LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Aminoacyl-tRNA hydrolase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Aminoacyl-tRNA hydrolase
Gene product:
Peptidyl-tRNA hydrolase PTH2 - putative
Species:
Leishmania infantum
UniProt:
A4HSY3_LEIIN
TriTrypDb:
LINF_060014800 *
Length:
131

Annotations

Annotations by Jardim et al.

tRNA synthetase, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 1
NetGPI no yes: 0, no: 1
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HSY3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSY3

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 2
GO:0004045 aminoacyl-tRNA hydrolase activity 5 2
GO:0016787 hydrolase activity 2 2
GO:0016788 hydrolase activity, acting on ester bonds 3 2
GO:0052689 carboxylic ester hydrolase activity 4 2
GO:0140098 catalytic activity, acting on RNA 3 2
GO:0140101 catalytic activity, acting on a tRNA 4 2
GO:0140640 catalytic activity, acting on a nucleic acid 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 5 7 PF00675 0.399
CLV_PCSK_SKI1_1 43 47 PF00082 0.349
CLV_PCSK_SKI1_1 67 71 PF00082 0.324
CLV_PCSK_SKI1_1 7 11 PF00082 0.324
DOC_USP7_MATH_1 33 37 PF00917 0.614
DOC_WW_Pin1_4 38 43 PF00397 0.614
LIG_BIR_II_1 1 5 PF00653 0.524
LIG_FHA_1 123 129 PF00498 0.594
LIG_Pex14_1 53 57 PF04695 0.524
LIG_SH2_STAT5 93 96 PF00017 0.524
LIG_UBA3_1 78 83 PF00899 0.524
MOD_CDK_SPK_2 38 43 PF00069 0.524
MOD_CK1_1 36 42 PF00069 0.524
MOD_CK1_1 63 69 PF00069 0.584
MOD_CMANNOS 53 56 PF00535 0.324
MOD_GlcNHglycan 43 46 PF01048 0.334
MOD_GlcNHglycan 49 52 PF01048 0.354
MOD_GlcNHglycan 62 65 PF01048 0.241
MOD_GSK3_1 33 40 PF00069 0.609
MOD_N-GLC_1 60 65 PF02516 0.324
MOD_NEK2_1 34 39 PF00069 0.624
MOD_NEK2_1 9 14 PF00069 0.524
MOD_PIKK_1 98 104 PF00454 0.524
MOD_Plk_4 106 112 PF00069 0.524
MOD_Plk_4 116 122 PF00069 0.449
MOD_ProDKin_1 38 44 PF00069 0.614

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IED2 Leishmania donovani 38% 79%
A3DMF7 Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1) 38% 100%
A4FYL9 Methanococcus maripaludis (strain C5 / ATCC BAA-1333) 38% 100%
A4HIH3 Leishmania braziliensis 28% 69%
A4I5S0 Leishmania infantum 38% 79%
A4YD82 Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2) 40% 100%
A6USA3 Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB) 35% 100%
A6UWF5 Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3) 31% 100%
A6VJR3 Methanococcus maripaludis (strain C7 / ATCC BAA-1331) 39% 100%
A8MBW8 Caldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167) 39% 100%
A9A6B6 Methanococcus maripaludis (strain C6 / ATCC BAA-1332) 36% 100%
B0R2Y5 Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1) 33% 100%
B6YTE3 Thermococcus onnurineus (strain NA1) 39% 100%
B9LTP1 Halorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34) 35% 100%
C3MJ30 Sulfolobus islandicus (strain L.S.2.15 / Lassen #1) 39% 100%
C3MYS2 Sulfolobus islandicus (strain M.14.25 / Kamchatka #1) 39% 100%
C3MZS7 Sulfolobus islandicus (strain M.16.27) 39% 100%
C3N851 Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1) 39% 100%
C3NF60 Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2) 39% 100%
C4KJ09 Sulfolobus islandicus (strain M.16.4 / Kamchatka #3) 39% 100%
C6A1K8 Thermococcus sibiricus (strain DSM 12597 / MM 739) 36% 100%
E9B115 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
O27732 Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) 31% 100%
O28185 Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) 34% 100%
O74017 Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) 41% 100%
O97067 Drosophila melanogaster 44% 70%
P61234 Methanococcus maripaludis (strain S2 / LL) 37% 100%
P61235 Nanoarchaeum equitans (strain Kin4-M) 30% 100%
P61414 Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) 33% 100%
Q12WH8 Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M) 36% 100%
Q18KN8 Haloquadratum walsbyi (strain DSM 16790 / HBSQ001) 36% 100%
Q3ZBL5 Bos taurus 45% 73%
Q466V4 Methanosarcina barkeri (strain Fusaro / DSM 804) 34% 100%
Q4Q751 Leishmania major 35% 79%
Q5JDB8 Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) 39% 100%
Q5V1D3 Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) 39% 100%
Q60363 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) 37% 100%
Q877G5 Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) 40% 100%
Q8Q0M4 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) 34% 100%
Q8R2Y8 Mus musculus 47% 72%
Q8TKX4 Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) 34% 100%
Q8TV04 Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938) 34% 100%
Q8U0N0 Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) 40% 100%
Q8ZYM4 Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2) 40% 100%
Q976I0 Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) 41% 100%
Q97CB4 Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1) 34% 100%
Q980V1 Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) 41% 100%
Q9HLW6 Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165) 36% 100%
Q9J5H2 Fowlpox virus (strain NVSL) 26% 100%
Q9V108 Pyrococcus abyssi (strain GE5 / Orsay) 40% 100%
Q9Y3E5 Homo sapiens 45% 73%
Q9YBD6 Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) 39% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS