Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HT03_LEIIN

TriTrypDb:

LINF_060016900

Length:

1107

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HT03

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HT03

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	291	295	PF00656	0.686
CLV_NRD_NRD_1	1100	1102	PF00675	0.649
CLV_NRD_NRD_1	240	242	PF00675	0.787
CLV_NRD_NRD_1	448	450	PF00675	0.793
CLV_NRD_NRD_1	469	471	PF00675	0.591
CLV_NRD_NRD_1	536	538	PF00675	0.631
CLV_NRD_NRD_1	547	549	PF00675	0.625
CLV_NRD_NRD_1	579	581	PF00675	0.725
CLV_NRD_NRD_1	612	614	PF00675	0.637
CLV_NRD_NRD_1	697	699	PF00675	0.715
CLV_NRD_NRD_1	754	756	PF00675	0.639
CLV_NRD_NRD_1	898	900	PF00675	0.644
CLV_PCSK_KEX2_1	240	242	PF00082	0.787
CLV_PCSK_KEX2_1	469	471	PF00082	0.591
CLV_PCSK_KEX2_1	536	538	PF00082	0.631
CLV_PCSK_KEX2_1	547	549	PF00082	0.625
CLV_PCSK_KEX2_1	579	581	PF00082	0.741
CLV_PCSK_KEX2_1	754	756	PF00082	0.619
CLV_PCSK_KEX2_1	838	840	PF00082	0.652
CLV_PCSK_KEX2_1	891	893	PF00082	0.525
CLV_PCSK_PC1ET2_1	838	840	PF00082	0.548
CLV_PCSK_PC1ET2_1	891	893	PF00082	0.450
CLV_PCSK_SKI1_1	1059	1063	PF00082	0.747
CLV_PCSK_SKI1_1	182	186	PF00082	0.707
CLV_PCSK_SKI1_1	536	540	PF00082	0.653
CLV_PCSK_SKI1_1	687	691	PF00082	0.768
CLV_Separin_Metazoa	1081	1085	PF03568	0.511
DEG_ODPH_VHL_1	269	280	PF01847	0.728
DEG_SPOP_SBC_1	567	571	PF00917	0.803
DOC_MAPK_gen_1	316	326	PF00069	0.668
DOC_MAPK_gen_1	454	463	PF00069	0.565
DOC_MAPK_gen_1	513	522	PF00069	0.714
DOC_MAPK_gen_1	899	909	PF00069	0.669
DOC_PP1_RVXF_1	65	72	PF00149	0.725
DOC_PP2B_LxvP_1	177	180	PF13499	0.689
DOC_PP2B_LxvP_1	278	281	PF13499	0.712
DOC_PP4_FxxP_1	853	856	PF00568	0.613
DOC_USP7_MATH_1	1012	1016	PF00917	0.720
DOC_USP7_MATH_1	1053	1057	PF00917	0.678
DOC_USP7_MATH_1	128	132	PF00917	0.731
DOC_USP7_MATH_1	2	6	PF00917	0.652
DOC_USP7_MATH_1	259	263	PF00917	0.707
DOC_USP7_MATH_1	288	292	PF00917	0.700
DOC_USP7_MATH_1	352	356	PF00917	0.760
DOC_USP7_MATH_1	386	390	PF00917	0.750
DOC_USP7_MATH_1	410	414	PF00917	0.623
DOC_USP7_MATH_1	490	494	PF00917	0.669
DOC_USP7_MATH_1	559	563	PF00917	0.636
DOC_USP7_MATH_1	586	590	PF00917	0.721
DOC_USP7_MATH_1	705	709	PF00917	0.688
DOC_USP7_MATH_1	841	845	PF00917	0.753
DOC_USP7_UBL2_3	1098	1102	PF12436	0.646
DOC_WW_Pin1_4	1001	1006	PF00397	0.658
DOC_WW_Pin1_4	1014	1019	PF00397	0.605
DOC_WW_Pin1_4	1091	1096	PF00397	0.590
DOC_WW_Pin1_4	209	214	PF00397	0.769
DOC_WW_Pin1_4	241	246	PF00397	0.663
DOC_WW_Pin1_4	263	268	PF00397	0.743
DOC_WW_Pin1_4	354	359	PF00397	0.786
DOC_WW_Pin1_4	374	379	PF00397	0.517
DOC_WW_Pin1_4	45	50	PF00397	0.703
DOC_WW_Pin1_4	578	583	PF00397	0.724
DOC_WW_Pin1_4	707	712	PF00397	0.738
DOC_WW_Pin1_4	871	876	PF00397	0.790
DOC_WW_Pin1_4	955	960	PF00397	0.792
LIG_14-3-3_CanoR_1	1019	1027	PF00244	0.800
LIG_14-3-3_CanoR_1	1042	1049	PF00244	0.713
LIG_14-3-3_CanoR_1	196	201	PF00244	0.685
LIG_14-3-3_CanoR_1	260	267	PF00244	0.734
LIG_14-3-3_CanoR_1	319	324	PF00244	0.553
LIG_14-3-3_CanoR_1	343	347	PF00244	0.762
LIG_14-3-3_CanoR_1	380	387	PF00244	0.790
LIG_14-3-3_CanoR_1	405	414	PF00244	0.630
LIG_14-3-3_CanoR_1	509	517	PF00244	0.719
LIG_14-3-3_CanoR_1	67	72	PF00244	0.731
LIG_14-3-3_CanoR_1	727	733	PF00244	0.828
LIG_14-3-3_CanoR_1	754	760	PF00244	0.606
LIG_14-3-3_CanoR_1	843	851	PF00244	0.729
LIG_APCC_ABBA_1	459	464	PF00400	0.542
LIG_BIR_III_4	981	985	PF00653	0.599
LIG_BRCT_BRCA1_1	634	638	PF00533	0.684
LIG_BRCT_BRCA1_1	69	73	PF00533	0.719
LIG_BRCT_BRCA1_1	992	996	PF00533	0.608
LIG_deltaCOP1_diTrp_1	246	254	PF00928	0.597
LIG_FHA_1	1046	1052	PF00498	0.717
LIG_FHA_1	509	515	PF00498	0.621
LIG_FHA_1	547	553	PF00498	0.666
LIG_FHA_1	6	12	PF00498	0.653
LIG_FHA_1	600	606	PF00498	0.647
LIG_FHA_1	801	807	PF00498	0.642
LIG_FHA_2	210	216	PF00498	0.650
LIG_FHA_2	227	233	PF00498	0.607
LIG_LIR_Gen_1	164	173	PF02991	0.735
LIG_LIR_Gen_1	606	615	PF02991	0.619
LIG_LIR_Nem_3	1085	1089	PF02991	0.564
LIG_LIR_Nem_3	164	168	PF02991	0.739
LIG_LIR_Nem_3	246	252	PF02991	0.595
LIG_LIR_Nem_3	322	326	PF02991	0.536
LIG_LIR_Nem_3	606	611	PF02991	0.626
LIG_LIR_Nem_3	957	963	PF02991	0.722
LIG_LIR_Nem_3	995	1000	PF02991	0.713
LIG_MYND_1	267	271	PF01753	0.728
LIG_PCNA_PIPBox_1	757	766	PF02747	0.710
LIG_PCNA_yPIPBox_3	122	133	PF02747	0.630
LIG_Rb_LxCxE_1	357	377	PF01857	0.620
LIG_SH2_CRK	1009	1013	PF00017	0.735
LIG_SH2_CRK	165	169	PF00017	0.735
LIG_SH2_STAP1	526	530	PF00017	0.746
LIG_SH2_STAT3	890	893	PF00017	0.563
LIG_SH2_STAT5	888	891	PF00017	0.463
LIG_SH2_STAT5	945	948	PF00017	0.689
LIG_SH2_STAT5	979	982	PF00017	0.697
LIG_SH3_1	848	854	PF00018	0.747
LIG_SH3_3	1008	1014	PF00018	0.718
LIG_SH3_3	1062	1068	PF00018	0.677
LIG_SH3_3	210	216	PF00018	0.752
LIG_SH3_3	356	362	PF00018	0.745
LIG_SH3_3	43	49	PF00018	0.717
LIG_SH3_3	50	56	PF00018	0.761
LIG_SH3_3	795	801	PF00018	0.695
LIG_SH3_3	848	854	PF00018	0.747
LIG_SH3_3	944	950	PF00018	0.556
LIG_SUMO_SIM_anti_2	189	195	PF11976	0.648
LIG_SUMO_SIM_par_1	601	609	PF11976	0.666
LIG_TRAF2_1	1078	1081	PF00917	0.585
LIG_TRAF2_1	16	19	PF00917	0.609
LIG_TRAF2_1	229	232	PF00917	0.743
LIG_TRAF2_1	591	594	PF00917	0.631
LIG_TRAF2_1	786	789	PF00917	0.702
LIG_TRAF2_1	856	859	PF00917	0.767
LIG_TRAF2_1	912	915	PF00917	0.595
LIG_WRC_WIRS_1	129	134	PF05994	0.688
LIG_WRC_WIRS_1	320	325	PF05994	0.538
LIG_WRC_WIRS_1	938	943	PF05994	0.651
MOD_CDC14_SPxK_1	217	220	PF00782	0.755
MOD_CDC14_SPxK_1	357	360	PF00782	0.705
MOD_CDC14_SPxK_1	377	380	PF00782	0.551
MOD_CDK_SPK_2	1014	1019	PF00069	0.605
MOD_CDK_SPK_2	707	712	PF00069	0.760
MOD_CDK_SPxK_1	214	220	PF00069	0.749
MOD_CDK_SPxK_1	354	360	PF00069	0.779
MOD_CDK_SPxK_1	374	380	PF00069	0.556
MOD_CDK_SPxK_1	955	961	PF00069	0.580
MOD_CDK_SPxxK_3	1014	1021	PF00069	0.603
MOD_CDK_SPxxK_3	1091	1098	PF00069	0.607
MOD_CDK_SPxxK_3	241	248	PF00069	0.599
MOD_CK1_1	1001	1007	PF00069	0.647
MOD_CK1_1	131	137	PF00069	0.710
MOD_CK1_1	186	192	PF00069	0.663
MOD_CK1_1	420	426	PF00069	0.746
MOD_CK1_1	5	11	PF00069	0.791
MOD_CK1_1	568	574	PF00069	0.704
MOD_CK1_1	632	638	PF00069	0.772
MOD_CK1_1	710	716	PF00069	0.820
MOD_CK1_1	917	923	PF00069	0.713
MOD_CK1_1	990	996	PF00069	0.721
MOD_CK2_1	1075	1081	PF00069	0.619
MOD_CK2_1	209	215	PF00069	0.651
MOD_CK2_1	226	232	PF00069	0.613
MOD_CK2_1	369	375	PF00069	0.775
MOD_CK2_1	603	609	PF00069	0.678
MOD_CK2_1	753	759	PF00069	0.602
MOD_CK2_1	77	83	PF00069	0.723
MOD_DYRK1A_RPxSP_1	241	245	PF00069	0.602
MOD_DYRK1A_RPxSP_1	354	358	PF00069	0.648
MOD_DYRK1A_RPxSP_1	45	49	PF00069	0.701
MOD_GlcNHglycan	101	104	PF01048	0.734
MOD_GlcNHglycan	1021	1024	PF01048	0.687
MOD_GlcNHglycan	1068	1071	PF01048	0.730
MOD_GlcNHglycan	261	264	PF01048	0.706
MOD_GlcNHglycan	354	357	PF01048	0.700
MOD_GlcNHglycan	388	391	PF01048	0.772
MOD_GlcNHglycan	408	411	PF01048	0.453
MOD_GlcNHglycan	419	422	PF01048	0.737
MOD_GlcNHglycan	427	430	PF01048	0.726
MOD_GlcNHglycan	445	448	PF01048	0.828
MOD_GlcNHglycan	451	454	PF01048	0.676
MOD_GlcNHglycan	49	52	PF01048	0.635
MOD_GlcNHglycan	492	495	PF01048	0.718
MOD_GlcNHglycan	570	573	PF01048	0.785
MOD_GlcNHglycan	588	591	PF01048	0.720
MOD_GlcNHglycan	707	710	PF01048	0.839
MOD_GlcNHglycan	724	727	PF01048	0.627
MOD_GlcNHglycan	728	731	PF01048	0.720
MOD_GlcNHglycan	739	742	PF01048	0.606
MOD_GlcNHglycan	79	82	PF01048	0.658
MOD_GlcNHglycan	843	846	PF01048	0.714
MOD_GlcNHglycan	85	88	PF01048	0.692
MOD_GlcNHglycan	992	995	PF01048	0.775
MOD_GSK3_1	1041	1048	PF00069	0.748
MOD_GSK3_1	183	190	PF00069	0.680
MOD_GSK3_1	259	266	PF00069	0.787
MOD_GSK3_1	350	357	PF00069	0.749
MOD_GSK3_1	406	413	PF00069	0.677
MOD_GSK3_1	41	48	PF00069	0.662
MOD_GSK3_1	416	423	PF00069	0.713
MOD_GSK3_1	495	502	PF00069	0.845
MOD_GSK3_1	567	574	PF00069	0.825
MOD_GSK3_1	599	606	PF00069	0.655
MOD_GSK3_1	63	70	PF00069	0.679
MOD_GSK3_1	7	14	PF00069	0.840
MOD_GSK3_1	722	729	PF00069	0.724
MOD_GSK3_1	733	740	PF00069	0.740
MOD_GSK3_1	79	86	PF00069	0.707
MOD_GSK3_1	879	886	PF00069	0.611
MOD_GSK3_1	983	990	PF00069	0.732
MOD_LATS_1	348	354	PF00433	0.726
MOD_LATS_1	39	45	PF00433	0.703
MOD_N-GLC_1	186	191	PF02516	0.646
MOD_N-GLC_1	369	374	PF02516	0.621
MOD_N-GLC_1	67	72	PF02516	0.798
MOD_N-GLC_1	733	738	PF02516	0.717
MOD_NEK2_1	11	16	PF00069	0.741
MOD_NEK2_1	136	141	PF00069	0.691
MOD_NEK2_1	298	303	PF00069	0.601
MOD_NEK2_1	987	992	PF00069	0.769
MOD_PIKK_1	2	8	PF00454	0.745
MOD_PIKK_1	420	426	PF00454	0.704
MOD_PIKK_1	713	719	PF00454	0.610
MOD_PIKK_1	753	759	PF00454	0.648
MOD_PIKK_1	843	849	PF00454	0.649
MOD_PK_1	515	521	PF00069	0.666
MOD_PK_1	969	975	PF00069	0.690
MOD_PKA_1	449	455	PF00069	0.762
MOD_PKA_2	1041	1047	PF00069	0.700
MOD_PKA_2	259	265	PF00069	0.766
MOD_PKA_2	342	348	PF00069	0.719
MOD_PKA_2	508	514	PF00069	0.657
MOD_PKA_2	546	552	PF00069	0.738
MOD_PKA_2	559	565	PF00069	0.589
MOD_PKA_2	609	615	PF00069	0.608
MOD_PKA_2	669	675	PF00069	0.736
MOD_PKA_2	726	732	PF00069	0.829
MOD_PKA_2	753	759	PF00069	0.609
MOD_PKA_2	77	83	PF00069	0.794
MOD_PKA_2	87	93	PF00069	0.804
MOD_PKB_1	513	521	PF00069	0.673
MOD_PKB_1	55	63	PF00069	0.728
MOD_PKB_1	563	571	PF00069	0.769
MOD_Plk_1	1044	1050	PF00069	0.754
MOD_Plk_1	1059	1065	PF00069	0.591
MOD_Plk_1	18	24	PF00069	0.690
MOD_Plk_1	186	192	PF00069	0.641
MOD_Plk_1	67	73	PF00069	0.759
MOD_Plk_1	917	923	PF00069	0.611
MOD_Plk_4	128	134	PF00069	0.629
MOD_Plk_4	196	202	PF00069	0.694
MOD_Plk_4	515	521	PF00069	0.683
MOD_Plk_4	603	609	PF00069	0.630
MOD_Plk_4	983	989	PF00069	0.700
MOD_Plk_4	992	998	PF00069	0.633
MOD_ProDKin_1	1001	1007	PF00069	0.659
MOD_ProDKin_1	1014	1020	PF00069	0.603
MOD_ProDKin_1	1091	1097	PF00069	0.595
MOD_ProDKin_1	209	215	PF00069	0.768
MOD_ProDKin_1	241	247	PF00069	0.658
MOD_ProDKin_1	263	269	PF00069	0.743
MOD_ProDKin_1	354	360	PF00069	0.790
MOD_ProDKin_1	374	380	PF00069	0.517
MOD_ProDKin_1	45	51	PF00069	0.705
MOD_ProDKin_1	578	584	PF00069	0.722
MOD_ProDKin_1	707	713	PF00069	0.735
MOD_ProDKin_1	871	877	PF00069	0.790
MOD_ProDKin_1	955	961	PF00069	0.794
MOD_SUMO_for_1	776	779	PF00179	0.613
MOD_SUMO_rev_2	1080	1089	PF00179	0.560
MOD_SUMO_rev_2	244	250	PF00179	0.595
MOD_SUMO_rev_2	308	318	PF00179	0.587
MOD_SUMO_rev_2	446	452	PF00179	0.707
TRG_ENDOCYTIC_2	165	168	PF00928	0.738
TRG_ER_diArg_1	1018	1021	PF00400	0.733
TRG_ER_diArg_1	176	179	PF00400	0.732
TRG_ER_diArg_1	22	25	PF00400	0.584
TRG_ER_diArg_1	513	516	PF00400	0.723
TRG_ER_diArg_1	55	58	PF00400	0.650
TRG_ER_diArg_1	563	566	PF00400	0.647
TRG_ER_diArg_1	578	580	PF00400	0.655
TRG_ER_diArg_1	811	814	PF00400	0.660
TRG_Pf-PMV_PEXEL_1	1077	1081	PF00026	0.666
TRG_Pf-PMV_PEXEL_1	621	626	PF00026	0.715
TRG_Pf-PMV_PEXEL_1	712	717	PF00026	0.615
TRG_Pf-PMV_PEXEL_1	902	906	PF00026	0.569

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4J9	Leptomonas seymouri	33%	100%
A0A3S7WPM1	Leishmania donovani	100%	100%
A4H4S2	Leishmania braziliensis	48%	100%
E9AKZ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	98%
Q4QIW5	Leishmania major	82%	100%