Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HSW0_LEIIN

TriTrypDb:

LINF_060012500

Length:

403

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0031390	Ctf18 RFC-like complex	3	5
GO:0032991	protein-containing complex	1	5
GO:0140513	nuclear protein-containing complex	2	5

Expansion

Sequence features

A4HSW0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSW0

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	5
GO:0007062	sister chromatid cohesion	3	5
GO:0007064	mitotic sister chromatid cohesion	4	5
GO:0009987	cellular process	1	5
GO:0016043	cellular component organization	3	5
GO:0022402	cell cycle process	2	5
GO:0051276	chromosome organization	5	5
GO:0071840	cellular component organization or biogenesis	2	5
GO:1903047	mitotic cell cycle process	3	5

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	261	265	PF00656	0.599
CLV_C14_Caspase3-7	349	353	PF00656	0.632
CLV_NRD_NRD_1	144	146	PF00675	0.622
CLV_NRD_NRD_1	158	160	PF00675	0.668
CLV_NRD_NRD_1	169	171	PF00675	0.398
CLV_NRD_NRD_1	222	224	PF00675	0.565
CLV_NRD_NRD_1	226	228	PF00675	0.567
CLV_NRD_NRD_1	39	41	PF00675	0.715
CLV_NRD_NRD_1	43	45	PF00675	0.653
CLV_NRD_NRD_1	48	50	PF00675	0.607
CLV_PCSK_FUR_1	44	48	PF00082	0.571
CLV_PCSK_KEX2_1	144	146	PF00082	0.622
CLV_PCSK_KEX2_1	158	160	PF00082	0.668
CLV_PCSK_KEX2_1	169	171	PF00082	0.443
CLV_PCSK_KEX2_1	189	191	PF00082	0.338
CLV_PCSK_KEX2_1	208	210	PF00082	0.236
CLV_PCSK_KEX2_1	226	228	PF00082	0.464
CLV_PCSK_KEX2_1	338	340	PF00082	0.711
CLV_PCSK_KEX2_1	38	40	PF00082	0.722
CLV_PCSK_KEX2_1	43	45	PF00082	0.637
CLV_PCSK_KEX2_1	46	48	PF00082	0.615
CLV_PCSK_PC1ET2_1	189	191	PF00082	0.338
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.231
CLV_PCSK_PC1ET2_1	338	340	PF00082	0.711
CLV_PCSK_PC7_1	185	191	PF00082	0.337
CLV_PCSK_PC7_1	204	210	PF00082	0.362
CLV_PCSK_PC7_1	39	45	PF00082	0.604
CLV_PCSK_SKI1_1	236	240	PF00082	0.687
CLV_PCSK_SKI1_1	242	246	PF00082	0.663
CLV_PCSK_SKI1_1	33	37	PF00082	0.560
DEG_COP1_1	360	370	PF00400	0.556
DEG_Nend_Nbox_1	1	3	PF02207	0.553
DEG_SCF_FBW7_1	268	275	PF00400	0.516
DEG_SPOP_SBC_1	133	137	PF00917	0.693
DEG_SPOP_SBC_1	75	79	PF00917	0.627
DOC_MAPK_gen_1	169	176	PF00069	0.349
DOC_MAPK_gen_1	189	195	PF00069	0.338
DOC_MAPK_gen_1	208	214	PF00069	0.231
DOC_MAPK_MEF2A_6	169	178	PF00069	0.412
DOC_MAPK_RevD_3	176	190	PF00069	0.337
DOC_PP4_FxxP_1	207	210	PF00568	0.462
DOC_USP7_MATH_1	132	136	PF00917	0.747
DOC_USP7_MATH_1	138	142	PF00917	0.694
DOC_USP7_MATH_1	165	169	PF00917	0.369
DOC_USP7_MATH_1	314	318	PF00917	0.673
DOC_USP7_MATH_1	321	325	PF00917	0.732
DOC_USP7_MATH_1	51	55	PF00917	0.652
DOC_USP7_MATH_1	76	80	PF00917	0.623
DOC_WW_Pin1_4	145	150	PF00397	0.719
DOC_WW_Pin1_4	153	158	PF00397	0.767
DOC_WW_Pin1_4	161	166	PF00397	0.342
DOC_WW_Pin1_4	215	220	PF00397	0.429
DOC_WW_Pin1_4	264	269	PF00397	0.668
DOC_WW_Pin1_4	354	359	PF00397	0.761
LIG_14-3-3_CanoR_1	144	149	PF00244	0.747
LIG_14-3-3_CanoR_1	190	194	PF00244	0.394
LIG_14-3-3_CanoR_1	204	208	PF00244	0.281
LIG_Actin_WH2_2	15	32	PF00022	0.510
LIG_AP2alpha_1	295	299	PF02296	0.651
LIG_BRCT_BRCA1_1	390	394	PF00533	0.436
LIG_CtBP_PxDLS_1	71	75	PF00389	0.545
LIG_eIF4E_1	379	385	PF01652	0.457
LIG_FHA_1	190	196	PF00498	0.412
LIG_FHA_1	272	278	PF00498	0.537
LIG_FHA_2	347	353	PF00498	0.653
LIG_FHA_2	63	69	PF00498	0.617
LIG_FHA_2	92	98	PF00498	0.666
LIG_LIR_Apic_2	205	210	PF02991	0.459
LIG_LIR_Gen_1	381	388	PF02991	0.435
LIG_LIR_Nem_3	377	382	PF02991	0.553
LIG_Pex14_2	207	211	PF04695	0.412
LIG_Pex14_2	295	299	PF04695	0.651
LIG_SH2_NCK_1	382	386	PF00017	0.483
LIG_SH3_1	159	165	PF00018	0.672
LIG_SH3_2	154	159	PF14604	0.653
LIG_SH3_3	146	152	PF00018	0.775
LIG_SH3_3	154	160	PF00018	0.761
LIG_SH3_3	171	177	PF00018	0.224
LIG_SH3_3	226	232	PF00018	0.527
LIG_SH3_3	235	241	PF00018	0.588
LIG_SH3_3	352	358	PF00018	0.679
LIG_UBA3_1	15	21	PF00899	0.564
MOD_CDC14_SPxK_1	156	159	PF00782	0.656
MOD_CDK_SPK_2	153	158	PF00069	0.652
MOD_CDK_SPxK_1	153	159	PF00069	0.653
MOD_CDK_SPxK_1	215	221	PF00069	0.412
MOD_CK1_1	123	129	PF00069	0.679
MOD_CK1_1	153	159	PF00069	0.632
MOD_CK1_1	203	209	PF00069	0.412
MOD_CK1_1	290	296	PF00069	0.677
MOD_CK1_1	324	330	PF00069	0.731
MOD_CK1_1	357	363	PF00069	0.738
MOD_CK1_1	79	85	PF00069	0.663
MOD_CK1_1	87	93	PF00069	0.649
MOD_CK2_1	39	45	PF00069	0.579
MOD_DYRK1A_RPxSP_1	161	165	PF00069	0.362
MOD_GlcNHglycan	125	128	PF01048	0.705
MOD_GlcNHglycan	136	139	PF01048	0.656
MOD_GlcNHglycan	140	143	PF01048	0.701
MOD_GlcNHglycan	165	168	PF01048	0.309
MOD_GlcNHglycan	261	264	PF01048	0.609
MOD_GlcNHglycan	305	310	PF01048	0.678
MOD_GlcNHglycan	316	319	PF01048	0.671
MOD_GlcNHglycan	321	324	PF01048	0.660
MOD_GlcNHglycan	326	329	PF01048	0.658
MOD_GlcNHglycan	362	365	PF01048	0.742
MOD_GlcNHglycan	368	371	PF01048	0.681
MOD_GlcNHglycan	53	56	PF01048	0.671
MOD_GlcNHglycan	82	85	PF01048	0.599
MOD_GSK3_1	119	126	PF00069	0.679
MOD_GSK3_1	134	141	PF00069	0.719
MOD_GSK3_1	161	168	PF00069	0.371
MOD_GSK3_1	264	271	PF00069	0.689
MOD_GSK3_1	272	279	PF00069	0.523
MOD_GSK3_1	310	317	PF00069	0.741
MOD_GSK3_1	319	326	PF00069	0.649
MOD_GSK3_1	362	369	PF00069	0.721
MOD_GSK3_1	370	377	PF00069	0.587
MOD_GSK3_1	70	77	PF00069	0.729
MOD_GSK3_1	79	86	PF00069	0.588
MOD_GSK3_1	87	94	PF00069	0.605
MOD_NEK2_1	393	398	PF00069	0.566
MOD_NEK2_2	194	199	PF00069	0.412
MOD_PKA_1	144	150	PF00069	0.688
MOD_PKA_1	189	195	PF00069	0.337
MOD_PKA_1	38	44	PF00069	0.697
MOD_PKA_2	143	149	PF00069	0.721
MOD_PKA_2	189	195	PF00069	0.394
MOD_PKA_2	203	209	PF00069	0.281
MOD_PKA_2	38	44	PF00069	0.697
MOD_PKA_2	388	394	PF00069	0.398
MOD_Plk_1	272	278	PF00069	0.587
MOD_Plk_4	272	278	PF00069	0.587
MOD_Plk_4	290	296	PF00069	0.437
MOD_Plk_4	374	380	PF00069	0.577
MOD_Plk_4	388	394	PF00069	0.387
MOD_Plk_4	70	76	PF00069	0.626
MOD_ProDKin_1	145	151	PF00069	0.721
MOD_ProDKin_1	153	159	PF00069	0.768
MOD_ProDKin_1	161	167	PF00069	0.342
MOD_ProDKin_1	215	221	PF00069	0.429
MOD_ProDKin_1	264	270	PF00069	0.662
MOD_ProDKin_1	354	360	PF00069	0.763
TRG_DiLeu_BaEn_1	240	245	PF01217	0.662
TRG_ENDOCYTIC_2	382	385	PF00928	0.487
TRG_ER_diArg_1	143	145	PF00400	0.712
TRG_ER_diArg_1	157	159	PF00400	0.659
TRG_ER_diArg_1	225	227	PF00400	0.582
TRG_ER_diArg_1	38	40	PF00400	0.722
TRG_ER_diArg_1	46	49	PF00400	0.617
TRG_NLS_Bipartite_1	208	227	PF00514	0.362
TRG_NLS_MonoExtC_3	222	227	PF00514	0.574
TRG_NLS_MonoExtN_4	221	227	PF00514	0.566
TRG_Pf-PMV_PEXEL_1	223	228	PF00026	0.591

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WPI0	Leishmania donovani	97%	99%
A4H4N4	Leishmania braziliensis	63%	94%
E9AKU8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QJ09	Leishmania major	89%	100%