LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HSV7_LEIIN
TriTrypDb:
LINF_060012200
Length:
679

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 2
Forrest at al. (procyclic) yes yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HSV7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSV7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 157 161 PF00656 0.779
CLV_C14_Caspase3-7 201 205 PF00656 0.809
CLV_C14_Caspase3-7 610 614 PF00656 0.822
CLV_NRD_NRD_1 11 13 PF00675 0.761
CLV_NRD_NRD_1 252 254 PF00675 0.730
CLV_NRD_NRD_1 255 257 PF00675 0.722
CLV_NRD_NRD_1 272 274 PF00675 0.572
CLV_NRD_NRD_1 401 403 PF00675 0.793
CLV_NRD_NRD_1 411 413 PF00675 0.717
CLV_NRD_NRD_1 58 60 PF00675 0.717
CLV_PCSK_KEX2_1 11 13 PF00082 0.860
CLV_PCSK_KEX2_1 222 224 PF00082 0.828
CLV_PCSK_KEX2_1 252 254 PF00082 0.730
CLV_PCSK_KEX2_1 272 274 PF00082 0.572
CLV_PCSK_KEX2_1 401 403 PF00082 0.793
CLV_PCSK_KEX2_1 411 413 PF00082 0.717
CLV_PCSK_KEX2_1 58 60 PF00082 0.717
CLV_PCSK_PC1ET2_1 11 13 PF00082 0.751
CLV_PCSK_PC1ET2_1 222 224 PF00082 0.828
CLV_PCSK_SKI1_1 277 281 PF00082 0.869
CLV_PCSK_SKI1_1 339 343 PF00082 0.643
CLV_PCSK_SKI1_1 402 406 PF00082 0.728
CLV_PCSK_SKI1_1 450 454 PF00082 0.790
DEG_APCC_DBOX_1 401 409 PF00400 0.651
DEG_SCF_FBW7_1 517 523 PF00400 0.627
DEG_SPOP_SBC_1 261 265 PF00917 0.712
DEG_SPOP_SBC_1 543 547 PF00917 0.669
DOC_CKS1_1 384 389 PF01111 0.761
DOC_CKS1_1 517 522 PF01111 0.671
DOC_CYCLIN_RxL_1 447 457 PF00134 0.716
DOC_CYCLIN_yClb1_LxF_4 448 453 PF00134 0.701
DOC_CYCLIN_yCln2_LP_2 244 250 PF00134 0.684
DOC_MAPK_FxFP_2 676 679 PF00069 0.751
DOC_MAPK_gen_1 339 345 PF00069 0.655
DOC_MAPK_MEF2A_6 554 563 PF00069 0.803
DOC_PP1_RVXF_1 448 454 PF00149 0.698
DOC_PP2B_LxvP_1 244 247 PF13499 0.690
DOC_PP2B_LxvP_1 308 311 PF13499 0.788
DOC_PP2B_LxvP_1 561 564 PF13499 0.799
DOC_PP4_FxxP_1 404 407 PF00568 0.688
DOC_PP4_FxxP_1 504 507 PF00568 0.647
DOC_PP4_FxxP_1 676 679 PF00568 0.751
DOC_PP4_MxPP_1 433 436 PF00568 0.654
DOC_USP7_MATH_1 104 108 PF00917 0.578
DOC_USP7_MATH_1 117 121 PF00917 0.663
DOC_USP7_MATH_1 18 22 PF00917 0.852
DOC_USP7_MATH_1 212 216 PF00917 0.793
DOC_USP7_MATH_1 240 244 PF00917 0.904
DOC_USP7_MATH_1 261 265 PF00917 0.727
DOC_USP7_MATH_1 325 329 PF00917 0.879
DOC_USP7_MATH_1 33 37 PF00917 0.683
DOC_USP7_MATH_1 330 334 PF00917 0.815
DOC_USP7_MATH_1 41 45 PF00917 0.718
DOC_USP7_MATH_1 507 511 PF00917 0.801
DOC_USP7_MATH_1 51 55 PF00917 0.616
DOC_USP7_MATH_1 512 516 PF00917 0.734
DOC_USP7_MATH_1 525 529 PF00917 0.719
DOC_USP7_MATH_1 534 538 PF00917 0.697
DOC_USP7_MATH_1 548 552 PF00917 0.637
DOC_USP7_MATH_1 581 585 PF00917 0.771
DOC_USP7_MATH_1 617 621 PF00917 0.853
DOC_USP7_MATH_1 90 94 PF00917 0.898
DOC_USP7_UBL2_3 7 11 PF12436 0.743
DOC_WW_Pin1_4 131 136 PF00397 0.807
DOC_WW_Pin1_4 206 211 PF00397 0.839
DOC_WW_Pin1_4 222 227 PF00397 0.606
DOC_WW_Pin1_4 295 300 PF00397 0.738
DOC_WW_Pin1_4 321 326 PF00397 0.882
DOC_WW_Pin1_4 332 337 PF00397 0.710
DOC_WW_Pin1_4 377 382 PF00397 0.797
DOC_WW_Pin1_4 383 388 PF00397 0.779
DOC_WW_Pin1_4 403 408 PF00397 0.585
DOC_WW_Pin1_4 516 521 PF00397 0.715
DOC_WW_Pin1_4 60 65 PF00397 0.826
DOC_WW_Pin1_4 670 675 PF00397 0.638
LIG_14-3-3_CanoR_1 291 299 PF00244 0.668
LIG_14-3-3_CanoR_1 427 433 PF00244 0.732
LIG_BRCT_BRCA1_1 672 676 PF00533 0.735
LIG_CSL_BTD_1 132 135 PF09270 0.822
LIG_FHA_1 197 203 PF00498 0.890
LIG_FHA_1 206 212 PF00498 0.728
LIG_FHA_1 33 39 PF00498 0.833
LIG_FHA_1 435 441 PF00498 0.832
LIG_FHA_1 463 469 PF00498 0.791
LIG_FHA_1 471 477 PF00498 0.740
LIG_FHA_1 517 523 PF00498 0.705
LIG_FHA_1 651 657 PF00498 0.812
LIG_FHA_2 132 138 PF00498 0.822
LIG_FHA_2 157 163 PF00498 0.733
LIG_FHA_2 199 205 PF00498 0.810
LIG_FHA_2 359 365 PF00498 0.815
LIG_FHA_2 644 650 PF00498 0.777
LIG_FHA_2 94 100 PF00498 0.793
LIG_Integrin_isoDGR_2 490 492 PF01839 0.679
LIG_LIR_Apic_2 429 435 PF02991 0.812
LIG_LIR_Apic_2 673 679 PF02991 0.743
LIG_LIR_Nem_3 618 624 PF02991 0.707
LIG_MYND_1 391 395 PF01753 0.638
LIG_Pex14_1 400 404 PF04695 0.677
LIG_SH2_CRK 414 418 PF00017 0.710
LIG_SH2_CRK 432 436 PF00017 0.631
LIG_SH2_CRK 621 625 PF00017 0.811
LIG_SH2_GRB2like 414 417 PF00017 0.718
LIG_SH2_NCK_1 414 418 PF00017 0.854
LIG_SH2_SRC 648 651 PF00017 0.776
LIG_SH2_STAT5 295 298 PF00017 0.759
LIG_SH2_STAT5 414 417 PF00017 0.719
LIG_SH2_STAT5 439 442 PF00017 0.841
LIG_SH2_STAT5 634 637 PF00017 0.742
LIG_SH3_2 64 69 PF14604 0.699
LIG_SH3_3 189 195 PF00018 0.827
LIG_SH3_3 213 219 PF00018 0.770
LIG_SH3_3 293 299 PF00018 0.765
LIG_SH3_3 301 307 PF00018 0.618
LIG_SH3_3 319 325 PF00018 0.848
LIG_SH3_3 342 348 PF00018 0.788
LIG_SH3_3 389 395 PF00018 0.854
LIG_SH3_3 495 501 PF00018 0.684
LIG_SH3_3 609 615 PF00018 0.707
LIG_SH3_3 61 67 PF00018 0.795
LIG_SH3_3 621 627 PF00018 0.807
LIG_SH3_3 659 665 PF00018 0.661
LIG_SH3_3 84 90 PF00018 0.883
LIG_SH3_CIN85_PxpxPR_1 247 252 PF14604 0.776
LIG_SH3_CIN85_PxpxPR_1 307 312 PF14604 0.749
LIG_SxIP_EBH_1 401 414 PF03271 0.833
LIG_TRAF2_1 623 626 PF00917 0.805
LIG_TYR_ITIM 619 624 PF00017 0.811
LIG_WW_3 447 451 PF00397 0.804
MOD_CDC14_SPxK_1 66 69 PF00782 0.698
MOD_CDK_SPK_2 222 227 PF00069 0.851
MOD_CDK_SPK_2 60 65 PF00069 0.799
MOD_CDK_SPxK_1 63 69 PF00069 0.742
MOD_CDK_SPxxK_3 332 339 PF00069 0.749
MOD_CK1_1 127 133 PF00069 0.876
MOD_CK1_1 158 164 PF00069 0.768
MOD_CK1_1 225 231 PF00069 0.800
MOD_CK1_1 239 245 PF00069 0.686
MOD_CK1_1 259 265 PF00069 0.635
MOD_CK1_1 328 334 PF00069 0.892
MOD_CK1_1 550 556 PF00069 0.782
MOD_CK1_1 63 69 PF00069 0.805
MOD_CK1_1 644 650 PF00069 0.777
MOD_CK1_1 93 99 PF00069 0.758
MOD_CK2_1 131 137 PF00069 0.820
MOD_CK2_1 156 162 PF00069 0.760
MOD_CK2_1 358 364 PF00069 0.771
MOD_CK2_1 643 649 PF00069 0.779
MOD_CK2_1 93 99 PF00069 0.859
MOD_GlcNHglycan 20 23 PF01048 0.795
MOD_GlcNHglycan 236 239 PF01048 0.849
MOD_GlcNHglycan 396 399 PF01048 0.648
MOD_GlcNHglycan 49 52 PF01048 0.799
MOD_GlcNHglycan 498 501 PF01048 0.756
MOD_GlcNHglycan 53 56 PF01048 0.766
MOD_GlcNHglycan 531 534 PF01048 0.799
MOD_GlcNHglycan 536 539 PF01048 0.741
MOD_GlcNHglycan 540 543 PF01048 0.667
MOD_GlcNHglycan 615 618 PF01048 0.807
MOD_GSK3_1 127 134 PF00069 0.859
MOD_GSK3_1 172 179 PF00069 0.762
MOD_GSK3_1 236 243 PF00069 0.823
MOD_GSK3_1 252 259 PF00069 0.631
MOD_GSK3_1 260 267 PF00069 0.710
MOD_GSK3_1 268 275 PF00069 0.633
MOD_GSK3_1 286 293 PF00069 0.674
MOD_GSK3_1 321 328 PF00069 0.888
MOD_GSK3_1 358 365 PF00069 0.792
MOD_GSK3_1 43 50 PF00069 0.867
MOD_GSK3_1 453 460 PF00069 0.746
MOD_GSK3_1 512 519 PF00069 0.679
MOD_GSK3_1 525 532 PF00069 0.751
MOD_GSK3_1 534 541 PF00069 0.645
MOD_GSK3_1 543 550 PF00069 0.645
MOD_GSK3_1 582 589 PF00069 0.688
MOD_GSK3_1 613 620 PF00069 0.768
MOD_GSK3_1 644 651 PF00069 0.885
MOD_GSK3_1 90 97 PF00069 0.815
MOD_N-GLC_1 520 525 PF02516 0.663
MOD_N-GLC_1 601 606 PF02516 0.776
MOD_NEK2_1 290 295 PF00069 0.673
MOD_NEK2_1 453 458 PF00069 0.682
MOD_NEK2_1 529 534 PF00069 0.799
MOD_NMyristoyl 1 7 PF02799 0.843
MOD_PIKK_1 147 153 PF00454 0.773
MOD_PIKK_1 172 178 PF00454 0.794
MOD_PIKK_1 181 187 PF00454 0.692
MOD_PIKK_1 272 278 PF00454 0.789
MOD_PIKK_1 290 296 PF00454 0.672
MOD_PIKK_1 386 392 PF00454 0.823
MOD_PIKK_1 553 559 PF00454 0.827
MOD_PIKK_1 91 97 PF00454 0.792
MOD_PK_1 256 262 PF00069 0.885
MOD_PK_1 641 647 PF00069 0.676
MOD_PKA_1 252 258 PF00069 0.885
MOD_PKA_1 272 278 PF00069 0.575
MOD_PKA_2 252 258 PF00069 0.885
MOD_PKA_2 268 274 PF00069 0.632
MOD_PKA_2 290 296 PF00069 0.672
MOD_PKA_2 362 368 PF00069 0.730
MOD_PKA_2 426 432 PF00069 0.845
MOD_PKA_2 47 53 PF00069 0.769
MOD_PKA_2 553 559 PF00069 0.804
MOD_Plk_1 453 459 PF00069 0.604
MOD_Plk_1 617 623 PF00069 0.775
MOD_Plk_1 641 647 PF00069 0.773
MOD_Plk_1 98 104 PF00069 0.857
MOD_Plk_4 428 434 PF00069 0.824
MOD_ProDKin_1 131 137 PF00069 0.808
MOD_ProDKin_1 206 212 PF00069 0.838
MOD_ProDKin_1 222 228 PF00069 0.607
MOD_ProDKin_1 295 301 PF00069 0.738
MOD_ProDKin_1 321 327 PF00069 0.882
MOD_ProDKin_1 332 338 PF00069 0.708
MOD_ProDKin_1 377 383 PF00069 0.797
MOD_ProDKin_1 403 409 PF00069 0.648
MOD_ProDKin_1 516 522 PF00069 0.715
MOD_ProDKin_1 60 66 PF00069 0.825
MOD_ProDKin_1 670 676 PF00069 0.638
MOD_SUMO_for_1 221 224 PF00179 0.746
MOD_SUMO_rev_2 157 166 PF00179 0.777
TRG_DiLeu_BaLyEn_6 447 452 PF01217 0.727
TRG_DiLeu_BaLyEn_6 464 469 PF01217 0.504
TRG_ENDOCYTIC_2 621 624 PF00928 0.768
TRG_ER_diArg_1 251 253 PF00400 0.739
TRG_ER_diArg_1 272 274 PF00400 0.725
TRG_ER_diArg_1 400 402 PF00400 0.809
TRG_ER_diArg_1 410 412 PF00400 0.724
TRG_Pf-PMV_PEXEL_1 227 231 PF00026 0.805
TRG_Pf-PMV_PEXEL_1 277 281 PF00026 0.733
TRG_Pf-PMV_PEXEL_1 374 379 PF00026 0.738
TRG_Pf-PMV_PEXEL_1 450 454 PF00026 0.715

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S5H5R7 Leishmania donovani 100% 100%
A4H4N1 Leishmania braziliensis 46% 100%
E9AKU5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 78% 99%
Q4QJ12 Leishmania major 86% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS