Putative cell cycle associated protein MOB1

Quick info Annotations Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cell cycle associated protein MOB1 - putative

Species:

Leishmania infantum

UniProt:

A4HSY8_LEIIN

TriTrypDb:

LINF_060015300

Length:

223

Annotations

Annotations by Jardim et al.

Cell Cycle, cell cycle associated MOB1 MOB1

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	yes	yes: 2
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

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Phosphorylation

Promastigote/Amastigote: 40

Expansion

Sequence features

A4HSY8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSY8

Function

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Biological processes
Term	Name	Level	Count
GO:0001932	regulation of protein phosphorylation	7	1
GO:0001934	positive regulation of protein phosphorylation	8	1
GO:0007165	signal transduction	2	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010562	positive regulation of phosphorus metabolic process	6	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0019220	regulation of phosphate metabolic process	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1

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Molecular functions
Term	Name	Level	Count
GO:0008047	enzyme activator activity	3	1
GO:0019207	kinase regulator activity	3	1
GO:0019209	kinase activator activity	4	1
GO:0019887	protein kinase regulator activity	4	1
GO:0030234	enzyme regulator activity	2	1
GO:0030295	protein kinase activator activity	5	1
GO:0098772	molecular function regulator activity	1	1
GO:0140677	molecular function activator activity	2	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	155	157	PF00675	0.379
CLV_PCSK_KEX2_1	155	157	PF00082	0.326
CLV_PCSK_SKI1_1	151	155	PF00082	0.337
DEG_APCC_DBOX_1	199	207	PF00400	0.587
DEG_Nend_UBRbox_1	1	4	PF02207	0.638
DEG_SCF_FBW7_2	203	208	PF00400	0.606
DOC_USP7_MATH_1	87	91	PF00917	0.527
DOC_USP7_UBL2_3	147	151	PF12436	0.569
DOC_USP7_UBL2_3	18	22	PF12436	0.566
DOC_WW_Pin1_4	201	206	PF00397	0.540

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJX4	Leptomonas seymouri	97%	100%
A0A0S4JRY9	Bodo saltans	71%	99%
A0A1X0NMF7	Trypanosomatidae	75%	99%
A0A3R7LB49	Trypanosoma rangeli	75%	100%
A0A3S5H5T5	Leishmania donovani	100%	100%
A4H4Q9	Leishmania braziliensis	97%	100%
C9ZTL8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	77%	100%
E9AKX4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
F4K495	Arabidopsis thaliana	44%	100%
O74558	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	91%

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