Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

G-patch domain/DExH-box splicing factor binding site - putative

Species:

Leishmania infantum

UniProt:

A4HSZ4_LEIIN

TriTrypDb:

LINF_060016000

Length:

230

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HSZ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSZ4

Function

Biological processes
Term	Name	Level	Count
GO:0044087	regulation of cellular component biogenesis	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1
GO:0090069	regulation of ribosome biogenesis	5	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	162	166	PF00656	0.610
CLV_C14_Caspase3-7	47	51	PF00656	0.400
CLV_NRD_NRD_1	122	124	PF00675	0.574
CLV_NRD_NRD_1	155	157	PF00675	0.565
CLV_NRD_NRD_1	47	49	PF00675	0.289
CLV_PCSK_KEX2_1	122	124	PF00082	0.458
CLV_PCSK_KEX2_1	142	144	PF00082	0.556
CLV_PCSK_KEX2_1	153	155	PF00082	0.507
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.556
CLV_PCSK_PC1ET2_1	153	155	PF00082	0.507
CLV_PCSK_SKI1_1	123	127	PF00082	0.469
CLV_PCSK_SKI1_1	19	23	PF00082	0.334
DOC_CYCLIN_RxL_1	15	25	PF00134	0.417
DOC_CYCLIN_yCln2_LP_2	181	187	PF00134	0.677
DOC_MAPK_gen_1	45	55	PF00069	0.292
DOC_MAPK_MEF2A_6	182	189	PF00069	0.556
DOC_USP7_MATH_1	191	195	PF00917	0.648
DOC_USP7_MATH_1	96	100	PF00917	0.711
DOC_USP7_UBL2_3	15	19	PF12436	0.384
DOC_USP7_UBL2_3	195	199	PF12436	0.648
DOC_USP7_UBL2_3	45	49	PF12436	0.302
DOC_WW_Pin1_4	180	185	PF00397	0.496
DOC_WW_Pin1_4	203	208	PF00397	0.656
DOC_WW_Pin1_4	223	228	PF00397	0.538
DOC_WW_Pin1_4	98	103	PF00397	0.684
LIG_14-3-3_CanoR_1	78	87	PF00244	0.523
LIG_14-3-3_CanoR_1	9	17	PF00244	0.445
LIG_14-3-3_CanoR_1	98	102	PF00244	0.544
LIG_BIR_II_1	1	5	PF00653	0.548
LIG_BRCT_BRCA1_1	68	72	PF00533	0.409
LIG_deltaCOP1_diTrp_1	63	72	PF00928	0.455
LIG_FHA_1	126	132	PF00498	0.515
LIG_FHA_1	224	230	PF00498	0.583
LIG_FHA_1	65	71	PF00498	0.496
LIG_FHA_1	82	88	PF00498	0.515
LIG_FHA_2	102	108	PF00498	0.734
LIG_FHA_2	199	205	PF00498	0.582
LIG_FHA_2	45	51	PF00498	0.400
LIG_LIR_Gen_1	69	79	PF02991	0.407
LIG_LIR_Nem_3	114	120	PF02991	0.592
LIG_LIR_Nem_3	69	75	PF02991	0.405
LIG_PDZ_Class_2	225	230	PF00595	0.610
LIG_SH3_1	215	221	PF00018	0.507
LIG_SH3_3	210	216	PF00018	0.535
LIG_SUMO_SIM_par_1	209	214	PF11976	0.537
LIG_UBA3_1	186	195	PF00899	0.561
MOD_CK1_1	136	142	PF00069	0.531
MOD_CK1_1	172	178	PF00069	0.703
MOD_CK1_1	25	31	PF00069	0.324
MOD_CK1_1	97	103	PF00069	0.683
MOD_CK2_1	101	107	PF00069	0.703
MOD_CK2_1	191	197	PF00069	0.707
MOD_CK2_1	8	14	PF00069	0.496
MOD_DYRK1A_RPxSP_1	98	102	PF00069	0.510
MOD_GlcNHglycan	135	138	PF01048	0.575
MOD_GlcNHglycan	148	151	PF01048	0.539
MOD_GlcNHglycan	176	179	PF01048	0.698
MOD_GlcNHglycan	24	27	PF01048	0.305
MOD_GSK3_1	169	176	PF00069	0.702
MOD_GSK3_1	81	88	PF00069	0.580
MOD_GSK3_1	94	101	PF00069	0.615
MOD_N-GLC_1	169	174	PF02516	0.688
MOD_N-GLC_1	5	10	PF02516	0.466
MOD_NEK2_1	190	195	PF00069	0.641
MOD_NEK2_1	22	27	PF00069	0.314
MOD_PIKK_1	169	175	PF00454	0.706
MOD_PIKK_1	64	70	PF00454	0.454
MOD_PKA_2	191	197	PF00069	0.686
MOD_PKA_2	8	14	PF00069	0.510
MOD_PKA_2	97	103	PF00069	0.563
MOD_Plk_2-3	157	163	PF00069	0.568
MOD_ProDKin_1	180	186	PF00069	0.491
MOD_ProDKin_1	203	209	PF00069	0.656
MOD_ProDKin_1	223	229	PF00069	0.542
MOD_ProDKin_1	98	104	PF00069	0.682
MOD_SUMO_for_1	126	129	PF00179	0.479
MOD_SUMO_rev_2	101	111	PF00179	0.565
MOD_SUMO_rev_2	135	144	PF00179	0.552
MOD_SUMO_rev_2	193	201	PF00179	0.694
TRG_DiLeu_BaLyEn_6	181	186	PF01217	0.493
TRG_ER_diArg_1	154	156	PF00400	0.674

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5L2	Leptomonas seymouri	66%	89%
A0A0S4JRZ3	Bodo saltans	45%	100%
A0A1X0NMG7	Trypanosomatidae	43%	95%
A0A3R7RBC9	Trypanosoma rangeli	53%	100%
A0A3S7WPL1	Leishmania donovani	100%	100%
A4H4R5	Leishmania braziliensis	80%	100%
C9ZTM6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	85%
E9AKY1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QIX4	Leishmania major	94%	100%
V5BNM6	Trypanosoma cruzi	49%	100%