Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

2OG-Fe(II) oxygenase superfamily - putative

Species:

Leishmania infantum

UniProt:

A4HSZ8_LEIIN

TriTrypDb:

LINF_060016400

Length:

344

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HSZ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSZ8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0005488	binding	1	5
GO:0016491	oxidoreductase activity	2	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5
GO:0051213	dioxygenase activity	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	320	324	PF00656	0.714
CLV_C14_Caspase3-7	39	43	PF00656	0.680
CLV_NRD_NRD_1	265	267	PF00675	0.442
CLV_NRD_NRD_1	341	343	PF00675	0.745
CLV_PCSK_FUR_1	338	342	PF00082	0.713
CLV_PCSK_KEX2_1	264	266	PF00082	0.436
CLV_PCSK_KEX2_1	337	339	PF00082	0.725
CLV_PCSK_KEX2_1	340	342	PF00082	0.733
CLV_PCSK_PC1ET2_1	337	339	PF00082	0.761
CLV_PCSK_PC1ET2_1	340	342	PF00082	0.768
CLV_PCSK_SKI1_1	209	213	PF00082	0.301
CLV_PCSK_SKI1_1	28	32	PF00082	0.606
CLV_PCSK_SKI1_1	334	338	PF00082	0.761
DEG_Nend_Nbox_1	1	3	PF02207	0.689
DOC_CKS1_1	249	254	PF01111	0.487
DOC_CYCLIN_RxL_1	206	216	PF00134	0.487
DOC_MAPK_FxFP_2	222	225	PF00069	0.476
DOC_MAPK_gen_1	193	203	PF00069	0.472
DOC_MAPK_MEF2A_6	196	205	PF00069	0.476
DOC_PP1_RVXF_1	207	214	PF00149	0.476
DOC_PP1_SILK_1	88	93	PF00149	0.494
DOC_PP4_FxxP_1	141	144	PF00568	0.415
DOC_PP4_FxxP_1	222	225	PF00568	0.476
DOC_PP4_MxPP_1	315	318	PF00568	0.649
DOC_SPAK_OSR1_1	256	260	PF12202	0.517
DOC_USP7_MATH_1	207	211	PF00917	0.501
DOC_USP7_MATH_1	318	322	PF00917	0.702
DOC_USP7_MATH_1	56	60	PF00917	0.539
DOC_WW_Pin1_4	248	253	PF00397	0.487
LIG_14-3-3_CanoR_1	109	115	PF00244	0.547
LIG_14-3-3_CanoR_1	264	269	PF00244	0.451
LIG_BRCT_BRCA1_1	147	151	PF00533	0.370
LIG_BRCT_BRCA1_1	209	213	PF00533	0.501
LIG_deltaCOP1_diTrp_1	134	141	PF00928	0.432
LIG_FHA_1	1	7	PF00498	0.608
LIG_FHA_1	198	204	PF00498	0.476
LIG_FHA_1	206	212	PF00498	0.476
LIG_FHA_1	233	239	PF00498	0.476
LIG_FHA_1	241	247	PF00498	0.476
LIG_FHA_2	148	154	PF00498	0.449
LIG_FHA_2	265	271	PF00498	0.492
LIG_FHA_2	288	294	PF00498	0.473
LIG_FHA_2	318	324	PF00498	0.733
LIG_FHA_2	37	43	PF00498	0.686
LIG_LIR_Apic_2	221	225	PF02991	0.562
LIG_LIR_Gen_1	148	159	PF02991	0.360
LIG_LIR_Gen_1	255	261	PF02991	0.518
LIG_LIR_Gen_1	85	95	PF02991	0.462
LIG_LIR_Nem_3	148	154	PF02991	0.364
LIG_LIR_Nem_3	160	164	PF02991	0.328
LIG_LIR_Nem_3	221	227	PF02991	0.553
LIG_LIR_Nem_3	255	260	PF02991	0.519
LIG_LIR_Nem_3	59	63	PF02991	0.532
LIG_LIR_Nem_3	85	90	PF02991	0.406
LIG_PTB_Apo_2	140	147	PF02174	0.332
LIG_PTB_Phospho_1	140	146	PF10480	0.333
LIG_SH2_CRK	111	115	PF00017	0.424
LIG_SH2_STAP1	167	171	PF00017	0.486
LIG_SH2_STAT3	146	149	PF00017	0.332
LIG_SH2_STAT5	146	149	PF00017	0.458
LIG_SH2_STAT5	161	164	PF00017	0.457
LIG_SH2_STAT5	97	100	PF00017	0.366
LIG_SH3_3	246	252	PF00018	0.460
LIG_SH3_3	32	38	PF00018	0.686
MOD_CK1_1	145	151	PF00069	0.454
MOD_CK2_1	110	116	PF00069	0.499
MOD_CK2_1	264	270	PF00069	0.464
MOD_Cter_Amidation	262	265	PF01082	0.411
MOD_DYRK1A_RPxSP_1	248	252	PF00069	0.470
MOD_GlcNHglycan	128	131	PF01048	0.610
MOD_GlcNHglycan	20	23	PF01048	0.506
MOD_GlcNHglycan	277	280	PF01048	0.663
MOD_GlcNHglycan	320	323	PF01048	0.741
MOD_GlcNHglycan	7	10	PF01048	0.618
MOD_GlcNHglycan	75	78	PF01048	0.484
MOD_GSK3_1	197	204	PF00069	0.487
MOD_GSK3_1	318	325	PF00069	0.730
MOD_GSK3_1	5	12	PF00069	0.699
MOD_NEK2_1	110	115	PF00069	0.524
MOD_NEK2_1	126	131	PF00069	0.509
MOD_NEK2_1	205	210	PF00069	0.487
MOD_NEK2_1	44	49	PF00069	0.493
MOD_NEK2_2	56	61	PF00069	0.448
MOD_PIKK_1	145	151	PF00454	0.505
MOD_PIKK_1	175	181	PF00454	0.562
MOD_PIKK_1	215	221	PF00454	0.562
MOD_PKA_1	264	270	PF00069	0.451
MOD_PKA_2	255	261	PF00069	0.523
MOD_PKA_2	264	270	PF00069	0.458
MOD_Plk_1	197	203	PF00069	0.476
MOD_Plk_1	85	91	PF00069	0.528
MOD_Plk_4	142	148	PF00069	0.479
MOD_Plk_4	45	51	PF00069	0.445
MOD_Plk_4	86	92	PF00069	0.466
MOD_ProDKin_1	248	254	PF00069	0.487
MOD_SUMO_for_1	114	117	PF00179	0.409
MOD_SUMO_rev_2	21	30	PF00179	0.710
TRG_ENDOCYTIC_2	111	114	PF00928	0.402
TRG_ENDOCYTIC_2	161	164	PF00928	0.487
TRG_ER_diArg_1	264	266	PF00400	0.452
TRG_ER_diArg_1	341	343	PF00400	0.717
TRG_ER_diArg_1	50	53	PF00400	0.544
TRG_NES_CRM1_1	153	165	PF08389	0.379
TRG_NLS_MonoExtC_3	336	341	PF00514	0.640
TRG_NLS_MonoExtN_4	334	341	PF00514	0.644
TRG_Pf-PMV_PEXEL_1	193	197	PF00026	0.325
TRG_Pf-PMV_PEXEL_1	266	270	PF00026	0.511

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKD0	Leptomonas seymouri	75%	93%
A0A0S4JRX9	Bodo saltans	46%	100%
A0A1X0NKP4	Trypanosomatidae	65%	100%
A0A3R7KF49	Trypanosoma rangeli	56%	100%
A0A3S7WPM5	Leishmania donovani	100%	100%
A4H4R9	Leishmania braziliensis	83%	100%
C9ZTN1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
E9AKY5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	97%
Q4QIX0	Leishmania major	94%	100%
V5BXY4	Trypanosoma cruzi	58%	100%