MOD_NEK2_1	56	61	PF00069	0.553
MOD_NEK2_2	29	34	PF00069	0.690
MOD_PIKK_1	142	148	PF00454	0.342
MOD_PIKK_1	459	465	PF00454	0.419
MOD_PKA_2	107	113	PF00069	0.533
MOD_PKA_2	138	144	PF00069	0.354
MOD_PKA_2	149	155	PF00069	0.307
MOD_PKA_2	195	201	PF00069	0.751
MOD_PKA_2	237	243	PF00069	0.458
MOD_PKA_2	272	278	PF00069	0.668
MOD_PKA_2	346	352	PF00069	0.466
MOD_PKA_2	437	443	PF00069	0.420
MOD_PKA_2	67	73	PF00069	0.665
MOD_PKB_1	414	422	PF00069	0.428
MOD_Plk_4	240	246	PF00069	0.275
MOD_Plk_4	351	357	PF00069	0.282
MOD_ProDKin_1	126	132	PF00069	0.369
MOD_ProDKin_1	175	181	PF00069	0.683
MOD_ProDKin_1	251	257	PF00069	0.409
MOD_ProDKin_1	285	291	PF00069	0.781
MOD_ProDKin_1	316	322	PF00069	0.532
MOD_ProDKin_1	73	79	PF00069	0.555
TRG_ENDOCYTIC_2	211	214	PF00928	0.439
TRG_ENDOCYTIC_2	417	420	PF00928	0.477
TRG_ER_diArg_1	13	15	PF00400	0.700
TRG_ER_diArg_1	323	325	PF00400	0.553
TRG_ER_diArg_1	358	361	PF00400	0.288
TRG_ER_diArg_1	412	415	PF00400	0.481
TRG_ER_diArg_1	483	486	PF00400	0.554
TRG_ER_diArg_1	488	491	PF00400	0.509
TRG_NES_CRM1_1	84	97	PF08389	0.458
TRG_Pf-PMV_PEXEL_1	325	329	PF00026	0.382
TRG_Pf-PMV_PEXEL_1	374	379	PF00026	0.419

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ62	Leptomonas seymouri	62%	100%
A0A0S4KFW8	Bodo saltans	29%	100%
A0A1X0NIH3	Trypanosomatidae	37%	100%
A0A3R7NRE8	Trypanosoma rangeli	38%	100%
A0A3S5H5U3	Leishmania donovani	100%	100%
A4H4S6	Leishmania braziliensis	74%	100%
C9ZTN9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	92%
E9AKZ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QIW1	Leishmania major	93%	100%
V5BNK9	Trypanosoma cruzi	38%	100%