Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HSZ3_LEIIN

TriTrypDb:

LINF_060015900

Length:

767

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HSZ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSZ3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	150	154	PF00656	0.662
CLV_C14_Caspase3-7	242	246	PF00656	0.298
CLV_C14_Caspase3-7	34	38	PF00656	0.415
CLV_C14_Caspase3-7	459	463	PF00656	0.468
CLV_C14_Caspase3-7	591	595	PF00656	0.622
CLV_NRD_NRD_1	128	130	PF00675	0.680
CLV_NRD_NRD_1	163	165	PF00675	0.634
CLV_NRD_NRD_1	170	172	PF00675	0.570
CLV_NRD_NRD_1	296	298	PF00675	0.626
CLV_NRD_NRD_1	499	501	PF00675	0.497
CLV_NRD_NRD_1	51	53	PF00675	0.588
CLV_NRD_NRD_1	659	661	PF00675	0.363
CLV_NRD_NRD_1	761	763	PF00675	0.583
CLV_NRD_NRD_1	8	10	PF00675	0.605
CLV_PCSK_KEX2_1	128	130	PF00082	0.683
CLV_PCSK_KEX2_1	163	165	PF00082	0.634
CLV_PCSK_KEX2_1	170	172	PF00082	0.570
CLV_PCSK_KEX2_1	296	298	PF00082	0.597
CLV_PCSK_KEX2_1	499	501	PF00082	0.497
CLV_PCSK_KEX2_1	659	661	PF00082	0.363
CLV_PCSK_KEX2_1	761	763	PF00082	0.587
CLV_PCSK_KEX2_1	8	10	PF00082	0.605
CLV_PCSK_SKI1_1	100	104	PF00082	0.437
CLV_PCSK_SKI1_1	114	118	PF00082	0.466
CLV_PCSK_SKI1_1	214	218	PF00082	0.411
CLV_PCSK_SKI1_1	347	351	PF00082	0.366
CLV_PCSK_SKI1_1	382	386	PF00082	0.402
CLV_PCSK_SKI1_1	499	503	PF00082	0.505
CLV_PCSK_SKI1_1	651	655	PF00082	0.404
CLV_PCSK_SKI1_1	702	706	PF00082	0.427
CLV_PCSK_SKI1_1	738	742	PF00082	0.550
CLV_PCSK_SKI1_1	83	87	PF00082	0.419
DEG_APCC_DBOX_1	346	354	PF00400	0.363
DEG_APCC_DBOX_1	498	506	PF00400	0.497
DEG_APCC_DBOX_1	701	709	PF00400	0.419
DEG_COP1_1	27	35	PF00400	0.442
DEG_Nend_Nbox_1	1	3	PF02207	0.613
DOC_CYCLIN_RxL_1	100	109	PF00134	0.444
DOC_CYCLIN_RxL_1	379	388	PF00134	0.401
DOC_CYCLIN_RxL_1	521	532	PF00134	0.510
DOC_CYCLIN_RxL_1	735	745	PF00134	0.579
DOC_CYCLIN_yCln2_LP_2	262	268	PF00134	0.398
DOC_MAPK_gen_1	700	707	PF00069	0.462
DOC_MAPK_HePTP_8	656	673	PF00069	0.372
DOC_MAPK_MEF2A_6	664	673	PF00069	0.369
DOC_PP1_SILK_1	79	84	PF00149	0.316
DOC_PP2B_LxvP_1	262	265	PF13499	0.442
DOC_PP2B_LxvP_1	733	736	PF13499	0.504
DOC_USP7_MATH_1	123	127	PF00917	0.636
DOC_USP7_MATH_1	133	137	PF00917	0.715
DOC_USP7_MATH_1	26	30	PF00917	0.538
DOC_USP7_MATH_1	31	35	PF00917	0.540
DOC_USP7_MATH_1	318	322	PF00917	0.655
DOC_USP7_MATH_1	575	579	PF00917	0.663
DOC_WW_Pin1_4	313	318	PF00397	0.689
DOC_WW_Pin1_4	397	402	PF00397	0.503
DOC_WW_Pin1_4	414	419	PF00397	0.739
DOC_WW_Pin1_4	51	56	PF00397	0.547
DOC_WW_Pin1_4	578	583	PF00397	0.604
LIG_14-3-3_CanoR_1	134	139	PF00244	0.577
LIG_14-3-3_CanoR_1	382	388	PF00244	0.390
LIG_14-3-3_CanoR_1	426	430	PF00244	0.584
LIG_14-3-3_CanoR_1	457	465	PF00244	0.609
LIG_14-3-3_CanoR_1	507	513	PF00244	0.429
LIG_14-3-3_CanoR_1	610	619	PF00244	0.262
LIG_14-3-3_CanoR_1	664	669	PF00244	0.391
LIG_14-3-3_CanoR_1	700	705	PF00244	0.354
LIG_14-3-3_CanoR_1	8	15	PF00244	0.513
LIG_APCC_ABBAyCdc20_2	538	544	PF00400	0.480
LIG_BRCT_BRCA1_1	353	357	PF00533	0.332
LIG_Clathr_ClatBox_1	525	529	PF01394	0.517
LIG_DLG_GKlike_1	134	141	PF00625	0.579
LIG_DLG_GKlike_1	664	671	PF00625	0.399
LIG_FHA_1	185	191	PF00498	0.492
LIG_FHA_1	215	221	PF00498	0.346
LIG_FHA_1	231	237	PF00498	0.456
LIG_FHA_1	246	252	PF00498	0.294
LIG_FHA_1	322	328	PF00498	0.491
LIG_FHA_1	34	40	PF00498	0.600
LIG_FHA_1	402	408	PF00498	0.540
LIG_FHA_1	430	436	PF00498	0.495
LIG_FHA_1	478	484	PF00498	0.409
LIG_FHA_1	602	608	PF00498	0.493
LIG_FHA_1	611	617	PF00498	0.431
LIG_FHA_1	644	650	PF00498	0.417
LIG_FHA_1	682	688	PF00498	0.428
LIG_FHA_1	73	79	PF00498	0.421
LIG_FHA_2	148	154	PF00498	0.711
LIG_FHA_2	301	307	PF00498	0.633
LIG_FHA_2	369	375	PF00498	0.570
LIG_FHA_2	457	463	PF00498	0.465
LIG_FHA_2	466	472	PF00498	0.421
LIG_FHA_2	530	536	PF00498	0.546
LIG_FHA_2	579	585	PF00498	0.656
LIG_FHA_2	742	748	PF00498	0.544
LIG_Integrin_RGD_1	660	662	PF01839	0.345
LIG_LIR_Gen_1	269	277	PF02991	0.415
LIG_LIR_Gen_1	354	364	PF02991	0.449
LIG_LIR_Gen_1	630	640	PF02991	0.451
LIG_LIR_Gen_1	703	712	PF02991	0.363
LIG_LIR_Gen_1	76	87	PF02991	0.443
LIG_LIR_Nem_3	269	273	PF02991	0.414
LIG_LIR_Nem_3	354	360	PF02991	0.442
LIG_LIR_Nem_3	630	635	PF02991	0.365
LIG_LIR_Nem_3	703	707	PF02991	0.359
LIG_LIR_Nem_3	76	82	PF02991	0.443
LIG_NRBOX	81	87	PF00104	0.461
LIG_PCNA_PIPBox_1	392	401	PF02747	0.453
LIG_PCNA_yPIPBox_3	702	716	PF02747	0.389
LIG_Pex14_2	212	216	PF04695	0.426
LIG_Rb_pABgroove_1	442	450	PF01858	0.450
LIG_SH2_CRK	632	636	PF00017	0.350
LIG_SH2_CRK	640	644	PF00017	0.383
LIG_SH2_GRB2like	675	678	PF00017	0.476
LIG_SH2_NCK_1	399	403	PF00017	0.479
LIG_SH2_NCK_1	448	452	PF00017	0.448
LIG_SH2_SRC	448	451	PF00017	0.456
LIG_SH2_STAP1	542	546	PF00017	0.394
LIG_SH2_STAT3	377	380	PF00017	0.452
LIG_SH2_STAT5	352	355	PF00017	0.434
LIG_SH2_STAT5	383	386	PF00017	0.421
LIG_SH2_STAT5	399	402	PF00017	0.535
LIG_SH2_STAT5	497	500	PF00017	0.495
LIG_SH3_3	117	123	PF00018	0.475
LIG_SH3_3	714	720	PF00018	0.449
LIG_SUMO_SIM_anti_2	449	455	PF11976	0.449
LIG_SUMO_SIM_anti_2	684	689	PF11976	0.415
LIG_SUMO_SIM_par_1	186	191	PF11976	0.568
LIG_SUMO_SIM_par_1	275	281	PF11976	0.401
LIG_SUMO_SIM_par_1	383	388	PF11976	0.416
LIG_SUMO_SIM_par_1	524	532	PF11976	0.510
LIG_SUMO_SIM_par_1	652	658	PF11976	0.392
LIG_TRAF2_1	468	471	PF00917	0.463
LIG_TRAF2_1	726	729	PF00917	0.408
LIG_TRFH_1	179	183	PF08558	0.541
LIG_TYR_ITIM	106	111	PF00017	0.538
LIG_TYR_ITIM	268	273	PF00017	0.416
LIG_UBA3_1	81	88	PF00899	0.431
LIG_WW_3	316	320	PF00397	0.633
LIG_WW_3	735	739	PF00397	0.572
MOD_CDC14_SPxK_1	316	319	PF00782	0.639
MOD_CDK_SPxK_1	313	319	PF00069	0.646
MOD_CK1_1	142	148	PF00069	0.706
MOD_CK1_1	184	190	PF00069	0.591
MOD_CK1_1	20	26	PF00069	0.422
MOD_CK1_1	321	327	PF00069	0.566
MOD_CK1_1	413	419	PF00069	0.759
MOD_CK1_1	548	554	PF00069	0.443
MOD_CK1_1	578	584	PF00069	0.685
MOD_CK2_1	106	112	PF00069	0.412
MOD_CK2_1	465	471	PF00069	0.449
MOD_CK2_1	529	535	PF00069	0.551
MOD_CK2_1	548	554	PF00069	0.459
MOD_CK2_1	719	725	PF00069	0.400
MOD_GlcNHglycan	10	13	PF01048	0.541
MOD_GlcNHglycan	108	111	PF01048	0.634
MOD_GlcNHglycan	190	193	PF01048	0.523
MOD_GlcNHglycan	197	200	PF01048	0.456
MOD_GlcNHglycan	306	312	PF01048	0.561
MOD_GlcNHglycan	33	36	PF01048	0.534
MOD_GlcNHglycan	407	410	PF01048	0.655
MOD_GlcNHglycan	577	580	PF01048	0.729
MOD_GlcNHglycan	750	753	PF01048	0.600
MOD_GSK3_1	16	23	PF00069	0.429
MOD_GSK3_1	177	184	PF00069	0.560
MOD_GSK3_1	227	234	PF00069	0.565
MOD_GSK3_1	241	248	PF00069	0.534
MOD_GSK3_1	278	285	PF00069	0.372
MOD_GSK3_1	313	320	PF00069	0.697
MOD_GSK3_1	393	400	PF00069	0.461
MOD_GSK3_1	401	408	PF00069	0.606
MOD_GSK3_1	410	417	PF00069	0.625
MOD_GSK3_1	425	432	PF00069	0.554
MOD_GSK3_1	544	551	PF00069	0.548
MOD_GSK3_1	610	617	PF00069	0.347
MOD_GSK3_1	719	726	PF00069	0.457
MOD_LATS_1	132	138	PF00433	0.574
MOD_LATS_1	698	704	PF00433	0.432
MOD_N-GLC_1	139	144	PF02516	0.600
MOD_NEK2_1	188	193	PF00069	0.482
MOD_NEK2_1	385	390	PF00069	0.440
MOD_NEK2_1	425	430	PF00069	0.581
MOD_NEK2_1	434	439	PF00069	0.468
MOD_NEK2_1	545	550	PF00069	0.351
MOD_NEK2_1	688	693	PF00069	0.418
MOD_NEK2_1	748	753	PF00069	0.510
MOD_PIKK_1	227	233	PF00454	0.522
MOD_PIKK_1	393	399	PF00454	0.399
MOD_PIKK_1	601	607	PF00454	0.504
MOD_PKA_1	8	14	PF00069	0.577
MOD_PKA_2	133	139	PF00069	0.591
MOD_PKA_2	184	190	PF00069	0.538
MOD_PKA_2	318	324	PF00069	0.623
MOD_PKA_2	425	431	PF00069	0.629
MOD_PKA_2	456	462	PF00069	0.431
MOD_PKA_2	557	563	PF00069	0.605
MOD_PKA_2	72	78	PF00069	0.489
MOD_PKA_2	8	14	PF00069	0.516
MOD_Plk_1	123	129	PF00069	0.593
MOD_Plk_1	26	32	PF00069	0.436
MOD_Plk_2-3	529	535	PF00069	0.551
MOD_Plk_4	17	23	PF00069	0.355
MOD_Plk_4	177	183	PF00069	0.581
MOD_Plk_4	184	190	PF00069	0.487
MOD_Plk_4	74	80	PF00069	0.415
MOD_ProDKin_1	313	319	PF00069	0.689
MOD_ProDKin_1	397	403	PF00069	0.516
MOD_ProDKin_1	414	420	PF00069	0.738
MOD_ProDKin_1	51	57	PF00069	0.541
MOD_ProDKin_1	578	584	PF00069	0.609
MOD_SUMO_for_1	292	295	PF00179	0.504
MOD_SUMO_rev_2	725	733	PF00179	0.385
TRG_DiLeu_BaEn_4	470	476	PF01217	0.462
TRG_DiLeu_BaLyEn_6	521	526	PF01217	0.459
TRG_ENDOCYTIC_2	108	111	PF00928	0.479
TRG_ENDOCYTIC_2	270	273	PF00928	0.449
TRG_ENDOCYTIC_2	4	7	PF00928	0.553
TRG_ENDOCYTIC_2	448	451	PF00928	0.447
TRG_ENDOCYTIC_2	542	545	PF00928	0.366
TRG_ENDOCYTIC_2	632	635	PF00928	0.345
TRG_ENDOCYTIC_2	640	643	PF00928	0.382
TRG_ER_diArg_1	127	129	PF00400	0.649
TRG_ER_diArg_1	498	500	PF00400	0.511
TRG_ER_diArg_1	555	558	PF00400	0.453
TRG_ER_diArg_1	699	702	PF00400	0.375
TRG_ER_diArg_1	7	9	PF00400	0.626
TRG_ER_diArg_1	760	762	PF00400	0.610
TRG_NES_CRM1_1	517	531	PF08389	0.487
TRG_NES_CRM1_1	76	90	PF08389	0.393
TRG_Pf-PMV_PEXEL_1	485	490	PF00026	0.454
TRG_Pf-PMV_PEXEL_1	524	529	PF00026	0.512
TRG_Pf-PMV_PEXEL_1	550	554	PF00026	0.380
TRG_Pf-PMV_PEXEL_1	60	64	PF00026	0.450

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXP3	Leptomonas seymouri	54%	100%
A0A3R7K270	Trypanosoma rangeli	34%	100%
A0A3S5H5T7	Leishmania donovani	100%	100%
A4H4R4	Leishmania braziliensis	81%	98%
C9ZTM4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AKY0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	99%
Q4QIX5	Leishmania major	93%	100%