Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

U-box domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4HSU3_LEIIN

TriTrypDb:

LINF_060010700

Length:

660

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HSU3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSU3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004842	ubiquitin-protein transferase activity	4	7
GO:0016740	transferase activity	2	7
GO:0019787	ubiquitin-like protein transferase activity	3	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	105	109	PF00656	0.751
CLV_C14_Caspase3-7	165	169	PF00656	0.625
CLV_C14_Caspase3-7	551	555	PF00656	0.739
CLV_NRD_NRD_1	237	239	PF00675	0.572
CLV_NRD_NRD_1	486	488	PF00675	0.499
CLV_NRD_NRD_1	494	496	PF00675	0.448
CLV_NRD_NRD_1	500	502	PF00675	0.504
CLV_NRD_NRD_1	66	68	PF00675	0.481
CLV_PCSK_FUR_1	64	68	PF00082	0.593
CLV_PCSK_KEX2_1	237	239	PF00082	0.572
CLV_PCSK_KEX2_1	485	487	PF00082	0.509
CLV_PCSK_KEX2_1	494	496	PF00082	0.425
CLV_PCSK_KEX2_1	500	502	PF00082	0.480
CLV_PCSK_KEX2_1	591	593	PF00082	0.346
CLV_PCSK_KEX2_1	64	66	PF00082	0.481
CLV_PCSK_PC1ET2_1	591	593	PF00082	0.346
CLV_PCSK_SKI1_1	189	193	PF00082	0.476
CLV_PCSK_SKI1_1	243	247	PF00082	0.499
CLV_PCSK_SKI1_1	283	287	PF00082	0.470
CLV_PCSK_SKI1_1	307	311	PF00082	0.499
CLV_PCSK_SKI1_1	315	319	PF00082	0.467
CLV_PCSK_SKI1_1	487	491	PF00082	0.461
CLV_PCSK_SKI1_1	501	505	PF00082	0.470
CLV_PCSK_SKI1_1	59	63	PF00082	0.577
DEG_Nend_UBRbox_3	1	3	PF02207	0.553
DEG_ODPH_VHL_1	39	51	PF01847	0.612
DEG_ODPH_VHL_1	458	471	PF01847	0.491
DEG_SCF_FBW7_1	98	105	PF00400	0.716
DEG_SPOP_SBC_1	103	107	PF00917	0.802
DEG_SPOP_SBC_1	445	449	PF00917	0.551
DEG_SPOP_SBC_1	557	561	PF00917	0.748
DOC_CKS1_1	564	569	PF01111	0.699
DOC_CYCLIN_yCln2_LP_2	359	365	PF00134	0.770
DOC_CYCLIN_yCln2_LP_2	505	511	PF00134	0.749
DOC_MAPK_gen_1	500	507	PF00069	0.674
DOC_MAPK_MEF2A_6	283	290	PF00069	0.629
DOC_MAPK_MEF2A_6	38	47	PF00069	0.411
DOC_MAPK_MEF2A_6	500	507	PF00069	0.701
DOC_MAPK_NFAT4_5	283	291	PF00069	0.627
DOC_MAPK_RevD_3	49	65	PF00069	0.773
DOC_PP1_RVXF_1	502	508	PF00149	0.703
DOC_PP1_RVXF_1	57	64	PF00149	0.779
DOC_PP1_RVXF_1	633	639	PF00149	0.530
DOC_PP2B_LxvP_1	509	512	PF13499	0.651
DOC_PP2B_LxvP_1	514	517	PF13499	0.626
DOC_PP4_FxxP_1	507	510	PF00568	0.754
DOC_USP7_MATH_1	103	107	PF00917	0.732
DOC_USP7_MATH_1	201	205	PF00917	0.683
DOC_USP7_MATH_1	266	270	PF00917	0.673
DOC_USP7_MATH_1	353	357	PF00917	0.705
DOC_USP7_MATH_1	445	449	PF00917	0.566
DOC_USP7_MATH_1	460	464	PF00917	0.365
DOC_USP7_MATH_1	74	78	PF00917	0.793
DOC_WW_Pin1_4	324	329	PF00397	0.800
DOC_WW_Pin1_4	334	339	PF00397	0.719
DOC_WW_Pin1_4	358	363	PF00397	0.767
DOC_WW_Pin1_4	521	526	PF00397	0.697
DOC_WW_Pin1_4	563	568	PF00397	0.775
DOC_WW_Pin1_4	569	574	PF00397	0.701
DOC_WW_Pin1_4	98	103	PF00397	0.711
LIG_14-3-3_CanoR_1	128	132	PF00244	0.703
LIG_14-3-3_CanoR_1	151	156	PF00244	0.721
LIG_14-3-3_CanoR_1	163	167	PF00244	0.661
LIG_14-3-3_CanoR_1	189	195	PF00244	0.662
LIG_14-3-3_CanoR_1	368	373	PF00244	0.749
LIG_14-3-3_CanoR_1	392	396	PF00244	0.340
LIG_14-3-3_CanoR_1	431	437	PF00244	0.511
LIG_14-3-3_CanoR_1	443	452	PF00244	0.561
LIG_APCC_ABBA_1	530	535	PF00400	0.694
LIG_BIR_III_2	570	574	PF00653	0.749
LIG_BRCT_BRCA1_1	203	207	PF00533	0.613
LIG_BRCT_BRCA1_1	286	290	PF00533	0.773
LIG_EVH1_1	507	511	PF00568	0.675
LIG_FHA_1	152	158	PF00498	0.667
LIG_FHA_1	2	8	PF00498	0.391
LIG_FHA_1	259	265	PF00498	0.673
LIG_FHA_1	342	348	PF00498	0.763
LIG_FHA_1	409	415	PF00498	0.473
LIG_FHA_1	431	437	PF00498	0.531
LIG_FHA_1	576	582	PF00498	0.642
LIG_FHA_1	619	625	PF00498	0.523
LIG_FHA_1	631	637	PF00498	0.526
LIG_FHA_2	279	285	PF00498	0.769
LIG_GBD_Chelix_1	43	51	PF00786	0.598
LIG_Integrin_isoDGR_2	178	180	PF01839	0.488
LIG_Integrin_isoDGR_2	429	431	PF01839	0.710
LIG_LIR_Apic_2	332	338	PF02991	0.776
LIG_LIR_Apic_2	394	399	PF02991	0.350
LIG_LIR_Gen_1	130	139	PF02991	0.738
LIG_LIR_Gen_1	150	158	PF02991	0.664
LIG_LIR_Gen_1	204	214	PF02991	0.660
LIG_LIR_Nem_3	130	134	PF02991	0.740
LIG_LIR_Nem_3	150	156	PF02991	0.679
LIG_LIR_Nem_3	204	210	PF02991	0.661
LIG_LIR_Nem_3	22	28	PF02991	0.326
LIG_LIR_Nem_3	240	245	PF02991	0.689
LIG_LIR_Nem_3	585	590	PF02991	0.549
LIG_PDZ_Class_1	655	660	PF00595	0.682
LIG_Pex14_1	131	135	PF04695	0.743
LIG_Pex14_1	30	34	PF04695	0.411
LIG_Pex14_2	194	198	PF04695	0.659
LIG_SH2_CRK	335	339	PF00017	0.823
LIG_SH2_NCK_1	651	655	PF00017	0.616
LIG_SH2_STAP1	123	127	PF00017	0.756
LIG_SH2_STAP1	452	456	PF00017	0.462
LIG_SH2_STAP1	651	655	PF00017	0.671
LIG_SH2_STAT5	155	158	PF00017	0.663
LIG_SH2_STAT5	213	216	PF00017	0.669
LIG_SH2_STAT5	377	380	PF00017	0.492
LIG_SH2_STAT5	470	473	PF00017	0.397
LIG_SH2_STAT5	651	654	PF00017	0.599
LIG_SH2_STAT5	78	81	PF00017	0.746
LIG_SH3_1	335	341	PF00018	0.819
LIG_SH3_2	510	515	PF14604	0.640
LIG_SH3_3	143	149	PF00018	0.685
LIG_SH3_3	335	341	PF00018	0.809
LIG_SH3_3	438	444	PF00018	0.528
LIG_SH3_3	454	460	PF00018	0.350
LIG_SH3_3	505	511	PF00018	0.685
LIG_SH3_3	561	567	PF00018	0.723
LIG_SUMO_SIM_anti_2	138	144	PF11976	0.713
LIG_SUMO_SIM_anti_2	411	418	PF11976	0.532
LIG_SUMO_SIM_par_1	140	147	PF11976	0.742
LIG_TRAF2_1	519	522	PF00917	0.627
LIG_TRAF2_1	611	614	PF00917	0.563
LIG_TRAF2_2	598	603	PF00917	0.546
LIG_TRFH_1	507	511	PF08558	0.742
LIG_UBA3_1	586	591	PF00899	0.546
LIG_WRC_WIRS_1	191	196	PF05994	0.655
MOD_CDK_SPK_2	363	368	PF00069	0.744
MOD_CDK_SPK_2	571	576	PF00069	0.732
MOD_CDK_SPxxK_3	569	576	PF00069	0.740
MOD_CK1_1	115	121	PF00069	0.750
MOD_CK1_1	144	150	PF00069	0.668
MOD_CK1_1	193	199	PF00069	0.662
MOD_CK1_1	220	226	PF00069	0.720
MOD_CK1_1	249	255	PF00069	0.713
MOD_CK1_1	299	305	PF00069	0.688
MOD_CK1_1	337	343	PF00069	0.766
MOD_CK1_1	357	363	PF00069	0.588
MOD_CK1_1	447	453	PF00069	0.603
MOD_CK1_1	81	87	PF00069	0.722
MOD_CK2_1	266	272	PF00069	0.714
MOD_CK2_1	278	284	PF00069	0.669
MOD_CK2_1	286	292	PF00069	0.588
MOD_CK2_1	324	330	PF00069	0.841
MOD_CK2_1	608	614	PF00069	0.602
MOD_Cter_Amidation	235	238	PF01082	0.586
MOD_GlcNHglycan	119	122	PF01048	0.574
MOD_GlcNHglycan	201	204	PF01048	0.534
MOD_GlcNHglycan	222	225	PF01048	0.525
MOD_GlcNHglycan	234	237	PF01048	0.522
MOD_GlcNHglycan	239	242	PF01048	0.429
MOD_GlcNHglycan	298	301	PF01048	0.562
MOD_GlcNHglycan	363	366	PF01048	0.556
MOD_GlcNHglycan	388	391	PF01048	0.411
MOD_GlcNHglycan	539	543	PF01048	0.476
MOD_GlcNHglycan	567	570	PF01048	0.591
MOD_GlcNHglycan	644	647	PF01048	0.444
MOD_GlcNHglycan	83	86	PF01048	0.546
MOD_GSK3_1	112	119	PF00069	0.723
MOD_GSK3_1	147	154	PF00069	0.684
MOD_GSK3_1	158	165	PF00069	0.573
MOD_GSK3_1	189	196	PF00069	0.660
MOD_GSK3_1	209	216	PF00069	0.504
MOD_GSK3_1	246	253	PF00069	0.728
MOD_GSK3_1	284	291	PF00069	0.777
MOD_GSK3_1	3	10	PF00069	0.509
MOD_GSK3_1	337	344	PF00069	0.754
MOD_GSK3_1	353	360	PF00069	0.619
MOD_GSK3_1	400	407	PF00069	0.521
MOD_GSK3_1	444	451	PF00069	0.592
MOD_GSK3_1	565	572	PF00069	0.712
MOD_GSK3_1	618	625	PF00069	0.483
MOD_GSK3_1	74	81	PF00069	0.762
MOD_GSK3_1	98	105	PF00069	0.716
MOD_N-GLC_1	630	635	PF02516	0.266
MOD_N-GLC_1	74	79	PF02516	0.526
MOD_NEK2_1	1	6	PF00069	0.498
MOD_NEK2_1	112	117	PF00069	0.734
MOD_NEK2_1	127	132	PF00069	0.716
MOD_NEK2_1	158	163	PF00069	0.634
MOD_NEK2_1	190	195	PF00069	0.660
MOD_NEK2_1	206	211	PF00069	0.663
MOD_NEK2_1	246	251	PF00069	0.750
MOD_NEK2_1	278	283	PF00069	0.800
MOD_NEK2_1	286	291	PF00069	0.677
MOD_NEK2_1	296	301	PF00069	0.550
MOD_NEK2_1	34	39	PF00069	0.400
MOD_NEK2_1	386	391	PF00069	0.372
MOD_NEK2_1	45	50	PF00069	0.704
MOD_NEK2_1	629	634	PF00069	0.530
MOD_NEK2_1	649	654	PF00069	0.680
MOD_NEK2_1	7	12	PF00069	0.477
MOD_NEK2_1	79	84	PF00069	0.787
MOD_PIKK_1	158	164	PF00454	0.657
MOD_PIKK_1	368	374	PF00454	0.816
MOD_PKA_1	237	243	PF00069	0.738
MOD_PKA_2	127	133	PF00069	0.697
MOD_PKA_2	162	168	PF00069	0.682
MOD_PKA_2	237	243	PF00069	0.701
MOD_PKA_2	391	397	PF00069	0.342
MOD_PKA_2	430	436	PF00069	0.501
MOD_PKA_2	575	581	PF00069	0.660
MOD_PKA_2	608	614	PF00069	0.537
MOD_Plk_1	354	360	PF00069	0.736
MOD_Plk_1	629	635	PF00069	0.530
MOD_Plk_1	74	80	PF00069	0.745
MOD_Plk_2-3	603	609	PF00069	0.546
MOD_Plk_4	141	147	PF00069	0.703
MOD_Plk_4	194	200	PF00069	0.667
MOD_Plk_4	201	207	PF00069	0.667
MOD_Plk_4	209	215	PF00069	0.679
MOD_Plk_4	258	264	PF00069	0.670
MOD_Plk_4	29	35	PF00069	0.389
MOD_Plk_4	3	9	PF00069	0.441
MOD_Plk_4	354	360	PF00069	0.763
MOD_Plk_4	39	45	PF00069	0.389
MOD_Plk_4	558	564	PF00069	0.668
MOD_Plk_4	74	80	PF00069	0.798
MOD_ProDKin_1	324	330	PF00069	0.801
MOD_ProDKin_1	334	340	PF00069	0.718
MOD_ProDKin_1	358	364	PF00069	0.767
MOD_ProDKin_1	521	527	PF00069	0.696
MOD_ProDKin_1	563	569	PF00069	0.774
MOD_ProDKin_1	571	577	PF00069	0.654
MOD_ProDKin_1	98	104	PF00069	0.714
TRG_DiLeu_BaEn_1	526	531	PF01217	0.612
TRG_DiLeu_BaLyEn_6	494	499	PF01217	0.751
TRG_DiLeu_BaLyEn_6	56	61	PF01217	0.777
TRG_ENDOCYTIC_2	155	158	PF00928	0.663
TRG_ER_diArg_1	349	352	PF00400	0.670
TRG_ER_diArg_1	484	487	PF00400	0.703
TRG_ER_diArg_1	494	496	PF00400	0.585
TRG_ER_diArg_1	499	501	PF00400	0.676
TRG_ER_diArg_1	63	66	PF00400	0.679
TRG_ER_diArg_1	638	641	PF00400	0.563
TRG_ER_FFAT_2	398	407	PF00635	0.422
TRG_NES_CRM1_1	308	321	PF08389	0.697
TRG_Pf-PMV_PEXEL_1	592	597	PF00026	0.346

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIV8	Leptomonas seymouri	50%	100%
A0A3S5H5Q9	Leishmania donovani	99%	100%
A4H4L7	Leishmania braziliensis	78%	100%
E9AKT0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QJ27	Leishmania major	93%	100%