LeishMANIAdb
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Putative arginine N-methyltransferase, type III

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative arginine N-methyltransferase, type III
Gene product:
arginine N-methyltransferase - type III - putative
Species:
Leishmania infantum
UniProt:
A4HSX9_LEIIN
TriTrypDb:
LINF_060014400
Length:
438

Annotations

Annotations by Jardim et al.

Protein modification, arginine N-methyltransferase, type III PRMT7

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HSX9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSX9

Function

Biological processes
Term Name Level Count
GO:0006479 protein methylation 4 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0008213 protein alkylation 5 12
GO:0009987 cellular process 1 12
GO:0018193 peptidyl-amino acid modification 5 12
GO:0018195 peptidyl-arginine modification 6 12
GO:0018216 peptidyl-arginine methylation 5 12
GO:0019538 protein metabolic process 3 12
GO:0032259 methylation 2 12
GO:0036211 protein modification process 4 12
GO:0043170 macromolecule metabolic process 3 12
GO:0043412 macromolecule modification 4 12
GO:0043414 macromolecule methylation 3 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0044260 obsolete cellular macromolecule metabolic process 3 12
GO:0071704 organic substance metabolic process 2 12
GO:1901564 organonitrogen compound metabolic process 3 12
GO:0016570 histone modification 5 1
GO:0016571 histone methylation 5 1
GO:0034969 histone arginine methylation 6 1
GO:0035246 peptidyl-arginine N-methylation 6 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0008168 methyltransferase activity 4 12
GO:0008170 N-methyltransferase activity 5 12
GO:0008276 protein methyltransferase activity 3 12
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 5 12
GO:0016273 arginine N-methyltransferase activity 6 12
GO:0016274 protein-arginine N-methyltransferase activity 4 12
GO:0016740 transferase activity 2 12
GO:0016741 transferase activity, transferring one-carbon groups 3 12
GO:0140096 catalytic activity, acting on a protein 2 12
GO:0035241 protein-arginine omega-N monomethyltransferase activity 5 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 290 292 PF00675 0.314
CLV_NRD_NRD_1 424 426 PF00675 0.503
CLV_NRD_NRD_1 433 435 PF00675 0.488
CLV_NRD_NRD_1 87 89 PF00675 0.501
CLV_PCSK_FUR_1 85 89 PF00082 0.443
CLV_PCSK_KEX2_1 290 292 PF00082 0.281
CLV_PCSK_KEX2_1 307 309 PF00082 0.411
CLV_PCSK_KEX2_1 423 425 PF00082 0.501
CLV_PCSK_KEX2_1 433 435 PF00082 0.480
CLV_PCSK_KEX2_1 87 89 PF00082 0.451
CLV_PCSK_PC1ET2_1 307 309 PF00082 0.521
CLV_PCSK_PC1ET2_1 423 425 PF00082 0.501
CLV_PCSK_SKI1_1 227 231 PF00082 0.361
CLV_PCSK_SKI1_1 312 316 PF00082 0.509
DEG_Kelch_Keap1_1 380 385 PF01344 0.356
DOC_CYCLIN_yCln2_LP_2 292 298 PF00134 0.297
DOC_MAPK_DCC_7 190 200 PF00069 0.436
DOC_MAPK_DCC_7 291 301 PF00069 0.442
DOC_MAPK_gen_1 290 298 PF00069 0.280
DOC_MAPK_gen_1 312 319 PF00069 0.466
DOC_PP2B_PxIxI_1 195 201 PF00149 0.454
DOC_PP4_FxxP_1 34 37 PF00568 0.418
DOC_USP7_MATH_1 124 128 PF00917 0.524
DOC_USP7_MATH_1 19 23 PF00917 0.659
DOC_USP7_MATH_1 253 257 PF00917 0.482
DOC_USP7_MATH_1 321 325 PF00917 0.312
DOC_USP7_MATH_1 392 396 PF00917 0.473
DOC_USP7_MATH_1 43 47 PF00917 0.571
DOC_USP7_UBL2_3 145 149 PF12436 0.479
DOC_WW_Pin1_4 185 190 PF00397 0.485
DOC_WW_Pin1_4 372 377 PF00397 0.405
LIG_14-3-3_CanoR_1 283 288 PF00244 0.324
LIG_14-3-3_CanoR_1 308 312 PF00244 0.507
LIG_14-3-3_CanoR_1 397 403 PF00244 0.406
LIG_14-3-3_CanoR_1 55 61 PF00244 0.578
LIG_Actin_WH2_2 73 89 PF00022 0.392
LIG_BRCT_BRCA1_1 200 204 PF00533 0.423
LIG_BRCT_BRCA1_1 272 276 PF00533 0.314
LIG_BRCT_BRCA1_1 285 289 PF00533 0.320
LIG_BRCT_BRCA1_1 385 389 PF00533 0.339
LIG_BRCT_BRCA1_2 272 278 PF00533 0.310
LIG_Clathr_ClatBox_1 298 302 PF01394 0.286
LIG_EVH1_1 192 196 PF00568 0.479
LIG_FHA_1 168 174 PF00498 0.491
LIG_FHA_1 204 210 PF00498 0.289
LIG_FHA_1 226 232 PF00498 0.343
LIG_FHA_1 269 275 PF00498 0.328
LIG_FHA_2 186 192 PF00498 0.501
LIG_FHA_2 335 341 PF00498 0.368
LIG_FHA_2 343 349 PF00498 0.351
LIG_FHA_2 425 431 PF00498 0.558
LIG_GBD_Chelix_1 199 207 PF00786 0.254
LIG_LIR_Apic_2 31 37 PF02991 0.447
LIG_LIR_Gen_1 112 123 PF02991 0.401
LIG_LIR_Gen_1 99 109 PF02991 0.345
LIG_LIR_Nem_3 112 118 PF02991 0.405
LIG_LIR_Nem_3 201 207 PF02991 0.494
LIG_LIR_Nem_3 255 260 PF02991 0.348
LIG_LIR_Nem_3 286 292 PF02991 0.314
LIG_LIR_Nem_3 309 314 PF02991 0.441
LIG_Pex14_2 311 315 PF04695 0.482
LIG_Pex14_2 72 76 PF04695 0.392
LIG_SH2_CRK 115 119 PF00017 0.460
LIG_SH2_CRK 239 243 PF00017 0.275
LIG_SH2_GRB2like 114 117 PF00017 0.450
LIG_SH2_STAT3 60 63 PF00017 0.575
LIG_SH2_STAT5 216 219 PF00017 0.280
LIG_SH2_STAT5 404 407 PF00017 0.493
LIG_SH3_1 190 196 PF00018 0.377
LIG_SH3_3 190 196 PF00018 0.440
LIG_SH3_3 314 320 PF00018 0.401
LIG_SUMO_SIM_par_1 150 155 PF11976 0.412
LIG_SUMO_SIM_par_1 205 212 PF11976 0.335
LIG_SUMO_SIM_par_1 297 302 PF11976 0.303
LIG_UBA3_1 138 145 PF00899 0.479
MOD_CDK_SPK_2 185 190 PF00069 0.436
MOD_CK1_1 3 9 PF00069 0.670
MOD_CK1_1 380 386 PF00069 0.486
MOD_CK2_1 334 340 PF00069 0.373
MOD_CK2_1 342 348 PF00069 0.398
MOD_CK2_1 379 385 PF00069 0.497
MOD_CK2_1 424 430 PF00069 0.583
MOD_GlcNHglycan 126 129 PF01048 0.261
MOD_GlcNHglycan 135 138 PF01048 0.224
MOD_GlcNHglycan 211 214 PF01048 0.275
MOD_GlcNHglycan 323 326 PF01048 0.310
MOD_GlcNHglycan 408 411 PF01048 0.561
MOD_GlcNHglycan 56 59 PF01048 0.755
MOD_GlcNHglycan 6 9 PF01048 0.649
MOD_GSK3_1 13 20 PF00069 0.663
MOD_GSK3_1 133 140 PF00069 0.426
MOD_GSK3_1 155 162 PF00069 0.524
MOD_GSK3_1 163 170 PF00069 0.455
MOD_GSK3_1 181 188 PF00069 0.433
MOD_GSK3_1 194 201 PF00069 0.475
MOD_GSK3_1 270 277 PF00069 0.395
MOD_GSK3_1 303 310 PF00069 0.394
MOD_GSK3_1 319 326 PF00069 0.351
MOD_GSK3_1 368 375 PF00069 0.429
MOD_GSK3_1 379 386 PF00069 0.329
MOD_GSK3_1 398 405 PF00069 0.518
MOD_N-GLC_1 13 18 PF02516 0.650
MOD_N-GLC_1 352 357 PF02516 0.483
MOD_NEK2_1 163 168 PF00069 0.515
MOD_NEK2_1 209 214 PF00069 0.275
MOD_NEK2_1 268 273 PF00069 0.354
MOD_NEK2_1 282 287 PF00069 0.292
MOD_NEK2_1 303 308 PF00069 0.346
MOD_NEK2_1 379 384 PF00069 0.501
MOD_NEK2_1 402 407 PF00069 0.469
MOD_NEK2_2 347 352 PF00069 0.391
MOD_PK_1 283 289 PF00069 0.308
MOD_PKA_1 12 18 PF00069 0.698
MOD_PKA_1 307 313 PF00069 0.489
MOD_PKA_1 4 10 PF00069 0.662
MOD_PKA_1 424 430 PF00069 0.505
MOD_PKA_2 282 288 PF00069 0.307
MOD_PKA_2 307 313 PF00069 0.489
MOD_PKA_2 424 430 PF00069 0.633
MOD_PKA_2 54 60 PF00069 0.600
MOD_Plk_1 260 266 PF00069 0.365
MOD_Plk_1 269 275 PF00069 0.328
MOD_Plk_1 347 353 PF00069 0.512
MOD_Plk_1 43 49 PF00069 0.520
MOD_Plk_4 137 143 PF00069 0.424
MOD_Plk_4 194 200 PF00069 0.472
MOD_Plk_4 203 209 PF00069 0.227
MOD_Plk_4 270 276 PF00069 0.346
MOD_ProDKin_1 185 191 PF00069 0.485
MOD_ProDKin_1 372 378 PF00069 0.406
MOD_SUMO_rev_2 302 309 PF00179 0.409
TRG_DiLeu_BaEn_2 76 82 PF01217 0.506
TRG_DiLeu_BaLyEn_6 220 225 PF01217 0.339
TRG_DiLeu_BaLyEn_6 294 299 PF01217 0.377
TRG_ENDOCYTIC_2 102 105 PF00928 0.358
TRG_ENDOCYTIC_2 114 117 PF00928 0.349
TRG_ER_diArg_1 221 224 PF00400 0.411
TRG_ER_diArg_1 289 291 PF00400 0.322
TRG_ER_diArg_1 433 435 PF00400 0.738
TRG_ER_diArg_1 85 88 PF00400 0.449
TRG_Pf-PMV_PEXEL_1 190 194 PF00026 0.177
TRG_Pf-PMV_PEXEL_1 290 294 PF00026 0.279

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDL4 Leptomonas seymouri 75% 100%
A0A0S4IRB2 Bodo saltans 58% 98%
A0A1X0NKR3 Trypanosomatidae 58% 91%
A0A3S7WPK3 Leishmania donovani 100% 100%
A0A422NZF0 Trypanosoma rangeli 59% 100%
A2YPT7 Oryza sativa subsp. indica 29% 83%
A4H4P9 Leishmania braziliensis 83% 100%
B0W3L6 Culex quinquefasciatus 24% 73%
C9ZTK9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 55% 100%
E9AKW5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q174R2 Aedes aegypti 24% 74%
Q4AE70 Rattus norvegicus 27% 67%
Q4QIZ0 Leishmania major 96% 100%
Q582G4 Trypanosoma brucei brucei (strain 927/4 GUTat10.1) 54% 100%
Q5XK84 Xenopus laevis 27% 73%
Q7Q2B7 Anopheles gambiae 24% 70%
Q7XI75 Oryza sativa subsp. japonica 29% 83%
Q86X55 Homo sapiens 27% 72%
Q9WVG6 Mus musculus 27% 72%
V5BT47 Trypanosoma cruzi 58% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS