Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HSW6_LEIIN

TriTrypDb:

LINF_060013100

Length:

933

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HSW6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSW6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	296	300	PF00656	0.482
CLV_C14_Caspase3-7	376	380	PF00656	0.657
CLV_C14_Caspase3-7	449	453	PF00656	0.596
CLV_C14_Caspase3-7	681	685	PF00656	0.484
CLV_NRD_NRD_1	188	190	PF00675	0.679
CLV_NRD_NRD_1	213	215	PF00675	0.569
CLV_NRD_NRD_1	225	227	PF00675	0.577
CLV_NRD_NRD_1	357	359	PF00675	0.599
CLV_NRD_NRD_1	425	427	PF00675	0.622
CLV_NRD_NRD_1	464	466	PF00675	0.577
CLV_NRD_NRD_1	483	485	PF00675	0.477
CLV_NRD_NRD_1	523	525	PF00675	0.524
CLV_NRD_NRD_1	609	611	PF00675	0.513
CLV_NRD_NRD_1	682	684	PF00675	0.522
CLV_NRD_NRD_1	706	708	PF00675	0.520
CLV_NRD_NRD_1	758	760	PF00675	0.482
CLV_NRD_NRD_1	913	915	PF00675	0.522
CLV_PCSK_KEX2_1	188	190	PF00082	0.679
CLV_PCSK_KEX2_1	212	214	PF00082	0.572
CLV_PCSK_KEX2_1	224	226	PF00082	0.584
CLV_PCSK_KEX2_1	357	359	PF00082	0.599
CLV_PCSK_KEX2_1	425	427	PF00082	0.622
CLV_PCSK_KEX2_1	446	448	PF00082	0.653
CLV_PCSK_KEX2_1	464	466	PF00082	0.445
CLV_PCSK_KEX2_1	483	485	PF00082	0.477
CLV_PCSK_KEX2_1	523	525	PF00082	0.527
CLV_PCSK_KEX2_1	609	611	PF00082	0.513
CLV_PCSK_KEX2_1	682	684	PF00082	0.522
CLV_PCSK_KEX2_1	705	707	PF00082	0.522
CLV_PCSK_KEX2_1	758	760	PF00082	0.482
CLV_PCSK_KEX2_1	913	915	PF00082	0.522
CLV_PCSK_PC1ET2_1	446	448	PF00082	0.649
CLV_PCSK_SKI1_1	547	551	PF00082	0.419
CLV_PCSK_SKI1_1	707	711	PF00082	0.474
CLV_PCSK_SKI1_1	876	880	PF00082	0.571
DEG_APCC_DBOX_1	693	701	PF00400	0.549
DEG_APCC_DBOX_1	791	799	PF00400	0.468
DEG_SCF_FBW7_1	436	442	PF00400	0.570
DEG_SCF_TRCP1_1	167	172	PF00400	0.644
DEG_SPOP_SBC_1	5	9	PF00917	0.572
DEG_SPOP_SBC_1	882	886	PF00917	0.651
DOC_ANK_TNKS_1	225	232	PF00023	0.627
DOC_CKS1_1	436	441	PF01111	0.570
DOC_CYCLIN_RxL_1	541	553	PF00134	0.413
DOC_CYCLIN_yCln2_LP_2	18	24	PF00134	0.679
DOC_MAPK_DCC_7	426	436	PF00069	0.613
DOC_MAPK_gen_1	790	797	PF00069	0.463
DOC_PP2B_LxvP_1	820	823	PF13499	0.584
DOC_SPAK_OSR1_1	568	572	PF12202	0.472
DOC_USP7_MATH_1	155	159	PF00917	0.611
DOC_USP7_MATH_1	256	260	PF00917	0.571
DOC_USP7_MATH_1	439	443	PF00917	0.654
DOC_USP7_MATH_1	474	478	PF00917	0.581
DOC_USP7_MATH_1	5	9	PF00917	0.565
DOC_USP7_MATH_1	514	518	PF00917	0.542
DOC_USP7_MATH_1	533	537	PF00917	0.401
DOC_USP7_MATH_1	621	625	PF00917	0.589
DOC_USP7_MATH_1	630	634	PF00917	0.559
DOC_USP7_MATH_1	776	780	PF00917	0.509
DOC_USP7_MATH_1	81	85	PF00917	0.644
DOC_USP7_MATH_1	843	847	PF00917	0.491
DOC_USP7_MATH_1	882	886	PF00917	0.651
DOC_USP7_UBL2_3	790	794	PF12436	0.461
DOC_WW_Pin1_4	189	194	PF00397	0.649
DOC_WW_Pin1_4	20	25	PF00397	0.675
DOC_WW_Pin1_4	238	243	PF00397	0.599
DOC_WW_Pin1_4	322	327	PF00397	0.843
DOC_WW_Pin1_4	435	440	PF00397	0.567
DOC_WW_Pin1_4	617	622	PF00397	0.593
DOC_WW_Pin1_4	631	636	PF00397	0.546
DOC_WW_Pin1_4	637	642	PF00397	0.639
DOC_WW_Pin1_4	94	99	PF00397	0.686
LIG_14-3-3_CanoR_1	170	178	PF00244	0.671
LIG_14-3-3_CanoR_1	200	208	PF00244	0.534
LIG_14-3-3_CanoR_1	284	289	PF00244	0.582
LIG_14-3-3_CanoR_1	290	298	PF00244	0.494
LIG_14-3-3_CanoR_1	435	439	PF00244	0.592
LIG_14-3-3_CanoR_1	447	456	PF00244	0.518
LIG_14-3-3_CanoR_1	617	621	PF00244	0.551
LIG_14-3-3_CanoR_1	727	733	PF00244	0.484
LIG_AP2alpha_2	415	417	PF02296	0.562
LIG_APCC_ABBA_1	576	581	PF00400	0.466
LIG_BIR_III_4	272	276	PF00653	0.558
LIG_BIR_III_4	478	482	PF00653	0.646
LIG_BRCT_BRCA1_1	240	244	PF00533	0.591
LIG_Clathr_ClatBox_1	675	679	PF01394	0.487
LIG_Clathr_ClatBox_1	736	740	PF01394	0.364
LIG_FHA_1	194	200	PF00498	0.613
LIG_FHA_1	203	209	PF00498	0.514
LIG_FHA_1	322	328	PF00498	0.838
LIG_FHA_1	396	402	PF00498	0.624
LIG_FHA_1	504	510	PF00498	0.605
LIG_FHA_1	513	519	PF00498	0.519
LIG_FHA_1	544	550	PF00498	0.540
LIG_FHA_1	654	660	PF00498	0.564
LIG_FHA_1	822	828	PF00498	0.617
LIG_FHA_1	90	96	PF00498	0.538
LIG_FHA_2	502	508	PF00498	0.605
LIG_FHA_2	598	604	PF00498	0.440
LIG_FHA_2	824	830	PF00498	0.631
LIG_GBD_Chelix_1	737	745	PF00786	0.368
LIG_Integrin_RGD_1	361	363	PF01839	0.566
LIG_Integrin_RGD_1	867	869	PF01839	0.621
LIG_LIR_Apic_2	11	17	PF02991	0.669
LIG_PTAP_UEV_1	226	231	PF05743	0.569
LIG_SH2_GRB2like	851	854	PF00017	0.562
LIG_SH2_NCK_1	851	855	PF00017	0.649
LIG_SH2_SRC	849	852	PF00017	0.585
LIG_SH2_STAT5	579	582	PF00017	0.566
LIG_SH3_1	224	230	PF00018	0.647
LIG_SH3_1	50	56	PF00018	0.616
LIG_SH3_2	641	646	PF14604	0.668
LIG_SH3_3	18	24	PF00018	0.704
LIG_SH3_3	187	193	PF00018	0.615
LIG_SH3_3	224	230	PF00018	0.647
LIG_SH3_3	236	242	PF00018	0.536
LIG_SH3_3	50	56	PF00018	0.674
LIG_SH3_3	542	548	PF00018	0.542
LIG_SH3_3	61	67	PF00018	0.614
LIG_SH3_3	638	644	PF00018	0.673
LIG_SH3_3	92	98	PF00018	0.632
LIG_SH3_3	99	105	PF00018	0.628
LIG_SUMO_SIM_anti_2	656	661	PF11976	0.550
LIG_SUMO_SIM_anti_2	793	799	PF11976	0.468
LIG_SUMO_SIM_anti_2	824	829	PF11976	0.629
LIG_SUMO_SIM_par_1	653	661	PF11976	0.532
LIG_SUMO_SIM_par_1	734	740	PF11976	0.364
LIG_SUMO_SIM_par_1	823	829	PF11976	0.625
LIG_TRAF2_1	330	333	PF00917	0.640
LIG_TRAF2_1	411	414	PF00917	0.550
LIG_TRAF2_1	527	530	PF00917	0.506
LIG_TRAF2_1	600	603	PF00917	0.434
LIG_TRAF2_1	74	77	PF00917	0.664
LIG_TRAF2_1	918	921	PF00917	0.578
LIG_WRC_WIRS_1	554	559	PF05994	0.464
LIG_WW_2	53	56	PF00397	0.642
MOD_CDK_SPxxK_3	322	329	PF00069	0.644
MOD_CK1_1	143	149	PF00069	0.666
MOD_CK1_1	168	174	PF00069	0.648
MOD_CK1_1	183	189	PF00069	0.567
MOD_CK1_1	198	204	PF00069	0.523
MOD_CK1_1	243	249	PF00069	0.633
MOD_CK1_1	259	265	PF00069	0.486
MOD_CK1_1	316	322	PF00069	0.680
MOD_CK1_1	372	378	PF00069	0.690
MOD_CK1_1	387	393	PF00069	0.450
MOD_CK1_1	4	10	PF00069	0.668
MOD_CK1_1	437	443	PF00069	0.644
MOD_CK1_1	503	509	PF00069	0.633
MOD_CK1_1	653	659	PF00069	0.561
MOD_CK1_1	731	737	PF00069	0.441
MOD_CK1_1	793	799	PF00069	0.497
MOD_CK1_1	885	891	PF00069	0.615
MOD_CK2_1	290	296	PF00069	0.504
MOD_CK2_1	327	333	PF00069	0.637
MOD_CK2_1	514	520	PF00069	0.515
MOD_CK2_1	597	603	PF00069	0.439
MOD_CK2_1	793	799	PF00069	0.497
MOD_Cter_Amidation	186	189	PF01082	0.592
MOD_DYRK1A_RPxSP_1	189	193	PF00069	0.650
MOD_DYRK1A_RPxSP_1	20	24	PF00069	0.676
MOD_DYRK1A_RPxSP_1	617	621	PF00069	0.551
MOD_GlcNHglycan	125	128	PF01048	0.721
MOD_GlcNHglycan	142	145	PF01048	0.548
MOD_GlcNHglycan	157	161	PF01048	0.546
MOD_GlcNHglycan	165	170	PF01048	0.621
MOD_GlcNHglycan	235	238	PF01048	0.649
MOD_GlcNHglycan	292	295	PF01048	0.546
MOD_GlcNHglycan	3	6	PF01048	0.617
MOD_GlcNHglycan	379	382	PF01048	0.675
MOD_GlcNHglycan	441	444	PF01048	0.662
MOD_GlcNHglycan	448	451	PF01048	0.582
MOD_GlcNHglycan	470	473	PF01048	0.556
MOD_GlcNHglycan	623	626	PF01048	0.593
MOD_GlcNHglycan	829	833	PF01048	0.640
MOD_GlcNHglycan	845	848	PF01048	0.457
MOD_GlcNHglycan	887	890	PF01048	0.638
MOD_GlcNHglycan	899	902	PF01048	0.562
MOD_GSK3_1	1	8	PF00069	0.643
MOD_GSK3_1	123	130	PF00069	0.685
MOD_GSK3_1	139	146	PF00069	0.579
MOD_GSK3_1	165	172	PF00069	0.639
MOD_GSK3_1	176	183	PF00069	0.603
MOD_GSK3_1	189	196	PF00069	0.590
MOD_GSK3_1	198	205	PF00069	0.575
MOD_GSK3_1	238	245	PF00069	0.645
MOD_GSK3_1	313	320	PF00069	0.653
MOD_GSK3_1	364	371	PF00069	0.716
MOD_GSK3_1	373	380	PF00069	0.703
MOD_GSK3_1	434	441	PF00069	0.680
MOD_GSK3_1	442	449	PF00069	0.609
MOD_GSK3_1	501	508	PF00069	0.605
MOD_GSK3_1	512	519	PF00069	0.539
MOD_GSK3_1	617	624	PF00069	0.600
MOD_GSK3_1	658	665	PF00069	0.517
MOD_GSK3_1	81	88	PF00069	0.677
MOD_GSK3_1	881	888	PF00069	0.650
MOD_N-GLC_1	852	857	PF02516	0.569
MOD_NEK2_1	1	6	PF00069	0.646
MOD_NEK2_1	178	183	PF00069	0.703
MOD_NEK2_1	244	249	PF00069	0.631
MOD_NEK2_1	338	343	PF00069	0.596
MOD_NEK2_1	368	373	PF00069	0.644
MOD_NEK2_1	434	439	PF00069	0.678
MOD_NEK2_1	89	94	PF00069	0.541
MOD_NEK2_1	923	928	PF00069	0.580
MOD_NEK2_2	364	369	PF00069	0.663
MOD_PIKK_1	369	375	PF00454	0.644
MOD_PIKK_1	501	507	PF00454	0.619
MOD_PIKK_1	571	577	PF00454	0.438
MOD_PIKK_1	647	653	PF00454	0.666
MOD_PIKK_1	776	782	PF00454	0.510
MOD_PIKK_1	867	873	PF00454	0.598
MOD_PKA_1	225	231	PF00069	0.571
MOD_PKA_1	446	452	PF00069	0.627
MOD_PKA_2	169	175	PF00069	0.668
MOD_PKA_2	199	205	PF00069	0.535
MOD_PKA_2	225	231	PF00069	0.571
MOD_PKA_2	313	319	PF00069	0.584
MOD_PKA_2	328	334	PF00069	0.576
MOD_PKA_2	434	440	PF00069	0.637
MOD_PKA_2	446	452	PF00069	0.553
MOD_PKA_2	498	504	PF00069	0.630
MOD_PKA_2	616	622	PF00069	0.554
MOD_PKA_2	728	734	PF00069	0.446
MOD_PKA_2	923	929	PF00069	0.582
MOD_PKB_1	282	290	PF00069	0.639
MOD_Plk_1	146	152	PF00069	0.619
MOD_Plk_1	156	162	PF00069	0.628
MOD_Plk_1	203	209	PF00069	0.598
MOD_Plk_1	364	370	PF00069	0.662
MOD_Plk_1	384	390	PF00069	0.470
MOD_Plk_1	752	758	PF00069	0.501
MOD_Plk_2-3	553	559	PF00069	0.465
MOD_Plk_4	41	47	PF00069	0.634
MOD_Plk_4	658	664	PF00069	0.602
MOD_Plk_4	666	672	PF00069	0.564
MOD_Plk_4	793	799	PF00069	0.468
MOD_Plk_4	823	829	PF00069	0.625
MOD_ProDKin_1	189	195	PF00069	0.649
MOD_ProDKin_1	20	26	PF00069	0.672
MOD_ProDKin_1	238	244	PF00069	0.598
MOD_ProDKin_1	322	328	PF00069	0.845
MOD_ProDKin_1	435	441	PF00069	0.570
MOD_ProDKin_1	617	623	PF00069	0.596
MOD_ProDKin_1	631	637	PF00069	0.547
MOD_ProDKin_1	94	100	PF00069	0.686
TRG_DiLeu_BaEn_4	520	526	PF01217	0.448
TRG_DiLeu_BaLyEn_6	429	434	PF01217	0.661
TRG_DiLeu_BaLyEn_6	545	550	PF01217	0.525
TRG_DiLeu_BaLyEn_6	693	698	PF01217	0.549
TRG_ER_diArg_1	188	190	PF00400	0.679
TRG_ER_diArg_1	211	214	PF00400	0.568
TRG_ER_diArg_1	224	226	PF00400	0.575
TRG_ER_diArg_1	276	279	PF00400	0.654
TRG_ER_diArg_1	281	284	PF00400	0.631
TRG_ER_diArg_1	356	358	PF00400	0.567
TRG_ER_diArg_1	464	466	PF00400	0.577
TRG_ER_diArg_1	523	525	PF00400	0.527
TRG_ER_diArg_1	583	586	PF00400	0.508
TRG_ER_diArg_1	608	610	PF00400	0.437
TRG_ER_diArg_1	704	707	PF00400	0.500
TRG_ER_diArg_1	726	729	PF00400	0.589
TRG_ER_diArg_1	913	915	PF00400	0.522
TRG_NES_CRM1_1	786	801	PF08389	0.502
TRG_Pf-PMV_PEXEL_1	523	528	PF00026	0.439
TRG_Pf-PMV_PEXEL_1	547	551	PF00026	0.419
TRG_Pf-PMV_PEXEL_1	759	763	PF00026	0.467

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WPI2	Leishmania donovani	100%	88%
A4H4N8	Leishmania braziliensis	62%	100%
E9AKV3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QJ03	Leishmania major	85%	100%