LeishMANIAdb
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Pyridoxal phosphate phosphatase PHOSPHO2

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Pyridoxal phosphate phosphatase PHOSPHO2
Gene product:
Putative Phosphatase/Protein of unknown function DUF89 - putative
Species:
Leishmania infantum
UniProt:
A4HSV3_LEIIN
TriTrypDb:
LINF_060011800
Length:
1010

Annotations

Annotations by Jardim et al.

Phosphatase, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 3
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HSV3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSV3

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0016787 hydrolase activity 2 12
GO:0016788 hydrolase activity, acting on ester bonds 3 12
GO:0016791 phosphatase activity 5 12
GO:0042578 phosphoric ester hydrolase activity 4 12
GO:0005488 binding 1 4
GO:0043167 ion binding 2 4
GO:0043169 cation binding 3 4
GO:0046872 metal ion binding 4 4
GO:0016829 lyase activity 2 1
GO:0016830 carbon-carbon lyase activity 3 1
GO:0016832 aldehyde-lyase activity 4 1
GO:0097023 fructose 6-phosphate aldolase activity 5 1
GO:0103026 fructose-1-phosphatase activity 6 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 111 115 PF00656 0.536
CLV_C14_Caspase3-7 840 844 PF00656 0.694
CLV_MEL_PAP_1 419 425 PF00089 0.667
CLV_MEL_PAP_1 995 1001 PF00089 0.435
CLV_NRD_NRD_1 200 202 PF00675 0.341
CLV_NRD_NRD_1 272 274 PF00675 0.339
CLV_NRD_NRD_1 34 36 PF00675 0.400
CLV_NRD_NRD_1 356 358 PF00675 0.576
CLV_NRD_NRD_1 39 41 PF00675 0.349
CLV_NRD_NRD_1 421 423 PF00675 0.600
CLV_NRD_NRD_1 539 541 PF00675 0.551
CLV_NRD_NRD_1 66 68 PF00675 0.352
CLV_NRD_NRD_1 780 782 PF00675 0.375
CLV_NRD_NRD_1 894 896 PF00675 0.287
CLV_NRD_NRD_1 919 921 PF00675 0.741
CLV_PCSK_KEX2_1 272 274 PF00082 0.339
CLV_PCSK_KEX2_1 34 36 PF00082 0.400
CLV_PCSK_KEX2_1 349 351 PF00082 0.569
CLV_PCSK_KEX2_1 356 358 PF00082 0.572
CLV_PCSK_KEX2_1 39 41 PF00082 0.349
CLV_PCSK_KEX2_1 421 423 PF00082 0.667
CLV_PCSK_KEX2_1 539 541 PF00082 0.548
CLV_PCSK_KEX2_1 780 782 PF00082 0.371
CLV_PCSK_KEX2_1 894 896 PF00082 0.287
CLV_PCSK_PC1ET2_1 349 351 PF00082 0.565
CLV_PCSK_PC7_1 35 41 PF00082 0.352
CLV_PCSK_SKI1_1 108 112 PF00082 0.462
CLV_PCSK_SKI1_1 314 318 PF00082 0.537
CLV_PCSK_SKI1_1 343 347 PF00082 0.449
CLV_PCSK_SKI1_1 40 44 PF00082 0.470
CLV_PCSK_SKI1_1 577 581 PF00082 0.434
CLV_PCSK_SKI1_1 617 621 PF00082 0.298
CLV_PCSK_SKI1_1 738 742 PF00082 0.368
CLV_PCSK_SKI1_1 780 784 PF00082 0.380
CLV_PCSK_SKI1_1 785 789 PF00082 0.358
CLV_PCSK_SKI1_1 801 805 PF00082 0.237
CLV_PCSK_SKI1_1 971 975 PF00082 0.371
CLV_Separin_Metazoa 378 382 PF03568 0.510
CLV_Separin_Metazoa 556 560 PF03568 0.543
DEG_APCC_DBOX_1 355 363 PF00400 0.489
DEG_APCC_DBOX_1 780 788 PF00400 0.589
DEG_Nend_UBRbox_1 1 4 PF02207 0.653
DOC_CKS1_1 939 944 PF01111 0.702
DOC_CYCLIN_yCln2_LP_2 993 999 PF00134 0.443
DOC_MAPK_gen_1 371 379 PF00069 0.588
DOC_MAPK_gen_1 429 436 PF00069 0.527
DOC_MAPK_gen_1 971 981 PF00069 0.398
DOC_MAPK_gen_1 986 995 PF00069 0.503
DOC_MAPK_RevD_3 524 540 PF00069 0.596
DOC_PP1_RVXF_1 202 208 PF00149 0.339
DOC_PP1_RVXF_1 736 742 PF00149 0.490
DOC_PP2B_LxvP_1 159 162 PF13499 0.509
DOC_PP2B_LxvP_1 434 437 PF13499 0.522
DOC_PP2B_LxvP_1 993 996 PF13499 0.465
DOC_PP4_MxPP_1 388 391 PF00568 0.463
DOC_USP7_MATH_1 125 129 PF00917 0.373
DOC_USP7_MATH_1 162 166 PF00917 0.658
DOC_USP7_MATH_1 179 183 PF00917 0.675
DOC_USP7_MATH_1 287 291 PF00917 0.487
DOC_USP7_MATH_1 406 410 PF00917 0.629
DOC_USP7_MATH_1 515 519 PF00917 0.554
DOC_USP7_MATH_1 70 74 PF00917 0.450
DOC_USP7_MATH_1 863 867 PF00917 0.798
DOC_USP7_MATH_1 966 970 PF00917 0.434
DOC_WW_Pin1_4 100 105 PF00397 0.588
DOC_WW_Pin1_4 421 426 PF00397 0.660
DOC_WW_Pin1_4 502 507 PF00397 0.626
DOC_WW_Pin1_4 751 756 PF00397 0.500
DOC_WW_Pin1_4 938 943 PF00397 0.643
LIG_14-3-3_CanoR_1 108 113 PF00244 0.623
LIG_14-3-3_CanoR_1 234 244 PF00244 0.384
LIG_14-3-3_CanoR_1 343 348 PF00244 0.433
LIG_14-3-3_CanoR_1 356 360 PF00244 0.585
LIG_14-3-3_CanoR_1 501 506 PF00244 0.666
LIG_14-3-3_CanoR_1 6 10 PF00244 0.406
LIG_14-3-3_CanoR_1 780 785 PF00244 0.528
LIG_14-3-3_CanoR_1 971 981 PF00244 0.425
LIG_Actin_WH2_1 904 922 PF00022 0.636
LIG_Actin_WH2_2 341 358 PF00022 0.399
LIG_Actin_WH2_2 51 69 PF00022 0.400
LIG_BRCT_BRCA1_1 770 774 PF00533 0.472
LIG_Clathr_ClatBox_1 10 14 PF01394 0.324
LIG_Clathr_ClatBox_1 130 134 PF01394 0.461
LIG_deltaCOP1_diTrp_1 899 907 PF00928 0.487
LIG_EH1_1 274 282 PF00400 0.384
LIG_FHA_1 22 28 PF00498 0.384
LIG_FHA_1 236 242 PF00498 0.385
LIG_FHA_1 480 486 PF00498 0.597
LIG_FHA_1 503 509 PF00498 0.562
LIG_FHA_1 695 701 PF00498 0.531
LIG_FHA_1 830 836 PF00498 0.409
LIG_FHA_1 845 851 PF00498 0.586
LIG_FHA_1 903 909 PF00498 0.596
LIG_FHA_1 960 966 PF00498 0.466
LIG_FHA_2 109 115 PF00498 0.569
LIG_FHA_2 16 22 PF00498 0.339
LIG_FHA_2 356 362 PF00498 0.486
LIG_FHA_2 752 758 PF00498 0.487
LIG_FHA_2 949 955 PF00498 0.573
LIG_IBAR_NPY_1 154 156 PF08397 0.484
LIG_LIR_Apic_2 809 815 PF02991 0.487
LIG_LIR_Gen_1 409 419 PF02991 0.642
LIG_LIR_Gen_1 482 491 PF02991 0.562
LIG_LIR_Gen_1 590 599 PF02991 0.605
LIG_LIR_Gen_1 8 15 PF02991 0.339
LIG_LIR_Gen_1 82 90 PF02991 0.450
LIG_LIR_Gen_1 924 934 PF02991 0.643
LIG_LIR_Gen_1 951 959 PF02991 0.420
LIG_LIR_LC3C_4 8 12 PF02991 0.297
LIG_LIR_Nem_3 1000 1006 PF02991 0.423
LIG_LIR_Nem_3 153 159 PF02991 0.393
LIG_LIR_Nem_3 255 259 PF02991 0.386
LIG_LIR_Nem_3 341 345 PF02991 0.458
LIG_LIR_Nem_3 409 414 PF02991 0.627
LIG_LIR_Nem_3 448 454 PF02991 0.402
LIG_LIR_Nem_3 482 486 PF02991 0.557
LIG_LIR_Nem_3 571 576 PF02991 0.590
LIG_LIR_Nem_3 590 594 PF02991 0.530
LIG_LIR_Nem_3 608 614 PF02991 0.369
LIG_LIR_Nem_3 8 12 PF02991 0.339
LIG_LIR_Nem_3 816 821 PF02991 0.519
LIG_LIR_Nem_3 82 87 PF02991 0.358
LIG_LIR_Nem_3 890 896 PF02991 0.514
LIG_LIR_Nem_3 924 929 PF02991 0.653
LIG_LIR_Nem_3 951 955 PF02991 0.429
LIG_NRBOX 683 689 PF00104 0.589
LIG_PCNA_PIPBox_1 80 89 PF02747 0.339
LIG_PDZ_Class_2 1005 1010 PF00595 0.381
LIG_Pex14_1 401 405 PF04695 0.392
LIG_Pex14_2 9 13 PF04695 0.329
LIG_PTB_Apo_2 151 158 PF02174 0.533
LIG_PTB_Apo_2 401 408 PF02174 0.540
LIG_PTB_Apo_2 490 497 PF02174 0.646
LIG_PTB_Apo_2 824 831 PF02174 0.528
LIG_PTB_Phospho_1 151 157 PF10480 0.530
LIG_PTB_Phospho_1 401 407 PF10480 0.537
LIG_SH2_CRK 256 260 PF00017 0.384
LIG_SH2_CRK 405 409 PF00017 0.468
LIG_SH2_CRK 411 415 PF00017 0.571
LIG_SH2_CRK 611 615 PF00017 0.488
LIG_SH2_CRK 893 897 PF00017 0.589
LIG_SH2_GRB2like 721 724 PF00017 0.541
LIG_SH2_NCK_1 411 415 PF00017 0.674
LIG_SH2_SRC 208 211 PF00017 0.389
LIG_SH2_SRC 405 408 PF00017 0.541
LIG_SH2_STAP1 157 161 PF00017 0.490
LIG_SH2_STAP1 554 558 PF00017 0.490
LIG_SH2_STAP1 769 773 PF00017 0.524
LIG_SH2_STAT3 721 724 PF00017 0.589
LIG_SH2_STAT5 256 259 PF00017 0.363
LIG_SH2_STAT5 407 410 PF00017 0.566
LIG_SH2_STAT5 450 453 PF00017 0.381
LIG_SH2_STAT5 683 686 PF00017 0.577
LIG_SH2_STAT5 721 724 PF00017 0.589
LIG_SH2_STAT5 749 752 PF00017 0.515
LIG_SH2_STAT5 769 772 PF00017 0.579
LIG_SH2_STAT5 829 832 PF00017 0.417
LIG_SH2_STAT5 86 89 PF00017 0.481
LIG_SH2_STAT5 94 97 PF00017 0.688
LIG_SH3_3 259 265 PF00018 0.438
LIG_SH3_3 387 393 PF00018 0.475
LIG_SH3_3 420 426 PF00018 0.564
LIG_SH3_3 506 512 PF00018 0.651
LIG_SH3_3 523 529 PF00018 0.619
LIG_SH3_3 555 561 PF00018 0.641
LIG_SH3_3 562 568 PF00018 0.634
LIG_SH3_3 75 81 PF00018 0.467
LIG_SH3_3 784 790 PF00018 0.556
LIG_SH3_3 832 838 PF00018 0.613
LIG_SH3_3 93 99 PF00018 0.661
LIG_SH3_3 976 982 PF00018 0.404
LIG_TRAF2_1 358 361 PF00917 0.604
LIG_TRAF2_1 468 471 PF00917 0.576
LIG_TRAF2_1 912 915 PF00917 0.650
LIG_TYR_ITIM 891 896 PF00017 0.589
LIG_UBA3_1 588 593 PF00899 0.468
LIG_WW_2 390 393 PF00397 0.507
LIG_WW_3 821 825 PF00397 0.554
MOD_CDK_SPK_2 751 756 PF00069 0.591
MOD_CK1_1 366 372 PF00069 0.536
MOD_CK1_1 628 634 PF00069 0.509
MOD_CK1_1 751 757 PF00069 0.493
MOD_CK1_1 768 774 PF00069 0.603
MOD_CK1_1 836 842 PF00069 0.681
MOD_CK1_1 969 975 PF00069 0.467
MOD_CK2_1 355 361 PF00069 0.521
MOD_CK2_1 528 534 PF00069 0.488
MOD_CK2_1 924 930 PF00069 0.622
MOD_CK2_1 948 954 PF00069 0.587
MOD_CMANNOS 618 621 PF00535 0.298
MOD_Cter_Amidation 32 35 PF01082 0.400
MOD_GlcNHglycan 166 169 PF01048 0.398
MOD_GlcNHglycan 365 368 PF01048 0.708
MOD_GlcNHglycan 517 520 PF01048 0.619
MOD_GlcNHglycan 561 564 PF01048 0.693
MOD_GlcNHglycan 835 838 PF01048 0.609
MOD_GlcNHglycan 839 842 PF01048 0.701
MOD_GlcNHglycan 850 853 PF01048 0.560
MOD_GlcNHglycan 865 868 PF01048 0.567
MOD_GlcNHglycan 881 884 PF01048 0.228
MOD_GlcNHglycan 926 929 PF01048 0.592
MOD_GlcNHglycan 956 959 PF01048 0.501
MOD_GlcNHglycan 999 1002 PF01048 0.462
MOD_GSK3_1 146 153 PF00069 0.417
MOD_GSK3_1 528 535 PF00069 0.538
MOD_GSK3_1 829 836 PF00069 0.444
MOD_GSK3_1 844 851 PF00069 0.592
MOD_N-GLC_1 363 368 PF02516 0.595
MOD_N-GLC_1 414 419 PF02516 0.688
MOD_N-GLC_1 694 699 PF02516 0.363
MOD_N-GLC_2 225 227 PF02516 0.339
MOD_NEK2_1 15 20 PF00069 0.338
MOD_NEK2_1 226 231 PF00069 0.371
MOD_NEK2_1 235 240 PF00069 0.378
MOD_NEK2_1 48 53 PF00069 0.375
MOD_NEK2_1 635 640 PF00069 0.522
MOD_NEK2_1 758 763 PF00069 0.589
MOD_NEK2_1 765 770 PF00069 0.589
MOD_NEK2_1 848 853 PF00069 0.713
MOD_NEK2_1 857 862 PF00069 0.690
MOD_NEK2_1 907 912 PF00069 0.473
MOD_NEK2_1 929 934 PF00069 0.563
MOD_NEK2_2 568 573 PF00069 0.588
MOD_NEK2_2 966 971 PF00069 0.387
MOD_PIKK_1 146 152 PF00454 0.424
MOD_PIKK_1 162 168 PF00454 0.519
MOD_PIKK_1 484 490 PF00454 0.653
MOD_PIKK_1 494 500 PF00454 0.593
MOD_PIKK_1 571 577 PF00454 0.531
MOD_PIKK_1 810 816 PF00454 0.522
MOD_PIKK_1 829 835 PF00454 0.358
MOD_PIKK_1 935 941 PF00454 0.612
MOD_PIKK_1 959 965 PF00454 0.455
MOD_PK_1 350 356 PF00069 0.595
MOD_PK_1 528 534 PF00069 0.560
MOD_PKA_1 780 786 PF00069 0.541
MOD_PKA_2 200 206 PF00069 0.388
MOD_PKA_2 355 361 PF00069 0.494
MOD_PKA_2 5 11 PF00069 0.410
MOD_PKA_2 500 506 PF00069 0.705
MOD_PKA_2 780 786 PF00069 0.631
MOD_PKA_2 997 1003 PF00069 0.411
MOD_Plk_1 15 21 PF00069 0.324
MOD_Plk_1 625 631 PF00069 0.505
MOD_Plk_1 758 764 PF00069 0.544
MOD_Plk_1 765 771 PF00069 0.556
MOD_Plk_1 929 935 PF00069 0.630
MOD_Plk_2-3 21 27 PF00069 0.336
MOD_Plk_2-3 72 78 PF00069 0.400
MOD_Plk_2-3 948 954 PF00069 0.556
MOD_Plk_4 15 21 PF00069 0.324
MOD_Plk_4 226 232 PF00069 0.428
MOD_Plk_4 237 243 PF00069 0.332
MOD_Plk_4 327 333 PF00069 0.522
MOD_Plk_4 343 349 PF00069 0.475
MOD_Plk_4 350 356 PF00069 0.595
MOD_Plk_4 5 11 PF00069 0.395
MOD_Plk_4 53 59 PF00069 0.363
MOD_Plk_4 532 538 PF00069 0.509
MOD_Plk_4 568 574 PF00069 0.684
MOD_Plk_4 625 631 PF00069 0.509
MOD_Plk_4 807 813 PF00069 0.546
MOD_Plk_4 929 935 PF00069 0.624
MOD_ProDKin_1 100 106 PF00069 0.580
MOD_ProDKin_1 421 427 PF00069 0.662
MOD_ProDKin_1 502 508 PF00069 0.626
MOD_ProDKin_1 751 757 PF00069 0.500
MOD_ProDKin_1 938 944 PF00069 0.648
MOD_SUMO_for_1 678 681 PF00179 0.481
MOD_SUMO_for_1 912 915 PF00179 0.597
MOD_SUMO_for_1 973 976 PF00179 0.384
MOD_SUMO_rev_2 72 81 PF00179 0.461
TRG_DiLeu_BaEn_4 914 920 PF01217 0.614
TRG_DiLeu_BaLyEn_6 231 236 PF01217 0.339
TRG_DiLeu_BaLyEn_6 683 688 PF01217 0.589
TRG_ENDOCYTIC_2 1003 1006 PF00928 0.418
TRG_ENDOCYTIC_2 156 159 PF00928 0.495
TRG_ENDOCYTIC_2 256 259 PF00928 0.384
TRG_ENDOCYTIC_2 405 408 PF00928 0.457
TRG_ENDOCYTIC_2 411 414 PF00928 0.566
TRG_ENDOCYTIC_2 452 455 PF00928 0.411
TRG_ENDOCYTIC_2 554 557 PF00928 0.480
TRG_ENDOCYTIC_2 576 579 PF00928 0.438
TRG_ENDOCYTIC_2 611 614 PF00928 0.489
TRG_ENDOCYTIC_2 818 821 PF00928 0.487
TRG_ENDOCYTIC_2 893 896 PF00928 0.589
TRG_ENDOCYTIC_2 926 929 PF00928 0.489
TRG_ER_diArg_1 263 266 PF00400 0.324
TRG_ER_diArg_1 355 357 PF00400 0.508
TRG_ER_diArg_1 39 41 PF00400 0.352
TRG_ER_diArg_1 421 423 PF00400 0.600
TRG_ER_diArg_1 538 540 PF00400 0.520
TRG_ER_diArg_1 780 782 PF00400 0.446
TRG_ER_diArg_1 893 895 PF00400 0.487
TRG_NES_CRM1_1 114 127 PF08389 0.428
TRG_NES_CRM1_1 312 322 PF08389 0.544
TRG_Pf-PMV_PEXEL_1 314 318 PF00026 0.476
TRG_Pf-PMV_PEXEL_1 357 361 PF00026 0.463
TRG_Pf-PMV_PEXEL_1 894 899 PF00026 0.287

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDC9 Leptomonas seymouri 67% 100%
A0A0S4J9G5 Bodo saltans 35% 100%
A0A1X0NKN4 Trypanosomatidae 41% 100%
A0A3R7MAF3 Trypanosoma rangeli 39% 100%
A0A3S5H5R3 Leishmania donovani 100% 100%
A4H4M8 Leishmania braziliensis 83% 100%
C9ZTG3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 100%
E9AKU1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4QJ16 Leishmania major 96% 100%
V5BT19 Trypanosoma cruzi 41% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS