Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HSZ1_LEIIN

TriTrypDb:

LINF_060015700

Length:

155

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4HSZ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSZ1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	71	77	PF00089	0.400
CLV_NRD_NRD_1	63	65	PF00675	0.352
CLV_NRD_NRD_1	73	75	PF00675	0.417
CLV_PCSK_KEX2_1	63	65	PF00082	0.390
CLV_PCSK_KEX2_1	72	74	PF00082	0.355
DOC_ANK_TNKS_1	72	79	PF00023	0.591
DOC_MAPK_gen_1	48	57	PF00069	0.529
DOC_USP7_MATH_1	12	16	PF00917	0.340
DOC_USP7_MATH_1	28	32	PF00917	0.297
DOC_WW_Pin1_4	101	106	PF00397	0.666
DOC_WW_Pin1_4	114	119	PF00397	0.603
LIG_14-3-3_CanoR_1	108	114	PF00244	0.616
LIG_FHA_1	2	8	PF00498	0.469
LIG_FHA_1	66	72	PF00498	0.579
LIG_LIR_Apic_2	98	103	PF02991	0.671
LIG_LIR_Nem_3	38	43	PF02991	0.330
LIG_SH2_CRK	100	104	PF00017	0.671
LIG_SH2_CRK	3	7	PF00017	0.478
LIG_SH2_GRB2like	56	59	PF00017	0.548
LIG_SH2_NCK_1	100	104	PF00017	0.671
LIG_SH2_STAP1	3	7	PF00017	0.495
LIG_SH2_STAT5	146	149	PF00017	0.401
LIG_SH2_STAT5	3	6	PF00017	0.539
LIG_SH2_STAT5	51	54	PF00017	0.552
LIG_SH2_STAT5	56	59	PF00017	0.564
LIG_SH3_1	115	121	PF00018	0.475
LIG_SH3_3	115	121	PF00018	0.462
LIG_SH3_3	6	12	PF00018	0.388
LIG_SUMO_SIM_par_1	129	136	PF11976	0.318
LIG_WW_3	108	112	PF00397	0.672
MOD_CDK_SPxxK_3	101	108	PF00069	0.607
MOD_CK1_1	104	110	PF00069	0.627
MOD_CK1_1	132	138	PF00069	0.300
MOD_CK1_1	149	155	PF00069	0.423
MOD_GlcNHglycan	137	140	PF01048	0.466
MOD_GlcNHglycan	40	43	PF01048	0.305
MOD_GlcNHglycan	86	90	PF01048	0.497
MOD_GSK3_1	129	136	PF00069	0.415
MOD_NEK2_1	1	6	PF00069	0.632
MOD_NEK2_1	129	134	PF00069	0.312
MOD_NEK2_1	67	72	PF00069	0.588
MOD_NEK2_2	28	33	PF00069	0.333
MOD_NEK2_2	35	40	PF00069	0.404
MOD_Plk_4	2	8	PF00069	0.493
MOD_Plk_4	28	34	PF00069	0.303
MOD_Plk_4	35	41	PF00069	0.412
MOD_ProDKin_1	101	107	PF00069	0.664
MOD_ProDKin_1	114	120	PF00069	0.599
TRG_ENDOCYTIC_2	3	6	PF00928	0.512
TRG_ER_diArg_1	47	50	PF00400	0.522
TRG_ER_diArg_1	71	74	PF00400	0.587
TRG_Pf-PMV_PEXEL_1	148	153	PF00026	0.612

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBL5	Leptomonas seymouri	40%	100%
A0A3S7WPM7	Leishmania donovani	99%	100%
E9AI23	Leishmania braziliensis	61%	100%
E9AKX8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QIX7	Leishmania major	94%	100%