LeishMANIAdb
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DUF4476 domain-containing protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
DUF4476 domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HSY4_LEIIN
TriTrypDb:
LINF_060014900
Length:
449

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 4
Forrest at al. (procyclic) yes yes: 4
Silverman et al. no yes: 0
Pissara et al. no yes: 6
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 10
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HSY4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSY4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 298 302 PF00656 0.675
CLV_NRD_NRD_1 103 105 PF00675 0.403
CLV_NRD_NRD_1 141 143 PF00675 0.485
CLV_NRD_NRD_1 204 206 PF00675 0.322
CLV_PCSK_SKI1_1 149 153 PF00082 0.428
CLV_PCSK_SKI1_1 4 8 PF00082 0.362
DEG_APCC_DBOX_1 37 45 PF00400 0.341
DEG_APCC_DBOX_1 403 411 PF00400 0.540
DEG_COP1_1 383 393 PF00400 0.592
DEG_SCF_TRCP1_1 263 269 PF00400 0.518
DOC_CYCLIN_RxL_1 1 9 PF00134 0.380
DOC_CYCLIN_yCln2_LP_2 370 376 PF00134 0.598
DOC_MAPK_gen_1 104 111 PF00069 0.352
DOC_MAPK_gen_1 205 213 PF00069 0.344
DOC_MAPK_MEF2A_6 104 113 PF00069 0.347
DOC_MAPK_MEF2A_6 226 234 PF00069 0.329
DOC_PP2B_LxvP_1 170 173 PF13499 0.483
DOC_PP2B_LxvP_1 370 373 PF13499 0.590
DOC_PP2B_PxIxI_1 417 423 PF00149 0.589
DOC_USP7_MATH_1 334 338 PF00917 0.591
DOC_USP7_MATH_1 339 343 PF00917 0.615
DOC_USP7_MATH_1 346 350 PF00917 0.584
DOC_USP7_MATH_1 351 355 PF00917 0.558
DOC_USP7_MATH_1 416 420 PF00917 0.577
DOC_USP7_UBL2_3 145 149 PF12436 0.458
DOC_WW_Pin1_4 122 127 PF00397 0.404
DOC_WW_Pin1_4 255 260 PF00397 0.759
DOC_WW_Pin1_4 290 295 PF00397 0.567
LIG_14-3-3_CanoR_1 104 112 PF00244 0.473
LIG_14-3-3_CanoR_1 30 37 PF00244 0.479
LIG_14-3-3_CanoR_1 43 49 PF00244 0.331
LIG_AP2alpha_2 362 364 PF02296 0.608
LIG_BIR_III_2 415 419 PF00653 0.562
LIG_CaM_IQ_9 213 228 PF13499 0.445
LIG_Clathr_ClatBox_1 110 114 PF01394 0.349
LIG_FHA_1 104 110 PF00498 0.436
LIG_FHA_1 127 133 PF00498 0.469
LIG_FHA_1 135 141 PF00498 0.457
LIG_FHA_1 155 161 PF00498 0.177
LIG_FHA_1 176 182 PF00498 0.300
LIG_FHA_1 213 219 PF00498 0.377
LIG_FHA_2 123 129 PF00498 0.374
LIG_LIR_Gen_1 361 372 PF02991 0.613
LIG_LIR_Gen_1 47 56 PF02991 0.414
LIG_LIR_LC3C_4 176 181 PF02991 0.418
LIG_LIR_Nem_3 219 225 PF02991 0.459
LIG_LIR_Nem_3 361 367 PF02991 0.605
LIG_LIR_Nem_3 415 420 PF02991 0.568
LIG_LIR_Nem_3 47 51 PF02991 0.346
LIG_MYND_1 255 259 PF01753 0.713
LIG_NRBOX 40 46 PF00104 0.450
LIG_PDZ_Class_2 444 449 PF00595 0.606
LIG_SH2_CRK 222 226 PF00017 0.502
LIG_SH2_CRK 331 335 PF00017 0.633
LIG_SH2_CRK 48 52 PF00017 0.335
LIG_SH2_NCK_1 168 172 PF00017 0.407
LIG_SH2_NCK_1 331 335 PF00017 0.633
LIG_SH2_NCK_1 48 52 PF00017 0.370
LIG_SH2_STAP1 168 172 PF00017 0.442
LIG_SH2_STAP1 48 52 PF00017 0.426
LIG_SH2_STAP1 80 84 PF00017 0.465
LIG_SH2_STAT5 124 127 PF00017 0.468
LIG_SH2_STAT5 131 134 PF00017 0.469
LIG_SH2_STAT5 158 161 PF00017 0.314
LIG_SH2_STAT5 168 171 PF00017 0.411
LIG_SH2_STAT5 55 58 PF00017 0.298
LIG_SH2_STAT5 64 67 PF00017 0.361
LIG_SH3_3 177 183 PF00018 0.384
LIG_SH3_3 267 273 PF00018 0.524
LIG_SH3_3 315 321 PF00018 0.572
LIG_SH3_3 370 376 PF00018 0.632
LIG_SH3_3 387 393 PF00018 0.480
LIG_SH3_3 425 431 PF00018 0.575
LIG_SUMO_SIM_anti_2 114 120 PF11976 0.472
LIG_SUMO_SIM_anti_2 176 181 PF11976 0.334
LIG_SUMO_SIM_anti_2 9 15 PF11976 0.341
LIG_SUMO_SIM_par_1 209 215 PF11976 0.353
LIG_TYR_ITIM 220 225 PF00017 0.493
MOD_CK1_1 258 264 PF00069 0.610
MOD_CK1_1 288 294 PF00069 0.721
MOD_CK1_1 32 38 PF00069 0.470
MOD_CK1_1 383 389 PF00069 0.591
MOD_CK1_1 47 53 PF00069 0.323
MOD_CK2_1 138 144 PF00069 0.472
MOD_CK2_1 184 190 PF00069 0.533
MOD_CK2_1 355 361 PF00069 0.652
MOD_GlcNHglycan 186 189 PF01048 0.528
MOD_GlcNHglycan 222 225 PF01048 0.434
MOD_GlcNHglycan 245 248 PF01048 0.628
MOD_GlcNHglycan 250 253 PF01048 0.613
MOD_GlcNHglycan 263 266 PF01048 0.620
MOD_GlcNHglycan 297 300 PF01048 0.768
MOD_GlcNHglycan 334 337 PF01048 0.689
MOD_GlcNHglycan 353 356 PF01048 0.703
MOD_GlcNHglycan 358 361 PF01048 0.684
MOD_GlcNHglycan 382 385 PF01048 0.720
MOD_GSK3_1 122 129 PF00069 0.445
MOD_GSK3_1 134 141 PF00069 0.409
MOD_GSK3_1 154 161 PF00069 0.182
MOD_GSK3_1 257 264 PF00069 0.708
MOD_GSK3_1 288 295 PF00069 0.740
MOD_GSK3_1 32 39 PF00069 0.477
MOD_GSK3_1 346 353 PF00069 0.675
MOD_GSK3_1 78 85 PF00069 0.465
MOD_GSK3_1 90 97 PF00069 0.495
MOD_N-GLC_1 295 300 PF02516 0.712
MOD_N-GLC_1 346 351 PF02516 0.572
MOD_N-GLC_1 82 87 PF02516 0.460
MOD_NEK2_1 151 156 PF00069 0.469
MOD_NEK2_1 29 34 PF00069 0.523
MOD_NEK2_2 126 131 PF00069 0.512
MOD_NEK2_2 158 163 PF00069 0.389
MOD_NEK2_2 399 404 PF00069 0.519
MOD_PK_1 105 111 PF00069 0.292
MOD_PKA_2 184 190 PF00069 0.533
MOD_PKA_2 220 226 PF00069 0.390
MOD_PKA_2 29 35 PF00069 0.535
MOD_PKA_2 339 345 PF00069 0.620
MOD_PKA_2 65 71 PF00069 0.370
MOD_PKA_2 97 103 PF00069 0.454
MOD_Plk_1 126 132 PF00069 0.472
MOD_Plk_1 149 155 PF00069 0.426
MOD_Plk_1 166 172 PF00069 0.434
MOD_Plk_1 175 181 PF00069 0.350
MOD_Plk_4 105 111 PF00069 0.292
MOD_Plk_4 126 132 PF00069 0.474
MOD_Plk_4 154 160 PF00069 0.340
MOD_Plk_4 175 181 PF00069 0.336
MOD_Plk_4 383 389 PF00069 0.663
MOD_Plk_4 430 436 PF00069 0.554
MOD_Plk_4 47 53 PF00069 0.360
MOD_ProDKin_1 122 128 PF00069 0.405
MOD_ProDKin_1 255 261 PF00069 0.757
MOD_ProDKin_1 290 296 PF00069 0.570
MOD_SUMO_rev_2 190 199 PF00179 0.474
TRG_DiLeu_BaEn_1 114 119 PF01217 0.391
TRG_DiLeu_BaEn_1 40 45 PF01217 0.355
TRG_DiLeu_BaEn_1 9 14 PF01217 0.332
TRG_DiLeu_BaEn_2 429 435 PF01217 0.578
TRG_DiLeu_LyEn_5 40 45 PF01217 0.446
TRG_ENDOCYTIC_2 222 225 PF00928 0.502
TRG_ENDOCYTIC_2 48 51 PF00928 0.333
TRG_ER_diArg_1 404 407 PF00400 0.552
TRG_Pf-PMV_PEXEL_1 82 86 PF00026 0.460

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IKD5 Leptomonas seymouri 66% 100%
A0A3R7KW02 Trypanosoma rangeli 37% 100%
A0A3S5H5T3 Leishmania donovani 100% 100%
A4H4Q5 Leishmania braziliensis 73% 100%
E9AKX0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 97%
Q4QIY5 Leishmania major 92% 100%
V5BXU6 Trypanosoma cruzi 35% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS